TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
Vanderbilt University
Curated by ChEMBL
Vanderbilt University
Curated by ChEMBL
Affinity DataKi: 2.70E+3nMAssay Description:Displacement of [3H]NMS from human muscarinic M5 receptorMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Vanderbilt University School Of Medicine
Curated by ChEMBL
Vanderbilt University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Inhibition of mouse COX-2 assessed as inhibition of [14C]arachidonic acid to radiolabeled prostaglandins preincubated for 15 mins by TLC-based assayMore data for this Ligand-Target Pair
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Northwest Agriculture & Forestry University
Curated by ChEMBL
Northwest Agriculture & Forestry University
Curated by ChEMBL
Affinity DataIC50: 66nMAssay Description:Antagonist activity at PAR4 in PAR-4-AP-stimulated human platelets compound pretreated for 5 mins by fluorescent PAC1 integrin alpha2bb3 activation a...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Vanderbilt University School Of Medicine
Curated by ChEMBL
Vanderbilt University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:Inhibition of ovine COX-1 assessed as inhibition of [14C]arachidonic acid to radiolabeled prostaglandins preincubated for 15 mins by TLC-based assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Vanderbilt University School Of Medicine
Curated by ChEMBL
Vanderbilt University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Inhibition of ovine COX-1 assessed as inhibition of [14C]arachidonic acid to radiolabeled prostaglandins preincubated for 15 mins by TLC-based assayMore data for this Ligand-Target Pair
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Northwest Agriculture & Forestry University
Curated by ChEMBL
Northwest Agriculture & Forestry University
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Antagonist activity at PAR4 in PAR-4-AP-stimulated human platelets compound pretreated for 5 mins by fluorescent PAC1 integrin alpha2bb3 activation a...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Northwest Agriculture & Forestry University
Curated by ChEMBL
Northwest Agriculture & Forestry University
Curated by ChEMBL
Affinity DataIC50: 140nMAssay Description:Antagonist activity at PAR4 in PAR-4-AP-stimulated human platelets compound pretreated for 5 mins by fluorescent PAC1 integrin alpha2bb3 activation a...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Vanderbilt University School Of Medicine
Curated by ChEMBL
Vanderbilt University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 180nMAssay Description:Inhibition of COX-1 in human OVCAR3 cells by cell-based assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
Vanderbilt University
Curated by ChEMBL
Vanderbilt University
Curated by ChEMBL
Affinity DataIC50: 246nMAssay Description:Antagonist activity at human muscarinic M5 receptor assessed as inhibition of acetylcholine-induced calcium responseMore data for this Ligand-Target Pair
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Northwest Agriculture & Forestry University
Curated by ChEMBL
Northwest Agriculture & Forestry University
Curated by ChEMBL
Affinity DataIC50: 279nMAssay Description:Antagonist activity at PAR4 in PAR-4-AP-stimulated human platelets compound pretreated for 5 mins by fluorescent PAC1 integrin alpha2bb3 activation a...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
Vanderbilt University
Curated by ChEMBL
Vanderbilt University
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Antagonist activity at human muscarinic M5 receptor assessed as inhibition of acetylcholine-induced calcium responseMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Vanderbilt University School Of Medicine
Curated by ChEMBL
Vanderbilt University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Inhibition of ovine COX-1 assessed as inhibition of [14C]arachidonic acid to radiolabeled prostaglandins preincubated for 15 mins by TLC-based assayMore data for this Ligand-Target Pair
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Northwest Agriculture & Forestry University
Curated by ChEMBL
Northwest Agriculture & Forestry University
Curated by ChEMBL
Affinity DataIC50: 336nMAssay Description:Antagonist activity at PAR4 in PAR-4-AP-stimulated human platelets compound pretreated for 5 mins by fluorescent PAC1 integrin alpha2bb3 activation a...More data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Vanderbilt University Medical Center
Curated by ChEMBL
Vanderbilt University Medical Center
Curated by ChEMBL
Affinity DataIC50: 340nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Vanderbilt University School Of Medicine
Curated by ChEMBL
Vanderbilt University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 360nMAssay Description:Inhibition of ovine COX-1 assessed as inhibition of [14C]arachidonic acid to radiolabeled prostaglandins preincubated for 15 mins by TLC-based assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Vanderbilt University School Of Medicine
Curated by ChEMBL
Vanderbilt University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 360nMAssay Description:Inhibition of COX-1 in human OVCAR3 cells by cell-based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 410nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 15 mins followed by NADPH addition measured after 8 min...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Vanderbilt University School Of Medicine
Curated by ChEMBL
Vanderbilt University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 450nMAssay Description:Inhibition of mouse COX-2 assessed as inhibition of [14C]arachidonic acid to radiolabeled prostaglandins preincubated for 15 mins by TLC-based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 470nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 15 mins followed by NADPH addition measured after 8 min...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Vanderbilt University School Of Medicine
Curated by ChEMBL
Vanderbilt University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 470nMAssay Description:Inhibition of ovine COX-1 assessed as inhibition of [14C]arachidonic acid to radiolabeled prostaglandins preincubated for 15 mins by TLC-based assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Vanderbilt University School Of Medicine
Curated by ChEMBL
Vanderbilt University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 480nMAssay Description:Inhibition of ovine COX-1 assessed as inhibition of [14C]arachidonic acid to radiolabeled prostaglandins preincubated for 15 mins by TLC-based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 603nMAssay Description:Antagonist activity at human GLP-1R expressed in TREx293 cells co-expressing cAMP sensitive luciferase assessed as inhibition of GLP1 (7 to 36 residu...More data for this Ligand-Target Pair
Affinity DataIC50: 610nMAssay Description:Antagonist activity at human GLP-1R expressed in TREx293 cells co-expressing cAMP sensitive luciferase assessed as inhibition of GLP1 (7 to 36 residu...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Northwest Agriculture & Forestry University
Curated by ChEMBL
Northwest Agriculture & Forestry University
Curated by ChEMBL
Affinity DataIC50: 646nMAssay Description:Antagonist activity at PAR4 in PAR-4-AP-stimulated human platelets compound pretreated for 5 mins by fluorescent PAC1 integrin alpha2bb3 activation a...More data for this Ligand-Target Pair
Affinity DataIC50: 646nMAssay Description:Antagonist activity at human GLP-1R expressed in TREx293 cells co-expressing cAMP sensitive luciferase assessed as inhibition of GLP1 (7 to 36 residu...More data for this Ligand-Target Pair
Affinity DataIC50: 650nMAssay Description:Antagonist activity at human GLP-1R expressed in TREx293 cells co-expressing cAMP sensitive luciferase assessed as inhibition of GLP1 (7 to 36 residu...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
Vanderbilt University
Curated by ChEMBL
Vanderbilt University
Curated by ChEMBL
Affinity DataIC50: 660nMAssay Description:Antagonist activity at human muscarinic M5 receptor assessed as inhibition of acetylcholine-induced calcium responseMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
Vanderbilt University
Curated by ChEMBL
Vanderbilt University
Curated by ChEMBL
Affinity DataIC50: 661nMAssay Description:Antagonist activity at human muscarinic M5 receptor assessed as inhibition of acetylcholine-induced calcium responseMore data for this Ligand-Target Pair
Affinity DataIC50: 690nMAssay Description:Antagonist activity at human GLP-1R expressed in TREx293 cells co-expressing cAMP sensitive luciferase assessed as inhibition of exendin-4-induced cA...More data for this Ligand-Target Pair
Affinity DataIC50: 690nMAssay Description:Antagonist activity at human GLP-1R expressed in TREx293 cells co-expressing cAMP sensitive luciferase assessed as inhibition of exendin-4-induced cA...More data for this Ligand-Target Pair
Affinity DataIC50: 692nMAssay Description:Antagonist activity at human GLP-1R expressed in TREx293 cells co-expressing cAMP sensitive luciferase assessed as inhibition of exendin-4-induced cA...More data for this Ligand-Target Pair
Affinity DataIC50: 692nMAssay Description:Antagonist activity at human GLP-1R expressed in TREx293 cells co-expressing cAMP sensitive luciferase assessed as inhibition of exendin-4-induced cA...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Vanderbilt University School Of Medicine
Curated by ChEMBL
Vanderbilt University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 780nMAssay Description:Inhibition of COX-1 in human OVCAR3 cells by cell-based assayMore data for this Ligand-Target Pair
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Northwest Agriculture & Forestry University
Curated by ChEMBL
Northwest Agriculture & Forestry University
Curated by ChEMBL
Affinity DataIC50: 785nMAssay Description:Antagonist activity at PAR4 in PAR-4-AP-stimulated human platelets compound pretreated for 5 mins by fluorescent PAC1 integrin alpha2bb3 activation a...More data for this Ligand-Target Pair
TargetCytochrome P450 1A2(Homo sapiens (Human))
Vanderbilt University Medical Center
Curated by ChEMBL
Vanderbilt University Medical Center
Curated by ChEMBL
Affinity DataIC50: 790nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Northwest Agriculture & Forestry University
Curated by ChEMBL
Northwest Agriculture & Forestry University
Curated by ChEMBL
Affinity DataIC50: 793nMAssay Description:Antagonist activity at PAR4 in PAR-4-AP-stimulated human platelets compound pretreated for 5 mins by fluorescent PAC1 integrin alpha2bb3 activation a...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Vanderbilt University
Curated by ChEMBL
Vanderbilt University
Curated by ChEMBL
Affinity DataIC50: 930nMAssay Description:Antagonist activity at human muscarinic M2 receptor assessed as inhibition of acetylcholine-induced calcium responseMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Vanderbilt University School Of Medicine
Curated by ChEMBL
Vanderbilt University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 950nMAssay Description:Inhibition of ovine COX-1 assessed as inhibition of [14C]arachidonic acid to radiolabeled prostaglandins preincubated for 15 mins by TLC-based assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Vanderbilt University School Of Medicine
Curated by ChEMBL
Vanderbilt University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of ovine COX-1 assessed as inhibition of [14C]arachidonic acid to radiolabeled prostaglandins preincubated for 15 mins by TLC-based assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Vanderbilt University School Of Medicine
Curated by ChEMBL
Vanderbilt University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of ovine COX-1 assessed as inhibition of [14C]arachidonic acid to radiolabeled prostaglandins preincubated for 15 mins by TLC-based assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
Vanderbilt University
Curated by ChEMBL
Vanderbilt University
Curated by ChEMBL
Affinity DataIC50: 1.05E+3nMAssay Description:Negative allosteric modulation of human M5 receptor expressed in CHO cells assessed as inhibition of acetyl choline-induced calcium mobilization prei...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
Vanderbilt University
Curated by ChEMBL
Vanderbilt University
Curated by ChEMBL
Affinity DataIC50: 1.11E+3nMAssay Description:Negative allosteric modulation of human M5 receptor expressed in CHO cells assessed as inhibition of acetyl choline-induced calcium mobilization prei...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
Vanderbilt University
Curated by ChEMBL
Vanderbilt University
Curated by ChEMBL
Affinity DataIC50: 1.18E+3nMAssay Description:Negative allosteric modulation of human M5 receptor expressed in CHO cells assessed as inhibition of acetyl choline-induced calcium mobilization prei...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
Vanderbilt University
Curated by ChEMBL
Vanderbilt University
Curated by ChEMBL
Affinity DataIC50: 1.20E+3nMAssay Description:Negative allosteric modulation of human M5 receptor expressed in CHO cells assessed as inhibition of acetyl choline-induced calcium mobilization prei...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
Vanderbilt University
Curated by ChEMBL
Vanderbilt University
Curated by ChEMBL
Affinity DataIC50: 1.29E+3nMAssay Description:Negative allosteric modulation of human M5 receptor expressed in CHO cells assessed as inhibition of acetyl choline-induced calcium mobilization prei...More data for this Ligand-Target Pair
Affinity DataIC50: 1.29E+3nMAssay Description:Antagonist activity at human GLP-1R expressed in TREx293 cells co-expressing cAMP sensitive luciferase assessed as inhibition of GLP1 (7 to 36 residu...More data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:Antagonist activity at human GLP-1R expressed in TREx293 cells co-expressing cAMP sensitive luciferase assessed as inhibition of GLP1 (7 to 36 residu...More data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
Vanderbilt University Medical Center
Curated by ChEMBL
Vanderbilt University Medical Center
Curated by ChEMBL
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
Vanderbilt University
Curated by ChEMBL
Vanderbilt University
Curated by ChEMBL
Affinity DataIC50: 1.32E+3nMAssay Description:Negative allosteric modulation of human M5 receptor expressed in CHO cells assessed as inhibition of acetyl choline-induced calcium mobilization prei...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
Vanderbilt University
Curated by ChEMBL
Vanderbilt University
Curated by ChEMBL
Affinity DataIC50: 1.45E+3nMAssay Description:Negative allosteric modulation of human M5 receptor expressed in CHO cells assessed as inhibition of acetyl choline-induced calcium mobilization prei...More data for this Ligand-Target Pair