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Found 913 with Last Name = 'orbe' and Initial = 'j'
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ironwood Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50440220(CHEMBL2426624)
Affinity DataKi:  0.480nMAssay Description:Binding affinity to glucocorticoid receptor (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ironwood Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50440220(CHEMBL2426624)
Affinity DataKi:  0.480nMAssay Description:Binding affinity to glucocorticoid receptor (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Aventis Pharmaceuticals

LigandPNGBDBM84440(Isoindoline, 7 | Isoindoline, 8 | Isoindoline, 9)
Affinity DataKi:  0.5nMAssay Description:Dopamine D4.2 and D2S receptor binding was performed at NPS Allexlix Corp.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Aventis Pharmaceuticals

LigandPNGBDBM84445(Isoindoline, 12)
Affinity DataKi:  0.5nMAssay Description:Dopamine D4.2 and D2S receptor binding was performed at NPS Allexlix Corp.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Aventis Pharmaceuticals

LigandPNGBDBM84451(Isoindoline, 18 | Isoindoline, 19)
Affinity DataKi:  0.600nMAssay Description:Dopamine D4.2 and D2S receptor binding was performed at NPS Allexlix Corp.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ironwood Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50440216(CHEMBL2426648)
Affinity DataKi:  0.900nMAssay Description:Binding affinity to glucocorticoid receptor (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Aventis Pharmaceuticals

LigandPNGBDBM84440(Isoindoline, 7 | Isoindoline, 8 | Isoindoline, 9)
Affinity DataKi:  1nMAssay Description:Dopamine D4.2 and D2S receptor binding was performed at NPS Allexlix Corp.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ironwood Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50440230(CHEMBL2426639)
Affinity DataKi:  1.10nMAssay Description:Binding affinity to glucocorticoid receptor (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ironwood Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50348410(CHEMBL1801004)
Affinity DataKi:  1.10nMAssay Description:Binding affinity to glucocorticoid receptor (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ironwood Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18207((1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dih...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity to glucocorticoid receptor (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetD(4) dopamine receptor(Homo sapiens (Human))
Aventis Pharmaceuticals

LigandPNGBDBM84446(Isoindoline, 13)
Affinity DataKi:  1.20nMAssay Description:Dopamine D4.2 and D2S receptor binding was performed at NPS Allexlix Corp.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Aventis Pharmaceuticals

LigandPNGBDBM84443(Isoindoline, 10 | Isoindoline, 11)
Affinity DataKi:  1.20nMAssay Description:Dopamine D4.2 and D2S receptor binding was performed at NPS Allexlix Corp.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Aventis Pharmaceuticals

LigandPNGBDBM84453(Isoindoline, 20)
Affinity DataKi:  1.40nMAssay Description:Dopamine D4.2 and D2S receptor binding was performed at NPS Allexlix Corp.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ironwood Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50440233(CHEMBL2426636)
Affinity DataKi:  1.70nMAssay Description:Binding affinity to glucocorticoid receptor (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ironwood Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50440214(CHEMBL2426650)
Affinity DataKi:  1.90nMAssay Description:Binding affinity to glucocorticoid receptor (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ironwood Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50440220(CHEMBL2426624)
Affinity DataKi:  2.40nMAssay Description:Binding affinity to glucocorticoid receptor (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ironwood Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50440220(CHEMBL2426624)
Affinity DataKi:  2.40nMAssay Description:Binding affinity to glucocorticoid receptor (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ironwood Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50440232(CHEMBL2426637)
Affinity DataKi:  2.40nMAssay Description:Binding affinity to glucocorticoid receptor (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ironwood Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50440246(CHEMBL2426658)
Affinity DataKi:  2.70nMAssay Description:Binding affinity to glucocorticoid receptor (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Aventis Pharmaceuticals

LigandPNGBDBM84459(Isoindoline, 26)
Affinity DataKi:  3.60nMAssay Description:Dopamine D4.2 and D2S receptor binding was performed at NPS Allexlix Corp.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Aventis Pharmaceuticals

LigandPNGBDBM84449(Isoindoline, 16)
Affinity DataKi:  3.70nMAssay Description:Dopamine D4.2 and D2S receptor binding was performed at NPS Allexlix Corp.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ironwood Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50440215(CHEMBL2426649)
Affinity DataKi:  4nMAssay Description:Binding affinity to glucocorticoid receptor (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Rattus norvegicus (rat))
Aventis Pharmaceuticals

LigandPNGBDBM84456(Isoindoline, 23)
Affinity DataKi:  4.10nMAssay Description:All rat alpha-1 adrenoceptor binding was performed by Hugo M. vargas, Karen M. Brooks and Lynn Laws-Ricker.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Aventis Pharmaceuticals

LigandPNGBDBM84448(Isoindoline, 15)
Affinity DataKi:  4.5nMAssay Description:Dopamine D4.2 and D2S receptor binding was performed at NPS Allexlix Corp.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ironwood Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50440244(CHEMBL2426660)
Affinity DataKi:  5nMAssay Description:Binding affinity to glucocorticoid receptor (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ironwood Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50440243(CHEMBL2426662)
Affinity DataKi:  5.10nMAssay Description:Binding affinity to glucocorticoid receptor (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Aventis Pharmaceuticals

LigandPNGBDBM84456(Isoindoline, 23)
Affinity DataKi:  5.30nMAssay Description:Dopamine D4.2 and D2S receptor binding was performed at NPS Allexlix Corp.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ironwood Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50440209(CHEMBL2426656)
Affinity DataKi:  5.70nMAssay Description:Binding affinity to glucocorticoid receptor (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ironwood Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50440219(CHEMBL2426665)
Affinity DataKi:  6nMAssay Description:Binding affinity to glucocorticoid receptor (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ironwood Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50440242(CHEMBL2426663)
Affinity DataKi:  6.70nMAssay Description:Binding affinity to glucocorticoid receptor (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Laboratorios Del Dr. Esteve

US Patent
LigandPNGBDBM287137(1-(1-(2-(azepan- 1-yl)ethyl)-1H- pyrazolo[3,4- d]p...)
Affinity DataKi:  6.70nMpH: 7.4Assay Description:Brain membrane preparation and binding assays for the σ1-receptor were performed as described (DeHaven-Hudkins, D. L., L. C. Fleissner, and F. Y...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ironwood Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50440212(CHEMBL2426653)
Affinity DataKi:  7.20nMAssay Description:Binding affinity to glucocorticoid receptor (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ironwood Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50440231(CHEMBL2426638)
Affinity DataKi:  7.5nMAssay Description:Binding affinity to glucocorticoid receptor (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ironwood Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50440218(CHEMBL2426644)
Affinity DataKi:  7.90nMAssay Description:Binding affinity to glucocorticoid receptor (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ironwood Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50440240(CHEMBL2426647)
Affinity DataKi:  8.10nMAssay Description:Binding affinity to glucocorticoid receptor (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ironwood Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50440213(CHEMBL2426652)
Affinity DataKi:  8.80nMAssay Description:Binding affinity to glucocorticoid receptor (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Laboratorios Del Dr. Esteve

US Patent
LigandPNGBDBM287138(1-(1-(2-(azepan- 1-yl)ethyl)-1H- pyrazolo[3,4- d]p...)
Affinity DataKi:  9.20nMpH: 7.4Assay Description:Brain membrane preparation and binding assays for the σ1-receptor were performed as described (DeHaven-Hudkins, D. L., L. C. Fleissner, and F. Y...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Laboratorios Del Dr. Esteve

US Patent
LigandPNGBDBM287087(N-(1-(2-(azepan-1-yl)ethyl)-1H-pyrazolo[3,4-d]pyri...)
Affinity DataKi:  9.20nMpH: 7.4Assay Description:Brain membrane preparation and binding assays for the σ1-receptor were performed as described (DeHaven-Hudkins, D. L., L. C. Fleissner, and F. Y...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Laboratorios Del Dr. Esteve

US Patent
LigandPNGBDBM287101(N-(1-(2-(Azepan-1- yl)ethyl)-1H-pyrazolo[3,4- d]py...)
Affinity DataKi:  9.40nMpH: 7.4Assay Description:Brain membrane preparation and binding assays for the σ1-receptor were performed as described (DeHaven-Hudkins, D. L., L. C. Fleissner, and F. Y...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ironwood Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50440234(CHEMBL2426635)
Affinity DataKi:  9.80nMAssay Description:Binding affinity to glucocorticoid receptor (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ironwood Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50440211(CHEMBL2426654)
Affinity DataKi:  10nMAssay Description:Binding affinity to glucocorticoid receptor (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ironwood Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50440223(CHEMBL2426627)
Affinity DataKi:  11nMAssay Description:Binding affinity to glucocorticoid receptor (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ironwood Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50440225(CHEMBL2426625)
Affinity DataKi:  11nMAssay Description:Binding affinity to glucocorticoid receptor (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ironwood Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50440226(CHEMBL2426643)
Affinity DataKi:  11nMAssay Description:Binding affinity to glucocorticoid receptor (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222985(3,6-diethyl-N-((1R,2S)-2-(2-fluoroethoxy)-2,3-dihy...)
Affinity DataKi:  11nMAssay Description:Displacement of [125I]Tyr-o-CRF from CRF1 receptor in IMR32 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Laboratorios Del Dr. Esteve

US Patent
LigandPNGBDBM287111(N-(1-(2-(azepan-1- yl)ethyl)-1H-pyrazolo[3,4- d]py...)
Affinity DataKi:  11.1nMpH: 7.4Assay Description:Brain membrane preparation and binding assays for the σ1-receptor were performed as described (DeHaven-Hudkins, D. L., L. C. Fleissner, and F. Y...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-1B adrenergic receptor(Rattus norvegicus (rat))
Aventis Pharmaceuticals

LigandPNGBDBM84446(Isoindoline, 13)
Affinity DataKi:  11.9nMAssay Description:All rat alpha-1 adrenoceptor binding was performed by Hugo M. vargas, Karen M. Brooks and Lynn Laws-Ricker.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ironwood Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50440227(CHEMBL2426642)
Affinity DataKi:  12nMAssay Description:Binding affinity to glucocorticoid receptor (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ironwood Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50440207(CHEMBL2426633)
Affinity DataKi:  12nMAssay Description:Binding affinity to glucocorticoid receptor (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Laboratorios Del Dr. Esteve

US Patent
LigandPNGBDBM287140(N-(1-(2-(4-tert- butylpiperidin-1-yl)ethyl)- 1H-py...)
Affinity DataKi:  12.2nMpH: 7.4Assay Description:Brain membrane preparation and binding assays for the σ1-receptor were performed as described (DeHaven-Hudkins, D. L., L. C. Fleissner, and F. Y...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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