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Found 94 with Last Name = 'orro' and Initial = 'a'
TargetBeta-galactosidase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50235812(CHEMBL4085739)
Affinity DataIC50:  8nMAssay Description:Inhibitory concentration against cyclin dependent kinase-2 (CDK2)/Cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50236734(CHEMBL4071886)
Affinity DataIC50:  44nMAssay Description:Inhibition of wild type human recombinant LRRK2 expressed in baculovirus using fluorescein-ERM as substrate preincubated for 30 mins followed by subs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-hexosaminidase subunit alpha(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50235813(CHEMBL4097052)
Affinity DataIC50:  100nMAssay Description:Inhibitory concentration against cyclin dependent kinase-2 (CDK2)/Cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-galactosidase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50235812(CHEMBL4085739)
Affinity DataIC50:  180nMAssay Description:Inhibitory concentration against cyclin dependent kinase-2 (CDK2)/Cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-galactosidase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50350758(CHEMBL1818433)
Affinity DataIC50:  240nMAssay Description:Inhibitory concentration against cyclin dependent kinase-2 (CDK2)/Cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50236735(CHEMBL4060479)
Affinity DataIC50:  728nMAssay Description:Inhibition of wild type human recombinant LRRK2 expressed in baculovirus using fluorescein-ERM as substrate preincubated for 30 mins followed by subs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-galactosidase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50350758(CHEMBL1818433)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibitory concentration against cyclin dependent kinase-2 (CDK2)/Cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-galactosidase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50235815(CHEMBL4099495)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibitory concentration against cyclin dependent kinase-2 (CDK2)/Cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM257207(US9493440, 51)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM257207(US9493440, 51)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM257207(US9493440, 51)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCviR transcriptional regulator(Chromobacterium violaceum)
Instituto Polit£Cnico Nacional (Ipn)

Curated by ChEMBL
LigandPNGBDBM50136221(CHEMBL3754734)
Affinity DataIC50:  6.61E+4nMAssay Description:Inhibition of CviR in Chromobacterium violaceum CV026 assessed as reduction of violacein production after 15 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCviR transcriptional regulator(Chromobacterium violaceum)
Instituto Polit£Cnico Nacional (Ipn)

Curated by ChEMBL
LigandPNGBDBM50136219(CHEMBL3753564)
Affinity DataIC50:  9.09E+4nMAssay Description:Inhibition of CviR in Chromobacterium violaceum CV026 assessed as reduction of violacein production after 15 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCviR transcriptional regulator(Chromobacterium violaceum)
Instituto Polit£Cnico Nacional (Ipn)

Curated by ChEMBL
LigandPNGBDBM50136296(CHEMBL3754531)
Affinity DataIC50:  9.74E+4nMAssay Description:Inhibition of CviR in Chromobacterium violaceum CV026 assessed as reduction of violacein production after 15 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-galactosidase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50235814(CHEMBL4081472)
Affinity DataIC50: >1.50E+5nMAssay Description:Inhibitory concentration against cyclin dependent kinase-2 (CDK2)/Cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-hexosaminidase subunit alpha(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50235812(CHEMBL4085739)
Affinity DataIC50: >1.60E+5nMAssay Description:Inhibitory concentration against cyclin dependent kinase-2 (CDK2)/Cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCviR transcriptional regulator(Chromobacterium violaceum)
Instituto Polit£Cnico Nacional (Ipn)

Curated by ChEMBL
LigandPNGBDBM50136220(CHEMBL3752577)
Affinity DataIC50:  3.41E+5nMAssay Description:Inhibition of CviR in Chromobacterium violaceum CV026 assessed as reduction of violacein production after 15 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCviR transcriptional regulator(Chromobacterium violaceum)
Instituto Polit£Cnico Nacional (Ipn)

Curated by ChEMBL
LigandPNGBDBM50136222(CHEMBL3754036)
Affinity DataIC50:  6.70E+5nMAssay Description:Inhibition of CviR in Chromobacterium violaceum CV026 assessed as reduction of violacein production after 15 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50094009(CHEMBL136800 | CX-516 | Piperidin-1-yl-quinoxalin-...)
Affinity DataEC50:  1.56E+5nMAssay Description:Inhibition of GluR4 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50094009(CHEMBL136800 | CX-516 | Piperidin-1-yl-quinoxalin-...)
Affinity DataEC50: >1.00E+6nMAssay Description:Inhibition of GluR4 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50330411(1,2,3,7,8,11a-Hexahydro-6,9,11-trioxa-3a-aza-cyclo...)
Affinity DataEC50:  2.10E+4nMAssay Description:Inhibition of GluR1 expressed in HEK cellsMore data for this Ligand-Target Pair
TargetGlutamate receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50094008(CHEMBL337047 | N-[2-(2'-Fluoro-biphenyl-4-yl)-prop...)
Affinity DataEC50:  1.96E+4nMAssay Description:Inhibition of GluR4 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50330413((R)-N-(2-phenylpropyl)methanesulfonamide | CHEMBL1...)
Affinity DataEC50:  1.98E+6nMAssay Description:Inhibition of GluR2 flop expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50330414(CHEMBL1276217 | N-(2-(4-tert-butylphenyl)propyl)me...)
Affinity DataEC50:  1.20E+3nMAssay Description:Inhibition of GluR4 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50094018(CHEMBL137789 | N-[2-(4-Thiophen-3-yl-phenyl)-propy...)
Affinity DataEC50:  4.50E+3nMAssay Description:Inhibition of GluR4 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50094024((+/-) Propane-2-sulfonic acid [2-(4'-cyano-bipheny...)
Affinity DataEC50:  290nMAssay Description:Inhibition of GluR4 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50330415((R)-N-(2-(4'-(2-(methylsulfonamido)ethyl)biphenyl-...)
Affinity DataEC50:  150nMAssay Description:Inhibition of GluR4 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 4(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50330416(CHEMBL1277002 | N-{(R)-2-[4'-((S)-2-Methanesulfony...)
Affinity DataEC50:  870nMAssay Description:Inhibition of rat recombinant GluR4 in cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50330417(CHEMBL1277094 | N,N'-(octane-1,8-diyl)dipropane-2-...)
Affinity DataEC50:  910nMAssay Description:Inhibition of GluR1 expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50330418(CHEMBL1276246 | N,N'-(heptane-1,7-diyl)dipropane-2...)
Affinity DataEC50:  2.88E+3nMAssay Description:Inhibition of GluR1 expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50330419(CHEMBL1277095 | N,N'-(nonane-1,9-diyl)dipropane-2-...)
Affinity DataEC50:  660nMAssay Description:Inhibition of GluR1 expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50102263(CHEMBL105076 | N-{4-[1-Methyl-2-(propane-2-sulfony...)
Affinity DataEC50:  520nMAssay Description:Inhibition of GluR4 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50112771((+/-) Propane-2-sulfonic acid [2-(4-bromo-phenyl)-...)
Affinity DataEC50:  520nMAssay Description:Inhibition of GluR4 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50112770((+/-) Propane-2-sulfonic acid [2-(4-iodo-phenyl)-c...)
Affinity DataEC50:  230nMAssay Description:Inhibition of GluR4 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50330420(CHEMBL1277180 | N-((3S,4S)-1-methyl-4-(4'-(N-methy...)
Affinity DataEC50:  1.60E+3nMAssay Description:Inhibition of human recombinant GluR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323793(CHEMBL1214399 | N-[(2S)-5-(6-Fluoro-3-pyridinyl)-2...)
Affinity DataEC50:  2.50E+3nMAssay Description:Inhibition of human recombinant GluR2More data for this Ligand-Target Pair
TargetGlutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50330421(CHEMBL1277272 | N-(5-(thiophen-3-yl)-2,3-dihydro-1...)
Affinity DataEC50:  1.00E+4nMAssay Description:Inhibition of human recombinant GluR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50094024((+/-) Propane-2-sulfonic acid [2-(4'-cyano-bipheny...)
Affinity DataEC50:  150nMAssay Description:Agonist activity at GluR2 receptorMore data for this Ligand-Target Pair
TargetGlutamate receptor 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50094024((+/-) Propane-2-sulfonic acid [2-(4'-cyano-bipheny...)
Affinity DataEC50:  1.66E+3nMAssay Description:Inhibition of GluR3 expressed in HEK cellsMore data for this Ligand-Target Pair
TargetGlutamate receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50094024((+/-) Propane-2-sulfonic acid [2-(4'-cyano-bipheny...)
Affinity DataEC50:  5.65E+3nMAssay Description:Inhibition of GluR1 expressed in HEK cellsMore data for this Ligand-Target Pair
TargetGlutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50094024((+/-) Propane-2-sulfonic acid [2-(4'-cyano-bipheny...)
Affinity DataEC50:  1.44E+3nMAssay Description:Inhibition of GluR2 flop expressed in HEK cellsMore data for this Ligand-Target Pair
TargetGlutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50102263(CHEMBL105076 | N-{4-[1-Methyl-2-(propane-2-sulfony...)
Affinity DataEC50:  520nMAssay Description:Agonist activity at GluR2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50112771((+/-) Propane-2-sulfonic acid [2-(4-bromo-phenyl)-...)
Affinity DataEC50:  520nMAssay Description:Agonist activity at GluR2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50417555(CHEMBL1642160)
Affinity DataEC50:  794nMAssay Description:Modulatory activity at GluA2 receptor LBDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50417556(CHEMBL1230591)
Affinity DataEC50:  1.00E+3nMAssay Description:Modulatory activity at GluA2 receptor LBDMore data for this Ligand-Target Pair
TargetGlutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50417557(CHEMBL1642161)
Affinity DataEC50:  398nMAssay Description:Modulatory activity at GluA2 receptor LBDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50417558(CHEMBL1642162)
Affinity DataEC50:  5.01E+3nMAssay Description:Modulatory activity at GluA2 receptor LBDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50417559(CHEMBL1642163)
Affinity DataEC50:  2.51E+3nMAssay Description:Modulatory activity at GluA2 receptor LBDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50417560(CHEMBL1642164)
Affinity DataEC50:  2.51E+3nMAssay Description:Modulatory activity at GluA2 receptor LBDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50417561(CHEMBL1642165)
Affinity DataEC50:  1.00E+3nMAssay Description:Modulatory activity at GluA2 receptor LBDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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