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Found 441 with Last Name = 'palovich' and Initial = 'mr'
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50345693((3-endo)-3-(2-Cyano-2,2-diphenylethyl)-8,8-dimethy...)
Affinity DataKi:  0.0500nMAssay Description:Displacement of [3H]N-methyl Scopolamine from human muscarinic M1 receptor expressed in CHO cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50345693((3-endo)-3-(2-Cyano-2,2-diphenylethyl)-8,8-dimethy...)
Affinity DataKi:  0.0600nMAssay Description:Displacement of [3H]N-methyl Scopolamine from human muscarinic M3 receptor expressed in CHO cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50267614(4-[Hydroxy(diphenyl)methyl]-1-{2-[(phenylmethyl)ox...)
Affinity DataKi:  0.0600nMAssay Description:Displacement of [3H]N-methyl scopalamine from human cloned muscarinic M3 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50381654(CHEMBL2023764)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]-N-methyl scopolamine from muscarinic acetylcholine M2 receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50381654(CHEMBL2023764)
Affinity DataKi:  0.120nMAssay Description:Displacement of [3H]-N-methyl scopolamine from muscarinic acetylcholine M1 receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50267573(4-[Hydroxy(diphenyl)methyl]-1-[3-(phenyloxy)propyl...)
Affinity DataKi:  0.130nMAssay Description:Displacement of [3H]N-methyl scopalamine from human cloned muscarinic M3 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50267614(4-[Hydroxy(diphenyl)methyl]-1-{2-[(phenylmethyl)ox...)
Affinity DataKi:  0.150nMAssay Description:Displacement of [3H]N-methyl scopalamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50267614(4-[Hydroxy(diphenyl)methyl]-1-{2-[(phenylmethyl)ox...)
Affinity DataKi:  0.160nMAssay Description:Displacement of [3H]N-methyl scopalamine from human cloned muscarinic M1 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50381654(CHEMBL2023764)
Affinity DataKi:  0.160nMAssay Description:Displacement of [3H]-N-methyl scopolamine from muscarinic acetylcholine M3 receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50345693((3-endo)-3-(2-Cyano-2,2-diphenylethyl)-8,8-dimethy...)
Affinity DataKi:  0.170nMAssay Description:Displacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50345692((3-endo)-3-(2,2-Di-2-thienylethenyl)-8,8-dimethyl-...)
Affinity DataKi:  0.380nMAssay Description:Displacement of [3H]N-methyl Scopolamine from human muscarinic M1 receptor expressed in CHO cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50345692((3-endo)-3-(2,2-Di-2-thienylethenyl)-8,8-dimethyl-...)
Affinity DataKi:  0.450nMAssay Description:Displacement of [3H]N-methyl Scopolamine from human muscarinic M3 receptor expressed in CHO cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50267573(4-[Hydroxy(diphenyl)methyl]-1-[3-(phenyloxy)propyl...)
Affinity DataKi:  0.640nMAssay Description:Displacement of [3H]N-methyl scopalamine from human cloned muscarinic M1 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50345692((3-endo)-3-(2,2-Di-2-thienylethenyl)-8,8-dimethyl-...)
Affinity DataKi:  0.730nMAssay Description:Displacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50267573(4-[Hydroxy(diphenyl)methyl]-1-[3-(phenyloxy)propyl...)
Affinity DataKi:  0.940nMAssay Description:Displacement of [3H]N-methyl scopalamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50223976(8,8-dimethyl-3-(thiophen-3-yl-thiophen-3-ylmethyl-...)
Affinity DataIC50:  1nMAssay Description:Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50223976(8,8-dimethyl-3-(thiophen-3-yl-thiophen-3-ylmethyl-...)
Affinity DataIC50:  1.60nMAssay Description:Antagonist activity at cloned muscarinic M1 receptor expressed in CHO cells by measuring calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50223964(3-(benzyl-thiophen-3-yl-carbamoyloxy)-8,8-dimethyl...)
Affinity DataIC50:  2nMAssay Description:Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50223964(3-(benzyl-thiophen-3-yl-carbamoyloxy)-8,8-dimethyl...)
Affinity DataIC50:  2.10nMAssay Description:Antagonist activity at cloned muscarinic M1 receptor expressed in CHO cells by measuring calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50223990(8,8-dimethyl-3-(phenyl-thiophen-2-ylmethyl-carbamo...)
Affinity DataIC50:  2.30nMAssay Description:Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50223990(8,8-dimethyl-3-(phenyl-thiophen-2-ylmethyl-carbamo...)
Affinity DataIC50:  2.40nMAssay Description:Antagonist activity at cloned muscarinic M1 receptor expressed in CHO cells by measuring calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50223981(8,8-dimethyl-3-(phenyl-thiophen-3-ylmethyl-carbamo...)
Affinity DataIC50:  2.60nMAssay Description:Antagonist activity at cloned muscarinic M1 receptor expressed in CHO cells by measuring calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50223991(3-(benzyl-thiophen-2-yl-carbamoyloxy)-8,8-dimethyl...)
Affinity DataIC50:  2.70nMAssay Description:Antagonist activity at cloned muscarinic M1 receptor expressed in CHO cells by measuring calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50223981(8,8-dimethyl-3-(phenyl-thiophen-3-ylmethyl-carbamo...)
Affinity DataIC50:  2.80nMAssay Description:Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50223991(3-(benzyl-thiophen-2-yl-carbamoyloxy)-8,8-dimethyl...)
Affinity DataIC50:  3nMAssay Description:Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50223993(8,8-dimethyl-3-[(3-methyl-thiophen-2-ylmethyl)-phe...)
Affinity DataIC50:  3.80nMAssay Description:Antagonist activity at cloned muscarinic M1 receptor expressed in CHO cells by measuring calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50193985(3-{[[(2-bromophenyl)amino](cyanoimino)methyl]amino...)
Affinity DataIC50:  4nMAssay Description:Displacement of [125I]IL8 from CXCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50223980(3-(benzyl-phenyl-carbamoyloxy)-8,8-dimethyl-8-azon...)
Affinity DataIC50:  4.5nMAssay Description:Antagonist activity at cloned muscarinic M1 receptor expressed in CHO cells by measuring calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50223980(3-(benzyl-phenyl-carbamoyloxy)-8,8-dimethyl-8-azon...)
Affinity DataIC50:  4.60nMAssay Description:Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50193979(3-{[[(2-bromophenyl)amino](cyanoimino)methyl]amino...)
Affinity DataIC50:  5nMAssay Description:Displacement of [125I]IL8 from CXCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50223983(3-(cyclohexylmethyl-thiophen-3-yl-carbamoyloxy)-8,...)
Affinity DataIC50:  5.80nMAssay Description:Antagonist activity at cloned muscarinic M1 receptor expressed in CHO cells by measuring calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50193972(3-(2-bromophenyl)-2-cyano-1-(2-hydroxy-4-methyl-3-...)
Affinity DataIC50:  6nMAssay Description:Displacement of [125I]IL8 from CXCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50401890(CHEMBL2206606)
Affinity DataIC50:  6.10nMAssay Description:Antagonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50223993(8,8-dimethyl-3-[(3-methyl-thiophen-2-ylmethyl)-phe...)
Affinity DataIC50:  6.40nMAssay Description:Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50152761(3-[3-(2-Bromo-phenyl)-ureido]-6-chloro-2-hydroxy-b...)
Affinity DataIC50:  7nMAssay Description:Concentration required to inhibit [125I]IL-8 binding towards C-X-C chemokine receptor type 2 of human expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50193971(3-{[[(2-bromophenyl)amino](cyanoimino)methyl]amino...)
Affinity DataIC50:  7nMAssay Description:Displacement of [125I]IL8 from CXCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50193980(3-{[[(2-bromophenyl)amino](cyanoimino)methyl]amino...)
Affinity DataIC50:  7nMAssay Description:Displacement of [125I]IL8 from CXCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50223994(8-methyl-8-aza-bicyclo[3.2.1]octan-3-yl thiophen-3...)
Affinity DataIC50:  7.20nMAssay Description:Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50223976(8,8-dimethyl-3-(thiophen-3-yl-thiophen-3-ylmethyl-...)
Affinity DataIC50:  7.20nMAssay Description:Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50203016(6-chloro-3-(3,4-dioxo-2-(phenylamino)cyclobut-1-en...)
Affinity DataIC50:  8nMAssay Description:Displacement of [125I]IL8 from human recombinant CXCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50203030(3-[4-chloro-3-(4-ethyl-piperazine-1-sulfonyl)-2-hy...)
Affinity DataIC50:  8nMAssay Description:Displacement of [125I]IL8 from human recombinant CXCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50193974(6-chloro-3-({(cyanoimino)[(2-fluorophenyl)amino]me...)
Affinity DataIC50:  9nMAssay Description:Displacement of [125I]IL8 from CXCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50193970(3-[2-(benzyloxy)phenyl]-1-[4-chloro-3-(dimethylsul...)
Affinity DataIC50:  9nMAssay Description:Displacement of [125I]IL8 from CXCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50193978(3-(2-bromophenyl)-1-[4-chloro-3-({3-[(2R,6S)-2,6-d...)
Affinity DataIC50:  9nMAssay Description:Displacement of [125I]IL8 from CXCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50345679((3-endo)-3-[2-Hydroxy-2,2-bis(2-methylphenyl)ethyl...)
Affinity DataIC50:  10nMAssay Description:Antagonist activity against human M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50152759(3-[3-(2-Bromo-phenyl)-ureido]-6-chloro-2-hydroxy-b...)
Affinity DataIC50:  10nMAssay Description:Concentration required to inhibit [125I]IL-8 binding towards C-X-C chemokine receptor type 2 of human expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50203007(3-(2-bromophenylamino)-4-(4-chloro-2-hydroxy-3-(4-...)
Affinity DataIC50:  10nMAssay Description:Displacement of [125I]IL8 from human recombinant CXCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50401881(CHEMBL2206587)
Affinity DataIC50:  10.2nMAssay Description:Antagonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50223963(8-methyl-8-aza-bicyclo[3.2.1]octan-3-yl benzyl(thi...)
Affinity DataIC50:  10.9nMAssay Description:Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50223964(3-(benzyl-thiophen-3-yl-carbamoyloxy)-8,8-dimethyl...)
Affinity DataIC50:  10.9nMAssay Description:Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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