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Found 39 with Last Name = 'pimlott' and Initial = 'sl'
TargetTransporter(Rattus norvegicus (rat))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50198230((S)-2-((S)-(2-iodophenoxy)(phenyl)methyl)morpholin...)
Affinity DataKi:  0.840nMAssay Description:Displacement of [3H]nisoxetine from NAT in Sprague-Dawley rat brain after 4 hrs by liquid scintillation analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus (rat))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50301211((2R,3S)-2-[(2-Iodophenoxy)phenylmethyl]morpholine ...)
Affinity DataKi:  8.40nMAssay Description:Displacement of [3H]nisoxetine from NAT in Sprague-Dawley rat brain after 4 hrs by liquid scintillation analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM22032(1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoq...)
Affinity DataKi:  9.80nMAssay Description:Displacement of [3H]PK11195 from TSPO in Sprague-Dawley rat brain homogenates by liquid scintillation countingMore data for this Ligand-Target Pair
TargetTranslocator protein(Rattus norvegicus (rat))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50310140(CHEMBL605154 | N,N-Diethyl-3-iodomethyl-4-phenylqu...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]PK11195 from TSPO in Sprague-Dawley rat brain homogenates by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50310139(CHEMBL601203 | N-Benzyl-3-iodomethyl-N-methyl-4-ph...)
Affinity DataKi:  26.1nMAssay Description:Displacement of [3H]PK11195 from TSPO in Sprague-Dawley rat brain homogenates by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50301213((2R,3S)-2-[(4-Iodophenoxy)phenylmethyl]morpholine ...)
Affinity DataKi:  34.5nMAssay Description:Displacement of [3H]citalopram from SERT in Sprague-Dawley rat brain after 2 hrs by liquid scintillation analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50301211((2R,3S)-2-[(2-Iodophenoxy)phenylmethyl]morpholine ...)
Affinity DataKi:  51.5nMAssay Description:Displacement of [3H]citalopram from SERT in Sprague-Dawley rat brain after 2 hrs by liquid scintillation analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus (rat))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50264064((2S,3S)-iodoreboxetine | (S)-2-((S)-(2-ethoxypheno...)
Affinity DataKi:  53.8nMAssay Description:Displacement of [3H]nisoxetine from NAT in Sprague-Dawley rat brain after 4 hrs by liquid scintillation analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus (rat))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50264063((2R,3S)-iodoreboxetine | (R)-2-((S)-(2-ethoxypheno...)
Affinity DataKi:  58.2nMAssay Description:Displacement of [3H]nisoxetine from NAT in Sprague-Dawley rat brain after 4 hrs by liquid scintillation analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50301212((2R,3S)-2-[(3-Iodophenoxy)phenylmethyl]morpholine ...)
Affinity DataKi:  154nMAssay Description:Displacement of [3H]citalopram from SERT in Sprague-Dawley rat brain after 2 hrs by liquid scintillation analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50310141(4-Phenyl-3-iodomethylquinoline-2-N-methyl-N-sec-bu...)
Affinity DataKi:  173nMAssay Description:Displacement of [3H]PK11195 from TSPO in Sprague-Dawley rat brain homogenates by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50310138(3-Iodomethyl-N-methyl-N-phenethyl-4-phenylquinolin...)
Affinity DataKi:  411nMAssay Description:Displacement of [3H]PK11195 from TSPO in Sprague-Dawley rat brain homogenates by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50310137(3-Methyl-4-phenylquinoline-2-N-methyl-N-(3-iodoben...)
Affinity DataKi:  455nMAssay Description:Displacement of [3H]PK11195 from TSPO in Sprague-Dawley rat brain homogenates by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50301211((2R,3S)-2-[(2-Iodophenoxy)phenylmethyl]morpholine ...)
Affinity DataKi:  526nMAssay Description:Displacement of [3H]WIN-35,428 from DAT in Sprague-Dawley rat brain after 2 hrs by liquid scintillation analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50263316((2R,3R)-iodoreboxetine | CHEMBL477406)
Affinity DataKi:  646nMAssay Description:Displacement of [3H]citalopram from rat brain SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50263316((2R,3R)-iodoreboxetine | CHEMBL477406)
Affinity DataKi:  716nMAssay Description:Displacement of [3H]WIN-35428 from rat brain DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50310134(4-Phenylquinoline-2-N-methyl-N-(4-iodobenzyl)carbo...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]PK11195 from TSPO in Sprague-Dawley rat brain homogenates by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50310133(4-(4-Fluorophenyl)quinoline-2-N-methyl-N-(3-iodobe...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]PK11195 from TSPO in Sprague-Dawley rat brain homogenates by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50310132(4-(4-Fluorophenyl)quinoline-2-N-methyl-N-(4-iodobe...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]PK11195 from TSPO in Sprague-Dawley rat brain homogenates by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50310135(4-Phenylquinoline-2-N-methyl-N-(3-iodobenzyl)carbo...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]PK11195 from TSPO in Sprague-Dawley rat brain homogenates by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50310136(3-Methyl-4-phenylquinoline-2-N-methyl-N-(4-iodoben...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]PK11195 from TSPO in Sprague-Dawley rat brain homogenates by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus (rat))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50301213((2R,3S)-2-[(4-Iodophenoxy)phenylmethyl]morpholine ...)
Affinity DataKi:  1.10E+3nMAssay Description:Displacement of [3H]nisoxetine from NAT in Sprague-Dawley rat brain after 4 hrs by liquid scintillation analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50264064((2S,3S)-iodoreboxetine | (S)-2-((S)-(2-ethoxypheno...)
Affinity DataKi:  1.46E+3nMAssay Description:Displacement of [3H]WIN-35428 from rat brain DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus (rat))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50301212((2R,3S)-2-[(3-Iodophenoxy)phenylmethyl]morpholine ...)
Affinity DataKi:  1.70E+3nMAssay Description:Displacement of [3H]nisoxetine from NAT in Sprague-Dawley rat brain after 4 hrs by liquid scintillation analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50301212((2R,3S)-2-[(3-Iodophenoxy)phenylmethyl]morpholine ...)
Affinity DataKi:  1.90E+3nMAssay Description:Displacement of [3H]WIN-35,428 from DAT in Sprague-Dawley rat brain after 2 hrs by liquid scintillation analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50301213((2R,3S)-2-[(4-Iodophenoxy)phenylmethyl]morpholine ...)
Affinity DataKi:  2.10E+3nMAssay Description:Displacement of [3H]WIN-35,428 from DAT in Sprague-Dawley rat brain after 2 hrs by liquid scintillation analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50264064((2S,3S)-iodoreboxetine | (S)-2-((S)-(2-ethoxypheno...)
Affinity DataKi:  2.79E+3nMAssay Description:Displacement of [3H]citalopram from rat brain SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of PARP1 in human G7 cells incubated for 60 mins by immunofluorescence assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of PARP1 in human T98G cells incubated for 60 mins by immunofluorescence assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50499078(CHEMBL3735519)
Affinity DataIC50:  3nMAssay Description:Inhibition of PARP1 (unknown origin) incubated for 10 mins using biotinylated NAD+ and activated DNA by colorimetric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50499076(CHEMBL3735979)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of PARP1 (unknown origin) incubated for 10 mins using biotinylated NAD+ and activated DNA by colorimetric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50499080(CHEMBL3736047)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of PARP1 (unknown origin) incubated for 10 mins using biotinylated NAD+ and activated DNA by colorimetric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50499075(CHEMBL3735832)
Affinity DataIC50:  5.80nMAssay Description:Inhibition of PARP1 (unknown origin) incubated for 10 mins using biotinylated NAD+ and activated DNA by colorimetric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50499076(CHEMBL3735979)
Affinity DataIC50:  7nMAssay Description:Inhibition of PARP1 in human G7 cells incubated for 60 mins by immunofluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50499076(CHEMBL3735979)
Affinity DataIC50:  7.40nMAssay Description:Inhibition of PARP1 in human T98G cells incubated for 60 mins by immunofluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataIC50:  12nMAssay Description:Inhibition of PARP1 (unknown origin) incubated for 10 mins using biotinylated NAD+ and activated DNA by colorimetric assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50499081(CHEMBL3735916)
Affinity DataIC50:  17nMAssay Description:Inhibition of PARP1 (unknown origin) incubated for 10 mins using biotinylated NAD+ and activated DNA by colorimetric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50499079(CHEMBL3735363)
Affinity DataIC50:  18nMAssay Description:Inhibition of PARP1 (unknown origin) incubated for 10 mins using biotinylated NAD+ and activated DNA by colorimetric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50499077(CHEMBL3736506)
Affinity DataIC50:  23nMAssay Description:Inhibition of PARP1 (unknown origin) incubated for 10 mins using biotinylated NAD+ and activated DNA by colorimetric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed