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Found 150 with Last Name = 'pino' and Initial = 'm'
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Agouron Pharmaceuticals

LigandPNGBDBM519((2S)-N-[(2S,3R)-4-[(3S,4aS,8aS)-3-(tert-butylcarba...)
Affinity DataKi:  0.900nM ΔG°:  -53.7kJ/molepH: 5.6 T: 2°CAssay Description:Protease activity was measured by continuous chromogenic assay. The chromogenic peptide His-Lys-Ala-Arg-Val-Leu- (p-NO2-Phe)-Glu-Ala-Nleu-Ser (Bache...More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Agouron Pharmaceuticals

LigandPNGBDBM3414((2S)-N-[(2S,3R)-4-[2-(tert-butylcarbamoyl)phenyl]-...)
Affinity DataKi:  1.60nM ΔG°:  -52.2kJ/molepH: 5.6 T: 2°CAssay Description:Protease activity was measured by continuous chromogenic assay. The chromogenic peptide His-Lys-Ala-Arg-Val-Leu- (p-NO2-Phe)-Glu-Ala-Nleu-Ser (Bache...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Agouron Pharmaceuticals

LigandPNGBDBM3425(5-chloro-2-(4-{2-[(1-ethylcyclopentyl)(2-hydroxyet...)
Affinity DataKi:  2nM ΔG°:  -51.6kJ/molepH: 5.6 T: 2°CAssay Description:Protease activity was measured by continuous chromogenic assay. The chromogenic peptide His-Lys-Ala-Arg-Val-Leu- (p-NO2-Phe)-Glu-Ala-Nleu-Ser (Bache...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50061307(AG-1254 | CHEMBL128696 | N-[(1R,2R)-3-(2-tert-Buty...)
Affinity DataKi:  3nMAssay Description:Inhibitory activity HIV-1 protease enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Agouron Pharmaceuticals

LigandPNGBDBM3424(2-[(2R)-4-{2-[(1-ethylcyclopentyl)(2-hydroxyethyl)...)
Affinity DataKi:  4.80nM ΔG°:  -49.4kJ/molepH: 5.6 T: 2°CAssay Description:Protease activity was measured by continuous chromogenic assay. The chromogenic peptide His-Lys-Ala-Arg-Val-Leu- (p-NO2-Phe)-Glu-Ala-Nleu-Ser (Bache...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50005335(2-[4-(2-Amino-1,6,7,8-tetrahydro-imidazo[4,5-g]qui...)
Affinity DataKi:  5nMAssay Description:Inhibition of Escherichia coli Thymidylate synthase (TS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50286713(3,5-Diamino-N-[(1R,2R)-3-(2-tert-butylcarbamoyl-ph...)
Affinity DataKi:  5nMAssay Description:Inhibitory activity HIV-1 protease enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
TargetThymidylate synthase(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50005329(5-[4-(Morpholine-4-sulfonyl)-benzyl]-5,6,7,8-tetra...)
Affinity DataKi:  6nMAssay Description:Inhibition of human Thymidylate synthase (TS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50005324(4-[4-(2-Amino-1,6,7,8-tetrahydro-imidazo[4,5-g]qui...)
Affinity DataKi:  8nMAssay Description:Inhibition of Escherichia coli Thymidylate synthase (TS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50005335(2-[4-(2-Amino-1,6,7,8-tetrahydro-imidazo[4,5-g]qui...)
Affinity DataKi:  11nMAssay Description:Inhibition of human Thymidylate synthase (TS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50005329(5-[4-(Morpholine-4-sulfonyl)-benzyl]-5,6,7,8-tetra...)
Affinity DataKi:  11nMAssay Description:Inhibition of Escherichia coli Thymidylate synthase (TS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50005330(5-(4-Benzenesulfonyl-benzyl)-5,6,7,8-tetrahydro-1H...)
Affinity DataKi:  13nMAssay Description:Inhibition of human Thymidylate synthase (TS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50286699(AG-1309 | CHEMBL162065 | N-[(1R,2R)-3-(2-tert-Buty...)
Affinity DataKi:  15nMAssay Description:Inhibitory activity HIV-1 protease enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50286705(3-Amino-N-[(1R,2R)-3-(2-tert-butylcarbamoyl-phenyl...)
Affinity DataKi:  16nMAssay Description:Inhibitory activity HIV-1 protease enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50286701(5-Amino-N-[(1R,2R)-3-(2-tert-butylcarbamoyl-phenyl...)
Affinity DataKi:  17nMAssay Description:Inhibitory activity HIV-1 protease enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
TargetThymidylate synthase(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50005324(4-[4-(2-Amino-1,6,7,8-tetrahydro-imidazo[4,5-g]qui...)
Affinity DataKi:  20nMAssay Description:Inhibition of human Thymidylate synthase (TS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50061308((3S,4aS,8aS)-2-[(2R,3S)-2-Hydroxy-3-(3-hydroxy-2-m...)
Affinity DataKi:  21nMAssay Description:Inhibitory activity HIV-1 protease enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Agouron Pharmaceuticals

LigandPNGBDBM3423(2-(3-hydroxy-4-{2-[(2-hydroxyethyl)(2-phenylpropan...)
Affinity DataKi:  22nM ΔG°:  -45.5kJ/molepH: 5.6 T: 2°CAssay Description:Protease activity was measured by continuous chromogenic assay. The chromogenic peptide His-Lys-Ala-Arg-Val-Leu- (p-NO2-Phe)-Glu-Ala-Nleu-Ser (Bache...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50286703(1,2,3,4-Tetrahydro-quinoline-5-carboxylic acid [(1...)
Affinity DataKi:  24nMAssay Description:Inhibitory activity HIV-1 protease enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
TargetThymidylate synthase(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50005332(5-[4-(4-Methoxy-benzenesulfonyl)-benzyl]-5,6,7,8-t...)
Affinity DataKi:  24nMAssay Description:Inhibition of human Thymidylate synthase (TS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50286709(3-Amino-2-bromo-N-[(1R,2R)-3-(2-tert-butylcarbamoy...)
Affinity DataKi:  33nMAssay Description:Inhibitory activity HIV-1 protease enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
TargetThymidylate synthase(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50005322(CHEMBL353813 | [6-(2-Amino-1,6,7,8-tetrahydro-imid...)
Affinity DataKi:  38nMAssay Description:Inhibition of human Thymidylate synthase (TS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50005322(CHEMBL353813 | [6-(2-Amino-1,6,7,8-tetrahydro-imid...)
Affinity DataKi:  39nMAssay Description:Inhibition of Escherichia coli Thymidylate synthase (TS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50005332(5-[4-(4-Methoxy-benzenesulfonyl)-benzyl]-5,6,7,8-t...)
Affinity DataKi:  40nMAssay Description:Inhibition of Escherichia coli Thymidylate synthase (TS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50005330(5-(4-Benzenesulfonyl-benzyl)-5,6,7,8-tetrahydro-1H...)
Affinity DataKi:  43nMAssay Description:Inhibition of Escherichia coli Thymidylate synthase (TS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50286702(3-Amino-N-[(1R,2R)-3-(2-tert-butylcarbamoyl-phenyl...)
Affinity DataKi:  49nMAssay Description:Inhibitory activity HIV-1 protease enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
TargetThymidylate synthase(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50005327(5-[4-(4-Methoxy-benzenesulfonyl)-benzyl]-1-methyl-...)
Affinity DataKi:  51nMAssay Description:Inhibition of human Thymidylate synthase (TS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50005323(5-[4-(Piperazine-1-sulfonyl)-benzyl]-5,6,7,8-tetra...)
Affinity DataKi:  64nMAssay Description:Inhibition of human Thymidylate synthase (TS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Agouron Pharmaceuticals

LigandPNGBDBM3422(N-tert-butyl-2-(3-hydroxy-4-{2-[(2-hydroxyethyl)(2...)
Affinity DataKi:  90nM ΔG°:  -41.8kJ/molepH: 5.6 T: 2°CAssay Description:Protease activity was measured by continuous chromogenic assay. The chromogenic peptide His-Lys-Ala-Arg-Val-Leu- (p-NO2-Phe)-Glu-Ala-Nleu-Ser (Bache...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50286711(CHEMBL354231 | Quinoline-5-carboxylic acid [(1R,2R...)
Affinity DataKi:  113nMAssay Description:Inhibitory activity HIV-1 protease enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
TargetThymidylate synthase(Escherichia coli)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50005323(5-[4-(Piperazine-1-sulfonyl)-benzyl]-5,6,7,8-tetra...)
Affinity DataKi:  140nMAssay Description:Inhibition of Escherichia coli Thymidylate synthase (TS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50286710(1H-Indole-4-carboxylic acid [(1R,2R)-3-(2-tert-but...)
Affinity DataKi:  164nMAssay Description:Inhibitory activity HIV-1 protease enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50286712(2,3-Dihydro-1H-indole-4-carboxylic acid [(1R,2R)-3...)
Affinity DataKi:  166nMAssay Description:Inhibitory activity HIV-1 protease enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50286704(1,2,3,4-Tetrahydro-isoquinoline-5-carboxylic acid ...)
Affinity DataKi:  180nMAssay Description:Inhibitory activity HIV-1 protease enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
TargetThymidylate synthase(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50005331(5-(4-Benzenesulfonyl-phenylsulfanyl)-5,6,7,8-tetra...)
Affinity DataKi:  230nMAssay Description:Inhibition of human Thymidylate synthase (TS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50286700(CHEMBL162866 | Quinoline-4-carboxylic acid [(1R,2R...)
Affinity DataKi:  265nMAssay Description:Inhibitory activity HIV-1 protease enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
TargetThymidylate synthase(Escherichia coli)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50005331(5-(4-Benzenesulfonyl-phenylsulfanyl)-5,6,7,8-tetra...)
Affinity DataKi:  350nMAssay Description:Inhibition of Escherichia coli Thymidylate synthase (TS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50005325(5-[4-(4-Methoxy-benzenesulfonyl)-benzyl]-2-methyl-...)
Affinity DataKi:  440nMAssay Description:Inhibition of human Thymidylate synthase (TS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50005326(5-[4-(4-Methoxy-benzenesulfonyl)-benzyl]-1,2-dimet...)
Affinity DataKi:  480nMAssay Description:Inhibition of human Thymidylate synthase (TS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Agouron Pharmaceuticals

LigandPNGBDBM3410(2-Butanol deriv. 18 | N-tert-butyl-2-[(3S)-4-[1-(t...)
Affinity DataKi:  480nM ΔG°:  -37.5kJ/molepH: 5.6 T: 2°CAssay Description:Protease activity was measured by continuous chromogenic assay. The chromogenic peptide His-Lys-Ala-Arg-Val-Leu- (p-NO2-Phe)-Glu-Ala-Nleu-Ser (Bache...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Agouron Pharmaceuticals

LigandPNGBDBM3410(2-Butanol deriv. 18 | N-tert-butyl-2-[(3S)-4-[1-(t...)
Affinity DataKi:  481nM ΔG°:  -37.5kJ/molepH: 5.6 T: 2°CAssay Description:Protease activity was measured by continuous chromogenic assay. The chromogenic peptide His-Lys-Ala-Arg-Val-Leu- (p-NO2-Phe)-Glu-Ala-Nleu-Ser (Bache...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50005327(5-[4-(4-Methoxy-benzenesulfonyl)-benzyl]-1-methyl-...)
Affinity DataKi:  500nMAssay Description:Inhibition of Escherichia coli Thymidylate synthase (TS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50286706(AG-1273 | CHEMBL351021 | N-[(1R,2R)-3-(2-tert-Buty...)
Affinity DataKi:  500nMAssay Description:Inhibitory activity HIV-1 protease enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50286708(AG-1224 | CHEMBL351391 | N-[(1R,2R)-3-(2-tert-Buty...)
Affinity DataKi:  540nMAssay Description:Inhibitory activity HIV-1 protease enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
TargetThymidylate synthase(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50005333(CHEMBL169726 | [5-(4-Benzenesulfonyl-benzyl)-5,6,7...)
Affinity DataKi:  770nMAssay Description:Inhibition of human Thymidylate synthase (TS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50286707(CHEMBL445642 | Isoquinoline-5-carboxylic acid [(1R...)
Affinity DataKi:  800nMAssay Description:Inhibitory activity HIV-1 protease enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Agouron Pharmaceuticals

LigandPNGBDBM3421(N-tert-Butyl-N-(2-hydroxyethyl)-2-[3-hydroxy-4-[2-...)
Affinity DataKi:  1.10E+3nM ΔG°:  -35.4kJ/molepH: 5.6 T: 2°CAssay Description:Protease activity was measured by continuous chromogenic assay. The chromogenic peptide His-Lys-Ala-Arg-Val-Leu- (p-NO2-Phe)-Glu-Ala-Nleu-Ser (Bache...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Agouron Pharmaceuticals

LigandPNGBDBM3412(2-Butanol deriv. 20 | N-tert-butyl-2-{4-[4-tert-bu...)
Affinity DataKi:  1.20E+3nM ΔG°:  -35.2kJ/molepH: 5.6 T: 2°CAssay Description:Protease activity was measured by continuous chromogenic assay. The chromogenic peptide His-Lys-Ala-Arg-Val-Leu- (p-NO2-Phe)-Glu-Ala-Nleu-Ser (Bache...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50005325(5-[4-(4-Methoxy-benzenesulfonyl)-benzyl]-2-methyl-...)
Affinity DataKi:  1.30E+3nMAssay Description:Inhibition of Escherichia coli Thymidylate synthase (TS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Agouron Pharmaceuticals

LigandPNGBDBM3409(2-Butanol deriv. 17 | N-tert-butyl-2-{4-[1-(tert-b...)
Affinity DataKi:  1.40E+3nM ΔG°:  -34.8kJ/molepH: 5.6 T: 2°CAssay Description:Protease activity was measured by continuous chromogenic assay. The chromogenic peptide His-Lys-Ala-Arg-Val-Leu- (p-NO2-Phe)-Glu-Ala-Nleu-Ser (Bache...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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