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Found 166 with Last Name = 'pommery' and Initial = 'j'
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50000829(6-((3-fluoro-5-(4-methoxytetrahydro-2H-pyran-4-yl)...)
Affinity DataIC50:  20nMAssay Description:Inhibition of 5-lipoxygenase in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50108781(2-{[1-(2-Amino-3-mercapto-propionyl)-piperidin-4-y...)
Affinity DataIC50:  20nMAssay Description:Inhibition of Farnesyltransferase catalyzed transfer of the FPP moiety to dansyl-GCVLSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50108780(2-{2-[4-(2-Amino-3-methylsulfanyl-propylamino)-3-m...)
Affinity DataIC50:  34nMAssay Description:Inhibition of Farnesyltransferase catalyzed transfer of the FPP moiety to dansyl-GCVLSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50156581(3-[3-fluoro-5-(4-methoxytetrahydropyran-4-yl)pheno...)
Affinity DataIC50:  36nMAssay Description:Inhibition of COX1 expressed in CHO cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataIC50:  36nMAssay Description:Inhibition of COX2 expressed in CHO cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50110484(3-((3-fluoro-5-(1-methoxycyclohexyl)phenoxy)methyl...)
Affinity DataIC50:  45nMAssay Description:Inhibition of COX2 expressed in CHO cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50048955((S)-2-[4-((R)-2-Amino-3-mercapto-propionylamino)-b...)
Affinity DataIC50:  72nMAssay Description:Inhibition of Farnesyltransferase catalyzed transfer of the FPP moiety to dansyl-GCVLSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50000829(6-((3-fluoro-5-(4-methoxytetrahydro-2H-pyran-4-yl)...)
Affinity DataIC50:  83nMAssay Description:Inhibition of 5LOX in human whole blood assessed as inhibition of calcium ionophore A 23187-stimulated 5HETE production by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50156577(1-(4-aminosulfonylphenyl)-3-[3-fluoro-5-(4-methoxy...)
Affinity DataIC50:  100nMAssay Description:Inhibition of COX2 expressed in CHO cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50:  200nMAssay Description:Inhibition of COX1 in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50110484(3-((3-fluoro-5-(1-methoxycyclohexyl)phenoxy)methyl...)
Affinity DataIC50:  200nMAssay Description:Inhibition of 5-lipoxygenase in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50156584(1-(4-methanesulfonylphenyl)-3-[(3,4,5-trimethoxy)p...)
Affinity DataIC50:  220nMAssay Description:Inhibition of COX2 expressed in CHO cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50156581(3-[3-fluoro-5-(4-methoxytetrahydropyran-4-yl)pheno...)
Affinity DataIC50:  300nMAssay Description:Inhibition of COX2 expressed in CHO cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50110484(3-((3-fluoro-5-(1-methoxycyclohexyl)phenoxy)methyl...)
Affinity DataIC50:  300nMAssay Description:Inhibition of 5LOX in human whole blood assessed as inhibition of calcium ionophore A 23187-stimulated 5HETE production by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50156594(3-[(3-fluoro-5-methoxy)phenoxymethyl]-1-(4-methane...)
Affinity DataIC50:  310nMAssay Description:Inhibition of COX2 expressed in CHO cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50022271(2-(3-Benzoylphenyl)propionic acid | 2-(3-benzoylph...)
Affinity DataIC50:  330nMAssay Description:Inhibition of COX1 in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50156580(3-[3-fluoro-5-(4-methoxytetrahydropyran-4-yl)pheno...)
Affinity DataIC50:  410nMAssay Description:Inhibition of COX2 expressed in CHO cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50156590(1-(4-methanesulfonylphenyl)-3-[(3,4-methylenedioxy...)
Affinity DataIC50:  450nMAssay Description:Inhibition of COX2 expressed in CHO cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50272731(2-(3-Benzoyl-phenyl)-propionic acid 2-nitrooxy-eth...)
Affinity DataIC50:  450nMAssay Description:Inhibition of COX1 in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50272677(2-[4-(Thiophene-2-carbonyl)-phenyl]-propionic acid...)
Affinity DataIC50:  480nMAssay Description:Inhibition of COX1 in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50156585(3-[3-fluoro-5-(4-methoxytetrahydropyran-4-yl)pheno...)
Affinity DataIC50:  480nMAssay Description:Inhibition of 5LOX in human whole blood assessed as inhibition of calcium ionophore A 23187-stimulated 5HETE production by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50:  500nMAssay Description:Inhibition of COX2 in human whole bloodMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50:  500nMAssay Description:Inhibition of COX2 in human whole blood assessed as inhibition of 12-hydroxyheptadecatrienoic acid production by HPLC methodMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50090676((+-)-2-(p-(2-thenoyl)phenyl)propionic acid | 2-(4-...)
Affinity DataIC50:  560nMAssay Description:Inhibition of COX1 in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50272676(2-[4-(Thiophene-2-carbonyl)-phenyl]-propionic acid...)
Affinity DataIC50:  570nMAssay Description:Inhibition of COX1 in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50156582(3-[3-fluoro-5-(4-methoxytetrahydropyran-4-yl)pheno...)
Affinity DataIC50:  570nMAssay Description:Inhibition of 5LOX in human whole blood assessed as inhibition of calcium ionophore A 23187-stimulated 5HETE production by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50156587(3-[(5-cyano-3-fluoro)phenoxymethyl]-1-(4-methanesu...)
Affinity DataIC50:  570nMAssay Description:Inhibition of COX2 expressed in CHO cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50272733(2-(3-Benzoyl-phenyl)-propionic acid 2,3-bis-nitroo...)
Affinity DataIC50:  580nMAssay Description:Inhibition of COX1 in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50272675(2-[4-(Thiophene-2-carbonyl)-phenyl]-propionic acid...)
Affinity DataIC50:  580nMAssay Description:Inhibition of COX1 in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50272732(2-(3-Benzoyl-phenyl)-propionic acid 2-nitrooxy-pro...)
Affinity DataIC50:  600nMAssay Description:Inhibition of COX1 in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50156582(3-[3-fluoro-5-(4-methoxytetrahydropyran-4-yl)pheno...)
Affinity DataIC50:  610nMAssay Description:Inhibition of COX2 expressed in CHO cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50022271(2-(3-Benzoylphenyl)propionic acid | 2-(3-benzoylph...)
Affinity DataIC50:  690nMAssay Description:Inhibition of COX2 in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50000541((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Affinity DataIC50:  700nMAssay Description:Inhibition of 5-lipoxygenase in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50156583(1-(4-methanesulfonylphenyl)-3-[(3,4-dimethoxy)phen...)
Affinity DataIC50:  700nMAssay Description:Inhibition of COX2 expressed in CHO cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50000541((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Affinity DataIC50:  700nMAssay Description:Inhibition of 5-lipoxygenase in human whole blood assessed as inhibition of LTB4 production by HPLC methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50156579(1-(3,4-dichlorophenyl)-3-[3-fluoro-5-(4-methoxytet...)
Affinity DataIC50:  700nMAssay Description:Inhibition of COX2 expressed in CHO cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50156586(3-[3-fluoro-5-(4-methoxytetrahydropyran-4-yl)pheno...)
Affinity DataIC50:  720nMAssay Description:Inhibition of 5LOX in human whole blood assessed as inhibition of calcium ionophore A 23187-stimulated 5HETE production by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50272732(2-(3-Benzoyl-phenyl)-propionic acid 2-nitrooxy-pro...)
Affinity DataIC50:  730nMAssay Description:Inhibition of COX2 in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50156591(1-(4-methanesulfonylphenyl)-3-[(3-nitro)phenoxymet...)
Affinity DataIC50:  740nMAssay Description:Inhibition of COX2 expressed in CHO cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50156577(1-(4-aminosulfonylphenyl)-3-[3-fluoro-5-(4-methoxy...)
Affinity DataIC50:  740nMAssay Description:Inhibition of 5LOX in human whole blood assessed as inhibition of calcium ionophore A 23187-stimulated 5HETE production by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50272733(2-(3-Benzoyl-phenyl)-propionic acid 2,3-bis-nitroo...)
Affinity DataIC50:  740nMAssay Description:Inhibition of COX2 in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50156580(3-[3-fluoro-5-(4-methoxytetrahydropyran-4-yl)pheno...)
Affinity DataIC50:  760nMAssay Description:Inhibition of 5LOX in human whole blood assessed as inhibition of calcium ionophore A 23187-stimulated 5HETE production by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50156581(3-[3-fluoro-5-(4-methoxytetrahydropyran-4-yl)pheno...)
Affinity DataIC50:  770nMAssay Description:Inhibition of 5LOX in human whole blood assessed as inhibition of calcium ionophore A 23187-stimulated 5HETE production by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50272731(2-(3-Benzoyl-phenyl)-propionic acid 2-nitrooxy-eth...)
Affinity DataIC50:  770nMAssay Description:Inhibition of COX2 in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataIC50:  800nMAssay Description:Inhibition of COX2 in human whole blood assessed as inhibition of 12-hydroxyheptadecatrienoic acid production by HPLC methodMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50000541((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Affinity DataIC50:  800nMAssay Description:Inhibition of 5-lipoxygenase in human whole blood assessed as inhibition of 5-hydroxyeicosatetraenoic acid production by HPLC methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50156579(1-(3,4-dichlorophenyl)-3-[3-fluoro-5-(4-methoxytet...)
Affinity DataIC50:  800nMAssay Description:Inhibition of 5LOX in human whole blood assessed as inhibition of calcium ionophore A 23187-stimulated 5HETE production by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50156588(1-(4-trifluoromethoxyphenyl)-3-[3-fluoro-5-(4-meth...)
Affinity DataIC50:  820nMAssay Description:Inhibition of COX2 expressed in CHO cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50156589(1-(4-chlorophenyl)-3-[3-fluoro-5-(4-methoxytetrahy...)
Affinity DataIC50:  830nMAssay Description:Inhibition of 5LOX in human whole blood assessed as inhibition of calcium ionophore A 23187-stimulated 5HETE production by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50156588(1-(4-trifluoromethoxyphenyl)-3-[3-fluoro-5-(4-meth...)
Affinity DataIC50:  850nMAssay Description:Inhibition of 5LOX in human whole blood assessed as inhibition of calcium ionophore A 23187-stimulated 5HETE production by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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