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Found 181 with Last Name = 'reagan' and Initial = 'jd'
TargetProbable G-protein coupled receptor 142(Mus musculus)
Amgen

Curated by ChEMBL
LigandPNGBDBM50395775(CHEMBL2164857)
Affinity DataIC50:  15nMAssay Description:Partial agonist activity at mouse GPR142 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50440693(CHEMBL2430983)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable G-protein coupled receptor 142(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50440693(CHEMBL2430983)
Affinity DataEC50:  52nMAssay Description:Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable G-protein coupled receptor 142(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50440694(CHEMBL2430987)
Affinity DataEC50: >3.30E+4nMAssay Description:Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable G-protein coupled receptor 142(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50440695(CHEMBL2430982)
Affinity DataEC50:  78nMAssay Description:Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable G-protein coupled receptor 142(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50440696(CHEMBL2430979)
Affinity DataEC50:  26nMAssay Description:Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable G-protein coupled receptor 142(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50440697(CHEMBL2430980)
Affinity DataEC50:  71nMAssay Description:Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable G-protein coupled receptor 142(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50440698(CHEMBL2431064)
Affinity DataEC50:  2.78E+3nMAssay Description:Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable G-protein coupled receptor 142(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50440699(CHEMBL2430986)
Affinity DataEC50:  2.17E+3nMAssay Description:Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable G-protein coupled receptor 142(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50440700(CHEMBL2430984)
Affinity DataEC50:  95nMAssay Description:Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable G-protein coupled receptor 142(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50440701(CHEMBL2431061)
Affinity DataEC50:  1.25E+3nMAssay Description:Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable G-protein coupled receptor 142(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50440702(CHEMBL2431059)
Affinity DataEC50:  1.11E+3nMAssay Description:Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable G-protein coupled receptor 142(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50440702(CHEMBL2431059)
Affinity DataEC50:  1.08E+3nMAssay Description:Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable G-protein coupled receptor 142(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50440703(CHEMBL2431058)
Affinity DataEC50:  1.04E+3nMAssay Description:Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable G-protein coupled receptor 142(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50440704(CHEMBL2430981)
Affinity DataEC50:  42nMAssay Description:Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable G-protein coupled receptor 142(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50440703(CHEMBL2431058)
Affinity DataEC50:  734nMAssay Description:Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable G-protein coupled receptor 142(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50440705(CHEMBL2431065)
Affinity DataEC50:  516nMAssay Description:Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable G-protein coupled receptor 142(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50440706(CHEMBL2431066)
Affinity DataEC50:  502nMAssay Description:Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable G-protein coupled receptor 142(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50440707(CHEMBL2431060)
Affinity DataEC50:  452nMAssay Description:Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable G-protein coupled receptor 142(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50440708(CHEMBL2431067)
Affinity DataEC50:  306nMAssay Description:Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable G-protein coupled receptor 142(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50440707(CHEMBL2431060)
Affinity DataEC50:  287nMAssay Description:Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable G-protein coupled receptor 142(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50440708(CHEMBL2431067)
Affinity DataEC50:  263nMAssay Description:Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable G-protein coupled receptor 142(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50440709(CHEMBL2431063)
Affinity DataEC50:  180nMAssay Description:Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable G-protein coupled receptor 142(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50440710(CHEMBL2430985)
Affinity DataEC50:  164nMAssay Description:Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable G-protein coupled receptor 142(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50440711(CHEMBL2430988)
Affinity DataEC50:  161nMAssay Description:Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable G-protein coupled receptor 142(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50440701(CHEMBL2431061)
Affinity DataEC50:  121nMAssay Description:Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable G-protein coupled receptor 142(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50440710(CHEMBL2430985)
Affinity DataEC50:  95nMAssay Description:Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable G-protein coupled receptor 142(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50440711(CHEMBL2430988)
Affinity DataEC50:  90nMAssay Description:Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable G-protein coupled receptor 142(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50440706(CHEMBL2431066)
Affinity DataEC50:  90nMAssay Description:Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable G-protein coupled receptor 142(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50440712(CHEMBL2430978)
Affinity DataEC50:  49nMAssay Description:Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable G-protein coupled receptor 142(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50440713(CHEMBL2430977)
Affinity DataEC50:  37nMAssay Description:Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable G-protein coupled receptor 142(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50440714(CHEMBL2431062)
Affinity DataEC50:  37nMAssay Description:Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable G-protein coupled receptor 142(Mus musculus)
Amgen

Curated by ChEMBL
LigandPNGBDBM50440693(CHEMBL2430983)
Affinity DataEC50:  31nMAssay Description:Agonist activity at mouse GPR142More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50299669((R)-1-phenyl-N-((4-phenyl-1H-imidazol-2-yl)methyl)...)
Affinity DataEC50: >5.00E+3nMAssay Description:Activity at human CaSR expressed in HEK293 cells assessed as calcium release by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50299670((R)-3-(2-chlorophenyl)-N-(1-(3-methoxyphenyl)ethyl...)
Affinity DataEC50:  194nMAssay Description:Activity at human CaSR expressed in HEK293 cells assessed as calcium release by FLIPR assayMore data for this Ligand-Target Pair
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50299671((R)-N-((1-methyl-4-phenyl-1H-imidazol-2-yl)methyl)...)
Affinity DataEC50: >5.00E+3nMAssay Description:Activity at human CaSR expressed in HEK293 cells assessed as calcium release by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50299672((R)-1-phenyl-N-((2-phenyl-1,3-thiazol-5-yl)methyl)...)
Affinity DataEC50: >5.00E+3nMAssay Description:Activity at human CaSR expressed in HEK293 cells assessed as calcium release by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50299673((R)-1-phenyl-N-((4-phenyl-1,3-oxazol-2-yl)methyl)e...)
Affinity DataEC50: >5.00E+3nMAssay Description:Activity at human CaSR expressed in HEK293 cells assessed as calcium release by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50299674((R)-1-phenyl-N-((4-phenyl-1,3-thiazol-2-yl)methyl)...)
Affinity DataEC50: >5.00E+3nMAssay Description:Activity at human CaSR expressed in HEK293 cells assessed as calcium release by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50299675((1R)-1-phenyl-N-((1-phenyl-1H-pyrazol-3-yl)methyl)...)
Affinity DataEC50:  1.58E+3nMAssay Description:Activity at human CaSR expressed in HEK293 cells assessed as calcium release by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50299676((1R)-1-phenyl-N-((1R)-1-(1-(4-(trifluoromethyl)phe...)
Affinity DataEC50:  233nMAssay Description:Activity at human CaSR expressed in HEK293 cells assessed as calcium release by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50299677((1R)-N-((1R)-1-phenylethyl)-1-(1-(4-(trifluorometh...)
Affinity DataEC50:  1.18E+3nMAssay Description:Activity at human CaSR expressed in HEK293 cells assessed as calcium release by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50299678((1R)-2-methyl-N-((1R)-1-phenylethyl)-1-(1-(4-(trif...)
Affinity DataEC50:  2.34E+3nMAssay Description:Activity at human CaSR expressed in HEK293 cells assessed as calcium release by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50299679((1R)-1-(3-fluorophenyl)-N-((1-(4-(trifluoromethyl)...)
Affinity DataEC50:  148nMAssay Description:Activity at human CaSR expressed in HEK293 cells assessed as calcium release by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50299680((1R)-1-(3-chlorophenyl)-N-((1-(4-(trifluoromethyl)...)
Affinity DataEC50:  92nMAssay Description:Activity at human CaSR expressed in HEK293 cells assessed as calcium release by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50299681((R)-N-((R)-1-(5-methoxy-1-(4-(trifluoromethyl)phen...)
Affinity DataEC50:  70nMAssay Description:Activity at human CaSR expressed in HEK293 cells assessed as calcium release by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50299682((1R)-1-(3-chlorophenyl)-N-((1R)-1-(5-methoxy-1-(4-...)
Affinity DataEC50:  41nMAssay Description:Activity at human CaSR expressed in HEK293 cells assessed as calcium release by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50299683(1(R)-1-(1-(4-bromophenyl)-5-methoxy-1H-pyrazol-3-y...)
Affinity DataEC50:  23nMAssay Description:Activity at human CaSR expressed in HEK293 cells assessed as calcium release by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50299684((1R)-1-(3-chlorophenyl)-N-((1R)-1-(1-(3-chlorophen...)
Affinity DataEC50:  57nMAssay Description:Activity at human CaSR expressed in HEK293 cells assessed as calcium release by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50299685(4-(3-((R)-1-((R)-1-(3-chlorophenyl)ethylamino)ethy...)
Affinity DataEC50:  1.92E+3nMAssay Description:Activity at human CaSR expressed in HEK293 cells assessed as calcium release by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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