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Found 74 with Last Name = 'reid' and Initial = 'jc'
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50460673(CHEMBL4229054)
Affinity DataKi:  674nMAssay Description:Antagonist activity at DP1 receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50460670(CHEMBL4228792)
Affinity DataKi:  873nMAssay Description:Antagonist activity at DP1 receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50479470(CHEMBL489586 | MK-4965)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of wild type HIV1 RT polymerase by SPAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50479471(CHEMBL491019 | MK-1107)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of HIV1 RT polymerase Y181C mutant by SPAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50479471(CHEMBL491019 | MK-1107)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of wild type HIV1 RT polymerase by SPAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50479470(CHEMBL489586 | MK-4965)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of HIV1 RT polymerase Y181C mutant by SPAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetReverse transcriptase protein(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50479470(CHEMBL489586 | MK-4965)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of HIV1 RT polymerase K103N mutant by SPAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetReverse transcriptase protein(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50479471(CHEMBL491019 | MK-1107)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of HIV1 RT polymerase K103N mutant by SPAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50479472(CHEMBL523972)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of wild type HIV1 RT polymerase by SPAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM2483((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)
Affinity DataIC50:  1nMAssay Description:Inhibition of wild type HIV1 RT polymerase by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase protein(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50478383(CHEMBL402823)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of HIV1 RT polymerase K103N mutant by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50479473(CHEMBL491018)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of wild type HIV1 RT polymerase by SPAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase protein(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50479472(CHEMBL523972)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of HIV1 RT polymerase K103N mutant by SPAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50478383(CHEMBL402823)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of wild type HIV1 RT polymerase by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50460667(CHEMBL4226404)
Affinity DataIC50:  2nMAssay Description:Antagonist activity at DP1 receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50478383(CHEMBL402823)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of HIV1 RT polymerase Y181C mutant by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50479474(CHEMBL507164)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of wild type HIV1 RT polymerase by SPAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase protein(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50479473(CHEMBL491018)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of HIV1 RT polymerase K103N mutant by SPAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50479472(CHEMBL523972)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of HIV1 RT polymerase Y181C mutant by SPAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50460671(CHEMBL4228478)
Affinity DataIC50:  5nMAssay Description:Inhibition of PDE2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50155926(CHEMBL3183703)
Affinity DataIC50:  5nMAssay Description:Inhibition of NLRP3 in human monocyte derived macrophages assessed as reduction in LPS-induced IL-1beta production incubated for 30 mins followed by ...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50155926(CHEMBL3183703)
Affinity DataIC50:  5nMAssay Description:Inhibition of NLRP3 in human monocyte derived macrophages assessed as reduction in LPS-induced IL-1beta production incubated for 30 mins followed by ...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50155926(CHEMBL3183703)
Affinity DataIC50:  6nMAssay Description:Inhibition of NLRP3 in human monocyte derived macrophages assessed as reduction in LPS-induced IL-1beta production incubated for 30 mins followed by ...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50155926(CHEMBL3183703)
Affinity DataIC50:  6nMAssay Description:Inhibition of NLRP3 in human monocyte derived macrophages assessed as reduction in LPS-induced IL-1beta production incubated for 30 mins followed by ...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50479473(CHEMBL491018)
Affinity DataIC50:  6.20nMAssay Description:Inhibition of HIV1 RT polymerase Y181C mutant by SPAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50460673(CHEMBL4229054)
Affinity DataIC50:  7nMAssay Description:Inhibition of PDE2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50155926(CHEMBL3183703)
Affinity DataIC50:  7nMAssay Description:Inhibition of NLRP3 in human monocyte derived macrophages assessed as reduction in LPS-induced IL-1beta production incubated for 30 mins followed by ...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM2483((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)
Affinity DataIC50:  7.20nMAssay Description:Inhibition of HIV1 RT polymerase Y181C mutant by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mus musculus)
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50155926(CHEMBL3183703)
Affinity DataIC50:  7.5nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-stimulated mouse BMDM assessed as reduction in NLRP3 inflammasome-induced IL-1beta production prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50155926(CHEMBL3183703)
Affinity DataIC50:  8nMAssay Description:Inhibition of NLRP3 in human monocyte derived macrophages assessed as reduction in LPS-induced IL-1beta production by ELISAMore data for this Ligand-Target Pair
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50460672(CHEMBL4227417)
Affinity DataIC50:  13nMAssay Description:Antagonist activity at DP1 receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50460678(CHEMBL4227971)
Affinity DataIC50:  17nMAssay Description:Antagonist activity at DP1 receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50460679(CHEMBL4224708)
Affinity DataIC50:  18nMAssay Description:Inhibition of PDE2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase protein(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM2483((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)
Affinity DataIC50:  19nMAssay Description:Inhibition of HIV1 RT polymerase K103N mutant by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50460670(CHEMBL4228792)
Affinity DataIC50:  31nMAssay Description:Inhibition of PDE2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50460667(CHEMBL4226404)
Affinity DataIC50:  38nMAssay Description:Inhibition of PDE2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50460679(CHEMBL4224708)
Affinity DataIC50:  38nMAssay Description:Antagonist activity at DP1 receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase protein(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50479474(CHEMBL507164)
Affinity DataIC50:  40nMAssay Description:Inhibition of HIV1 RT polymerase K103N mutant by SPAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50460676(CHEMBL4225707)
Affinity DataIC50:  41nMAssay Description:Inhibition of PDE2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50460682(CHEMBL4225177)
Affinity DataIC50:  61nMAssay Description:Inhibition of PDE2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50460671(CHEMBL4228478)
Affinity DataIC50:  124nMAssay Description:Antagonist activity at DP1 receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM2580(K252a | methyl (15R,16S,18S)-16-hydroxy-15-methyl-...)
Affinity DataIC50:  210nMpH: 7.4 T: 2°CAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate.HTRF is based on the proximity of europium cryptate (donor fluorophore...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50199870(CHEMBL3904593)
Affinity DataIC50:  232nMAssay Description:Inhibition of NLRP3 inflammasome in LPS-stimulated human monocyte derived macrophages assessed as reduction in NLRP3 inflammasome-induced IL-1beta pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50460675(CHEMBL4227300)
Affinity DataIC50:  233nMAssay Description:Inhibition of PDE2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50460680(CHEMBL4225978)
Affinity DataIC50:  422nMAssay Description:Inhibition of PDE2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50184225(2-(9-(4-chlorobenzyl)-8-(methylsulfonyl)-2,3,4,9-t...)
Affinity DataIC50:  431nMAssay Description:Inhibition of PDE2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM2580(K252a | methyl (15R,16S,18S)-16-hydroxy-15-methyl-...)
Affinity DataIC50:  470nMpH: 7.4 T: 2°CAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate.HTRF is based on the proximity of europium cryptate (donor fluorophore...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM15015(2-tert-Butyl 4-Ethyl 3-Ethyl-5-formyl-1H-pyrrole-2...)
Affinity DataIC50:  490nMpH: 7.4 T: 2°CAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate.HTRF is based on the proximity of europium cryptate (donor fluorophore...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50479474(CHEMBL507164)
Affinity DataIC50:  740nMAssay Description:Inhibition of HIV1 RT polymerase Y181C mutant by SPAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM15012(2,4-diethyl 3-ethyl-5-formyl-1H-pyrrole-2,4-dicarb...)
Affinity DataIC50:  1.10E+3nMpH: 7.4 T: 2°CAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate.HTRF is based on the proximity of europium cryptate (donor fluorophore...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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