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Found 351 with Last Name = 'shishido' and Initial = 'y'
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262566((2S,3S)-3-[(1R)-6-Methoxy-1-methyl-1-trifluorometh...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50067935((2-Methoxy-5-trifluoromethoxy-benzyl)-((2S,3S)-2-p...)
Affinity DataKi:  20nMAssay Description:Binding affinity to human CYP2D6 using bufuralol as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262395(CHEMBL478620 | R/S-(2S,3S)-N-((6-methoxy-3-(triflu...)
Affinity DataKi:  20nMAssay Description:Binding affinity to human CYP2D6 using bufuralol as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262280(CHEMBL513351 | R/S-(2S,3S)-N-(2-methoxy-5-(1,1,1-t...)
Affinity DataKi:  70nMAssay Description:Binding affinity to human CYP2D6 using bufuralol as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262510(CHEMBL477365 | R/S-(2S,3S)-3-[((6-Methoxy-1-methyl...)
Affinity DataKi:  120nMAssay Description:Binding affinity to human CYP2D6 using bufuralol as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262567(((2S,3S)-2-Benzhydryl-1-aza-bicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  420nMAssay Description:Binding affinity to human CYP2D6 using bufuralol as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262279((2S,3S)-N-((6-methoxy-3-methyl-3-(trifluoromethyl)...)
Affinity DataKi:  660nMAssay Description:Binding affinity to human CYP2D6 using bufuralol as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50224198((2S,3S)-N-(2-methoxy-5-(1,1,1-trifluoro-2-methylpr...)
Affinity DataKi:  840nMAssay Description:Binding affinity to human CYP2D6 using bufuralol as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262337((2S,3S)-N-(5-(1,1,1,3,3,3-hexafluoropropan-2-yl)-2...)
Affinity DataKi:  2.10E+3nMAssay Description:Binding affinity to human CYP2D6 using bufuralol as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262281((2S,3S)-3-[2-Methoxy-5-(2,2,2-trifluoroethyl)benzy...)
Affinity DataKi:  4.25E+3nMAssay Description:Binding affinity to human CYP2D6 using bufuralol as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262279((2S,3S)-N-((6-methoxy-3-methyl-3-(trifluoromethyl)...)
Affinity DataIC50:  0.160nMAssay Description:Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50224198((2S,3S)-N-(2-methoxy-5-(1,1,1-trifluoro-2-methylpr...)
Affinity DataIC50:  0.200nMAssay Description:Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50225899((+/-)-4-[(N-(2-methoxy-5-trifluoromethoxybenzyl)am...)
Affinity DataIC50:  0.220nMAssay Description:Displacement of [3H]substance P from NK1 human receptor expressed in IM9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50224198((2S,3S)-N-(2-methoxy-5-(1,1,1-trifluoro-2-methylpr...)
Affinity DataIC50:  0.300nMAssay Description:Antagonist activity at neurokinin 1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262510(CHEMBL477365 | R/S-(2S,3S)-3-[((6-Methoxy-1-methyl...)
Affinity DataIC50:  0.340nMAssay Description:Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50261732((2S,3S)-N-(((S)-6-methoxy-1-methyl-1-(trifluoromet...)
Affinity DataIC50:  0.340nMAssay Description:Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262510(CHEMBL477365 | R/S-(2S,3S)-3-[((6-Methoxy-1-methyl...)
Affinity DataIC50:  0.340nMAssay Description:Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50067935((2-Methoxy-5-trifluoromethoxy-benzyl)-((2S,3S)-2-p...)
Affinity DataIC50:  0.400nMAssay Description:Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262280(CHEMBL513351 | R/S-(2S,3S)-N-(2-methoxy-5-(1,1,1-t...)
Affinity DataIC50:  0.400nMAssay Description:Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262453(CHEMBL479049 | R/S-(2S,3S)-N-((3-methoxy-8-(triflu...)
Affinity DataIC50:  0.5nMAssay Description:Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50224197((2S,3S)-N-(5-tert-butyl-2-methoxybenzyl)-2-phenylp...)
Affinity DataIC50:  0.600nMAssay Description:Antagonist activity at neurokinin 1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50000041((+) (2-Methoxy-benzyl)-(2-phenyl-piperidin-3-yl)-a...)
Affinity DataIC50:  0.630nMAssay Description:Displacement of [3H]substance P from NK1 human receptor expressed in IM9 cellsMore data for this Ligand-Target Pair
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262336(CHEMBL468163 | R/S-(2S,3S)-N-(2-methoxy-5-(1,2,2,2...)
Affinity DataIC50:  0.700nMAssay Description:Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262395(CHEMBL478620 | R/S-(2S,3S)-N-((6-methoxy-3-(triflu...)
Affinity DataIC50:  0.900nMAssay Description:Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262281((2S,3S)-3-[2-Methoxy-5-(2,2,2-trifluoroethyl)benzy...)
Affinity DataIC50:  0.900nMAssay Description:Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262394(CHEMBL515935 | R/S-(2S,3S)-N-(2-methoxy-5-(1,1,1-t...)
Affinity DataIC50:  0.900nMAssay Description:Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262395(CHEMBL478620 | R/S-(2S,3S)-N-((6-methoxy-3-(triflu...)
Affinity DataIC50:  0.900nMAssay Description:Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Raqualia Pharma

Curated by ChEMBL
LigandPNGBDBM50036542(CHEMBL3353600)
Affinity DataIC50:  0.960nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Raqualia Pharma

Curated by ChEMBL
LigandPNGBDBM50036544(CHEMBL3353601)
Affinity DataIC50:  3.30nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50225898((2-Methoxy-benzyl)-((2S,3S,3aR,6aS)-2-phenyl-octah...)
Affinity DataIC50:  3.40nMAssay Description:Displacement of [3H]substance P from NK1 human receptor expressed in IM9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
Raqualia Pharma

Curated by ChEMBL
LigandPNGBDBM50036517(CHEMBL3353597)
Affinity DataIC50:  5.80nMAssay Description:Antagonist activity at rat TRPM8 assessed as inhibition of menthol induced Ca2+ influx by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Raqualia Pharma

Curated by ChEMBL
LigandPNGBDBM50036555(CHEMBL3353610 | US9434711, 497)
Affinity DataIC50:  6.20nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Raqualia Pharma

Curated by ChEMBL
LigandPNGBDBM50036545(CHEMBL3353602)
Affinity DataIC50:  8nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Raqualia Pharma

Curated by ChEMBL
LigandPNGBDBM50036517(CHEMBL3353597)
Affinity DataIC50:  8.30nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Raqualia Pharma

Curated by ChEMBL
LigandPNGBDBM50036537(CHEMBL3353594)
Affinity DataIC50:  8.90nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
Raqualia Pharma

Curated by ChEMBL
LigandPNGBDBM50036554(CHEMBL3353609)
Affinity DataIC50:  9nMAssay Description:Antagonist activity at rat TRPM8 assessed as inhibition of menthol induced Ca2+ influx by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Raqualia Pharma

Curated by ChEMBL
LigandPNGBDBM50036554(CHEMBL3353609)
Affinity DataIC50:  11nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50231044(CHEMBL252011 | N-(2-(4,7-dihydroxynaphthalen-1-yl)...)
Affinity DataIC50:  14nMAssay Description:Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Raqualia Pharma

Curated by ChEMBL
LigandPNGBDBM50036541(CHEMBL3353599)
Affinity DataIC50:  14nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Raqualia Pharma

Curated by ChEMBL
LigandPNGBDBM50036551(CHEMBL3353606)
Affinity DataIC50:  15nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Raqualia Pharma

Curated by ChEMBL
LigandPNGBDBM50036553(CHEMBL3353608)
Affinity DataIC50:  16nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Raqualia Pharma

Curated by ChEMBL
LigandPNGBDBM50036552(CHEMBL3353607)
Affinity DataIC50:  18nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50231058(CHEMBL438345 | N-((6-hydroxy-9-methyl-2,3,4,9-tetr...)
Affinity DataIC50:  23nMAssay Description:Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Raqualia Pharma

Curated by ChEMBL
LigandPNGBDBM50036534(CHEMBL3353592)
Affinity DataIC50:  27nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
Raqualia Pharma

Curated by ChEMBL
LigandPNGBDBM50036552(CHEMBL3353607)
Affinity DataIC50:  28nMAssay Description:Antagonist activity at rat TRPM8 assessed as inhibition of menthol induced Ca2+ influx by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50160039(CHEMBL183752 | N-(4-tert-Butyl-phenyl)-4-(3-chloro...)
Affinity DataIC50:  37nMAssay Description:Antagonist activity at human TRPV1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Raqualia Pharma

Curated by ChEMBL
LigandPNGBDBM50036540(CHEMBL3353598)
Affinity DataIC50:  40nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Raqualia Pharma

Curated by ChEMBL
LigandPNGBDBM50036536(CHEMBL3353593)
Affinity DataIC50:  41nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50224199(4-(3-chloropyridin-2-yl)-N-(4-(1,1,1-trifluoro-2-m...)
Affinity DataIC50:  42nMAssay Description:Antagonist activity at human TRPV1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Raqualia Pharma

Curated by ChEMBL
LigandPNGBDBM50036521(CHEMBL3353573)
Affinity DataIC50:  42nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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