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Found 970 with Last Name = 'wen' and Initial = 'x'
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50004178(Nociceptin | Nociceptin/orphanin FQ | ORPHANIN FQ)
Affinity DataKi:  0.180nMAssay Description:Inhibition of [3H]nociceptin binding to human Opioid receptor like 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50437440(CHEMBL2409219)
Affinity DataKi:  0.620nMAssay Description:Inhibition of recombinant human coagulation factor 7AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50437438(CHEMBL2409314)
Affinity DataKi:  1.90nMAssay Description:Inhibition of recombinant human coagulation factor 7AMore data for this Ligand-Target Pair
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153127(2-{1-[1-(4-Isopropyl-cyclohexyl)-piperidin-4-yl]-2...)
Affinity DataKi:  3.90nMAssay Description:Inhibition of [3H]nociceptin binding to human Opioid receptor like 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50032651(1-((1S,2S)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-y...)
Affinity DataKi:  4.60nMAssay Description:Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153124(CHEMBL182967 | N-(2-{1-[1-(4-Isopropyl-cyclohexyl)...)
Affinity DataKi:  5nMAssay Description:Inhibition of [3H]nociceptin binding to human Opioid receptor like 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153121(1-[1-(4-Isopropyl-cyclohexyl)-piperidin-4-yl]-3,4-...)
Affinity DataKi:  6.10nMAssay Description:Inhibition of [3H]nociceptin binding to human Opioid receptor like 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153132(2-{1-[1-(4-Isopropyl-cyclohexyl)-piperidin-4-yl]-2...)
Affinity DataKi:  7.40nMAssay Description:Inhibition of [3H]nociceptin binding to human Opioid receptor like 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50437439(CHEMBL2409220)
Affinity DataKi:  8.10nMAssay Description:Inhibition of recombinant human coagulation factor 7AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344250(CHEMBL1779003 | N-((5-(4-fluoro-2-methoxyphenyl)py...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153135(1-[1-(3,3-Diphenyl-propyl)-piperidin-4-yl]-3,4-dih...)
Affinity DataKi:  13nMAssay Description:Inhibition of [3H]diprenorphine binding to human Opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50437440(CHEMBL2409219)
Affinity DataKi:  16nMAssay Description:Inhibition of purified human coagulation factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153137(3-Butyl-1-[1-(4-isopropyl-cyclohexyl)-piperidin-4-...)
Affinity DataKi:  18nMAssay Description:Inhibition of [3H]nociceptin binding to human Opioid receptor like 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153131(CHEMBL185415 | {1-[1-(4-Isopropyl-cyclohexyl)-pipe...)
Affinity DataKi:  25nMAssay Description:Inhibition of [3H]diprenorphine binding to human Opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344232(1-cyclopropyl-N-((6-(4-fluoro-2-methoxyphenyl)pyra...)
Affinity DataKi:  27nMAssay Description:Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153129(1-[1-(Decahydro-naphthalen-2-yl)-piperidin-4-yl]-3...)
Affinity DataKi:  29nMAssay Description:Inhibition of [3H]nociceptin binding to human Opioid receptor like 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50430383(CHEMBL2334315)
Affinity DataKi:  32nMAssay Description:Inhibition of thrombin (unknown origin) by chromogenic substrate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153131(CHEMBL185415 | {1-[1-(4-Isopropyl-cyclohexyl)-pipe...)
Affinity DataKi:  33nMAssay Description:Inhibition of [3H]nociceptin binding to human Opioid receptor like 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50430403(CHEMBL2334322)
Affinity DataKi:  35nMAssay Description:Inhibition of thrombin (unknown origin) by chromogenic substrate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50430399(CHEMBL2334326)
Affinity DataKi:  36nMAssay Description:Inhibition of thrombin (unknown origin) by chromogenic substrate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM21015((2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl...)
Affinity DataKi:  37nMAssay Description:Inhibition of [3H]diprenorphine binding to human Opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153137(3-Butyl-1-[1-(4-isopropyl-cyclohexyl)-piperidin-4-...)
Affinity DataKi:  38nMAssay Description:Inhibition of [3H]diprenorphine binding to human Opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153123(1-[1-(1,4-Dimethyl-pentyl)-piperidin-4-yl]-3,4-dih...)
Affinity DataKi:  40nMAssay Description:Agonist activity as stimulation of [35S]-GTP-gamma binding to human Opioid receptor like 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153125(CHEMBL364844 | {1-[1-(4-Isopropyl-cyclohexyl)-pipe...)
Affinity DataKi:  41nMAssay Description:Agonist activity as stimulation of [35S]-GTP-gamma binding to human Opioid receptor like 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153141(1-(1-Indan-2-yl-piperidin-4-yl)-3,4-dihydro-1H-ben...)
Affinity DataKi:  46nMAssay Description:Inhibition of [3H]nociceptin binding to human Opioid receptor like 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344251(CHEMBL1779004 | N-((4'-fluoro-2'-methoxybiphenyl-3...)
Affinity DataKi:  48nMAssay Description:Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344233(CHEMBL1778866 | N-((6-(4-fluoro-2-methoxyphenyl)py...)
Affinity DataKi:  53nMAssay Description:Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344234(CHEMBL1778867 | N-((6-(4-fluoro-2-methoxyphenyl)py...)
Affinity DataKi:  54nMAssay Description:Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153122(CHEMBL181545 | {1-[1-(4-Isopropyl-cyclohexyl)-pipe...)
Affinity DataKi:  63nMAssay Description:Inhibition of [3H]nociceptin binding to human Opioid receptor like 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344252(CHEMBL1779005 | N-((6-(4-fluoro-2-methoxyphenyl)py...)
Affinity DataKi:  66nMAssay Description:Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153123(1-[1-(1,4-Dimethyl-pentyl)-piperidin-4-yl]-3,4-dih...)
Affinity DataKi:  73nMAssay Description:Inhibition of [3H]diprenorphine binding to human Opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50430396(CHEMBL2334300)
Affinity DataKi:  78nMAssay Description:Inhibition of thrombin (unknown origin) by chromogenic substrate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344259(CHEMBL1779012 | N-((5-(4-fluoro-2-methoxyphenyl)py...)
Affinity DataKi:  80nMAssay Description:Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153135(1-[1-(3,3-Diphenyl-propyl)-piperidin-4-yl]-3,4-dih...)
Affinity DataKi:  83nMAssay Description:Inhibition of [3H]nociceptin binding to human Opioid receptor like 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153132(2-{1-[1-(4-Isopropyl-cyclohexyl)-piperidin-4-yl]-2...)
Affinity DataKi:  86nMAssay Description:Inhibition of [3H]diprenorphine binding to human Opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153129(1-[1-(Decahydro-naphthalen-2-yl)-piperidin-4-yl]-3...)
Affinity DataKi:  92nMAssay Description:Inhibition of [3H]diprenorphine binding to human Opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153127(2-{1-[1-(4-Isopropyl-cyclohexyl)-piperidin-4-yl]-2...)
Affinity DataKi:  92nMAssay Description:Inhibition of [3H]diprenorphine binding to human Opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153124(CHEMBL182967 | N-(2-{1-[1-(4-Isopropyl-cyclohexyl)...)
Affinity DataKi:  106nMAssay Description:Inhibition of [3H]diprenorphine binding to human Opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50430398(CHEMBL2334298)
Affinity DataKi:  110nMAssay Description:Inhibition of thrombin (unknown origin) by chromogenic substrate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344254(CHEMBL1779007 | N-((5-(4-fluoro-2-methoxyphenyl)py...)
Affinity DataKi:  112nMAssay Description:Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344260(CHEMBL1779013 | N-((5-(4-fluoro-2-methoxyphenyl)py...)
Affinity DataKi:  116nMAssay Description:Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50498202(CHEMBL3416136)
Affinity DataKi:  130nMAssay Description:Inhibition of human soluble tissue factor/factor VIIa expressed in Origami B (DE3) using D-Ile-Pro-Arg-pNA as substrate after 30 mins by spectrophoto...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50430390(CHEMBL2334306)
Affinity DataKi:  130nMAssay Description:Inhibition of thrombin (unknown origin) by chromogenic substrate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50430382(CHEMBL2334317)
Affinity DataKi:  150nMAssay Description:Inhibition of thrombin (unknown origin) by chromogenic substrate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50430387(CHEMBL2334309)
Affinity DataKi:  160nMAssay Description:Inhibition of thrombin (unknown origin) by chromogenic substrate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50437441(CHEMBL2409218)
Affinity DataKi:  160nMAssay Description:Inhibition of recombinant human coagulation factor 7AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50430397(CHEMBL2334299)
Affinity DataKi:  170nMAssay Description:Inhibition of thrombin (unknown origin) by chromogenic substrate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153125(CHEMBL364844 | {1-[1-(4-Isopropyl-cyclohexyl)-pipe...)
Affinity DataKi:  182nMAssay Description:Inhibition of [3H]diprenorphine binding to human Opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344241(CHEMBL1778994 | N-((6-(2,3-difluorophenyl)pyrazin-...)
Affinity DataKi:  186nMAssay Description:Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153128(1-(1-Cyclooctyl-piperidin-4-yl)-3,4-dihydro-1H-ben...)
Affinity DataKi:  187nMAssay Description:Inhibition of [3H]nociceptin binding to human Opioid receptor like 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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