TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Institute For Theoretical Medicine
Curated by ChEMBL
Institute For Theoretical Medicine
Curated by ChEMBL
Affinity DataKi: 20nMAssay Description:Competitive inhibition of mushroom tyrosinase after 15 mins by Lineweaver-Bulk plot analysisMore data for this Ligand-Target Pair
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Institute For Theoretical Medicine
Curated by ChEMBL
Institute For Theoretical Medicine
Curated by ChEMBL
Affinity DataKi: 60nMAssay Description:Competitive inhibition of mushroom tyrosinase after 15 mins by Lineweaver-Bulk plot analysisMore data for this Ligand-Target Pair
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Institute For Theoretical Medicine
Curated by ChEMBL
Institute For Theoretical Medicine
Curated by ChEMBL
Affinity DataKi: 3.30E+3nMAssay Description:Competitive inhibition of mushroom tyrosinase after 15 mins by Lineweaver-Bulk plot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 0.360nMAssay Description:Inhibition of neutral endopeptidase in human fibroblasts homogenates using glutaryl-Ala-Ala-Phe-4-methoxy-2-naphtylamide as substrate after 1 hrs by ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.510nMAssay Description:Inhibition of neutral endopeptidase in human fibroblasts homogenates using glutaryl-Ala-Ala-Phe-4-methoxy-2-naphtylamide as substrate after 1 hrs by ...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of neutral endopeptidase in human fibroblasts homogenates using glutaryl-Ala-Ala-Phe-4-methoxy-2-naphtylamide as substrate after 1 hrs by ...More data for this Ligand-Target Pair
Affinity DataIC50: 9.70nMAssay Description:Inhibition of neutral endopeptidase in human fibroblasts homogenates using glutaryl-Ala-Ala-Phe-4-methoxy-2-naphtylamide as substrate after 1 hrs by ...More data for this Ligand-Target Pair
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Institute For Theoretical Medicine
Curated by ChEMBL
Institute For Theoretical Medicine
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:Non-competitive inhibition of mushroom tyrosinaseMore data for this Ligand-Target Pair
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Institute For Theoretical Medicine
Curated by ChEMBL
Institute For Theoretical Medicine
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:Inhibition of mushroom tyrosinase after 15 minsMore data for this Ligand-Target Pair
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Institute For Theoretical Medicine
Curated by ChEMBL
Institute For Theoretical Medicine
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:Non-competitive inhibition of mushroom tyrosinaseMore data for this Ligand-Target Pair
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Institute For Theoretical Medicine
Curated by ChEMBL
Institute For Theoretical Medicine
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:Inhibition of mushroom tyrosinase after 15 minsMore data for this Ligand-Target Pair
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Institute For Theoretical Medicine
Curated by ChEMBL
Institute For Theoretical Medicine
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:Non-competitive inhibition of mushroom tyrosinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 420nMAssay Description:Inhibition of neutral endopeptidase in human fibroblasts homogenates using glutaryl-Ala-Ala-Phe-4-methoxy-2-naphtylamide as substrate after 1 hrs by ...More data for this Ligand-Target Pair
Affinity DataIC50: 430nMAssay Description:Inhibition of neutral endopeptidase in human fibroblasts homogenates using glutaryl-Ala-Ala-Phe-4-methoxy-2-naphtylamide as substrate after 1 hrs by ...More data for this Ligand-Target Pair
Affinity DataIC50: 560nMAssay Description:Inhibition of human recombinant His-tagged Glyoxalase 1 expressed in Sf21-Baculovirus systemMore data for this Ligand-Target Pair
Affinity DataIC50: 560nMAssay Description:Inhibition of recombinant human His-tagged glyoxalase 1 expressed in Escherichia coli BL21 assessed as formation of S-D-lactoylglutathione after 5 mi...More data for this Ligand-Target Pair
Affinity DataIC50: 760nMAssay Description:Inhibition of human N-terminal His6-tagged GLO1 expressed in baculovirus infected sf21 cells assessed as reduction in S-D-lactoylglutathione formatio...More data for this Ligand-Target Pair
Affinity DataIC50: 1.15E+3nMAssay Description:Competitive inhibition of tyrosinase in human G-361 cells incubated for 10 mins measured for 2 hrs by MBTH-based spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of human recombinant glyoxalase 1 assessed as S-D-lactoylglutathione after 15 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of recombinant human His-tagged glyoxalase 1 expressed in Escherichia coli BL21 assessed as formation of S-D-lactoylglutathione after 5 mi...More data for this Ligand-Target Pair
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of Glyoxalase-1 (unknown origin) assessed as inhibition of S-D-lactoylglutathione formation using MG and reduced glutathione as substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of Glyoxalase-1 (unknown origin) assessed as inhibition of S-D-lactoylglutathione formation using MG and reduced glutathione as substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of Glyoxalase-1 (unknown origin) assessed as inhibition of S-D-lactoylglutathione formation using MG and reduced glutathione as substrate ...More data for this Ligand-Target Pair
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Institute For Theoretical Medicine
Curated by ChEMBL
Institute For Theoretical Medicine
Curated by ChEMBL
Affinity DataIC50: 2.89E+3nMAssay Description:Non-competitive inhibition of mushroom tyrosinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of Glyoxalase-1 (unknown origin) assessed as inhibition of S-D-lactoylglutathione formation using MG and reduced glutathione as substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of Glyoxalase-1 (unknown origin) assessed as inhibition of S-D-lactoylglutathione formation using MG and reduced glutathione as substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of human recombinant His-tagged Glyoxalase 1 expressed in Sf21-Baculovirus systemMore data for this Ligand-Target Pair
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of Glyoxalase-1 (unknown origin) assessed as inhibition of S-D-lactoylglutathione formation using MG and reduced glutathione as substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of Glyoxalase-1 (unknown origin) assessed as inhibition of S-D-lactoylglutathione formation using MG and reduced glutathione as substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of Glyoxalase-1 (unknown origin) assessed as inhibition of S-D-lactoylglutathione formation using MG and reduced glutathione as substrate ...More data for this Ligand-Target Pair
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Institute For Theoretical Medicine
Curated by ChEMBL
Institute For Theoretical Medicine
Curated by ChEMBL
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of mushroom tyrosinase using L-tyrosine as substrate assessed as dopachrome formation preincubated for 10 mins followed by protein additio...More data for this Ligand-Target Pair
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Institute For Theoretical Medicine
Curated by ChEMBL
Institute For Theoretical Medicine
Curated by ChEMBL
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of mushroom tyrosinase using L-tyrosine as substrate assessed as dopachrome formation preincubated for 10 mins followed by protein additio...More data for this Ligand-Target Pair
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of Glyoxalase-1 (unknown origin) assessed as inhibition of S-D-lactoylglutathione formation using MG and reduced glutathione as substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of Glyoxalase-1 (unknown origin) assessed as inhibition of S-D-lactoylglutathione formation using MG and reduced glutathione as substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of Glyoxalase-1 (unknown origin) assessed as inhibition of S-D-lactoylglutathione formation using MG and reduced glutathione as substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 5.40E+3nMAssay Description:Inhibition of Glyoxalase-1 (unknown origin) assessed as inhibition of S-D-lactoylglutathione formation using MG and reduced glutathione as substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of Glyoxalase-1 (unknown origin) assessed as inhibition of S-D-lactoylglutathione formation using MG and reduced glutathione as substrate ...More data for this Ligand-Target Pair
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Institute For Theoretical Medicine
Curated by ChEMBL
Institute For Theoretical Medicine
Curated by ChEMBL
Affinity DataIC50: 6.97E+3nMAssay Description:Inhibition of mushroom tyrosinase monophenolase activity using L-tyrosine as substrate measured every 60 s for 25 timesMore data for this Ligand-Target Pair
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Institute For Theoretical Medicine
Curated by ChEMBL
Institute For Theoretical Medicine
Curated by ChEMBL
Affinity DataIC50: 6.97E+3nMAssay Description:Inhibition of mushroom tyrosinase monophenolase activity using L-tyrosine as substrate measured every 60 s for 25 timesMore data for this Ligand-Target Pair
Affinity DataIC50: 7.70E+3nMAssay Description:Inhibition of human recombinant His-tagged Glyoxalase 1 expressed in Sf21-Baculovirus systemMore data for this Ligand-Target Pair
Affinity DataIC50: 8.20E+3nMAssay Description:Inhibition of Glyoxalase-1 (unknown origin) assessed as inhibition of S-D-lactoylglutathione formation using MG and reduced glutathione as substrate ...More data for this Ligand-Target Pair
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Institute For Theoretical Medicine
Curated by ChEMBL
Institute For Theoretical Medicine
Curated by ChEMBL
Affinity DataIC50: 8.40E+3nMAssay Description:Non-competitive inhibition of mushroom tyrosinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 8.98E+3nMAssay Description:Competitive inhibition of tyrosinase in human G-361 cells incubated for 10 mins measured for 2 hrs by MBTH-based spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of tyrosinase in human HMV-2 melanoma cells after 5 mins by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 9.50E+3nMAssay Description:Inhibition of Glyoxalase-1 (unknown origin) assessed as inhibition of S-D-lactoylglutathione formation using MG and reduced glutathione as substrate ...More data for this Ligand-Target Pair
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Institute For Theoretical Medicine
Curated by ChEMBL
Institute For Theoretical Medicine
Curated by ChEMBL
Affinity DataIC50: 9.53E+3nMAssay Description:Inhibition of mushroom tyrosinase after 15 minsMore data for this Ligand-Target Pair
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Institute For Theoretical Medicine
Curated by ChEMBL
Institute For Theoretical Medicine
Curated by ChEMBL
Affinity DataIC50: 9.53E+3nMAssay Description:Non-competitive inhibition of mushroom tyrosinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of human recombinant His-tagged Glyoxalase 1 expressed in Sf21-Baculovirus systemMore data for this Ligand-Target Pair
Affinity DataIC50: 1.17E+4nMAssay Description:Inhibition of human recombinant glyoxalase 1 assessed as S-D-lactoylglutathione after 15 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.36E+4nMAssay Description:Inhibition of human recombinant caspase 3 preincubated for 10 minsMore data for this Ligand-Target Pair