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Target
Lactoylglutathione lyase
Ligand
BDBM50355547
Substrate
n/a
Meas. Tech.
ChEMBL_776454 (CHEMBL1913551)
IC50
2000±n/a nM
Citation
 Takasawa, R; Tao, A; Saeki, K; Shionozaki, N; Tanaka, R; Uchiro, H; Takahashi, S; Yoshimori, A; Tanuma, S Discovery of a new type inhibitor of human glyoxalase I by myricetin-based 4-point pharmacophore. Bioorg Med Chem Lett 21:4337-42 (2011) [PubMed]  Article 
Target
Name:
Lactoylglutathione lyase
Synonyms:
Aldoketomutase | GLO1 | Glx I | Glyoxalase 1 (GLO1) | Glyoxalase I | Ketone-aldehyde mutase | LGUL_HUMAN | Methylglyoxalase | S-D-lactoylglutathione methylglyoxal lyase
Type:
Enzyme
Mol. Mass.:
20772.95
Organism:
Homo sapiens (Human)
Description:
Q04760
Residue:
184
Sequence:
MAEPQPPSGGLTDEAALSCCSDADPSTKDFLLQQTMLRVKDPKKSLDFYTRVLGMTLIQKCDFPIMKFSLYFLAYEDKNDIPKEKDEKIAWALSRKATLELTHNWGTEDDETQSYHNGNSDPRGFGHIGIAVPDVYSACKRFEELGVKFVKKPDDGKMKGLAFIQDPDGYWIEILNPNKMATLM
  
Inhibitor
Name:
BDBM50355547
Synonyms:
CHEMBL1910548
Type:
Small organic molecule
Emp. Form.:
C18H15NO3S
Mol. Mass.:
325.382
SMILES:
COc1ccc(\C=C(\CC(O)=O)c2nc3ccccc3s2)cc1
Structure:
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