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Found 1679 with Last Name = 'you' and Initial = 'h'
TargetKappa-type opioid receptor(Homo sapiens (Human))
Biomedizinische Forschungsreagenzien

Curated by ChEMBL
LigandPNGBDBM50300442((20R)-4,5-alpha-Epoxy-17-methyl-3-hydroxy-6-methox...)
Affinity DataKi:  0.120nMAssay Description:Displacement of [3H]diprenorphine from human cloned kappa opioid receptor expressed in CHO cells after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Biomedizinische Forschungsreagenzien

Curated by ChEMBL
LigandPNGBDBM50300442((20R)-4,5-alpha-Epoxy-17-methyl-3-hydroxy-6-methox...)
Affinity DataKi:  0.180nMAssay Description:Displacement of [3H]diprenorphine from human cloned mu opioid receptor expressed in CHO cells after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultifunctional protein ADE2(Gallus gallus)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50247807(((2R,3S,4R,5R)-5-(5-AMINO-4-NITRO-1H-IMIDAZOL-1-YL...)
Affinity DataKi:  0.340nMAssay Description:Inhibition of Gallus gallus AIR carboxylase by CAIR decarboxylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Mus musculus (mouse))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50585443(CHEMBL5082250)
Affinity DataKi:  1.20nMAssay Description:Inhibition of mouse AChE assessed as inhibition constant using acetylthiocholine iodide as substrate measured every 2 mins by lineweaver-burk plot an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50554754(CHEMBL4790764)
Affinity DataKi:  1.40nMAssay Description:Inhibition of AlexaFluor647-tagged cyclic peptide binding to avi-tagged-biotinylated human PCSK9 measured after 2 hrs by Lance Streptavidin Europium ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Research Institute Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50184391((R,Z)-2-(2-(hydroxymethyl)-4-(3-isobutyl-5-methylh...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [20-3H]PDBu from recombinant PKC alpha in presence of phosphatidylserineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50554734(CHEMBL4761415 | US11530244, Compound 289)
Affinity DataKi:  1.5nMAssay Description:Inhibition of AlexaFluor647-tagged cyclic peptide binding to avi-tagged-biotinylated human PCSK9 measured after 2 hrs by Lance Streptavidin Europium ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50554755(CHEMBL4782157)
Affinity DataKi:  1.5nMAssay Description:Inhibition of AlexaFluor647-tagged cyclic peptide binding to avi-tagged-biotinylated human PCSK9 measured after 2 hrs by Lance Streptavidin Europium ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRas guanyl-releasing protein 3(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50244866(CHEMBL511820 | rac-(E)-{2-(Hydroxymethyl)-4-[(4-ni...)
Affinity DataKi:  1.80nMAssay Description:Binding affinity to RasGRP3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(MOUSE)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50244416(CHEMBL527875 | rac-(E)-{4-[(3-Bromo-4-fluorophenyl...)
Affinity DataKi:  2.07nMAssay Description:Displacement of [3H]PDBu form mouse PKCalpha by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(MOUSE)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50244416(CHEMBL527875 | rac-(E)-{4-[(3-Bromo-4-fluorophenyl...)
Affinity DataKi:  2.07nMAssay Description:Displacement of [3H]PDBu form mouse PKCalpha by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50554743(CHEMBL4759174)
Affinity DataKi:  2.10nMAssay Description:Inhibition of AlexaFluor647-tagged cyclic peptide binding to avi-tagged-biotinylated human PCSK9 measured after 2 hrs by Lance Streptavidin Europium ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50484947(CHEMBL2017621)
Affinity DataKi:  2.10nMAssay Description:Displacement of [3H]Pittsburgh compound B from human Abeta1-40 after 3 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRas guanyl-releasing protein 3(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50245091(CHEMBL519398 | rac-(E)-{2-(Hydroxymethyl)-4-[(4-ni...)
Affinity DataKi:  2.22nMAssay Description:Binding affinity to RasGRP3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRas guanyl-releasing protein 3(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50244865(CHEMBL471153 | rac-(E)-{2-(Hydroxymethyl)-4-[(4-ni...)
Affinity DataKi:  2.30nMAssay Description:Binding affinity to RasGRP3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(MOUSE)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50244693(CHEMBL516638 | rac-(E)-{4-[(3-Chloro-4-fluoropheny...)
Affinity DataKi:  2.45nMAssay Description:Displacement of [3H]PDBu form mouse PKCalpha by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(MOUSE)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50244693(CHEMBL516638 | rac-(E)-{4-[(3-Chloro-4-fluoropheny...)
Affinity DataKi:  2.45nMAssay Description:Displacement of [3H]PDBu form mouse PKCalpha by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(MOUSE)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50244961(CHEMBL472520 | rac-(E/Z)-(4-heptylidene-2-(hydroxy...)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]PDBu form mouse PKCalpha by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(MOUSE)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50244961(CHEMBL472520 | rac-(E/Z)-(4-heptylidene-2-(hydroxy...)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]PDBu form mouse PKCalpha by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(MOUSE)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50244413(CHEMBL488498 | rac-(E)-{4-[(3-Bromo-4-fluorophenyl...)
Affinity DataKi:  2.66nMAssay Description:Displacement of [3H]PDBu form mouse PKCalpha by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(MOUSE)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50244413(CHEMBL488498 | rac-(E)-{4-[(3-Bromo-4-fluorophenyl...)
Affinity DataKi:  2.66nMAssay Description:Displacement of [3H]PDBu form mouse PKCalpha by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50554736(CHEMBL4789838)
Affinity DataKi:  2.70nMAssay Description:Inhibition of AlexaFluor647-tagged cyclic peptide binding to avi-tagged-biotinylated human PCSK9 measured after 2 hrs by Lance Streptavidin Europium ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50554760(CHEMBL4798026)
Affinity DataKi:  2.80nMAssay Description:Inhibition of AlexaFluor647-tagged cyclic peptide binding to avi-tagged-biotinylated human PCSK9 measured after 2 hrs by Lance Streptavidin Europium ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50484946((18F)AV-45 | 18F-AV-45 | AV-45 F-18 | Amyvid | CHE...)
Affinity DataKi:  2.90nMAssay Description:Binding affinity to amyloid beta aggregates in postmortem human Alzheimer's disease brain homogenates after 2 hrs by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Research Institute Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50107112((Z) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...)
Affinity DataKi:  2.90nMAssay Description:Displacement of [20-3H]PDBu from recombinant PKC alpha in presence of phosphatidylserineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(MOUSE)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50244414(CHEMBL488500 | rac-(E)-{4-[(4-Chlorophenyl)methyle...)
Affinity DataKi:  2.90nMAssay Description:Displacement of [3H]PDBu form mouse PKCalpha by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(MOUSE)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50244414(CHEMBL488500 | rac-(E)-{4-[(4-Chlorophenyl)methyle...)
Affinity DataKi:  2.90nMAssay Description:Displacement of [3H]PDBu form mouse PKCalpha by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(MOUSE)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50244648(CHEMBL453598 | rac-(E)-(2-(Hydroxymethyl)-5-oxo-4-...)
Affinity DataKi:  2.96nMAssay Description:Displacement of [3H]PDBu form mouse PKCalpha by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(MOUSE)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50244648(CHEMBL453598 | rac-(E)-(2-(Hydroxymethyl)-5-oxo-4-...)
Affinity DataKi:  2.96nMAssay Description:Displacement of [3H]PDBu form mouse PKCalpha by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(MOUSE)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50245049(CHEMBL488706 | rac-(E)-{2-(Hydroxymethyl)-4-[(4-ni...)
Affinity DataKi:  3.10nMAssay Description:Displacement of [3H]PDBu form mouse PKCalpha by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50484947(CHEMBL2017621)
Affinity DataKi:  3.20nMAssay Description:Displacement of [3H]Pittsburgh compound B from human Abeta1-42 after 3 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(MOUSE)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50244740(CHEMBL461372 | rac-(E)-{4-[(3-Chloro-4-fluoropheny...)
Affinity DataKi:  3.38nMAssay Description:Displacement of [3H]PDBu form mouse PKCalpha by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(MOUSE)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50244740(CHEMBL461372 | rac-(E)-{4-[(3-Chloro-4-fluoropheny...)
Affinity DataKi:  3.38nMAssay Description:Displacement of [3H]PDBu form mouse PKCalpha by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50483423(CHEMBL1671878)
Affinity DataKi:  3.5nMAssay Description:Displacement of [3H]PiB from human amyloid beta (1-40) at 100 nM after 180 mins by liquid scintillation counterMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(MOUSE)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50244908(CHEMBL511301 | rac-(E)-{2-(Hydroxymethyl)-4-[(4-me...)
Affinity DataKi:  3.70nMAssay Description:Displacement of [3H]PDBu form mouse PKCalpha by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(MOUSE)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50244908(CHEMBL511301 | rac-(E)-{2-(Hydroxymethyl)-4-[(4-me...)
Affinity DataKi:  3.70nMAssay Description:Displacement of [3H]PDBu form mouse PKCalpha by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Research Institute Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50184395(5-hexanoyloxymethyl-5-hydroxymethyl-3-[(Z)-3-isobu...)
Affinity DataKi:  3.80nMAssay Description:Displacement of [20-3H]PDBu from recombinant PKC alpha in presence of phosphatidylserineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRas guanyl-releasing protein 3(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50244482((4-(4-nitrobenzylidene)-2-(hydroxymethyl)-5-oxo-te...)
Affinity DataKi:  3.80nMAssay Description:Binding affinity to RasGRP3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50554735(CHEMBL4742833)
Affinity DataKi:  3.90nMAssay Description:Inhibition of AlexaFluor647-tagged cyclic peptide binding to avi-tagged-biotinylated human PCSK9 measured after 2 hrs by Lance Streptavidin Europium ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRas guanyl-releasing protein 3(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50244915(CHEMBL472002 | rac-(E)-{2-(Hydroxymethyl)-4-[(3-ni...)
Affinity DataKi:  3.90nMAssay Description:Binding affinity to RasGRP3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50554731(CHEMBL4789480)
Affinity DataKi:  4nMAssay Description:Inhibition of AlexaFluor647-tagged cyclic peptide binding to avi-tagged-biotinylated human PCSK9 measured after 2 hrs by Lance Streptavidin Europium ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50554759(CHEMBL4745053)
Affinity DataKi:  4nMAssay Description:Inhibition of AlexaFluor647-tagged cyclic peptide binding to avi-tagged-biotinylated human PCSK9 measured after 2 hrs by Lance Streptavidin Europium ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50554750(CHEMBL4755930)
Affinity DataKi:  4.20nMAssay Description:Inhibition of AlexaFluor647-tagged cyclic peptide binding to avi-tagged-biotinylated human PCSK9 measured after 2 hrs by Lance Streptavidin Europium ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50554733(CHEMBL4754486)
Affinity DataKi:  4.20nMAssay Description:Inhibition of AlexaFluor647-tagged cyclic peptide binding to avi-tagged-biotinylated human PCSK9 measured after 2 hrs by Lance Streptavidin Europium ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50554739(CHEMBL4789893)
Affinity DataKi:  4.20nMAssay Description:Inhibition of AlexaFluor647-tagged cyclic peptide binding to avi-tagged-biotinylated human PCSK9 measured after 2 hrs by Lance Streptavidin Europium ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50554732(CHEMBL4743963)
Affinity DataKi:  4.30nMAssay Description:Inhibition of AlexaFluor647-tagged cyclic peptide binding to avi-tagged-biotinylated human PCSK9 measured after 2 hrs by Lance Streptavidin Europium ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Research Institute Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50107118(3-Isopropyl-4-methyl-pentanoic acid 2-hydroxymethy...)
Affinity DataKi:  4.5nMAssay Description:Displacement of [20-3H]PDBu from recombinant PKC alpha in presence of phosphatidylserineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Research Institute Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50107120((E) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...)
Affinity DataKi:  4.5nMAssay Description:Displacement of [20-3H]PDBu from recombinant PKC alpha in presence of phosphatidylserineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRas guanyl-releasing protein 3(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50244643(CHEMBL452307 | rac-(E)-(4-{[4-(Dimethylamino)pheny...)
Affinity DataKi:  4.68nMAssay Description:Binding affinity to RasGRP3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(MOUSE)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50244863(CHEMBL472362 | rac-(E)-{4-[(4-Chloro-3-fluoropheny...)
Affinity DataKi:  4.89nMAssay Description:Displacement of [3H]PDBu form mouse PKCalpha by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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