Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 12596,50123764,50123774,50123775,50123777,12596,50123764,50123774,50123775,50123777   

TargetCoagulation factor X(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM12596(4-{[(E)-2-(5-CHLOROTHIEN-2-YL)VINYL]SULFONYL}-1-(1...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity (in vitro) towards human Coagulation factor X was determined at 5 mg/kg peroral doseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM12596(4-{[(E)-2-(5-CHLOROTHIEN-2-YL)VINYL]SULFONYL}-1-(1...)
Affinity DataKi:  1.10nM ΔG°:  -12.1kcal/molepH: 7.5 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2006
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM12596(4-{[(E)-2-(5-CHLOROTHIEN-2-YL)VINYL]SULFONYL}-1-(1...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123775(4-[2-(4-Chloro-phenyl)-ethenesulfonyl]-1-(1H-pyrro...)
Affinity DataKi:  48nMAssay Description:In vitro binding affinity for human Coagulation factor XMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123774(4-[2-(5-Chloro-thiophen-2-yl)-ethanesulfonyl]-1-(1...)
Affinity DataKi:  128nMAssay Description:In vitro binding affinity for human Coagulation factor XMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123777(4-[2-(5-Chloro-4-methoxy-thiophen-2-yl)-ethenesulf...)
Affinity DataKi: >1.20E+3nMAssay Description:In vitro binding affinity for human Coagulation factor XMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123764(4-(4'-Chloro-biphenyl-4-sulfonyl)-1-(1H-pyrrolo[3,...)
Affinity DataKi: >1.20E+3nMAssay Description:In vitro binding affinity for human Coagulation factor XMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Aventis Pharma

LigandPNGBDBM12596(4-{[(E)-2-(5-CHLOROTHIEN-2-YL)VINYL]SULFONYL}-1-(1...)
Affinity DataKi: >2.90E+3nM ΔG°: >-7.47kcal/molepH: 7.5 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2006
Entry Details Article
PubMed
TargetProthrombin(Human)
Aventis Pharma

LigandPNGBDBM12596(4-{[(E)-2-(5-CHLOROTHIEN-2-YL)VINYL]SULFONYL}-1-(1...)
Affinity DataKi: >4.00E+3nM ΔG°: >-7.28kcal/molepH: 7.5 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2006
Entry Details Article
PubMed