Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 25308,50098389,50318032,50422442,50422477,25308,50098389,50318032,50422442,50422477   

TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL

LigandBDBM50098389([1-Hydroxy-2-(1H-imidazol-4-yl)-1-phosphono-ethyl]...)Copy SMILESCopy InChI

Affinity DataIC50: 1.10nMAssay Description:Negative logarithm of inhibitory concentration against bone resorptionMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/22/2013
Entry Details Article
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TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL

LigandBDBM25308((1-hydroxy-2-{imidazo[1,2-a]pyridin-3-yl}-1-phosph...)Copy SMILESCopy InChI

Affinity DataIC50: 1.90nMAssay Description:Inhibition of human FPPSMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
4/22/2016
Entry Details Article
Copy BDB DOIPubMedPDB3D Structure (crystal)
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TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL

LigandBDBM25308((1-hydroxy-2-{imidazo[1,2-a]pyridin-3-yl}-1-phosph...)Copy SMILESCopy InChI

Affinity DataIC50: 3nMAssay Description:Inhibition of FDPS (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/18/2021
Entry Details Article
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TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL

LigandBDBM25308((1-hydroxy-2-{imidazo[1,2-a]pyridin-3-yl}-1-phosph...)Copy SMILESCopy InChI

Affinity DataIC50: 3nMAssay Description:Inhibition of human FPPS after 10 mins using [14C]IPP as substrate by liquid scintillation countingMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
12/30/2012
Entry Details Article
Copy BDB DOIPubMedPDB3D Structure (crystal)
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TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL

LigandBDBM50422477(CHEMBL317646)Copy SMILESCopy InChI

Affinity DataIC50: 5.10nMAssay Description:Negative logarithm of inhibitory concentration against bone resorptionMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/22/2013
Entry Details Article
Copy BDB DOIPubMed
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TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL

LigandBDBM50098389([1-Hydroxy-2-(1H-imidazol-4-yl)-1-phosphono-ethyl]...)Copy SMILESCopy InChI

Affinity DataKi:  30nMAssay Description:Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligandMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
11/10/2009
Entry Details Article
Copy BDB DOIPubMed
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TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL

LigandBDBM50422442(CHEMBL323299)Copy SMILESCopy InChI

Affinity DataIC50: 51nMAssay Description:Negative logarithm of inhibitory concentration against bone resorptionMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/22/2013
Entry Details Article
Copy BDB DOIPubMed
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TargetGeranylgeranyl pyrophosphate synthase BTS1(Baker's yeast)
Institute of Biological Chemistry

Curated by ChEMBL

LigandBDBM25308((1-hydroxy-2-{imidazo[1,2-a]pyridin-3-yl}-1-phosph...)Copy SMILESCopy InChI

Affinity DataKi:  130nMAssay Description:Binding affinity to Saccharomyces cerevisiae GGPPSMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
12/15/2012
Entry Details Article
Copy BDB DOIPubMedPDB3D Structure (crystal)
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TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL

LigandBDBM50098389([1-Hydroxy-2-(1H-imidazol-4-yl)-1-phosphono-ethyl]...)Copy SMILESCopy InChI

Affinity DataIC50: 309nMAssay Description:Inhibitory activity against farnesyl Pyrophosphate Synthase expressed as #NAME (M)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
11/10/2009
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL

LigandBDBM50098389([1-Hydroxy-2-(1H-imidazol-4-yl)-1-phosphono-ethyl]...)Copy SMILESCopy InChI

Affinity DataIC50: 330nMAssay Description:Inhibitory activity against farnesyl Pyrophosphate Synthase was determinedMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
11/10/2009
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetGeranylgeranyl pyrophosphate synthase BTS1(Baker's yeast)
Institute of Biological Chemistry

Curated by ChEMBL

LigandBDBM25308((1-hydroxy-2-{imidazo[1,2-a]pyridin-3-yl}-1-phosph...)Copy SMILESCopy InChI

Affinity DataIC50: 340nMAssay Description:Inhibition of Saccharomyces cerevisiae GGPPSMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
12/15/2012
Entry Details Article
Copy BDB DOIPubMedPDB3D Structure (crystal)
Copy reaction URL

TargetGeranylgeranyl pyrophosphate synthase(Human)
University of Southern California

Curated by ChEMBL

LigandBDBM25308((1-hydroxy-2-{imidazo[1,2-a]pyridin-3-yl}-1-phosph...)Copy SMILESCopy InChI

Affinity DataIC50: 670nMAssay Description:Inhibition of GGPPS after 10 mins using [14C]IPP as substrate by liquid scintillation countingMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
12/30/2012
Entry Details Article
Copy BDB DOIPubMed
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TargetFarnesyl diphosphate synthase(Escherichia coli (strain K12))
University of Illinois At Urbana - Champaign

Curated by ChEMBL

LigandBDBM25308((1-hydroxy-2-{imidazo[1,2-a]pyridin-3-yl}-1-phosph...)Copy SMILESCopy InChI

Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of Escherichia coli FPPSMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
8/23/2020
Entry Details Article
Copy BDB DOIPubMed
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TargetGeranylgeranyl pyrophosphate synthase(Human)
University of Southern California

Curated by ChEMBL

LigandBDBM25308((1-hydroxy-2-{imidazo[1,2-a]pyridin-3-yl}-1-phosph...)Copy SMILESCopy InChI

Affinity DataKi:  1.80E+3nMAssay Description:Binding affinity to human GGPPSMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
12/15/2012
Entry Details Article
Copy BDB DOIPubMed
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TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL

LigandBDBM50318032(CHEMBL1099309 | (+)-2-hydroxy-3-imidazo[1,2-a]pyri...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human FPPS after 10 mins using [14C]IPP as substrate by liquid scintillation countingMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
12/30/2012
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetGeranylgeranyl pyrophosphate synthase(Human)
University of Southern California

Curated by ChEMBL

LigandBDBM25308((1-hydroxy-2-{imidazo[1,2-a]pyridin-3-yl}-1-phosph...)Copy SMILESCopy InChI

Affinity DataIC50: 6.50E+4nMAssay Description:Inhibition of human GGPPSMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
12/15/2012
Entry Details Article
Copy BDB DOIPubMed
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TargetGeranylgeranyl pyrophosphate synthase(Human)
University of Southern California

Curated by ChEMBL

LigandBDBM25308((1-hydroxy-2-{imidazo[1,2-a]pyridin-3-yl}-1-phosph...)Copy SMILESCopy InChI

Affinity DataIC50: 1.07E+5nMAssay Description:The inhibitory activity of each test compound was evaluated by monitoring the formation of [14C]GGPP from FPP, using [14C]IPP as the substrate. To co...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
11/10/2008
Entry Details Article
Copy BDB DOIPubMed
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TargetGeranylgeranyl pyrophosphate synthase(Human)
University of Southern California

Curated by ChEMBL

LigandBDBM50098389([1-Hydroxy-2-(1H-imidazol-4-yl)-1-phosphono-ethyl]...)Copy SMILESCopy InChI

Affinity DataIC50: 2.20E+5nMAssay Description:Inhibitory activity against the human recombinant geranylgeranyl diphosphate synthase (GGPPSase).More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
11/10/2009
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetGeranylgeranyl pyrophosphate synthase(Human)
University of Southern California

Curated by ChEMBL

LigandBDBM50318032(CHEMBL1099309 | (+)-2-hydroxy-3-imidazo[1,2-a]pyri...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of GGPPS after 10 mins using [14C]IPP as substrate by liquid scintillation countingMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
12/30/2012
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetGeranylgeranyl pyrophosphate synthase(Human)
University of Southern California

Curated by ChEMBL

LigandBDBM50318032(CHEMBL1099309 | (+)-2-hydroxy-3-imidazo[1,2-a]pyri...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of GGPPS after 10 mins using [14C]IPP as substrate by liquid scintillation countingMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
12/30/2012
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL