Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50128051,50128053,50128054,50128058,50128067,50128051,50128053,50128054,50128058,50128067   

TargetLanosterol synthase(Human)
Casmedchem Laboratory

Curated by ChEMBL
LigandPNGBDBM50128054(N-allyl-6-(1-(4-bromophenyl)isoquinolin-6-yloxy)-N...)
Affinity DataIC50: 3.47nMAssay Description:Inhibition of oxidosqualene cyclaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Casmedchem Laboratory

Curated by ChEMBL
LigandPNGBDBM50128054(N-allyl-6-(1-(4-bromophenyl)isoquinolin-6-yloxy)-N...)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of oxidosqualene cyclaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Casmedchem Laboratory

Curated by ChEMBL
LigandPNGBDBM50128054(N-allyl-6-(1-(4-bromophenyl)isoquinolin-6-yloxy)-N...)
Affinity DataIC50: 3.5nMAssay Description:In vitro inhibition of human 2,3-oxidosqualene cyclase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Casmedchem Laboratory

Curated by ChEMBL
LigandPNGBDBM50128054(N-allyl-6-(1-(4-bromophenyl)isoquinolin-6-yloxy)-N...)
Affinity DataIC50: 3.5nMAssay Description:Inhibitory activity against Oxidosqualene-lanosterol cyclase from human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Casmedchem Laboratory

Curated by ChEMBL
LigandPNGBDBM50128058(CHEMBL115497 | Allyl-{6-[3-(4-bromo-phenyl)-1-meth...)
Affinity DataIC50: 19nMAssay Description:Inhibition of oxidosqualene cyclaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Casmedchem Laboratory

Curated by ChEMBL
LigandPNGBDBM50128058(CHEMBL115497 | Allyl-{6-[3-(4-bromo-phenyl)-1-meth...)
Affinity DataIC50: 19.6nMAssay Description:In vitro inhibition of human 2,3-oxidosqualene cyclase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Casmedchem Laboratory

Curated by ChEMBL
LigandPNGBDBM50128058(CHEMBL115497 | Allyl-{6-[3-(4-bromo-phenyl)-1-meth...)
Affinity DataIC50: 19.6nMAssay Description:Inhibitory activity against Oxidosqualene-lanosterol cyclase from human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Casmedchem Laboratory

Curated by ChEMBL
LigandPNGBDBM50128067((E)-N-allyl-4-(3-(4-bromophenyl)-5-fluoro-1-methyl...)
Affinity DataIC50: 29nMAssay Description:Inhibition of oxidosqualene cyclaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Casmedchem Laboratory

Curated by ChEMBL
LigandPNGBDBM50128067((E)-N-allyl-4-(3-(4-bromophenyl)-5-fluoro-1-methyl...)
Affinity DataIC50: 29nMAssay Description:Inhibitory activity against Oxidosqualene-lanosterol cyclase from human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Casmedchem Laboratory

Curated by ChEMBL
LigandPNGBDBM50128051(N-allyl-6-(3-(4-bromophenyl)-1H-indazol-6-yloxy)-N...)
Affinity DataIC50: 38.9nMAssay Description:Inhibition of oxidosqualene cyclaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Casmedchem Laboratory

Curated by ChEMBL
LigandPNGBDBM50128051(N-allyl-6-(3-(4-bromophenyl)-1H-indazol-6-yloxy)-N...)
Affinity DataIC50: 39nMAssay Description:Inhibitory activity against Oxidosqualene-lanosterol cyclase from human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Casmedchem Laboratory

Curated by ChEMBL
LigandPNGBDBM50128051(N-allyl-6-(3-(4-bromophenyl)-1H-indazol-6-yloxy)-N...)
Affinity DataIC50: 39nMAssay Description:Inhibition of oxidosqualene cyclaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetSqualene--hopene cyclase(Alicyclobacillus acidocaldarius)
Albert-Ludwigs-University of Freiburg

Curated by ChEMBL
LigandPNGBDBM50128051(N-allyl-6-(3-(4-bromophenyl)-1H-indazol-6-yloxy)-N...)
Affinity DataIC50: 180nMAssay Description:Inhibitory activity against squalene hopene cyclase from Alicyclobacillus acidocaldariusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSqualene--hopene cyclase(Alicyclobacillus acidocaldarius)
Albert-Ludwigs-University of Freiburg

Curated by ChEMBL
LigandPNGBDBM50128054(N-allyl-6-(1-(4-bromophenyl)isoquinolin-6-yloxy)-N...)
Affinity DataIC50: 186nMAssay Description:Inhibitory activity against squalene hopene cyclase from Alicyclobacillus acidocaldariusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLanosterol synthase(Human)
Casmedchem Laboratory

Curated by ChEMBL
LigandPNGBDBM50128053(Allyl-[6-(1,3-dimethyl-1H-indazol-6-yloxy)-hexyl]-...)
Affinity DataIC50: 240nMAssay Description:Inhibitory activity against Oxidosqualene-lanosterol cyclase from human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSqualene--hopene cyclase(Alicyclobacillus acidocaldarius)
Albert-Ludwigs-University of Freiburg

Curated by ChEMBL
LigandPNGBDBM50128067((E)-N-allyl-4-(3-(4-bromophenyl)-5-fluoro-1-methyl...)
Affinity DataIC50: 281nMAssay Description:Inhibitory activity against squalene hopene cyclase from Alicyclobacillus acidocaldariusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSqualene--hopene cyclase(Alicyclobacillus acidocaldarius)
Albert-Ludwigs-University of Freiburg

Curated by ChEMBL
LigandPNGBDBM50128058(CHEMBL115497 | Allyl-{6-[3-(4-bromo-phenyl)-1-meth...)
Affinity DataIC50: 289nMAssay Description:Inhibitory activity against squalene hopene cyclase from Alicyclobacillus acidocaldariusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLanosterol synthase ERG7(Baker's yeast)
Università

Curated by ChEMBL
LigandPNGBDBM50128058(CHEMBL115497 | Allyl-{6-[3-(4-bromo-phenyl)-1-meth...)
Affinity DataIC50: 290nMAssay Description:Inhibition of yeast OSC expressed in Saccharomyces cerevisiae SMY8More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSqualene--hopene cyclase(Alicyclobacillus acidocaldarius)
Albert-Ludwigs-University of Freiburg

Curated by ChEMBL
LigandPNGBDBM50128053(Allyl-[6-(1,3-dimethyl-1H-indazol-6-yloxy)-hexyl]-...)
Affinity DataIC50: 332nMAssay Description:Inhibitory activity against squalene hopene cyclase from Alicyclobacillus acidocaldariusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Casmedchem Laboratory

Curated by ChEMBL
LigandPNGBDBM50128058(CHEMBL115497 | Allyl-{6-[3-(4-bromo-phenyl)-1-meth...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of human OSC expressed in Saccharomyces cerevisiae SMY8More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCycloartenol synthase(Mouse-ear cress)
Università

Curated by ChEMBL
LigandPNGBDBM50128058(CHEMBL115497 | Allyl-{6-[3-(4-bromo-phenyl)-1-meth...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of Arabidopsis thaliana cycloartenol synthase expressed in Saccharomyces cerevisiae SMY8More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed