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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
121
hits in this display
Target
5-hydroxytryptamine receptor 3A
(RAT)
European Research Centre For Drug Discovery And Development (Natsyndrugs)
Curated by
ChEMBL
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 0.960nM
Assay Description:
Displacement of [3H]LY278584 from 5HT3 receptor in rat cortical homogenate
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Target
5-hydroxytryptamine receptor 3A
(RAT)
European Research Centre For Drug Discovery And Development (Natsyndrugs)
Curated by
ChEMBL
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 0.960nM
Assay Description:
Displacement of [3H]LY278584 from 5HT3 receptor in rat cortical homogenate
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Merrell Dow Research Institute
Curated by
ChEMBL
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 1nM
Assay Description:
Potency at neuronal 5-hydroxytryptamine 3 receptors in the rabbit heart
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Merrell Dow Research Institute
Curated by
ChEMBL
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 1.20nM
Assay Description:
Binding affinity for 5-hydroxytryptamine 3 receptor from rat cortex using [3H]BRL-43694 as radioligand
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Merrell Dow Research Institute
Curated by
ChEMBL
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 1.40nM
Assay Description:
Potency at neuronal 5-hydroxytryptamine 3 receptor in the rabbit heart
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Merrell Dow Research Institute
Curated by
ChEMBL
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 1.40nM
Assay Description:
Compound was evaluated for its binding affinity for 5-hydroxytryptamine 3 receptor by measuring displacement [3H]GR-65630 in rat cerebral cortex
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Target
5-hydroxytryptamine receptor 3A
(RAT)
European Research Centre For Drug Discovery And Development (Natsyndrugs)
Curated by
ChEMBL
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 1.5nM
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Merrell Dow Research Institute
Curated by
ChEMBL
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 1.80nM
Assay Description:
Inhibition of [3H]granisetron binding to 5-hydroxytryptamine 3 receptor of rat cortical membrane
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Merrell Dow Research Institute
Curated by
ChEMBL
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 1.80nM
Assay Description:
Ability to displace [3H]granisetron specifically bound to 5-hydroxytryptamine 3 receptor in rat cortical membrane
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Target
5-hydroxytryptamine receptor 3A/3B/3C/3D/3E
(Homo sapiens (Human))
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 2nM
Assay Description:
Compound was tested for the inhibition of [3H]-GR-65,630 binding to 5-hydroxytryptamine 3 receptor expressed in NG 108-15 cells
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5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Merrell Dow Research Institute
Curated by
ChEMBL
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 3nM
Assay Description:
Inhibitory activity against 5-hydroxytryptamine 3 receptor in rat cortical membranes using [3H]- 1-Methyl-1H-indazole-3-carboxylic acid (8-methyl-8-a...
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Merrell Dow Research Institute
Curated by
ChEMBL
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 3nM
Assay Description:
pKi value for inhibition of [3H]LY-278584 binding to 5-hydroxytryptamine 3 receptor
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Target
5-hydroxytryptamine receptor 3A
(Mus musculus (house mouse))
Sri International
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 3.20nM
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Target
5-hydroxytryptamine receptor 3A
(Homo sapiens (Human))
University Of Copenhagen
Curated by
ChEMBL
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 4nM
Assay Description:
Displacement of [3H]GR65630 from human 5HT3A receptor in HEK293 cells
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Target
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat))
Stanford University
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 5nM
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Target
5-hydroxytryptamine receptor 3A
(Mus musculus (house mouse))
Sri International
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 8.70nM
Assay Description:
The binding affinity was measured for 5-hydroxytryptamine 3 receptor on NG 108-15 cell line of mouse neuroblastoma-glioma cells in presence of [3H]5 ...
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Target
Serotonin 2 (5-HT2) receptor
(RAT)
TBA
Curated by
ChEMBL
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 17nM
Assay Description:
Binding affinity to rat cortical membranes at 5-hydroxytryptamine 2 receptor binding site by using [3H]- DOB as a radioligand
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Target
Sodium-dependent serotonin transporter
(Homo sapiens (Human))
National Medicines Institute
Curated by
ChEMBL
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 30nM
Assay Description:
Displacement of [3H]-5HT from human SERT
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Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
Universit£
Curated by
ChEMBL
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 31nM
Assay Description:
Ability to displace [3H]paroxetine bound to Serotonin transporter receptor in rat forebrain
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Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
Universit£
Curated by
ChEMBL
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 31nM
Assay Description:
Binding affinity towards Serotonin transporter was determined in rat forebrain membrane
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Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
Universit£
Curated by
ChEMBL
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 43nM
Assay Description:
Effect of compound on Serotonin transporter uptake from rat cortex using [3H]citalopram as radioligand
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Target
5-hydroxytryptamine receptor 2B
(Homo sapiens (Human))
Eli Lilly
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 48.7nM
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Target
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human))
Vernalis Research
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Ki: 53.7nM
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Target
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human))
Albany Medical College
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Ki: 59nM
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Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
Universit£
Curated by
ChEMBL
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 63nM
Assay Description:
Inhibition of [3H]citalopram binding to Serotonin transporter of rat cerebral cortex
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5-hydroxytryptamine receptor 2B
(Homo sapiens (Human))
Eli Lilly
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Ki: 85.1nM
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Target
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat))
Stanford University
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Ki: 92nM
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Target
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat))
Stanford University
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 100nM
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5-hydroxytryptamine receptor 2A
(Homo sapiens (Human))
Albany Medical College
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Ki: 129nM
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5-hydroxytryptamine receptor 2B
(RAT)
University of Alberta
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Ki: 129nM
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5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat))
Stanford University
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 130nM
Assay Description:
Binding affinity to 5-hydroxytryptamine 2A receptor from rat cortex assayed using [3H]ketanserin as radioligand.
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5-hydroxytryptamine receptor 2B
(RAT)
University of Alberta
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Ki: 131nM
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5-hydroxytryptamine receptor 2C
(Rattus norvegicus (Rat))
Albany Medical College
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 160nM
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Target
5-hydroxytryptamine receptor 2C
(Rattus norvegicus (Rat))
Albany Medical College
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Ki: 160nM
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5-hydroxytryptamine receptor 2B
(Homo sapiens (Human))
Eli Lilly
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Ki: 178nM
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Target
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat))
Stanford University
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Ki: 180nM
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5-hydroxytryptamine receptor 2C
(Rattus norvegicus (Rat))
Albany Medical College
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 190nM
Assay Description:
Binding affinity against 5-hydroxytryptamine 2C receptor of rat cortex.
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Target
5-hydroxytryptamine receptor 2C
(Rattus norvegicus (Rat))
Albany Medical College
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 190nM
Assay Description:
Ability to displace [3H]mesulergine bound to 5-hydroxytryptamine 2C receptor in rat cortex
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5-hydroxytryptamine receptor 1B
(Rattus norvegicus (Rat))
Virginia Commonwealth University
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Ki: 200nM
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5-hydroxytryptamine receptor 2C
(Homo sapiens (Human))
Vernalis Research
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 200nM
Assay Description:
Evaluated for the binding affinity to porcine choroid plexus at 5-hydroxytryptamine 2C receptor binding site by using [3H]-MES as a radioligand.
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Target
5-hydroxytryptamine receptor 1B
(Rattus norvegicus (Rat))
Virginia Commonwealth University
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 208nM
Assay Description:
The compound was tested for their binding affinity towards 5-hydroxytryptamine 1B receptor from rat striatum using [3H]5-HT as radioligand
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5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat))
Stanford University
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Ki: 226nM
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5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
National Medicines Institute
Curated by
ChEMBL
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 230nM
Assay Description:
Displacement of [3H]8-OH-DPAT from 5HT1A receptor in cerebral cortex homogenates after 15 mins
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Target
Serotonin 2 (5-HT2) receptor
(RAT)
TBA
Curated by
ChEMBL
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 230nM
Assay Description:
Binding affinity to rat cortical membranes at 5-hydroxytryptamine 2 (5-HT2) receptor using [3H]KET as a radioligand
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Target
5-hydroxytryptamine receptor 1A/1B/1D/1F
(RAT)
TBA
Curated by
ChEMBL
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 230nM
Assay Description:
Evaluated for binding affinity towards rat cortical membranes at 5-hydroxytryptamine 1 receptor binding site by using [3H]-5-HT as a radioligand.
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Target
Serotonin 2 (5-HT2) receptor
(RAT)
TBA
Curated by
ChEMBL
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
Copy SMILES
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Affinity Data
Ki: 230nM
Assay Description:
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor of rat cortical membrane homogenates
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5-hydroxytryptamine receptor 1B
(Rattus norvegicus (Rat))
Virginia Commonwealth University
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 249nM
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Target
5-hydroxytryptamine receptor 2C
(Rattus norvegicus (Rat))
Albany Medical College
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 257nM
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5-hydroxytryptamine receptor 2A
(Homo sapiens (Human))
Albany Medical College
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 309nM
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Target
5-hydroxytryptamine receptor 1B
(Rattus norvegicus (Rat))
Virginia Commonwealth University
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 310nM
Assay Description:
Ability to displace [3H]5-HT bound to 5-hydroxytryptamine 1B receptor in rat striatum
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Target
5-hydroxytryptamine receptor 1B
(Rattus norvegicus (Rat))
Virginia Commonwealth University
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 310nM
Assay Description:
Binding affinity against 5-hydroxytryptamine 1B receptor of rat striatum.
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Target
5-hydroxytryptamine receptor 1B
(Rattus norvegicus (Rat))
Virginia Commonwealth University
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 320nM
Assay Description:
Binding affinity (Ki) to rat cortical membranes at 5-HT1B binding site by using [125 I] ICYP as a radioligand.
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5-hydroxytryptamine receptor 2C
(Rattus norvegicus (Rat))
Albany Medical College
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Ki: 336nM
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Target
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human))
Vernalis Research
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 339nM
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5-hydroxytryptamine receptor 2A
(Homo sapiens (Human))
Albany Medical College
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 362nM
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5-hydroxytryptamine receptor 2B
(BOVINE)
Stanford University
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Ki: 460nM
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Target
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat))
Stanford University
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 575nM
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Target
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat))
Stanford University
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Ki: 613nM
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Target
Serotonin 2 (5-HT2) receptor
(RAT)
TBA
Curated by
ChEMBL
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 645nM
Assay Description:
Binding affinity to 5-hydroxytryptamine 2 receptor in rat frontal cortical membranes by [3H]- KET displacement.
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5-hydroxytryptamine receptor 2C
(Rattus norvegicus (Rat))
Albany Medical College
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Ki: 653nM
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Target
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat))
Stanford University
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 794nM
Assay Description:
Displacement of [3H]ketanserin from 5HT2A receptor in rat cortex
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Target
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat))
Stanford University
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
Copy SMILES
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Affinity Data
Ki: 794nM
Assay Description:
Displacement of [3H]ketanserin from 5HT2A receptor in rat cortex
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Target
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat))
National Institute of Neurological Disorders and Stroke
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 1.00E+3nM
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Target
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat))
National Institute of Neurological Disorders and Stroke
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 1.00E+3nM
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Target
5-hydroxytryptamine receptor 1B
(Homo sapiens (Human))
Synaptic Pharmaceutical
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 1.00E+3nM
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5-hydroxytryptamine receptor 1D
(Homo sapiens (Human))
Synaptic Pharmaceutical
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 1.00E+3nM
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Target
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat))
College of France
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 1.17E+3nM
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Target
5-hydroxytryptamine receptor 2C
(Rattus norvegicus (Rat))
Albany Medical College
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 1.34E+3nM
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Target
5-hydroxytryptamine receptor 2C
(Rattus norvegicus (Rat))
Albany Medical College
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 1.34E+3nM
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Target
5-hydroxytryptamine 1D receptor
(Bos taurus (Bovine))
Synaptic Pharmaceutical
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 1.38E+3nM
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Target
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat))
College of France
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 1.50E+3nM
Assay Description:
The compound was tested for their binding affinity towards 5-hydroxytryptamine 1A receptor from rat hippocampus using [3H]-8-OH-DPAT as radioligand
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Target
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat))
College of France
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 1.58E+3nM
Assay Description:
Displacement of [3H]8-OHDPAT from 5HT1A receptor in rat hippocampus
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Target
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat))
College of France
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 1.58E+3nM
Assay Description:
Displacement of [3H]8-OHDPAT from 5HT1A receptor in rat hippocampus
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5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
National Medicines Institute
Curated by
ChEMBL
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Ki: 1.70E+3nM
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5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat))
Stanford University
Curated by
PDSP K
i
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Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 1.80E+3nM
Assay Description:
Binding affinity against 5-hydroxytryptamine 2A receptor of rat pre-frontal cortex.
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5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat))
Stanford University
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 1.80E+3nM
Assay Description:
Ability to displace [3H]- ketanserin bound to 5-hydroxytryptamine 2A receptor in rat pre-frontal cortex
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Beta-2 adrenergic receptor
(Rattus norvegicus)
Virginia Commonwealth University
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Ki: 2.90E+3nM
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5-hydroxytryptamine receptor 7
(Homo sapiens (Human))
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 3.03E+3nM
Assay Description:
Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor
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5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat))
College of France
Curated by
PDSP K
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Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 3.30E+3nM
Assay Description:
Evaluated for the binding affinity to hippocampus striatal membranes at 5-hydroxytryptamine 1A receptor binding site by using [3H]-8-OH- DPAT as a ra...
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5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat))
College of France
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Ki: 3.39E+3nM
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5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat))
College of France
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 3.60E+3nM
Assay Description:
Binding affinity against 5-hydroxytryptamine 1A receptor of rat hippocampus tissue.
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5-hydroxytryptamine receptor 6
(Homo sapiens (Human))
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 3.60E+3nM
Assay Description:
Binding affinity towards human 5-hydroxytryptamine 6 receptor was evaluated using [3H]-LSD as radioligand
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5-hydroxytryptamine receptor 6
(Homo sapiens (Human))
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Ki: 3.60E+3nM
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Target
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat))
College of France
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 3.60E+3nM
Assay Description:
Ability to displace [3H]- -OH-DPAT bound to 5-hydroxytryptamine 1A receptor in rat hippocampus
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D(2) dopamine receptor
(Rattus norvegicus (rat))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Ki: 3.92E+3nM
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Solute carrier family 22 member 2
(RAT)
Virginia Commonwealth University
Curated by
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i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Ki: 5.00E+3nM
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5-hydroxytryptamine receptor 2B
(RAT)
University of Alberta
Curated by
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i
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Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Ki: 6.31E+3nM
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5-hydroxytryptamine receptor 2B
(Mus musculus (Mouse))
University of Alberta
Curated by
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Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Ki: 6.61E+3nM
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Solute carrier family 22 member 1
(RAT)
Virginia Commonwealth University
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Ki: >1.00E+4nM
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Muscarinic acetylcholine receptor M2
(RAT)
Virginia Commonwealth University
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Ki: >1.00E+4nM
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Target
D(1A) dopamine receptor
(Homo sapiens (Human))
Sri International
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Ki: >1.00E+4nM
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Sri International
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Ki: >1.00E+4nM
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Target
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
National Medicines Institute
Curated by
ChEMBL
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Ki: >1.00E+4nM
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5-hydroxytryptamine receptor 5A
(MOUSE)
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
Binding affinity towards mouse 5-hydroxytryptamine 5A receptor was evaluated using [3H]LSD as radioligand
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5-hydroxytryptamine receptor 4
(GUINEA PIG)
European Research Centre For Drug Discovery And Development (Natsyndrugs)
Curated by
ChEMBL
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
Displacement of [3H]GR113808 from 5HT4 receptor in guinea pig striatum
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5-hydroxytryptamine receptor 5A
(MOUSE)
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
Binding affinity towards murine 5-hydroxytryptamine 5A receptor
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5-hydroxytryptamine receptor 4
(GUINEA PIG)
European Research Centre For Drug Discovery And Development (Natsyndrugs)
Curated by
ChEMBL
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
Displacement of [3H]GR-113808 from 5HT4 receptor in guinea pig striatum
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Neutrophil cytosol factor 1
(Homo sapiens)
University Of Copenhagen
Curated by
ChEMBL
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Ki: 1.41E+6nM
Assay Description:
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...
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5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Merrell Dow Research Institute
Curated by
ChEMBL
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
IC50: 0.447nM
Assay Description:
Binding affinity towards 5-hydroxytryptamine 3 receptor
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5-hydroxytryptamine receptor 3A/3B/3C/3D/3E
(Homo sapiens (Human))
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
IC50: 0.447nM
Assay Description:
Binding affinity against 5-hydroxytryptamine 3 receptor was measured using [3H]granisetron as radioligand
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5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Merrell Dow Research Institute
Curated by
ChEMBL
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
IC50: 3.80nM
Assay Description:
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand
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5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Merrell Dow Research Institute
Curated by
ChEMBL
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
IC50: 6.20nM
Assay Description:
Inhibition of [3H]BRL-43694 binding to 5-hydroxytryptamine 3 receptor of rat cortical homogenate.
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5-hydroxytryptamine receptor 2C
(Homo sapiens (Human))
Vernalis Research
Curated by
PDSP K
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Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
IC50: 61.7nM
Assay Description:
Binding affinity against 5-Hydroxytryptamine 2C Receptor was measured using [3H]N-methyl-mesulergine as radioligand
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Target
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human))
Vernalis Research
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
IC50: 61.7nM
Assay Description:
Binding affinity towards 5-hydroxytryptamine 2C receptor
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5-hydroxytryptamine receptor 1B
(Rattus norvegicus (Rat))
Virginia Commonwealth University
Curated by
PDSP K
i
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Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
IC50: 380nM
Assay Description:
Inhibition of radiolabeled [3H]-5-HT ligand binding to 5-hydroxytryptamine 1B receptor
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5-hydroxytryptamine receptor 2C
(Rattus norvegicus (Rat))
Albany Medical College
Curated by
PDSP K
i
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Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
IC50: 470nM
Assay Description:
Inhibition of radiolabeled [3H]mesulergine ligand binding to 5-hydroxytryptamine 2C receptor
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5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat))
Stanford University
Curated by
PDSP K
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Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
IC50: 1.40E+3nM
Assay Description:
Inhibition of radiolabeled [3H]-Ketanserin ligand binding to 5-hydroxytryptamine 2A receptor
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Target
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
National Medicines Institute
Curated by
ChEMBL
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
IC50: 1.45E+3nM
Assay Description:
Binding affinity against 5-hydroxytryptamine 1A receptor was measured using [3H]8-OH-DPAT as radioligand
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Target
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
National Medicines Institute
Curated by
ChEMBL
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
IC50: 1.45E+3nM
Assay Description:
Binding affinity for 5-hydroxytryptamine 1A receptor
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5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat))
College of France
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
IC50: 2.70E+3nM
Assay Description:
Inhibition of radiolabeled [3H]-8-OH-DPAT ligand binding to 5-hydroxytryptamine 1A receptor
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Target
5-hydroxytryptamine receptor 2A
(BOVINE)
Universit£
Curated by
ChEMBL
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
IC50: 3.47E+3nM
Assay Description:
Binding affinity against 5-hydroxytryptamine 2A receptor was measured using [3H]ketanserin as radioligand
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Target
5-hydroxytryptamine receptor 2A
(BOVINE)
Universit£
Curated by
ChEMBL
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
IC50: 3.47E+3nM
Assay Description:
Binding affinity towards 5-hydroxytryptamine 2A receptor
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5-hydroxytryptamine receptor 1D
(Sus scrofa)
Universit£
Curated by
ChEMBL
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
IC50: 3.72E+3nM
Assay Description:
Binding affinity for 5-hydroxytryptamine 1D receptor
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Target
5-hydroxytryptamine receptor 1D
(Sus scrofa)
Universit£
Curated by
ChEMBL
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
IC50: 3.72E+3nM
Assay Description:
Binding affinity against 5-hydroxytryptamine 1D receptor was measured using [3H]5-HT as radioligand
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5-hydroxytryptamine receptor 1B
(Rattus norvegicus (Rat))
Virginia Commonwealth University
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
IC50: 7.08E+3nM
Assay Description:
Binding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligand
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5-hydroxytryptamine receptor 1B
(Rattus norvegicus (Rat))
Virginia Commonwealth University
Curated by
PDSP K
i
Database
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
IC50: 7.08E+3nM
Assay Description:
Binding affinity for 5-hydroxytryptamine 1B receptor
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Target
5-hydroxytryptamine receptor 4
(RAT)
Universit£
Curated by
ChEMBL
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of radiolabeled [3H]GR-113808 ligand binding to 5-hydroxytryptamine 4 receptor
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Target
Neutrophil cytosol factor 1
(Homo sapiens)
University Of Copenhagen
Curated by
ChEMBL
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Kd: 4.20E+5nM
Assay Description:
Binding affinity to immobilized recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cel...
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5-hydroxytryptamine receptor 3A/3B
(Homo sapiens (Human))
Universita' Degli Studi Di Salerno
Curated by
ChEMBL
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
EC50: 1nM
Assay Description:
Effective concentration against 5-Hydroxytryptamine 3 receptor by measuring [14C]-guanidinium uptake on NG108-15 cells.
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5-hydroxytryptamine receptor 3A/3B
(Mus musculus (house mouse))
Merrell Dow Research Institute
Curated by
ChEMBL
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Kd: 2nM
Assay Description:
Potency at neuronal 5-hydroxytryptamine 3 receptors in the rabbit heart
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Beta-1 adrenergic receptor
(Homo sapiens (Human))
Heptares Therapeutics
Curated by
ChEMBL
Ligand
BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
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Affinity Data
Kd: 5.60E+3nM
Assay Description:
Binding affinity to His-tagged human beta1 adrenergic receptor expressed in HEK293 cell membranes by surface plasmon resonance analysis
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