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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
198
hits in this display
Target
Prostaglandin G/H synthase 1
(Homo sapiens (Human))
University of Maryland Hospital
Curated by
PDSP K
i
Database
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
Ki: 48nM
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Target
Ras-related protein Rab-7a
(Canis lupus familiaris)
Nmmlsc
Curated by
PubChem BioAssay
Ligand
BDBM50169047
((S)-2-(4-Isobutyl-phenyl)-propionic acid | (S)-2-(...)
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Affinity Data
Ki: 310nM
Assay Description:
University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...
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Target
Cell division control protein 42 homolog
(Homo sapiens (Human))
Nmmlsc
Curated by
PubChem BioAssay
Ligand
BDBM50169047
((S)-2-(4-Isobutyl-phenyl)-propionic acid | (S)-2-(...)
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Affinity Data
Ki: 990nM
Assay Description:
University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...
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Target
Solute carrier family 22 member 20
(Mus musculus)
University Of California
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
Ki: 1.10E+3nM
Assay Description:
Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr
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Target
Solute carrier family 22 member 6
(Rattus norvegicus)
Kyorin University
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
Ki: 3.50E+3nM
Assay Description:
TP_TRANSPORTER: inhibition of PAH uptake in Xenopus laevis oocytes
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Target
Cell division control protein 42 homolog
(Homo sapiens (Human))
Nmmlsc
Curated by
PubChem BioAssay
Ligand
BDBM50169047
((S)-2-(4-Isobutyl-phenyl)-propionic acid | (S)-2-(...)
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Affinity Data
Ki: 3.51E+3nM
Assay Description:
University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...
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Target
Solute carrier family 22 member 6
(Mus musculus)
University Of California
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
Ki: 4.70E+3nM
Assay Description:
Inhibition of mouse Oat1-mediated [3H]PAH uptake in Xenopus oocytes after 1 hr
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Target
Prostaglandin G/H synthase 1
(Homo sapiens (Human))
University of Maryland Hospital
Curated by
PDSP K
i
Database
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
Ki: 4.80E+3nM
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Target
Prostaglandin G/H synthase 1
(Homo sapiens (Human))
University of Maryland Hospital
Curated by
PDSP K
i
Database
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Copy SMILES
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Affinity Data
Ki: 5.90E+3nM
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Target
Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by
PDSP K
i
Database
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
Ki: 7.20E+3nM
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Target
Prostaglandin G/H synthase 1
(Homo sapiens (Human))
University of Maryland Hospital
Curated by
PDSP K
i
Database
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Copy SMILES
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Affinity Data
Ki: 7.60E+3nM
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Target
Prostaglandin G/H synthase 2
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
Ki: 9.00E+3nM
Assay Description:
Inhibition of sheep placental cotyledons COX2
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Target
Prostaglandin G/H synthase 1
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
Ki: 9.00E+3nM
Assay Description:
Inhibition of sheep placental cotyledons COX1
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Target
Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by
PDSP K
i
Database
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Copy SMILES
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Affinity Data
Ki: 9.90E+3nM
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Target
Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by
PDSP K
i
Database
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Copy SMILES
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Affinity Data
Ki: >1.00E+4nM
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Target
Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by
PDSP K
i
Database
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
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Target
Fatty acid-binding protein, liver
(Rattus norvegicus (Rat))
Monash University (Parkville Campus)
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
Ki: 4.76E+4nM
Assay Description:
Displacement of 1-anilinonaphthalene-8-sulphonic acid from rat recombinant L-FABP high binding affinity site expressed in Escherichia coli BL21 by co...
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Target
Cytochrome P450 2C9
(Homo sapiens (Human))
Washington State University
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
Ki: 5.00E+4nM
Assay Description:
Binding affinity measured on human cytochrome P450 2C9 (CYP2C9) enzyme
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Target
Solute carrier organic anion transporter family member 1A1
(Rattus norvegicus)
Kitasato University
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
Ki: 1.26E+5nM
Assay Description:
TP_TRANSPORTER: inhibition of E217betaG uptake in Oatp1-expressing LLC-PK1 cells
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Target
Albumin
(Homo sapiens (Human))
Molecular Discovery
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
Ki: 1.65E+5nM
Assay Description:
Binding affinity towards human serum albumin
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Target
Fatty acid-binding protein, intestinal
(Homo sapiens (Human))
Monash University
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
Ki: 2.64E+5nM ΔG°: -38.8kJ/mole
T: 2°C
Assay Description:
Briefly, steady-state fluorescence spectra of ANS binding was monitored by measuring the increase in fluorescence signal between 450?550 nm following...
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Target
Fatty acid-binding protein, liver
(Rattus norvegicus (Rat))
Monash University (Parkville Campus)
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
Ki: 4.48E+5nM
Assay Description:
Displacement of 1-anilinonaphthalene-8-sulphonic acid from rat recombinant L-FABP low binding affinity site expressed in Escherichia coli BL21 by com...
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Target
Dihydrofolate reductase
(Homo sapiens (Human))
University Of Tennessee
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
Ki: 5.60E+5nM
Assay Description:
Inhibition of human DHFR in presence of DHF and NADPH by UV-vis spectrometry by Lineweaver-Burk plot analysis
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Target
Solute carrier family 22 member 8
(Homo sapiens (Human))
Kyorin University
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
Ki: 1.17E+6nM
Assay Description:
TP_TRANSPORTER: inhibition of MTX uptake in OAT3-expressing S2 cells
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Solute carrier organic anion transporter family member 1A4
(Rattus norvegicus)
Kitasato University
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
Ki: 2.43E+6nM
Assay Description:
TP_TRANSPORTER: inhibition of Digoxin uptake in Oatp2-expressing LLC-PK1 cells
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Target
Interleukin-8
(Homo sapiens (Human))
Grupo Uriach
Curated by
ChEMBL
Ligand
BDBM50169044
((-)-ibuprofen | (2R)-2-(4-isobutylphenyl)propanoic...)
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Affinity Data
IC50: 50nM
Assay Description:
Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay
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Target
Prostaglandin G/H synthase 1
(Homo sapiens (Human))
University of Maryland Hospital
Curated by
PDSP K
i
Database
Ligand
BDBM50169047
((S)-2-(4-Isobutyl-phenyl)-propionic acid | (S)-2-(...)
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Affinity Data
IC50: 99nM
Assay Description:
Inhibition of COX1 in human HEL 92.1.7 cells assessed as thromboxane B2 production incubated for 30 mins before arachidonic acid addition measured af...
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Target
C-X-C chemokine receptor type 1/2
(Homo sapiens (Human))
Domp£
Curated by
ChEMBL
Ligand
BDBM50169047
((S)-2-(4-Isobutyl-phenyl)-propionic acid | (S)-2-(...)
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Affinity Data
IC50: 100nM
Assay Description:
Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear cells
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Target
Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by
PDSP K
i
Database
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 100nM
Assay Description:
Inhibition activity against recombinant human Prostaglandin G/H synthase 2
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Target
C-X-C chemokine receptor type 1/2
(Homo sapiens (Human))
Domp£
Curated by
ChEMBL
Ligand
BDBM50169044
((-)-ibuprofen | (2R)-2-(4-isobutylphenyl)propanoic...)
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Affinity Data
IC50: 110nM
Assay Description:
Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear cells
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Prostaglandin G/H synthase 1
(Homo sapiens (Human))
University of Maryland Hospital
Curated by
PDSP K
i
Database
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 290nM
Assay Description:
Inhibition of COX-1 in human washed platelet assessed as inhibition of 0.5 uM arachidonic acid-induced TXB2 formation incubated for 25 mins prior to ...
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Prostaglandin G/H synthase 1/2
(RAT)
University Of Pennsylvania
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 600nM
Assay Description:
Inhibition of COX in RBL1 cells assessed as reduction in PGE2/D2 production using A23187-induced arachidonic acid as substrate preincubated for 2 hrs...
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Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by
PDSP K
i
Database
Ligand
BDBM50169047
((S)-2-(4-Isobutyl-phenyl)-propionic acid | (S)-2-(...)
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Affinity Data
IC50: 730nM
Assay Description:
Inhibition of COX2 in LPS-stimulated and PMA-treated human U937 cells assessed as PGE2 production after 15 mins by ELISA
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Prostaglandin G/H synthase 2
(Mus musculus (Mouse))
Kyung Hee University
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 860nM
Assay Description:
Inhibition of COX-2 in mouse RAW264.7 cells assessed as decrease in LPS-induced PGE2 production treated prior to LPS challenge by enzyme immunoassay
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Prostaglandin G/H synthase 1
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 1.06E+3nM
Assay Description:
Reverisible competitive inhibition of prostaglandin G/H synthase 1
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Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by
PDSP K
i
Database
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 1.08E+3nM
Assay Description:
Inhibition of recombinant human N-terminal His-tagged COX2 expressed in baculovirus infected Sf21 cells assessed as reduction in prostaglandin produc...
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Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by
PDSP K
i
Database
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Copy SMILES
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Affinity Data
IC50: 1.10E+3nM
Assay Description:
Inhibition of recombinant human COX-2 preincubated for 15 mins by fluorescence analysis
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Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by
PDSP K
i
Database
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Copy SMILES
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Affinity Data
IC50: 1.10E+3nM
Assay Description:
Inhibition of human recombinant COX2 by enzyme immunoassay
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Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by
PDSP K
i
Database
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Copy SMILES
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Affinity Data
IC50: 1.10E+3nM
Assay Description:
Inhibition of human recombinant COX-2 by enzyme immuno assay
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Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by
PDSP K
i
Database
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Copy SMILES
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Affinity Data
IC50: 1.10E+3nM
Assay Description:
Inhibition of human recombinant COX2
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Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by
PDSP K
i
Database
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Copy SMILES
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Affinity Data
IC50: 1.10E+3nM
Assay Description:
Inhibition of human recombinant COX2
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Prostaglandin G/H synthase 2
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Copy SMILES
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Affinity Data
IC50: 1.10E+3nM
Assay Description:
Inhibition of ovine COX2 by enzyme immuno assay
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Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by
PDSP K
i
Database
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Copy SMILES
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Affinity Data
IC50: 1.10E+3nM
Assay Description:
Inhibition of human recombinant COX2 by enzyme immuno assay
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Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by
PDSP K
i
Database
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Copy SMILES
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Affinity Data
IC50: 1.10E+3nM
Assay Description:
Inhibition of human COX2 by enzyme immunoassay
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Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by
PDSP K
i
Database
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.10E+3nM
Assay Description:
Inhibition of human recombinant COX2 by enzyme immuno assay
More data for this Ligand-Target Pair
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Target
Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by
PDSP K
i
Database
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.10E+3nM
Assay Description:
Inhibition of human recombinant COX2 by enzyme immunoassay
More data for this Ligand-Target Pair
Target Info
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Target
Prostaglandin G/H synthase 2
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Copy SMILES
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Affinity Data
IC50: 1.10E+3nM
Assay Description:
Inhibition of ovine COX2 by enzyme immuno assay
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Target
Prostaglandin G/H synthase 2
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.10E+3nM
Assay Description:
Inhibition of ovine COX2 by enzyme immunoassay
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Target
Prostaglandin G/H synthase 2
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.10E+3nM
Assay Description:
Inibition of ovine COX2 by enzyme immuno assay
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Prostaglandin G/H synthase 2
(Bos taurus)
University Of Alberta
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 1.10E+3nM
Assay Description:
Inhibition of bovine COX2 by enzyme immunoassay
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Target
Prostaglandin G/H synthase 2
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Copy SMILES
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Affinity Data
IC50: 1.10E+3nM
Assay Description:
In vitro inhibitory concentration of the compound against COX-2 enzyme
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Target
Prostaglandin G/H synthase 2
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.10E+3nM
Assay Description:
Inhibition of ovine COX2 by enzyme immuno assay
More data for this Ligand-Target Pair
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Target
Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by
PDSP K
i
Database
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Copy SMILES
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Affinity Data
IC50: 1.10E+3nM
Assay Description:
Inhibition of human recombinant COX2 by enzyme immuno assay
More data for this Ligand-Target Pair
Target Info
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Target
Prostaglandin G/H synthase 2
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.10E+3nM
Assay Description:
Inhibition of ovine COX2 by enzyme immuno assay
More data for this Ligand-Target Pair
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Target
Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by
PDSP K
i
Database
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Copy SMILES
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Affinity Data
IC50: 1.35E+3nM
Assay Description:
Inhibition of human COX2 expressed in baculovirus system
More data for this Ligand-Target Pair
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Target
Prostaglandin G/H synthase 2
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Copy SMILES
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Affinity Data
IC50: 1.40E+3nM
Assay Description:
Inhibition of ovine COX2 assessed as reduction in PGH2 production by enzyme immunoassay
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Target
Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by
PDSP K
i
Database
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.40E+3nM
Assay Description:
Inhibition of human recombinant COX-2
More data for this Ligand-Target Pair
Target Info
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Target
Prostaglandin G/H synthase 1
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 1.42E+3nM
Assay Description:
Inhibition of ovine COX1 assessed as reduction in Prostaglandin production by enzyme immunoassay
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Prostaglandin G/H synthase 1
(Homo sapiens (Human))
University of Maryland Hospital
Curated by
PDSP K
i
Database
Ligand
BDBM50169047
((S)-2-(4-Isobutyl-phenyl)-propionic acid | (S)-2-(...)
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Affinity Data
IC50: 1.48E+3nM
Assay Description:
Inhibition of ovine COX1 by EIA
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Prostaglandin G/H synthase 2
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50169047
((S)-2-(4-Isobutyl-phenyl)-propionic acid | (S)-2-(...)
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Affinity Data
IC50: 1.50E+3nM
Assay Description:
Inhibition of sheep COX2 by spectrophotometry
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Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by
PDSP K
i
Database
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 1.79E+3nM
Assay Description:
Inhibition of COX2 (unknown origin) assessed as reduction in PGF2alpha content using arachidonic acid as substrate preincubated for 10 mins followed ...
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Target
Prostaglandin G/H synthase 1
(Homo sapiens (Human))
University of Maryland Hospital
Curated by
PDSP K
i
Database
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 1.86E+3nM
Assay Description:
Inhibition of COX-1 in human washed platelet assessed as inhibition of 10 uM arachidonic acid-induced TXB2 formation incubated for 25 mins prior to a...
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Prostaglandin G/H synthase 1/2
(RAT)
University Of Pennsylvania
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 2.00E+3nM
Assay Description:
Inhibition of Prostaglandin G/H synthase in intact RBL-1 cell line
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Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by
PDSP K
i
Database
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 2.00E+3nM
Assay Description:
Inhibition of human recombinant COX2 assessed as reduction in PGE2 production using arachidonic acid substrate by ELISA
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Prostaglandin G/H synthase 1
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 2.19E+3nM
Assay Description:
Inhibition of ovine COX-1 assessed as reduction in PGE2 production using 10 uM arachidonic acid as substrate preincubated with enzyme for 5 mins foll...
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Target
Prostaglandin G/H synthase 1
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50169047
((S)-2-(4-Isobutyl-phenyl)-propionic acid | (S)-2-(...)
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Affinity Data
IC50: 2.26E+3nM
Assay Description:
In vitro inhibitory concentration of the compound against ram seminal vescicle prostaglandin G/H synthase 1
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Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by
PDSP K
i
Database
Ligand
BDBM50169047
((S)-2-(4-Isobutyl-phenyl)-propionic acid | (S)-2-(...)
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Affinity Data
IC50: 2.46E+3nM
Assay Description:
Inhibition of human recombinant COX-2 assessed as reduction in PGE2 level using 10 uM arachidonic acid as substrate preincubated with enzyme for 5 mi...
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Prostaglandin G/H synthase 1
(Homo sapiens (Human))
University of Maryland Hospital
Curated by
PDSP K
i
Database
Ligand
BDBM50169047
((S)-2-(4-Isobutyl-phenyl)-propionic acid | (S)-2-(...)
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Affinity Data
IC50: 2.60E+3nM
Assay Description:
Inhibition of COX1
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Target
Prostaglandin G/H synthase 1
(Homo sapiens (Human))
University of Maryland Hospital
Curated by
PDSP K
i
Database
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 2.70E+3nM
Assay Description:
Inhibition of COX-1 (unknown origin) using arachidonic acid as substrate measured after 10 mins by fluorometric based multimode microplate reader
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Target
Prostaglandin G/H synthase 1
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 2.90E+3nM
Assay Description:
In vitro inhibitory concentration of the compound against COX-1 enzyme
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Target
Prostaglandin G/H synthase 1
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Copy SMILES
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Affinity Data
IC50: 2.90E+3nM
Assay Description:
Inhibition of ovine COX1
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Target
Prostaglandin G/H synthase 1
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.90E+3nM
Assay Description:
Inhibition of ovine COX1
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Target Info
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Target
Prostaglandin G/H synthase 1
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.90E+3nM
Assay Description:
Inhibition of ovine COX1 by enzyme immuno assay
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Target
Prostaglandin G/H synthase 1
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.90E+3nM
Assay Description:
Inhibition of ovine COX1 by enzyme immuno assay
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Target
Prostaglandin G/H synthase 1
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.90E+3nM
Assay Description:
Inhibition of sheep COX1 by enzyme immunoassay
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Target
Prostaglandin G/H synthase 1
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.90E+3nM
Assay Description:
Inhibition of ovine COX1 by enzyme immuno assay
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Target
Prostaglandin G/H synthase 1
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.90E+3nM
Assay Description:
Inhibition of ovine COX1 by enzyme immunoassay
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Target Info
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Target
Prostaglandin G/H synthase 1
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.90E+3nM
Assay Description:
Inhibition of ovine COX1 by enzyme immuno assay
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Target
Prostaglandin G/H synthase 1
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.90E+3nM
Assay Description:
Inhibition of ovine COX1 by enzyme immunoassay
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Target Info
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Target
Prostaglandin G/H synthase 1
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.90E+3nM
Assay Description:
Inhibition of ovine COX1 by enzyme immuno assay
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Target
Prostaglandin G/H synthase 1
(Bos taurus)
University Of Alberta
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 2.90E+3nM
Assay Description:
Inhibition of bovine COX1 by enzyme immunoassay
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Target
Prostaglandin G/H synthase 1
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.90E+3nM
Assay Description:
Inhibition of ovine COX1 by enzyme immuno assay
More data for this Ligand-Target Pair
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Target
Prostaglandin G/H synthase 1
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.90E+3nM
Assay Description:
Inhibition of ovine COX1 by enzyme immuno assay
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Target
Prostaglandin G/H synthase 1
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.90E+3nM
Assay Description:
Inhibition of ovine COX1 by enzyme immuno assay
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Target
Prostaglandin G/H synthase 1
(Bos taurus)
University Of Alberta
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Copy SMILES
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Affinity Data
IC50: 2.90E+3nM
Assay Description:
Inhibition of bovine COX-1 by enzyme immuno assay
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Target
Prostaglandin G/H synthase 1
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.90E+3nM
Assay Description:
Inhibition of ovine COX1 by enzyme immunoassay
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Target
Prostaglandin G/H synthase 1
(Homo sapiens (Human))
University of Maryland Hospital
Curated by
PDSP K
i
Database
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Copy SMILES
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Affinity Data
IC50: 3.00E+3nM
Assay Description:
Concentration (in microM) to inhibit 50% of Prostaglandin G/H synthase 1 (COX-1) and is expressed in IC50.
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Prostaglandin G/H synthase 1
(Homo sapiens (Human))
University of Maryland Hospital
Curated by
PDSP K
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Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 3.00E+3nM
Assay Description:
Inhibition of Prostaglandin G/H synthase 1 (COX-1).
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Albumin
(Bos taurus)
European Molecular Biology Laboratory
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ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 3.00E+3nM
Assay Description:
Binding affinity to bovine serum albumin
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Prostaglandin G/H synthase 1
(Homo sapiens (Human))
University of Maryland Hospital
Curated by
PDSP K
i
Database
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 3.00E+3nM
Assay Description:
Inhibitory activity against prostaglandin G/H synthase 1 (COX-1)
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Prostaglandin G/H synthase 1
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50169047
((S)-2-(4-Isobutyl-phenyl)-propionic acid | (S)-2-(...)
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Affinity Data
IC50: 3.20E+3nM
Assay Description:
Inhibition of sheep COX1 by spectrophotometry
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Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
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PDSP K
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Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 3.30E+3nM
Assay Description:
Inhibition of human recombinant COX-2 assessed as reduction in PGE2 production using 10 uM arachidonic acid as substrate preincubated with enzyme for...
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Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by
PDSP K
i
Database
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 3.30E+3nM
Assay Description:
Inhibition of human recombinant COX2 expressed in Sf9 cells using arachidonic acid and ADHP incubated for 5 mins by fluorimetry
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Prostaglandin G/H synthase 1
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 3.35E+3nM
Assay Description:
Inhibition of ovine COX1 assessed as reduction in PGH2 production by enzyme immunoassay
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Prostaglandin G/H synthase 1
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 4.00E+3nM
Assay Description:
Competitive inhibition of ovine COX-1 assessed as reduction in PGE2 production using 250 nM arachidonic acid as substrate preincubated with enzyme fo...
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Prostaglandin G/H synthase 1
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 4.00E+3nM
Assay Description:
Inhibition of ovine COX-1
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Prostaglandin G/H synthase 1
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 4.00E+3nM
pH: 8.0
Assay Description:
Approximately 2 µg of either COX-1 or COX-2 was added to buffer containing 100 µM AA, 0.1 M Tris-HCl buffer (pH 8.0), 5 mM EDTA, 2 mM phenol, and 1 µ...
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Prostaglandin G/H synthase 1
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 4.12E+3nM
Assay Description:
Inhibition of ovine COX1 using arachidonic acid as substrate pretreated for 5 mins followed by substrate addition and measured after 2 mins by fluore...
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Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by
PDSP K
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Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 4.20E+3nM
Assay Description:
Inhibition of human recombinant COX2 assessed as reduction in PGE2 formation pre-incubated for 5 mins before arachidonic acid addition and measured a...
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Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by
PDSP K
i
Database
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 4.30E+3nM
Assay Description:
Inhibition of human recombinant COX2 pre-treated for 1 hr before 10-acetyl-3,7-dihydroxyphenoxazin substrate addition in absence of porcine liver est...
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Prostaglandin G/H synthase 1
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50169047
((S)-2-(4-Isobutyl-phenyl)-propionic acid | (S)-2-(...)
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Affinity Data
IC50: 4.50E+3nM
Assay Description:
Inhibition of ovine COX-1 assessed as reduction in PGE2 level using 10 uM arachidonic acid as substrate preincubated with enzyme for 5 mins followed ...
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Caspase-9
(Homo sapiens (Human))
University of Colorado
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 4.90E+3nM
pH: 7.4
Assay Description:
Experiments were performed in a 384-well format (Greiner no. 781207) as per the conditions noted here. Caspase-1: 2.5 nM enzyme, 6.5 mM WEHD substrat...
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Prostaglandin G/H synthase 1
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50169047
((S)-2-(4-Isobutyl-phenyl)-propionic acid | (S)-2-(...)
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Affinity Data
IC50: 4.96E+3nM
Assay Description:
Competitive inhibition of ovine COX-1 assessed as reduction in PGE2 level using 50 nM arachidonic acid as substrate preincubated with enzyme for 5 mi...
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Prostaglandin G/H synthase 1
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 5.00E+3nM
Assay Description:
Inhibition of ovine COX1 pre-incubated for 10 mins before arachidonic acid substrate addition by enzyme immunoassay
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Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by
PDSP K
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Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 5.33E+3nM
Assay Description:
Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate measured after 10 mins by fluorometric based multimode microplate reader
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Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by
PDSP K
i
Database
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 5.33E+3nM
Assay Description:
Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate incubated for 5 to 10 mins by fluorometric analysis
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Target
Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by
PDSP K
i
Database
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 6.20E+3nM
Assay Description:
Inhibition of COX2 in human whole blood after 15 mins
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Prostaglandin G/H synthase 1
(Homo sapiens (Human))
University of Maryland Hospital
Curated by
PDSP K
i
Database
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 6.30E+3nM
Assay Description:
Compound was evaluated for inhibition of Prostaglandin G/H synthase 1
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Prostaglandin G/H synthase 1
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 6.30E+3nM
Assay Description:
Inhibition of ram seminal vesicle COX1 assessed as reduction in PGE2 formation pre-incubated for 5 mins before arachidonic acid addition and measured...
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Prostaglandin G/H synthase 1
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 6.90E+3nM
Assay Description:
Inhibition of ram seminal vesicle COX1 assessed as reduction in PGE2 production using arachidonic acid substrate by ELISA
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Prostaglandin G/H synthase 1
(Homo sapiens (Human))
University of Maryland Hospital
Curated by
PDSP K
i
Database
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 6.90E+3nM
Assay Description:
Inhibition of COX1 in human whole blood after 15 mins
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Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by
PDSP K
i
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Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 7.20E+3nM
Assay Description:
Inhibition of COX2 in human whole blood measured after 30 mins by radioimmunoassay
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Prostaglandin G/H synthase 2 [E165G]
(Homo sapiens (Human))
Beni-Suef University
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 7.20E+3nM
Assay Description:
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...
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Prostaglandin G/H synthase 1
(Homo sapiens (Human))
University of Maryland Hospital
Curated by
PDSP K
i
Database
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 7.60E+3nM
Assay Description:
Inhibition of COX1 (unknown origin)
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Prostaglandin G/H synthase 1
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 7.60E+3nM
Assay Description:
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...
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Solute carrier family 22 member 6
(Homo sapiens (Human))
Gilead Sciences
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ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 8.00E+3nM
Assay Description:
TP_TRANSPORTER: inhibition of Adefovir uptake in OAT1-expressing CHO cells
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Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by
PDSP K
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Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 8.00E+3nM
Assay Description:
Tested for inhibitory activity against Prostaglandin G/H synthase 2 from human
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Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by
PDSP K
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Database
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 8.00E+3nM
pH: 8.0
Assay Description:
Approximately 2 µg of either COX-1 or COX-2 was added to buffer containing 100 µM AA, 0.1 M Tris-HCl buffer (pH 8.0), 5 mM EDTA, 2 mM phenol, and 1 µ...
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Caspase-5
(Homo sapiens (Human))
University of Colorado
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 8.10E+3nM
pH: 7.4
Assay Description:
Experiments were performed in a 384-well format (Greiner no. 781207) as per the conditions noted here. Caspase-1: 2.5 nM enzyme, 6.5 mM WEHD substrat...
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Caspase-4
(Homo sapiens (Human))
University of Colorado
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 8.80E+3nM
pH: 7.4
Assay Description:
Experiments were performed in a 384-well format (Greiner no. 781207) as per the conditions noted here. Caspase-1: 2.5 nM enzyme, 6.5 mM WEHD substrat...
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Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by
PDSP K
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Database
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 8.91E+3nM
Assay Description:
Inhibition of recombinant human COX2 using arachidonic acid as substrate pretreated for 5 mins followed by substrate addition and measured after 2 mi...
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Prostaglandin G/H synthase 1
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 9.00E+3nM
Assay Description:
Tested for inhibitory activity against Prostaglandin G/H synthase 1 from ovine
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Prostaglandin G/H synthase 1
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of Ovine COX-1 preincubated for 15 mins by fluorescence analysis
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Epidermal growth factor receptor
(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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IC50: >1.00E+4nM
Assay Description:
Inhibition of EGFR (unknown origin) using tyrosine 4 as substrate by fluorescence analysis
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Prostaglandin G/H synthase 1
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 1.01E+4nM
Assay Description:
Inhibition of purified ovine COX1 pre-treated for 1 hr before 10-acetyl-3,7-dihydroxyphenoxazin substrate addition in absence of porcine liver estera...
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Prostaglandin G/H synthase 1
(Homo sapiens (Human))
University of Maryland Hospital
Curated by
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Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 1.11E+4nM
Assay Description:
Inhibition activity against recombinant human Prostaglandin G/H synthase 1
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Prostaglandin G/H synthase 1
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 1.20E+4nM
Assay Description:
Inhibition of ovine COX-1 assessed as residual activity by measuring formation of 12-HHT from arachidonic acid by HPLC analysis
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Prostaglandin G/H synthase 1
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 1.20E+4nM
Assay Description:
Inhibition of ovine COX1 after 5 mins
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Prostaglandin-H2 D-isomerase
(Mus musculus)
Sterling Research Group
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 1.30E+4nM
Assay Description:
Concentration required to inhibit 50% activity of prostaglandin synthetase was determined in vitro in mouse brain microsomes
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Prostaglandin G/H synthase 1
(Bos taurus)
University Of Alberta
Curated by
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Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 1.30E+4nM
Assay Description:
Inhibition of bovine seminal microsomal COX1 assessed as PGE2 production
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Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus)
Abbott Laboratories
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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IC50: 1.40E+4nM
Assay Description:
Inhibitory activity against 5-lipoxygenase catalysis (5-LO) in sonicated rat basophilic leukemia cell lysate
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Prostaglandin G/H synthase 1
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
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Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 1.44E+4nM
Assay Description:
Inhibitory concentration against Prostaglandin G/H synthase 1 of ram seminal vesicles at 100 uM
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Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by
PDSP K
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Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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IC50: 1.45E+4nM
Assay Description:
Inhibition of COX2 (unknown origin)
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Prostaglandin G/H synthase 1
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50169047
((S)-2-(4-Isobutyl-phenyl)-propionic acid | (S)-2-(...)
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Affinity Data
IC50: 1.62E+4nM
Assay Description:
Competitive inhibition of ovine COX-1 assessed as reduction in PGE2 level using 250 nM arachidonic acid as substrate preincubated with enzyme for 5 m...
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Abbott Laboratories
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 1.70E+4nM
Assay Description:
Inhibitory activity against 5-lipoxygenase in Human whole blood (HWBL) stimulated with calcium ionophore (A23187) and LTB4 measured by enzyme immunoa...
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Prostaglandin G/H synthase 1
(Homo sapiens (Human))
University of Maryland Hospital
Curated by
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i
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BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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IC50: 1.80E+4nM
Assay Description:
Inhibition of COX1-catalyzed prostaglandin biosynthesis 10 mins of preincubation
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Prostaglandin G/H synthase 1
(Bos taurus)
University Of Alberta
Curated by
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Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 1.80E+4nM
Assay Description:
Inhibition of bovine seminal microsomal COX1 assessed as PGE2 production preincubated for 10 mins
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Prostaglandin G/H synthase 1
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50169047
((S)-2-(4-Isobutyl-phenyl)-propionic acid | (S)-2-(...)
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Affinity Data
IC50: >2.00E+4nM
Assay Description:
Competitive inhibition of ovine COX-1 assessed as reduction in PGE2 level using 1250 nM arachidonic acid as substrate preincubated with enzyme for 5 ...
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Prostaglandin G/H synthase 1
(Homo sapiens (Human))
University of Maryland Hospital
Curated by
PDSP K
i
Database
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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IC50: 2.50E+4nM
Assay Description:
Inhibition of PGHS1 assessed as conversion of arachidonic acid to prostaglandin
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Prostaglandin G/H synthase 1
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 2.60E+4nM
Assay Description:
Inhibition of ovine COX-1 assessed as decrease in PGH2 production using arachidonic acid as substrate treated with enzyme for 10 mins prior to substr...
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Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by
PDSP K
i
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Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 3.00E+4nM
Assay Description:
Concentration (in microM) to inhibit 50% of Prostaglandin G/H synthase 2 (COX-2) and is expressed in IC50.
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Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by
PDSP K
i
Database
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 3.00E+4nM
Assay Description:
Inhibitory activity against prostaglandin G/H synthase 2 (COX-2)
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Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by
PDSP K
i
Database
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 3.00E+4nM
Assay Description:
Inhibition of human recombinant COX-2 assessed as decrease in PGH2 production using arachidonic acid as substrate treated with enzyme for 10 mins pri...
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Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by
PDSP K
i
Database
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 3.00E+4nM
Assay Description:
Inhibition of Prostaglandin G/H synthase 2 (COX-2).
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Aldo-keto reductase family 1 member C3
(Homo sapiens (Human))
University Of Auckland
Curated by
ChEMBL
Ligand
BDBM50169047
((S)-2-(4-Isobutyl-phenyl)-propionic acid | (S)-2-(...)
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Affinity Data
IC50: 3.27E+4nM
Assay Description:
Inhibition of human recombinant N-terminal His6-tagged AKR1C3 expressed in Escherichia coli BL21(DE3) cells using 8-Acetyl-2,3,5,6-tetrahydro-1H,4H-1...
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Aldo-keto reductase family 1 member C3
(Homo sapiens (Human))
University Of Auckland
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 3.30E+4nM
Assay Description:
Inhibition of recombinant human AKR1C3
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Prostaglandin G/H synthase 1
(Homo sapiens (Human))
University of Maryland Hospital
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i
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Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 3.40E+4nM
Assay Description:
Inhibition of human recombinant COX1 expressed in Sf9 cells using arachidonic acid and ADHP incubated for 3 mins by fluorimetry
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Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by
PDSP K
i
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Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 3.60E+4nM
Assay Description:
Inhibition of human COX2 pre-incubated for 10 mins before substrate addition by enzyme immunoassay
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Aldo-keto reductase family 1 member C2
(Homo sapiens (Human))
University Of Auckland
Curated by
ChEMBL
Ligand
BDBM50169047
((S)-2-(4-Isobutyl-phenyl)-propionic acid | (S)-2-(...)
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Affinity Data
IC50: 4.24E+4nM
Assay Description:
Inhibition of human recombinant N-terminal His6-tagged AKR1C2 expressed in Escherichia coli BL21(DE3) cells using 8-Acetyl-2,3,5,6-tetrahydro-1H,4H-1...
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Cytochrome P450 2J2
(Homo sapiens (Human))
Tongji University
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: >5.00E+4nM
Assay Description:
Inhibition of human recombinant CYP2J2 assessed as reduction in astemizole O-demethylation by LC-MS/MS method
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Caspase-3
(Homo sapiens (Human))
University of Colorado
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: >6.60E+4nM
pH: 7.4
Assay Description:
Experiments were performed in a 384-well format (Greiner no. 781207) as per the conditions noted here. Caspase-1: 2.5 nM enzyme, 6.5 mM WEHD substrat...
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Prostaglandin G/H synthase 1
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 7.01E+4nM
Assay Description:
Competitive inhibition of ovine COX-1 assessed as reduction in PGE2 production using 6250 nM arachidonic acid as substrate preincubated with enzyme f...
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Prostaglandin G/H synthase 1
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 7.28E+4nM
Assay Description:
Inhibition of ovine COX1 using arachidonic acid as substrate pretreated for 3 mins followed by substrate addition measured immediately
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Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by
PDSP K
i
Database
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 8.00E+4nM
Assay Description:
Inhibition of human recombinant COX2 after 5 mins
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Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by
PDSP K
i
Database
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 8.00E+4nM
Assay Description:
Inhibition of human recombinant COX-2 assessed as residual activity by measuring formation of 12-HHT from arachidonic acid by HPLC analysis
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Aldo-keto reductase family 1 member C1
(Homo sapiens (Human))
University Of Auckland
Curated by
ChEMBL
Ligand
BDBM50169047
((S)-2-(4-Isobutyl-phenyl)-propionic acid | (S)-2-(...)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of human recombinant N-terminal His6-tagged AKR1C1 expressed in Escherichia coli BL21(DE3) cells using 8-Acetyl-2,3,5,6-tetrahydro-1H,4H-1...
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Aldo-keto reductase family 1 member C4
(Homo sapiens (Human))
University Of Auckland
Curated by
ChEMBL
Ligand
BDBM50169047
((S)-2-(4-Isobutyl-phenyl)-propionic acid | (S)-2-(...)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of human recombinant N-terminal His6-tagged AKR1C4 expressed in Escherichia coli BL21(DE3) cells using 8-Acetyl-2,3,5,6-tetrahydro-1H,4H-1...
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Dehydrogenase/reductase SDR family member 9
(Rattus norvegicus)
Universitat De Barcelona
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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IC50: 1.00E+5nM
Assay Description:
Inhibition of rat liver 3-alpha-HSD assessed as 5-beta-dihydrocortisone reduction
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Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus)
Abbott Laboratories
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of 5-LOX in RBL1 cells assessed as reduction in LTB4 production using A23187-induced arachidonic acid as substrate preincubated for 2 hrs ...
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Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat))
Umeå University
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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IC50: 1.34E+5nM
pH: 7.0 T: 2°C
Assay Description:
Frozen (−80°C) brains (minus cerebella) from adult Wistar or Sprague-Dawley rats were thawed and homogenized in 20 mM HEPES, 1 mM MgCl2, pH 7....
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Acid-sensing ion channel 1
(Rattus norvegicus)
University of Copenhagen
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Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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IC50: 1.35E+5nM
Assay Description:
Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes at pH 6.9 by two electrode voltage clamp
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Acid-sensing ion channel 1
(Rattus norvegicus)
University of Copenhagen
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 1.35E+5nM
Assay Description:
Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes at pH 6.9 by two electrode voltage clamp
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Bile salt export pump
(Homo sapiens (Human))
Amgen
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ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: >1.35E+5nM
Assay Description:
Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...
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Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat))
Umeå University
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 1.63E+5nM
pH: 7.0 T: 2°C
Assay Description:
Frozen (−80°C) brains (minus cerebella) from adult Wistar or Sprague-Dawley rats were thawed and homogenized in 20 mM HEPES, 1 mM MgCl2, pH 7....
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Seed linoleate 13S-lipoxygenase-1
(Glycine max (soybean))
TBA
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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IC50: 2.00E+5nM
Assay Description:
Inhibition of Glycine max (soybean) lipoxygenase assessed as formation of 13-hydroperoxylinoleic acid using sodium linoleate as substrate after 7 min
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Acetylcholinesterase
(Homo sapiens (Human))
University Of Education
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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IC50: 2.35E+5nM
Assay Description:
Inhibition of AChE (unknown origin) using acetylcholine iodide as substrate by Ellman method
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Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat))
Umeå University
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 2.40E+5nM
pH: 7.4
Assay Description:
Inhibition of FAAH-mediated [3H]AEA hydrolysis in rat brain homogenate at pH 7.4 by liquid scintillation spectroscopy
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Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat))
Umeå University
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 2.63E+5nM
Assay Description:
Inhibition of FAAH-mediated [3H]AEA hydrolysis in rat brain homogenate by liquid scintillation spectroscopy
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Prostaglandin G/H synthase 2
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 2.66E+5nM
Assay Description:
Inhibitory concentration against Prostaglandin G/H synthase 2 from sheep placenta at 100 uM
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Prostaglandin G/H synthase 2
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50169047
((S)-2-(4-Isobutyl-phenyl)-propionic acid | (S)-2-(...)
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IC50: 2.66E+5nM
Assay Description:
In vitro inhibitory concentration of the compound against sheep placenta Prostaglandin G/H synthase 2
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Acid-sensing ion channel 1
(Rattus norvegicus)
University of Copenhagen
Curated by
ChEMBL
Ligand
BDBM50169044
((-)-ibuprofen | (2R)-2-(4-isobutylphenyl)propanoic...)
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Affinity Data
IC50: 2.88E+5nM
Assay Description:
Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clamp
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Target
Bile salt export pump
(Rattus norvegicus)
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 2.91E+5nM
Assay Description:
Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
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Acid-sensing ion channel 1
(Rattus norvegicus)
University of Copenhagen
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 2.95E+5nM
Assay Description:
Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes at pH 6.4 by two electrode voltage clamp
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Target
Acid-sensing ion channel 1
(Rattus norvegicus)
University of Copenhagen
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Copy SMILES
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Affinity Data
IC50: 2.95E+5nM
Assay Description:
Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clamp
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Target
Acid-sensing ion channel 1
(Rattus norvegicus)
University of Copenhagen
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Copy SMILES
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Affinity Data
IC50: 2.95E+5nM
Assay Description:
Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes at pH 6.4 by two electrode voltage clamp
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Acid-sensing ion channel 3
(Rattus norvegicus)
University of Copenhagen
Curated by
ChEMBL
Ligand
BDBM50169047
((S)-2-(4-Isobutyl-phenyl)-propionic acid | (S)-2-(...)
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Affinity Data
IC50: 3.09E+5nM
Assay Description:
Inhibition of rat ASIC3 receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.4-gated currents by two electrode voltage clamp
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Target
Acid-sensing ion channel 1
(Rattus norvegicus)
University of Copenhagen
Curated by
ChEMBL
Ligand
BDBM50169047
((S)-2-(4-Isobutyl-phenyl)-propionic acid | (S)-2-(...)
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Affinity Data
IC50: 3.47E+5nM
Assay Description:
Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clamp
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Prostaglandin G/H synthase 2
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 3.70E+5nM
Assay Description:
Inhibition of sheep placental cotyledons COX2 assessed as PGE2 production
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Target
Acid-sensing ion channel 3
(Rattus norvegicus)
University of Copenhagen
Curated by
ChEMBL
Ligand
BDBM50169044
((-)-ibuprofen | (2R)-2-(4-isobutylphenyl)propanoic...)
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Affinity Data
IC50: 3.89E+5nM
Assay Description:
Inhibition of rat ASIC3 receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.4-gated currents by two electrode voltage clamp
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Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat))
Umeå University
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: >5.00E+5nM
pH: 9.0
Assay Description:
Inhibition of FAAH-mediated [3H]AEA hydrolysis in rat brain homogenate at pH 9.0 by liquid scintillation spectroscopy
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Target
Acid-sensing ion channel 1
(Rattus norvegicus)
University of Copenhagen
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 5.13E+5nM
Assay Description:
Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes at pH 6.7 by two electrode voltage clamp
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Target
Acid-sensing ion channel 3
(Rattus norvegicus)
University of Copenhagen
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5.13E+5nM
Assay Description:
Inhibition of rat ASIC3 receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.4-gated currents by two electrode voltage clamp
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Target
Acid-sensing ion channel 1
(Rattus norvegicus)
University of Copenhagen
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 5.13E+5nM
Assay Description:
Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes at pH 6.7 by two electrode voltage clamp
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Target
Bile salt export pump
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 5.99E+5nM
Assay Description:
Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
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Target
Cholinesterase
(Homo sapiens (Human))
University Of Education
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: <6.00E+5nM
Assay Description:
Inhibition of BuChE (unknown origin) using butyrylthiocholine bromide as substrate by Ellman method
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Target
Bile salt export pump
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: >7.89E+5nM
Assay Description:
Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...
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Target
Prostaglandin G/H synthase 2
(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 1.03E+6nM
Assay Description:
Inhibition of sheep placental cotyledons COX2 assessed as PGE2 production preincubated for 10 mins
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Target
Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by
PDSP K
i
Database
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
IC50: 1.03E+6nM
Assay Description:
Inhibition of COX2-catalyzed prostaglandin biosynthesis after 10 mins of preincubation
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Target
GTPase KRas [1-37]
(Homo sapiens (Human))
Nmmlsc
Curated by
PubChem BioAssay
Ligand
BDBM50169047
((S)-2-(4-Isobutyl-phenyl)-propionic acid | (S)-2-(...)
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Affinity Data
EC50: 3.00E+4nM
Assay Description:
University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...
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Ras-related protein Rab-2A
(Canis lupus familiaris)
Nmmlsc
Curated by
PubChem BioAssay
Ligand
BDBM50169047
((S)-2-(4-Isobutyl-phenyl)-propionic acid | (S)-2-(...)
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Affinity Data
EC50: 3.00E+4nM
Assay Description:
University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...
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Cell division control protein 42 homolog
(Homo sapiens (Human))
Nmmlsc
Curated by
PubChem BioAssay
Ligand
BDBM50169047
((S)-2-(4-Isobutyl-phenyl)-propionic acid | (S)-2-(...)
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Affinity Data
EC50: 6.41E+3nM
Assay Description:
University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...
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Target
Cell division control protein 42 homolog
(Homo sapiens (Human))
Nmmlsc
Curated by
PubChem BioAssay
Ligand
BDBM50169047
((S)-2-(4-Isobutyl-phenyl)-propionic acid | (S)-2-(...)
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Affinity Data
EC50: 1.66E+4nM
Assay Description:
University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...
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Ras-related protein Rab-7a
(Canis lupus familiaris)
Nmmlsc
Curated by
PubChem BioAssay
Ligand
BDBM50169047
((S)-2-(4-Isobutyl-phenyl)-propionic acid | (S)-2-(...)
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Affinity Data
EC50: 4.78E+3nM
Assay Description:
University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...
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Target
GTPase KRas [1-37]
(Homo sapiens (Human))
Nmmlsc
Curated by
PubChem BioAssay
Ligand
BDBM50169047
((S)-2-(4-Isobutyl-phenyl)-propionic acid | (S)-2-(...)
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Affinity Data
EC50: 3.00E+4nM
Assay Description:
University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...
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Ras-related C3 botulinum toxin substrate 1
(Mus musculus)
Nmmlsc
Curated by
PubChem BioAssay
Ligand
BDBM50169047
((S)-2-(4-Isobutyl-phenyl)-propionic acid | (S)-2-(...)
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Affinity Data
EC50: 3.00E+4nM
Assay Description:
University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...
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Target
Ras-related C3 botulinum toxin substrate 1
(Mus musculus)
Nmmlsc
Curated by
PubChem BioAssay
Ligand
BDBM50169047
((S)-2-(4-Isobutyl-phenyl)-propionic acid | (S)-2-(...)
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Affinity Data
EC50: 3.00E+4nM
Assay Description:
University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...
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Target
Albumin
(Rattus norvegicus)
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
Kd: 1.47E+3nM
Assay Description:
Binding affinity to Wistar rat serum albumin
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Albumin
(Homo sapiens (Human))
Molecular Discovery
Curated by
ChEMBL
Ligand
BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
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Affinity Data
Kd: 7.30E+4nM
Assay Description:
Binding affinity to human serum albumin assessed as dissociation constant and measured after 5 mins by MST assay
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