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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
147
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Target
Cytochrome P450 1A2
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
ChEMBL
Ligand
BDBM50418083
(CHEMBL1743359 | ZILEUTON)
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Affinity Data
Ki: 6.60E+4nM
Assay Description:
Mechanism based inhibition of human cytochrome P450 1A2 measured by phenacetin O-deethylation (POD)
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Target
Cytochrome P450 1A2
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
ChEMBL
Ligand
BDBM50320449
((-)-ZILEUTON | CHEMBL1164975)
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Affinity Data
Ki: 9.82E+4nM
Assay Description:
Mechanism based inhibition of human cytochrome P450 1A2 measured by phenacetin O-deethylation (POD)
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Target
Cytochrome P450 1A2
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
Ki: 1.17E+5nM
Assay Description:
Mechanism based inhibition of human cytochrome P450 1A2 measured by phenacetin O-deethylation (POD)
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 100nM
Assay Description:
Inhibition of human recombinant 5-LOX assessed as reduction in leukotriene B4 synthesis using arachidonic acid substrate by ELISA
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus)
TBA
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 140nM
Assay Description:
Inhibition of 5-Lipoxygenase of rat basophilic leukemia cells
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 150nM
Assay Description:
Inhibition of human 5-Lipoxygenase using H2DCFDA as substrate preincubated for 5 mins and measured by Spectrophotometric assay
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 150nM
Assay Description:
Inhibition of human 5-lipoxygenase using arachidonic acid as substrate pretreated for 10 mins followed by substrate and ATP addition and measured aft...
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 180nM
pH: 7.4 T: 2°C
Assay Description:
5-LOX enzyme assay was carried out with some modifications of ferric oxidation of xylenol orange (FOX) assay, which is based on the complex formation...
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Mus musculus)
Sookmyung Women'S University
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 190nM
Assay Description:
Inhibition of 5-LO in mouse BMM cells assessed as formation of LTC4 after 30 mins by enzyme immunoassay
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus)
TBA
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 200nM
Assay Description:
Compound was tested for its inhibitory activity against 5-lipoxygenase in rat.
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 300nM
Assay Description:
Inhibition of 5-LOX (unknown origin) using arachidonic acid as substrate after 5 mins by EIA
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus)
TBA
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 320nM
Assay Description:
The compound was tested for its inhibitory activity against arachidonic acid in rat 5-lipoxygenase
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 320nM
Assay Description:
Inhibition of calcium ionophore (A-23187)-stimulated LTB4 formation in human neutrophil assay
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 350nM
Assay Description:
Inhibition of human recombinant 5-LOX assessed as reduction in leukotriene B4 production pre-incubated for 10 mins before arachidonic acid addition a...
More data for this Ligand-Target Pair
Target Info
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus)
TBA
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 370nM
Assay Description:
In vitro inhibition of 5-lipoxygenase (5-HETE) derived from the 9000xg supernatant of RBL broken cell assay
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 390nM
Assay Description:
Inhibition of 5-LOX (unknown origin)
More data for this Ligand-Target Pair
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Target
Polyunsaturated fatty acid lipoxygenase ALOX15
(Homo sapiens (Human))
Universidad De Chile
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 400nM
Assay Description:
Binding affinity towards human peroxisome proliferator activated receptor gamma (PPAR gamma) was determined by HTRF assay
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 400nM
Assay Description:
Inhibition of human recombinant 5-LO expressed in Escherichia coli by cell-free assay
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 410nM
Assay Description:
Inhibition of 5-LOX (unknown origin)-mediated leukotriene (LT)B4 biosynthesis
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Target
Leukotriene B4 receptor 1
(Homo sapiens (Human))
Eisai
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 420nM
Assay Description:
In vitro activities of Leukotriene B4 receptor (LTB4) in human neutrophils
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 500nM
Assay Description:
Inhibition of 5-lipoxygenase
More data for this Ligand-Target Pair
Target Info
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus)
TBA
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 500nM
Assay Description:
The compound was tested for inhibitory activity against 5-Lipoxygenase in rat RBL-1
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus)
TBA
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
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Affinity Data
IC50: 500nM
Assay Description:
Inhibition of 5-lipoxygenase on rat basophil leukemia cell line lysate (RBL-1 2H3 subline) by measuring 5-HETE production
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 500nM
Assay Description:
Inhibition of recombinant human 5-lipoxygenase expressed in Escherichia coli BL21 (DE3) cells using arachidonic acid as substrate preincubated for 10...
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 500nM
Assay Description:
Inhibition of recombinant human 5-lipoxygenase expressed in Escherichia coli BL21 (DE3) cells using arachidonic acid as substrate preincubated for 10...
More data for this Ligand-Target Pair
Target Info
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus)
TBA
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
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Affinity Data
IC50: 500nM
Assay Description:
Inhibitory activity against 5-lipoxygenase catalysis (5-LO) in sonicated rat basophilic leukemia cell lysate
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50320449
((-)-ZILEUTON | CHEMBL1164975)
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Affinity Data
IC50: 500nM
Assay Description:
Inhibition of human N-terminal His6-tagged 5-lipoxygenase arachidonic acid by UV-vis spectrometry
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 500nM
Assay Description:
Inhibition of 5-LOX
More data for this Ligand-Target Pair
Target Info
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
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Affinity Data
IC50: 500nM
Assay Description:
Inhibition of 5-lipooxygenase in cell free S100 freshly isolated human PMNL cells assessed as inhibition of A23187-stimulated 5-LO product formation ...
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 500nM
Assay Description:
Inhibition of 5-LOX in stimulated leukocytes
More data for this Ligand-Target Pair
Target Info
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus)
TBA
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 500nM
Assay Description:
Inhibitory activity against 5-lipoxygenase obtained from rat basophilic leukemia cells
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 500nM
Assay Description:
Inhibition of 5-lipooxygenase in human polynuclear leukocytes assessed as inhibition of A23187-stimulated 5-LO product formation preincubated for 15 ...
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 518nM
Assay Description:
Inhibitory concentration against human 5-lipoxygenase
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
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Affinity Data
IC50: 521nM
Assay Description:
Inhibition of 5-LO in human PMNL cells assessed as reduction in LTB4, 5-H(P)ETE, 12-HETE and 15-HETE products formation using arachidonic acid as sub...
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
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Affinity Data
IC50: 540nM
Assay Description:
Inhibition of 5-LOX in human neutrophils assessed as reduction in LTB4 and 5-H(P)ETE) formation pre-incubated for 15 mins before A23187 and arachidon...
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
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Affinity Data
IC50: 560nM
Assay Description:
Inhibition of 5-LO (unknown origin)
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
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Affinity Data
IC50: 560nM
Assay Description:
Inhibition of human recombinant 5-LO expressed in Escherichia coli BL21 using arachidonic acid as substrate after 10 mins
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Target
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human))
Gazi University
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 580nM
Assay Description:
Inhibition of FLAP in Ca+2 ionophore A23187 stimulated human neutrophils assessed as 5-LO product formation preincubated for 15 mins measured after 1...
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
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Affinity Data
IC50: 590nM
Assay Description:
Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 incubated for 10 mins in presence of arachidonic acid by RP-HPLC based cell-...
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 590nM
Assay Description:
Inhibition of human 5-LOX using arachidonic acid as substrate measured after 10 mins by ELISA
More data for this Ligand-Target Pair
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 590nM
Assay Description:
Inhibition of human 5-LOX using arachidonic acid as substrate measured after 10 mins by ELISA
More data for this Ligand-Target Pair
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Target
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human))
Goethe-University Frankfurt
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 591nM
Assay Description:
Inhibition of human recombinant soluble epoxide hydrolase expressed in Escherichia coli using 3-phenyl-cyano(6-methoxy-2-naphthalenyl)methylester-2-o...
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
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Affinity Data
IC50: 600nM
Assay Description:
Inhibition of human recombinant 5-LO assessed as product formation by cell-free assay relative to control
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 600nM
Assay Description:
Inhibition of human recombinant 5-lipoxygenase expressed in Escherichia coli BL21 using arachidonic acid as substrate incubated 5 to 10 mins prior to...
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 600nM
Assay Description:
Inhibition of 5-Lipoxygenase (unknown origin)
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus)
TBA
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 600nM
Assay Description:
In vitro inhibition of 5-lipoxygenase (5-lo) from the 20000 g supernatant of RBI-1 cells
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Target
Prostaglandin E synthase
(Homo sapiens (Human))
Goethe-University Frankfurt
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 600nM
Assay Description:
Inhibition of mPGES-1 isolated from microsomes of interleukin-1 beta-stimulated human A549 cells using PGH2 as substrate preincubated for 15 mins fol...
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 600nM
Assay Description:
Inhibition of human recombinant 5-LO expressed in Escherichia coli BL21 using arachidonic acid as substrate preincubated for 5 to 10 mins by HPLC ana...
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
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Affinity Data
IC50: 630nM
Assay Description:
Inhibition of recombinant human 5LOX expressed in baculovirus infected Sf insect cells using linoleic acid as substrate preincubated for 5 mins follo...
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 660nM
Assay Description:
Inhibition of human recombinant 5-LOX assessed as reduction in LTB4 level using 800 uM arachidonic acid as substrate preincubated with enzyme for 10 ...
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 700nM
Assay Description:
Inhibition of 5-LO in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production from arachidonic acid preincubated for 15 mins by ...
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 700nM
Assay Description:
Inhibition of 5-lipoxygenase in human whole blood assessed as inhibition of LTB4 production by HPLC method
More data for this Ligand-Target Pair
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 700nM
Assay Description:
Inhibition of 5-lipoxygenase in human whole blood
More data for this Ligand-Target Pair
Target Info
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 740nM
Assay Description:
Inhibition of 5-lipoxygenase (5-LO) measured as LTB4 production in human whole blood stimulated with calcium ionophore (A23187).
More data for this Ligand-Target Pair
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
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Affinity Data
IC50: 740nM
Assay Description:
5-lipoxygenase Inhibitory activity was measured by enzyme immunoassay using human whole blood stimulated with calcium ionophore (A23187) and LTB4 (le...
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 760nM
Assay Description:
Inhibitory activity against 5-lipoxygenase in Human whole blood (HWBL) stimulated with calcium ionophore (A23187) and LTB4 measured by enzyme immunoa...
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 800nM
Assay Description:
Inhibition of human recombinant 5-LO expressed in Escherichia coli MV1190 using arachidonic acid as substrate preincubated for 10 mins followed by su...
More data for this Ligand-Target Pair
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 800nM
Assay Description:
Inhibition of human recombinant 5-lipoxygenase expressed in Escherichia coli MV1190 pre-incubated for 10 mins before arachidonic acid substrate addit...
More data for this Ligand-Target Pair
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 800nM
Assay Description:
Inhibition of 5-lipoxygenase in human whole blood assessed as inhibition of 5-hydroxyeicosatetraenoic acid production by HPLC method
More data for this Ligand-Target Pair
Target Info
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 800nM
Assay Description:
Inhibition of 5-Lipoxygenase in arachidonic acid-stimulated human neutrophils after 15 mins by HPLC analysis in presence of A23187
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 800nM
Assay Description:
Inhibition of 5-LOX (unknown origin)
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus)
TBA
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 804nM
Assay Description:
Inhibition of 5-lipoxygenase mediated conversion of [14C]-arachidonic acid to leukotrienes in RBL-2H3 cells
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 810nM
Assay Description:
Inhibition of recombinant human 5-LO expressed in Escherichia coli BL21(DE3) assessed as reduction in LTB4 and 5-H(P)ETE formation using arachidonic ...
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus)
TBA
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 830nM
Assay Description:
Inhibition of 5-LOX in rat peritoneal leukocytes
More data for this Ligand-Target Pair
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus)
TBA
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 830nM
Assay Description:
Inhibition of Sprague-Dawley rat 5-LOX assessed as calcium ionophore A23187-stimulated LTB4 production preincubated for 30 mins followed by calcium i...
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 840nM
Assay Description:
Inhibitory concentration against human platelet 5-lipoxygenase in dog whole blood
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Target
Leukotriene A-4 hydrolase
(Homo sapiens (Human))
Searle Research And Development
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 850nM
Assay Description:
Inhibitory activity was determined for LTB4 production in human whole blood.
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 873nM
Assay Description:
In vitro inhibitory activity against 5-lipoxygenase in a human whole blood assay
More data for this Ligand-Target Pair
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 873nM
Assay Description:
Inhibition of 5-lipooxygenase activity in human whole blood assay
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
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Affinity Data
IC50: 873nM
Assay Description:
Inhibitory concentration against 5-lipoxygenase in human whole blood
More data for this Ligand-Target Pair
Target Info
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
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Affinity Data
IC50: 900nM
Assay Description:
Inhibition of 5-lipoxygenase in A23187-stimulated human polymorphonuclear leukocytes using arachidonic acid as substrate incubated 15 mins prior to s...
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Target Info
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 900nM
Assay Description:
Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation pre-incubated for 15 mins followed...
More data for this Ligand-Target Pair
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 910nM
Assay Description:
Inhibition of recombinant human 5-LO expressed in Escherichia coli BL21 assessed as 5-LO product formation preincubated for 15 mins followed by addit...
More data for this Ligand-Target Pair
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 1.00E+3nM
Assay Description:
Inhibition of human recombinant 5-lipoxygenase using arachidonic acid as substrate preincubated for 10 mins before substrate addition measured after ...
More data for this Ligand-Target Pair
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 1.00E+3nM
Assay Description:
Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 assessed as decrease in 5-HPETE production preincubated with enzyme followed...
More data for this Ligand-Target Pair
Target Info
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
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Affinity Data
IC50: 1.05E+3nM
Assay Description:
Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 assessed as conversion of arachidonic acid to 5-HPETE using arachidonic acid...
More data for this Ligand-Target Pair
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50418083
(CHEMBL1743359 | ZILEUTON)
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Affinity Data
IC50: 1.10E+3nM
Assay Description:
Inhibition of recombinant human LOX5 using arachidonic acid as substrate preincubated for 5 mins prior to substrate addition measured for 4 mins by s...
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
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Affinity Data
IC50: 1.10E+3nM
Assay Description:
Inhibition of human 5-LOX using arachidonic acid as substrate measured as H2DCFDA conversion to 2',7'-dichlorofluorescein preincubated for 10 mins by...
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
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Affinity Data
IC50: 1.10E+3nM
Assay Description:
Inhibition of human 5-LOX using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition by H2DCFDA staining-based fluor...
More data for this Ligand-Target Pair
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
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Affinity Data
IC50: 1.10E+3nM
Assay Description:
Inhibition of 5-LO (unknown origin) by cell based assay
More data for this Ligand-Target Pair
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
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Affinity Data
IC50: 1.10E+3nM
Assay Description:
Inhibition of 5-LO in human PMNL using arachidonic acid as substrate preincubated for 15 mins
More data for this Ligand-Target Pair
Target Info
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
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Affinity Data
IC50: 1.11E+3nM
Assay Description:
Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL2-DE3 incubated 10 mins before substrate addition by fluorescence spectrophotom...
More data for this Ligand-Target Pair
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus)
TBA
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 1.25E+3nM
Assay Description:
In vitro inhibition of 5-lipoxygenase in RBL-2H3 (Rat basophilic leukaemia) cells.
More data for this Ligand-Target Pair
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Copy BDB DOI
Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
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Affinity Data
IC50: 1.30E+3nM
Assay Description:
Inhibition of human 5-LOX expressed in Escherichia coli Bl21 (DE3) assessed as reduction in LTB4 and 5-H(P)ETE) formation pre-incubated for 10 mins b...
More data for this Ligand-Target Pair
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus)
TBA
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
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Affinity Data
IC50: 1.35E+3nM
Assay Description:
Inhibition of 5-LOX in Sprague Dawley rat Leukocytes assessed as reduction in calcium ionophore A23187-induced LTB4 production preincubated for 30 mi...
More data for this Ligand-Target Pair
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
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Affinity Data
IC50: 1.40E+3nM
Assay Description:
Inhibition of recombinant human 5-LOX expressed in Escherichia coli using arachidonic acid as substrate by UV-vis spectrophotometric method
More data for this Ligand-Target Pair
Target Info
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.40E+3nM
Assay Description:
Inhibition of recombinant human 5-LOX expressed in Escherichia coli using arachidonic acid as substrate by UV-vis spectrophotometric method
More data for this Ligand-Target Pair
Target Info
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.50E+3nM
Assay Description:
Inhibition of recombinant human 5-LOX expressed in Escherichia coli BL21 using arachidonic acid as substrate by UV-vis spectrophotometric method
More data for this Ligand-Target Pair
Target Info
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.70E+3nM
Assay Description:
Inhibition of 5-LO in human neutrophils assessed as product formation by cell-intact assay relative to control in presence of 2.5 uM A23187 ionophore
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 1.70E+3nM
Assay Description:
Inhibition of 5-LO in human peripheral blood neutrophils using arachidonic acid as substrate preincubated for 15 mins followed by substrate addition ...
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 1.80E+3nM
Assay Description:
In vitro 5-lipoxygenase inhibitory activity against A-23,187-stimulated conversion of [14C]-AA to 5-HETE in guinea pig peritoneal polymorphonuclear l...
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 1.80E+3nM
Assay Description:
Inhibitory concentration against human platelet 5-lipoxygenase in dog whole blood
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 1.80E+3nM
Assay Description:
In vitro 5-lipoxygenase inhibition in guinea pig PMNs was determined based on 5-hydroxyeicosapentaenoic acid (5-HETE) production
More data for this Ligand-Target Pair
Target Info
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 2.00E+3nM
Assay Description:
Inhibitory activity against partially-purified Guinea pig PMN 5-lipoxygenase
More data for this Ligand-Target Pair
Target Info
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
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Affinity Data
IC50: 2.20E+3nM
Assay Description:
In vitro 5-lipoxygenase inhibition in guinea pig PMNs was determined based on LTB4 production
More data for this Ligand-Target Pair
Target Info
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
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Affinity Data
IC50: 2.20E+3nM
Assay Description:
Inhibitory concentration against human platelet 5-lipoxygenase in human whole blood
More data for this Ligand-Target Pair
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Target
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human))
Gazi University
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 2.20E+3nM
Assay Description:
Inhibition of FLAP in human whole blood assessed as inhibition of calcium ionophore A23187-induced LTB4 production preincubated for 15 mins by ELISA
More data for this Ligand-Target Pair
Target Info
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
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Affinity Data
IC50: 2.20E+3nM
Assay Description:
In vitro 5-lipoxygenase inhibitory activity against A-23,187-stimulated conversion of [14C]-AA to LTB4 in guinea pig peritoneal polymorphonuclear leu...
More data for this Ligand-Target Pair
Target Info
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
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Affinity Data
IC50: 2.31E+3nM
Assay Description:
Inhibition of 5-LO in human PMNL cells assessed as reduction in leukotriene formation preincubated for 5 mins followed by thapsigargin stimulation me...
More data for this Ligand-Target Pair
Target Info
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.31E+3nM
Assay Description:
Inhibition of 5-LO in human PMNL cells assessed as reduction in leukotriene formation preincubated for 5 mins followed by thapsigargin stimulation me...
More data for this Ligand-Target Pair
Target Info
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
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Affinity Data
IC50: 2.31E+3nM
Assay Description:
Inhibition of 5-LO in thapsigargin stimulated human PMNL cells assessed as reduction in 5-LO product level preincubated for 5 mins followed by thapsi...
More data for this Ligand-Target Pair
Target Info
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
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Affinity Data
IC50: 2.50E+3nM
Assay Description:
Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation in presence of arachidonic acid pr...
More data for this Ligand-Target Pair
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
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Affinity Data
IC50: 2.60E+3nM
Assay Description:
In vitro inhibition of leukotriene B4 synthesis in human whole blood by inhibiting 5-lipoxygenase
More data for this Ligand-Target Pair
Target Info
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
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Affinity Data
IC50: 2.90E+3nM
Assay Description:
The compound was evaluated for its inhibitory activity against 5-lipoxygenase using granulocytes-type cells
More data for this Ligand-Target Pair
Target Info
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
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Affinity Data
IC50: 3.00E+3nM
Assay Description:
Inhibition of 5-LO in human neutrophils assessed as product formation by cell-intact assay relative to control in presence of 20 uM A23187/AA ionopho...
More data for this Ligand-Target Pair
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus)
TBA
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 3.20E+3nM
Assay Description:
Inhibitory activity against rat 5-lipoxygenase by using continuous oxygen consumption assay.
More data for this Ligand-Target Pair
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus)
TBA
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
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Affinity Data
IC50: 3.20E+3nM
Assay Description:
Inhibitory concentration against 5-lipoxygenase in rat RBL-1 cells
More data for this Ligand-Target Pair
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
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Affinity Data
IC50: 3.30E+3nM
Assay Description:
Inhibition of human 5-LOX in A23187-induced human whole blood assessed as reduction in LTB4 production pre-incubated for 20 mins before A23187 additi...
More data for this Ligand-Target Pair
Target Info
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
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Affinity Data
IC50: 3.30E+3nM
Assay Description:
The compound was tested in vitro for inhibition against 5-lipoxygenase in intact human neutrophils
More data for this Ligand-Target Pair
Target Info
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
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Affinity Data
IC50: 3.50E+3nM
Assay Description:
Tested for activity against 5-lipoxygenase
More data for this Ligand-Target Pair
Target Info
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3.70E+3nM
Assay Description:
Inhibition of 5-LOX in human whole blood assessed as inhibition of A23187-induced LTB4 production preincubated for 15 mins followed by A23187 inducti...
More data for this Ligand-Target Pair
Target Info
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3.70E+3nM
Assay Description:
Inhibition of oxidation of arachidonic acid by human 5-Lipoxygenase using spectrophotometric assay
More data for this Ligand-Target Pair
Target Info
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
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Affinity Data
IC50: 3.70E+3nM
Assay Description:
Potency to inhibit oxidation of arachidonic acid by recombinant human 5-lipoxygenase
More data for this Ligand-Target Pair
Target Info
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
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Affinity Data
IC50: 3.70E+3nM
Assay Description:
In vitro potency against human 5-Lipoxygenase
More data for this Ligand-Target Pair
Target Info
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
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Affinity Data
IC50: 3.70E+3nM
Assay Description:
Inhibition of 5LOX (unknown origin) using arachidonic acid as substrate after 5 mins by spectrophotometric analysis
More data for this Ligand-Target Pair
Target Info
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Target
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human))
Gazi University
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
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Affinity Data
IC50: 4.20E+3nM
Assay Description:
Inhibition of FLAP in human whole blood assessed as inhibition of calcium ionophore A23187-induced LTB4 production preincubated for 5 hrs by ELISA
More data for this Ligand-Target Pair
Target Info
PDB
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antibodypedia
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
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Affinity Data
IC50: 5.00E+3nM
Assay Description:
Inhibition of 5-LOX-mediated LTB4 production in stimulated human neutrophile granulocytes after 10 mins by EIA
More data for this Ligand-Target Pair
Target Info
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Copy SMILES
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Affinity Data
IC50: 5.00E+3nM
Assay Description:
Inhibition of 5LOX-mediated LTB4 formation in stimulated human polymorphonuclear leukocytes
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Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 5.12E+3nM
Assay Description:
In vitro inhibitory activity against 5-lipoxygenase by reduction of 5-hydroxyeicosatetraenoic acid (5-HETE) formed in guinea pig polymorphonuclear le...
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 5.30E+3nM
Assay Description:
The enzyme activity of 5-LOX was determined fluorescence spectrophotometrically by oxidation of the substrate H2DCFDA to the highly fluorescent 2'...
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 5.30E+3nM
Assay Description:
Inhibition of 5-LOX (unknown origin)
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 6.30E+3nM
Assay Description:
Inhibition of 5-lipoxygenase in human neutrophils assessed as inhibition of LTB4 production
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Target
Prostaglandin G/H synthase 1
(Homo sapiens (Human))
Laboratoires Innothera
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
The compound was evaluated for its inhibitory activity against Prostaglandin G/H synthase 1 using monocytes-like cells
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Prostaglandin G/H synthase 2
(Homo sapiens (Human))
Laboratoires Innothera
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
The compound was evaluated for its inhibitory activity against Prostaglandin G/H synthase 2 using osteosarcomes cells
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Polyunsaturated fatty acid lipoxygenase ALOX15
(Homo sapiens (Human))
Universidad De Chile
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 1.56E+4nM
Assay Description:
Inhibition of 15-LOX (unknown origin)
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Tumor necrosis factor ligand superfamily member 11
(Mus musculus)
Sookmyung Women'S University
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: >2.00E+4nM
Assay Description:
Antiosteoclast activity in mouse BMM cells assessed as reduction of RANKL-induced osteoclasts differentiation by measuring TRAP positive multinucleat...
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Thromboxane-A synthase
(Rattus norvegicus)
Ciba-Geigy
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: >2.00E+4nM
Assay Description:
Inhibitory concentration against human platelet thromboxane synthetase
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Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 2.39E+4nM
Assay Description:
Inhibition of human recombinant 5-LOX expressed in insect cells assessed as decrease in production of 5-HPETE and 5-HETE using arachidonic acid as su...
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 2.39E+4nM
Assay Description:
Inhibition of human recombinant 5-LOX expressed in insect cells assessed as decrease in production of 5-HPETE and 5-HETE using arachidonic acid as su...
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Polyunsaturated fatty acid lipoxygenase ALOX12
(Homo sapiens (Human))
Ciba-Geigy
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 5.50E+4nM
Assay Description:
Inhibitory concentration against human platelet 12-lipoxygenase
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 1.00E+5nM
Assay Description:
Inhibition of human cytomegalovirus DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes at 26 d...
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Target
Seed linoleate 13S-lipoxygenase-1
(Glycine max (soybean))
Lomonosov Moscow State University
Curated by
ChEMBL
Ligand
BDBM50418083
(CHEMBL1743359 | ZILEUTON)
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IC50: >1.00E+5nM
Assay Description:
Inhibition of soybean LOX1 assessed as reduction in linoleic acid oxidation measured every 10 s for 10 mins by spectrophotometry analysis
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Leukotriene A-4 hydrolase
(Homo sapiens (Human))
Searle Research And Development
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibitory activity was determined against Leukotriene A4 hydrolase
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Prostaglandin G/H synthase 1/2
(Ovis aries (Sheep))
Ciba-Geigy
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
In vitro inhibitory activity against 5-lipoxygenase by reduction of LTB4 formed in guinea pig polymorphonuclear leukocytes (PMNs).
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 1.00E+5nM
Assay Description:
Inhibition of herpes simplex virus type 1 DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes a...
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Leukotriene B4 receptor 2
(Homo sapiens (Human))
Zentiva Vufb
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Displacement of [3H]LTB4 from LTB4 receptor in guinea pig spleen membrane
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Target
Bile salt export pump
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...
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ATP-binding cassette sub-family C member 2
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...
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ATP-binding cassette sub-family C member 4
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...
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ATP-binding cassette sub-family C member 3
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...
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Prostaglandin G/H synthase 1
(Ovis aries (Sheep))
Universidad De Santiago
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: >1.50E+5nM
pH: 8.0
Assay Description:
Approximately 2 µg of either COX-1 or COX-2 was added to buffer containing 100 µM AA, 0.1 M Tris-HCl buffer (pH 8.0), 5 mM EDTA, 2 mM phenol, and 1 µ...
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Bile salt export pump
(Rattus norvegicus)
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: 5.64E+5nM
Assay Description:
Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate up...
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Prostaglandin G/H synthase 1/2
(Bos taurus)
TBA
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: >7.50E+5nM
Assay Description:
Compound was evaluated for inhibition against cyclooxygenase of bovine seminal vesicles
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Target
Bile salt export pump
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: >7.51E+5nM
Assay Description:
Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...
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Phospholipase A2, membrane associated
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: >1.00E+6nM
Assay Description:
Compound was evaluated for inhibition against Phospholipase A2 of Croatalus adamanteus
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Target
Bile salt export pump
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
IC50: >1.00E+6nM
Assay Description:
Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50000541
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
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Affinity Data
EC50: 470nM
Assay Description:
In vitro inhibition of ionophore stimulated LTB4 release from human peripheral blood leukocytes.
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