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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
132
hits in this display
Target
Aldo-keto reductase family 1 member B10
(Homo sapiens (Human))
Gifu Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
Ki: 72nM
Assay Description:
Competitive inhibition of dehydrogenase activity of N-terminal 6His-tagged human AKR1B10 expressed in Escherichia coli BL21(DE3) assessed as NADP+-li...
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Target
Tyrosine-protein phosphatase non-receptor type 1 [1-405]
(Homo sapiens (Human))
Cold Spring Harbor Laboratory
US Patent
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
Ki: 2.00E+3nM
Assay Description:
Glucose in tail blood was measured using a glucometer (One-Touch Basic; Lifescan, CA). For glucose tolerance tests (GTTs), mice were fasted for 10 ho...
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Target
Tyrosine-protein phosphatase non-receptor type 1 [1-321]
(Homo sapiens (Human))
Cold Spring Harbor Laboratory
US Patent
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
Ki: 4.00E+3nM
Assay Description:
Glucose in tail blood was measured using a glucometer (One-Touch Basic; Lifescan, CA). For glucose tolerance tests (GTTs), mice were fasted for 10 ho...
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Target
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
Ki: 6.00E+3nM
Assay Description:
Mixed-type inhibition of purified human GST-tagged PTP-1B using p-nitrophenylphosphate as substrate by double-reciprocal plot method
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Target
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
Ki: 6.00E+3nM
Assay Description:
Mixed type inhibition of human recombinant PTP-1B expressed in Escherichia coli TB1 using p-nitrophenyl phosphate as substrate
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Target
Tissue factor
(Homo sapiens (Human))
China Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: 5nM
Assay Description:
Inhibition of LPS-induced tissue factor procoagulant activity in human THP1 cells preincubated for 1 hr followed by LPS addition measured after 5 hrs...
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Target
Aldo-keto reductase family 1 member B10
(Homo sapiens (Human))
Gifu Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: 90nM
Assay Description:
Inhibition of reductase activity of N-terminal 6His-tagged human AKR1B10 expressed in Escherichia coli BL21(DE3) assessed as pyridine-3-aldehyde redu...
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Target
Liver carboxylesterase 1
(Homo sapiens (Human))
Chinese Academy Of Medical Sciences And Peking Union Medical College
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: 100nM
Assay Description:
Inhibition of CES1A1 in human liver microsomes using D-luciferin methyl ester as substrate preincubated for 10 mins followed by substrate addition an...
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Target
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: 500nM
Assay Description:
Inhibition of human recombinant PTP1B using pNPP as substrate assessed as reduction in p-nitrophenol release incubated for 30 mins by absorbance base...
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Target Info
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Target
Tyrosine-protein phosphatase non-receptor type 2
(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: 700nM
Assay Description:
Inhibition of human recombinant TCPTP using pNPP as substrate assessed as reduction in p-nitrophenol release incubated for 30 mins by absorbance base...
More data for this Ligand-Target Pair
Target Info
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Target
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
Copy SMILES
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Affinity Data
IC50: 700nM
Assay Description:
Inhibition of PTP1B (unknown origin)
More data for this Ligand-Target Pair
Target Info
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Target
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 700nM
Assay Description:
Inhibition of PTP1B (unknown origin) pre-incubated for 10 mins before addition of p-nitrophenyl phosphate substrate and measured 30 mins post substra...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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Target
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
Copy SMILES
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Affinity Data
IC50: 730nM
Assay Description:
Inhibition of recombinant human PTP1B using pNPP as substrate incubated for 10 mins prior to substrate addition measured after 30 mins by microplate ...
More data for this Ligand-Target Pair
Target Info
PDB
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Target
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 990nM
Assay Description:
Inhibition of PTP1B (unknown origin) by DAS-ELISA
More data for this Ligand-Target Pair
Target Info
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Target
Receptor-type tyrosine-protein phosphatase C
(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: 1.00E+3nM
Assay Description:
Inhibition of human CD45 cytoplasmic domain (584 to 1281 residues) expressed in yeast using pNPP as substrate preincubated for 10 mins followed by su...
More data for this Ligand-Target Pair
Target Info
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Target
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.00E+3nM
Assay Description:
Inhibition of human recombinant PTP1B using pNPP as substrate assessed as rate of hydrolysis incubated for 10 mins prior to substrate addition measur...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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Target
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.03E+3nM
Assay Description:
Inhibition of PTP1B (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
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Target
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.10E+3nM
Assay Description:
Inhibition of PTP1B (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
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Target
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.10E+3nM
Assay Description:
Inhibition of recombinant human PTP1B (1 to 322 residues) expressed in Escherichia coli using pNPP as substrate preincubated for 10 mins followed by ...
More data for this Ligand-Target Pair
Target Info
PDB
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Target
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.54E+3nM
Assay Description:
Inhibition of recombinant PTP1B (unknown origin) assessed as hydrolysis of pNPP to pNP after 30 mins
More data for this Ligand-Target Pair
Target Info
PDB
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Target
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.54E+3nM
Assay Description:
Inhibition of recombinant PTP1B (unknown origin) using pNPP as substrate incubated for 30 mins
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
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Target
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.54E+3nM
Assay Description:
Inhibition of recombinant PTP1B (unknown origin) assessed as pNPP hydrolysis after 30 mins
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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Target
Tyrosine-protein phosphatase non-receptor type 2
(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: 1.60E+3nM
Assay Description:
Inhibition of full length recombinant N-terminal GST-tagged human TCPTP expressed in Escherichia coli using pNPP as substrate preincubated for 10 min...
More data for this Ligand-Target Pair
Target Info
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Target
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
Copy SMILES
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Affinity Data
IC50: 1.62E+3nM
Assay Description:
Inhibition of PTP1B (unknown origin) using pNPP as substrate
More data for this Ligand-Target Pair
Target Info
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Target
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: 1.86E+3nM
Assay Description:
Inhibition of PTP1B (unknown origin)
More data for this Ligand-Target Pair
Target Info
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Target
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: 1.90E+3nM
Assay Description:
IC50 values were determined by pNPP assay.
More data for this Ligand-Target Pair
Target Info
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Target
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: 1.95E+3nM
pH: 6.5
Assay Description:
Briefly, the tested compounds were solubilized in DMSO and serially diluted into concentrations for the inhibitory test. The assays were carried out ...
More data for this Ligand-Target Pair
Target Info
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Target
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.00E+3nM
Assay Description:
Inhibition of PTP1B (unknown origin) using p-nitrophenyl phosphate as substrate measured after 30 mins
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
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Target
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
Copy SMILES
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Affinity Data
IC50: 2.01E+3nM
Assay Description:
Inhibition of GST-tagged PTP1B (unknown origin) using pNPP as substrate measured for 2 mins by colorimetric analysis
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
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Target
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.06E+3nM
Assay Description:
Inhibition of recombinant human PTP1B using pNNP as substrate after 30 mins
More data for this Ligand-Target Pair
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Target
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: 2.30E+3nM
Assay Description:
Inhibition of PTP1B (unknown origin) using pNPP as substrate after 3 mins by colorimetric analysis
More data for this Ligand-Target Pair
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Target
Transcription factor p65
(Homo sapiens (Human))
The Ohio State University
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: 2.40E+3nM
Assay Description:
Inhibition of biotinylated consensus sequence binding to NF-kB p65 in human HeLa nuclear extracts after 3 hrs by ELISA
More data for this Ligand-Target Pair
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Target
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
Copy SMILES
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Affinity Data
IC50: 2.50E+3nM
Assay Description:
Inhibition of recombinant human PTP1B catalytic domain (91 to 1053 residues) expressed in Escherichia coli BL21-codon plus (DE3) using pNPP as substr...
More data for this Ligand-Target Pair
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Target
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
Copy SMILES
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Affinity Data
IC50: 2.50E+3nM
Assay Description:
Inhibition of recombinant PTP1B catalytic domain (unknown origin) assessed as reduction in pNP formation using pNPP as substrate by absorbance based ...
More data for this Ligand-Target Pair
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Target
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
Copy SMILES
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Affinity Data
IC50: 2.56E+3nM
Assay Description:
Inhibition of PTP1B (unknown origin) using pNPP substrate measured after 3 mins by colorimetric assay
More data for this Ligand-Target Pair
Target Info
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Target
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
Copy SMILES
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Affinity Data
IC50: 2.60E+3nM
Assay Description:
Inhibition of GST-tagged PTP1B (unknown origin) using pNPP as substrate measured for 3 mins by colorimetric assay
More data for this Ligand-Target Pair
Target Info
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Target
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
Copy SMILES
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Affinity Data
IC50: 2.60E+3nM
Assay Description:
Inhibition of GST-tagged PTP1B (unknown origin) using pNPP as substrate measured for 3 mins by colorimetric assay
More data for this Ligand-Target Pair
Target Info
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Target
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
Copy SMILES
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Affinity Data
IC50: 2.60E+3nM
Assay Description:
Inhibition of human PTP1B
More data for this Ligand-Target Pair
Target Info
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Target
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: 2.69E+3nM
Assay Description:
Inhibition of human recombinant GST-tagged PTP1B expressed in Escherichia coli BL21 (DE3) using pNPP as substrate measured for 2 mins by colorimetric...
More data for this Ligand-Target Pair
Target Info
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Target
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
Copy SMILES
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Affinity Data
IC50: 2.95E+3nM
Assay Description:
Inhibition of PTP1B (unknown origin) by SpectraMax 340 microplate reader Analysis
More data for this Ligand-Target Pair
Target Info
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Target
Tyrosine-protein phosphatase non-receptor type 2
(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: 2.95E+3nM
Assay Description:
Inhibition of TCPTP (unknown origin) by SpectraMax 340 microplate reader Analysis
More data for this Ligand-Target Pair
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Target
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: 2.96E+3nM
Assay Description:
Inhibition of PTP1B (unknown origin) assessed as reduction in nitrophenol production using pNPP as substrate incubated for 30 mins by EnVisionMultila...
More data for this Ligand-Target Pair
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Target
Phospholipase A2
(Homo sapiens (Human))
Gifu Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: 3.00E+3nM
Assay Description:
Inhibition of phospholipase A2
More data for this Ligand-Target Pair
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Target
DNA polymerase beta
(Homo sapiens (Human))
Gifu Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: 3.00E+3nM
Assay Description:
Inhibition of DNA polymerase beta
More data for this Ligand-Target Pair
Target Info
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Target
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: 3.02E+3nM
Assay Description:
Inhibition of recombinant human PTP1B catalytic domain assessed as hydrolysis of pNPP after 2 mins
More data for this Ligand-Target Pair
Target Info
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Target
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
Copy SMILES
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Affinity Data
IC50: 3.02E+3nM
Assay Description:
Inhibition of PTP1B (unknown origin)
More data for this Ligand-Target Pair
Target Info
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Target
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
Copy SMILES
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Affinity Data
IC50: 3.02E+3nM
Assay Description:
Inhibition of PTP1B (unknown origin)
More data for this Ligand-Target Pair
Target Info
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Target
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
Copy SMILES
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Affinity Data
IC50: 3.30E+3nM
Assay Description:
Inhibition of human PTP1B
More data for this Ligand-Target Pair
Target Info
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Target
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: 3.32E+3nM
Assay Description:
Compound is evaluated for the inhibition of porcine plasma Angiotensin I converting enzyme
More data for this Ligand-Target Pair
Target Info
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Target
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
Copy SMILES
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Affinity Data
IC50: 3.48E+3nM
Assay Description:
Inhibition of recombinant human PTP1B catalytic domain expressed in Escherichia coli BL21-CodonPlus (DE3) using pNPP as substrate measured for 2 mins
More data for this Ligand-Target Pair
Target Info
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Target
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: 3.84E+3nM
Assay Description:
Inhibition of GST-tagged human recombinant PTP1B assessed as dephosphorylation of para-nitrophenyl phosphate after 10 mins by spectrophotometric anal...
More data for this Ligand-Target Pair
Target Info
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Target
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: 3.90E+3nM
Assay Description:
Inhibition of human recombinant PTP1B
More data for this Ligand-Target Pair
Target Info
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Target
Protease
(Human immunodeficiency virus 1 (HIV-1))
Osaka University Of Pharmaceutical Sciences
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: 4.00E+3nM
Assay Description:
Inhibition of HIV1 protease activity
More data for this Ligand-Target Pair
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Target
Aldo-keto reductase family 1 member B10
(Homo sapiens (Human))
Gifu Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: 4.00E+3nM
Assay Description:
Inhibition of N-terminal 6His-tagged human AKR1B10 overexpressed in human HeLa cells assessed as inhibition of [1-14C]farnesol reduction pretreated f...
More data for this Ligand-Target Pair
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Target
Tyrosine-protein phosphatase non-receptor type 2
(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: 4.23E+3nM
Assay Description:
IC50 values were determined by pNPP assay.
More data for this Ligand-Target Pair
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Target
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: 4.30E+3nM
Assay Description:
Inhibition of N-terminal GST tagged recombinant human PTP1B catalytic domain (1 to 321 residues) expressed in Escherichia coli using pNPP as substrat...
More data for this Ligand-Target Pair
Target Info
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Target
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
Copy SMILES
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Affinity Data
IC50: 4.30E+3nM
Assay Description:
Inhibition of N-terminal GST tagged recombinant human PTP1B catalytic domain (1 to 321 residues) expressed in Escherichia coli using pNPP as substrat...
More data for this Ligand-Target Pair
Target Info
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Target
Tyrosine-protein phosphatase non-receptor type 2
(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
Copy SMILES
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Affinity Data
IC50: 4.89E+3nM
Assay Description:
Inhibition of TCPTP (unknown origin) using pNPP as substrate
More data for this Ligand-Target Pair
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Target
Tyrosine-protein phosphatase non-receptor type 2
(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: 5.00E+3nM
Assay Description:
Inhibition of GST-tagged TCPTP (unknown origin) using pNPP as substrate measured for 3 mins by colorimetric assay
More data for this Ligand-Target Pair
Target Info
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Target
Tyrosine-protein phosphatase non-receptor type 2
(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: 5.00E+3nM
Assay Description:
Inhibition of GST-tagged TCPTP (unknown origin) using pNPP as substrate measured for 3 mins by colorimetric assay
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Target
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: 5.05E+3nM
Assay Description:
Inhibition of PTP1B (unknown origin)
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Target
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: 5.05E+3nM
Assay Description:
Inhibition of PTP1B (unknown origin)
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Target
Dual specificity protein phosphatase 3
(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: 5.40E+3nM
Assay Description:
Inhibition of human VHR expressed in Escherichia coli using pNPP as substrate preincubated for 10 mins followed by substrate addition measured after ...
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Target
Tyrosine-protein phosphatase non-receptor type 2
(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: 5.46E+3nM
Assay Description:
Inhibition of human TCPTP using pNNP as substrate after 30 mins
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Target
Tyrosine-protein phosphatase non-receptor type 2
(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: 5.46E+3nM
Assay Description:
Inhibition of human TCPTP using pNPP as substrate incubated for 30 mins
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Target
Tyrosine-protein phosphatase non-receptor type 2
(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: 5.46E+3nM
Assay Description:
Inhibition of TCPTP (unknown origin) assessed as pNPP hydrolysis after 30 mins
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Target
Tyrosine-protein phosphatase non-receptor type 2
(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: 5.46E+3nM
Assay Description:
Inhibition of TCPTP (unknown origin) assessed as hydrolysis of pNPP to pNP after 30 mins
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Target
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: 5.60E+3nM
Assay Description:
Inhibition of GST-tagged human recombinant PTP1B using para-nitrophenyl phosphate as substrate by spectrophotometric analysis
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Target
Tyrosine-protein phosphatase non-receptor type 2
(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: 6.42E+3nM
Assay Description:
Inhibition of human recombinant GST-tagged TCPTP (catalytic domain 41 to 1075 residues) expressed in Escherichia coli BL21 (DE3) using pNPP as substr...
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Target
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: 7.60E+3nM
Assay Description:
Inhibition of human recombinant PTP1B after 30 mins
More data for this Ligand-Target Pair
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Target
Tyrosine-protein phosphatase non-receptor type 2
(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: 7.86E+3nM
Assay Description:
Inhibition of GST-tagged human TCPCP expressed in Escherichia coli using pNPP as substrate
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Target
Protease
(Human immunodeficiency virus 1 (HIV-1))
Osaka University Of Pharmaceutical Sciences
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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IC50: 8.00E+3nM
Assay Description:
Inhibition of HIV1 protease activity
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Target
DNA polymerase beta
(Homo sapiens (Human))
Gifu Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: 8.80E+3nM
Assay Description:
Inhibition of DNA polymerase beta lyase activity by deoxyribose phosphate excision assay
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Target
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: 9.50E+3nM
Assay Description:
Inhibition of purified human GST-tagged PTP-1B using p-nitrophenylphosphate as substrate by spectrophotometry
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Target
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: 9.50E+3nM
Assay Description:
Inhibition of human recombinant PTP-1B expressed in Escherichia coli TB1 using p-nitrophenyl phosphate as substrate after 1 hr
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Target
Tyrosine-protein phosphatase non-receptor type 2
(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: 1.06E+4nM
Assay Description:
Inhibition of TCPTP (unknown origin) assessed as reduction in nitrophenol production using pNPP as substrate incubated for 30 mins by EnVisionMultila...
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Target
Tyrosine-protein phosphatase non-receptor type 11
(Homo sapiens (Human))
Qilu University Of Technology
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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IC50: 1.16E+4nM
Assay Description:
Inhibition of human SHP2 using pNPP as substrate incubated for 30 mins
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Target
Receptor-type tyrosine-protein phosphatase F
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: 1.18E+4nM
Assay Description:
Inhibition of human recombinant LAR expressed in Escherichia coli TB1 using p-nitrophenyl phosphate as substrate after 1 hr
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Target
Tyrosine-protein phosphatase non-receptor type 2
(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: 1.20E+4nM
Assay Description:
Inhibition of TCPTP (unknown origin)
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Target
Ubiquitin carboxyl-terminal hydrolase 7
(Homo sapiens (Human))
TBA
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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IC50: 1.25E+4nM
Assay Description:
Inhibition of human USP7 using human N-terminal GST-tagged UBA52 as substrate preincubated for 10 mins followed by substrate addition measured after ...
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Target
Glycogen phosphorylase, muscle form
(Oryctolagus cuniculus (rabbit))
Chinese Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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IC50: 1.40E+4nM
Assay Description:
Inhibition of rabbit muscle glycogen phosphorylase A assessed as release of phosphate from glucose-1-phosphate after 25 mins by microplate reader bas...
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Target
TYR_PHOSPHATASE_2 domain-containing protein
(Mycobacterium tuberculosis)
Guangdong Institute Of Microbiology
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: 1.40E+4nM
Assay Description:
Inhibition of Mycobacterium tuberculosis H37Rv ptpB expressed in Escherichia coli BL21 (DH3) cells using 6,8-difluoromethylumbelliferyl phosphate as ...
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Target
Glycogen phosphorylase, muscle form
(Oryctolagus cuniculus (rabbit))
Chinese Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: 1.40E+4nM
pH: 7.2 T: 2°C
Assay Description:
Rabbit muscle glycogen phosphorylase a (RMGPa) activity was measured by the release of phosphate from glucose-1-phosphate at 655 nm. Each compound wa...
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Target
Glycogen phosphorylase, muscle form
(Oryctolagus cuniculus (rabbit))
Chinese Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: 1.40E+4nM
Assay Description:
Inhibition of rabbit muscle GPa
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Target
Tyrosine-protein phosphatase non-receptor type 6
(Homo sapiens (Human))
Qilu University Of Technology
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: 1.42E+4nM
Assay Description:
Inhibition of human SHP1 using pNPP as substrate incubated for 30 mins
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Target
Epidermal growth factor receptor
(Homo sapiens (Human))
Soochow University
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: >2.00E+4nM
Assay Description:
Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR (668 to 1210 residues) expressed in a Baculovirus infected Sf9 cell...
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Target
Epidermal growth factor receptor
(Homo sapiens (Human))
Soochow University
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: >2.00E+4nM
Assay Description:
Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR L858R/T790M double mutant (668 to 1210 residues) expressed in a Bac...
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Target
Epidermal growth factor receptor
(Homo sapiens (Human))
Soochow University
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: >2.00E+4nM
Assay Description:
Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR L858R/T790M/C797S mutant (668 to 1210 residues) expressed in a Bacu...
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Target
Epidermal growth factor receptor
(Homo sapiens (Human))
Soochow University
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: >2.00E+4nM
Assay Description:
Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR L858R/T790M/C797S mutant (668 to 1210 residues) expressed in a Bacu...
More data for this Ligand-Target Pair
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Target
Epidermal growth factor receptor
(Homo sapiens (Human))
Soochow University
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: >2.00E+4nM
Assay Description:
Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR L858R/T790M double mutant (668 to 1210 residues) expressed in a Bac...
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Epidermal growth factor receptor
(Homo sapiens (Human))
Soochow University
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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IC50: >2.00E+4nM
Assay Description:
Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR (668 to 1210 residues) expressed in a Baculovirus infected Sf9 cell...
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Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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IC50: 2.12E+4nM
Assay Description:
Inhibition of human LMW-PTP IF1 using p-nitrophenylphosphate as substrate by spectrophotometry
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Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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IC50: 2.12E+4nM
Assay Description:
Inhibition of human recombinant LMW-PTP1 expressed in Escherichia coli TB1 using p-nitrophenyl phosphate as substrate after 1 hr
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Protease
(Human immunodeficiency virus 1 (HIV-1))
Osaka University Of Pharmaceutical Sciences
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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IC50: 2.18E+4nM
Assay Description:
Inhibition of HIV1 protease
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TYR_PHOSPHATASE_2 domain-containing protein
(Mycobacterium tuberculosis)
Guangdong Institute Of Microbiology
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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IC50: 2.20E+4nM
Assay Description:
Inhibition of Mycobacterium tuberculosis H37Ra PTPB expressed in Escherichia coli BL21 (DE3) using p-nitrophenyl phosphate as substrate preincubated ...
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TYR_PHOSPHATASE_2 domain-containing protein
(Mycobacterium tuberculosis)
Guangdong Institute Of Microbiology
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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IC50: 2.21E+4nM
Assay Description:
Inhibition of Mycobacterium tuberculosis H37Ra PTPB expressed in Escherichia coli BL21 (DE3) using p-nitrophenyl phosphate as substrate preincubated ...
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Receptor-type tyrosine-protein phosphatase F
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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IC50: 2.23E+4nM
Assay Description:
Inhibition of human LAR using pNPP as substrate incubated for 30 mins
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Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
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BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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IC50: 2.29E+4nM
Assay Description:
Inhibition of human recombinant LMW-PTP2 expressed in Escherichia coli TB1 using p-nitrophenyl phosphate as substrate after 1 hr
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Glycogen phosphorylase, muscle form
(Oryctolagus cuniculus (rabbit))
Chinese Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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IC50: 2.29E+4nM
Assay Description:
Inhibition of rabbit muscle glycogen phosphorylase a assessed as release of phosphate from glucose-1-phosphate after 25 mins using malachite green st...
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Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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IC50: 2.29E+4nM
Assay Description:
Inhibition of human LMW-PTP IF2 using p-nitrophenylphosphate as substrate by spectrophotometry
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DNA polymerase beta
(Homo sapiens (Human))
Gifu Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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IC50: 2.50E+4nM
Assay Description:
Inhibition of polymerase activity of DNA polymerase beta
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DNA polymerase beta
(Homo sapiens (Human))
Gifu Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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IC50: 2.63E+4nM
Assay Description:
Inhibition of lyase activity of DNA polymerase beta
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Prostaglandin G/H synthase 2
(Homo sapiens (Human))
Osaka University
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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IC50: >4.00E+4nM
Assay Description:
Inhibition of human recombinant COX2 expressed in baculovirus infected sf21 cells assessed as decrease in PGE2 formation using arachidonic acid as su...
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Prostaglandin G/H synthase 2
(Homo sapiens (Human))
Osaka University
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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IC50: >4.00E+4nM
Assay Description:
Inhibition of human recombinant COX2 expressed in baculovirus infected sf21 cells assessed as decrease in PGE2 formation using arachidonic acid as su...
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Nitric oxide synthase, inducible
(Homo sapiens (Human))
Dartmouth College
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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IC50: >4.00E+4nM
Assay Description:
Inhibition of inducible nitric oxide synthase in activated macrophages
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Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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IC50: 4.07E+4nM
Assay Description:
Inhibition of PTP1B (unknown origin) using pNPP as substrate incubated for 30 mins by ELISA
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Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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IC50: 4.07E+4nM
Assay Description:
Inhibition of PTP1B (unknown origin) using pNPP as substrate incubated for 30 mins by ELISA
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Prostaglandin G/H synthase 1
(Ovis aries (Sheep))
Osaka University
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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IC50: 4.20E+4nM
Assay Description:
Inhibition of ovine recombinant COX1 assessed as decrease in formation of PGE2 using arachidonic acid as substrate preincubated for 10 mins followed ...
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Prostaglandin G/H synthase 1
(Ovis aries (Sheep))
Osaka University
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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IC50: 4.20E+4nM
Assay Description:
Inhibition of ovine recombinant COX1 assessed as decrease in formation of PGE2 using arachidonic acid as substrate preincubated for 10 mins followed ...
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Target
Signal transducer and activator of transcription 3
(Homo sapiens (Human))
Universit£
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ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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IC50: >5.00E+4nM
Assay Description:
Inhibition of IFN-gamma stimulated STAT3 (unknown origin) expressed in human HeLa cells after 6 hrs by luciferase reporter gene assay
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Protease
(Human immunodeficiency virus 1 (HIV-1))
Osaka University Of Pharmaceutical Sciences
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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IC50: 5.77E+4nM
Assay Description:
Inhibition of HIV1 recombinant protease expressed in Escherichia coli using Abz-Ala-Arg-Val-Nle-Tyr(NO2)-Glu-Ala-Nle-NH2 as substrate by FRET assay
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Target
Protease
(Human immunodeficiency virus 1 (HIV-1))
Osaka University Of Pharmaceutical Sciences
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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IC50: 5.77E+4nM
Assay Description:
Inhibition of HIV1 protease expressed in Escherichia coli using Abz-Ala-Arg-Val-Nle-Tyr(NO2)-Glu-Ala-Nle-NH2 peptide as substrate by FRET assay
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Target
NAD-dependent protein deacylase sirtuin-5, mitochondrial
(Homo sapiens (Human))
China Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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IC50: 7.00E+4nM
Assay Description:
Inhibition of SIRT5 (unknown origin)
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Acetyl-CoA acetyltransferase, mitochondrial
(Rattus norvegicus)
China Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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IC50: 7.79E+4nM
Assay Description:
Inhibition of rat liver microsomal ACAT
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Target
Pancreatic alpha-amylase
(Sus scrofa (Pig))
Dalian University of Technology
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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IC50: 9.41E+4nM
Assay Description:
Inhibition of porcine pancreatic alpha-amylase using starch as substrate preincubated for 15 mins followed by substrate addition measured after 10 mi...
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Target
Receptor-type tyrosine-protein phosphatase F
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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IC50: >1.20E+5nM
Assay Description:
Inhibition of human LAR as hydrolysis of pNPP after 2 mins
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Target
Tyrosine-protein phosphatase non-receptor type 2
(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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IC50: >1.20E+5nM
Assay Description:
Inhibition of human TCPTP as hydrolysis of pNPP after 2 mins
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Tyrosine-protein phosphatase non-receptor type 11
(Homo sapiens (Human))
Qilu University Of Technology
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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IC50: >1.20E+5nM
Assay Description:
Inhibition of human SHP2 as hydrolysis of pNPP after 2 mins
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Target
Tyrosine-protein phosphatase non-receptor type 6
(Homo sapiens (Human))
Qilu University Of Technology
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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IC50: >1.20E+5nM
Assay Description:
Inhibition of human SHP1 as hydrolysis of pNPP after 2 mins
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Target
Aldo-keto reductase family 1 member B1
(Homo sapiens (Human))
Gifu Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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IC50: 1.24E+5nM
Assay Description:
Inhibition of reductase activity of N-terminal 6His-tagged human recombinant AKR1B1 expressed in Escherichia coli BL21(DE3) assessed as assessed as p...
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Target
Pancreatic triacylglycerol lipase
(Sus scrofa (Pig))
China Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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IC50: 1.81E+5nM
Assay Description:
Inhibition of porcine pancreatic lipase using 2,3-dimercaptopropan-1-ol tributyrate as substrate preincubated for 5 mins followed by substrate additi...
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DNA ligase 1
(Homo sapiens (Human))
University Of Allahabad
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: 1.86E+5nM
Assay Description:
Inhibition of human DNA ligase 1 using 52-mer DNA/25-mer DNA/27-mer DNA as substrate by fluorescence assay
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Prostaglandin G/H synthase 2
(Homo sapiens (Human))
Osaka University
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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IC50: 2.95E+5nM
Assay Description:
Inhibition of COX2-catalyzed prostaglandin biosynthesis after 10 mins of preincubation
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Prostaglandin G/H synthase 2
(Homo sapiens (Human))
Osaka University
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: 2.95E+5nM
Assay Description:
Inhibition of COX2
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Prostaglandin G/H synthase 1
(Homo sapiens (Human))
Uppsala University
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: 3.80E+5nM
Assay Description:
Inhibition of COX1
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Target
Prostaglandin G/H synthase 1
(Homo sapiens (Human))
Uppsala University
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: 3.80E+5nM
Assay Description:
Inhibition of COX1-catalyzed prostaglandin biosynthesis 10 mins of preincubation
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Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
IC50: 2.39E+6nM
Assay Description:
Inhibition of human recombinant GST-tagged PTP1B catalytic domain expressed in Escherichia coli BL21-Conden plus (DE3) using pNPP as substrate
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Hemagglutinin
(Influenza A virus (strain A/Wilson-Smith/1933 H1N1...)
Peking University
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Kd: 1.09E+4nM
Assay Description:
Binding affinity to recombinant influenza A hemagglutinin assessed as dissociation constant by SPR assay
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Egl nine homolog 1/Prolyl hydroxylase EGLN2/Prolyl hydroxylase EGLN3/Transmembrane prolyl 4-hydroxylase
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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EC50: >5.00E+4nM
Assay Description:
Inhibition of PHD (unknown origin) expressed in mouse NIH/3T3 cells harboring HRE-driven luciferase gene assessed as transactivation of HIF1alpha aft...
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Egl nine homolog 1/Prolyl hydroxylase EGLN2/Prolyl hydroxylase EGLN3/Transmembrane prolyl 4-hydroxylase
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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Affinity Data
EC50: >5.00E+4nM
Assay Description:
Inhibition of PHD (unknown origin) expressed in mouse NIH/3T3 cells harboring HRE-driven luciferase gene assessed as transactivation of HIF1alpha aft...
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G-protein coupled bile acid receptor 1
(Homo sapiens (Human))
Universite Louis Pasteur
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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EC50: 2.25E+3nM
Assay Description:
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
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Env polyprotein
(Human immunodeficiency virus 1)
Beijing Institute Of Pharmacology & Toxicology
Curated by
ChEMBL
Ligand
BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
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EC50: >1.00E+5nM
Assay Description:
Inhibition of HIV1 gp41-induced cell-cell fusion between viral envelope expressing human HL2/3 cells to CD4/CCR5 receptor expressing TZM-bl cells aft...
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