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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 19 hits in this display   

TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50016504((S)-3-(2-{[(S)-2-(2-{2-[2-tert-Butoxycarbonylamino...)
Affinity DataKi:  0.150nMAssay Description:Tested for the inhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50016425((S)-3-{(S)-2-[(S)-2-(2-{(S)-2-[(S)-2-tert-Butoxyca...)
Affinity DataKi:  0.191nMAssay Description:Binding affinity measured by inhibiting [3H]Boc[Nle28,31]CCK27-33 specific binding to Cholecystokinin receptor in mouse brain membranes at a KD conce...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholecystokinin receptor type A(Cavia porcellus)
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50016504((S)-3-(2-{[(S)-2-(2-{2-[2-tert-Butoxycarbonylamino...)
Affinity DataKi:  0.230nMAssay Description:The compound was tested for the inhibition of [3H]-Propionyl specific binding to Cholecystokinin 8 receptor of guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50016425((S)-3-{(S)-2-[(S)-2-(2-{(S)-2-[(S)-2-tert-Butoxyca...)
Affinity DataKi:  0.230nMAssay Description:Displacement of 0.2 nM [3H]-pCCK-8 from guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholecystokinin receptor type A(Cavia porcellus)
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50016504((S)-3-(2-{[(S)-2-(2-{2-[2-tert-Butoxycarbonylamino...)
Affinity DataKi:  0.310nMAssay Description:Ability to displace 1 nM [3H]pCCK-8 from Cholecystokinin type A receptor in guinea pig pancreatic membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholecystokinin receptor type A(Cavia porcellus)
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50016425((S)-3-{(S)-2-[(S)-2-(2-{(S)-2-[(S)-2-tert-Butoxyca...)
Affinity DataKi:  0.930nMAssay Description:Displacement of 0.1 nM [3H]-pCCK-8 from guinea pig pancreatic membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholecystokinin receptor type A(Cavia porcellus)
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50016504((S)-3-(2-{[(S)-2-(2-{2-[2-tert-Butoxycarbonylamino...)
Affinity DataKi:  0.930nMAssay Description:The compound was tested for the inhibition of [3H]-Propionyl specific binding to Cholecystokinin 8 receptor of guinea pig pancreatic membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholecystokinin receptor type A(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50016425((S)-3-{(S)-2-[(S)-2-(2-{(S)-2-[(S)-2-tert-Butoxyca...)
Affinity DataKi:  4.30nMAssay Description:Evaluated for binding affinity measured by inhibiting [3H]Boc[Nle28,31]CCK27-33 specific binding to Cholecystokinin receptor in rat pancreas membrane...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholecystokinin receptor type A(Cavia porcellus)
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50016504((S)-3-(2-{[(S)-2-(2-{2-[2-tert-Butoxycarbonylamino...)
Affinity DataKi:  78nMAssay Description:Tested for the inhibition of [3H]-pCCK-8 binding to Cholecystokinin type A receptor in pancreatic membranes of guinea-pigMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGastrin/cholecystokinin type B receptor(RAT)
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50016504((S)-3-(2-{[(S)-2-(2-{2-[2-tert-Butoxycarbonylamino...)
Affinity DataKi:  96nMAssay Description:Ability to displace 1 nM [3H]pCCK-8 from rat Cholecystokinin type B receptor stably expressing in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50016425((S)-3-{(S)-2-[(S)-2-(2-{(S)-2-[(S)-2-tert-Butoxyca...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of [125I]-BH-CCK- binding to cholecystokinin type B receptor from jurkat TcellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50016425((S)-3-{(S)-2-[(S)-2-(2-{(S)-2-[(S)-2-tert-Butoxyca...)
Affinity DataIC50:  0.290nMAssay Description:In vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50016425((S)-3-{(S)-2-[(S)-2-(2-{(S)-2-[(S)-2-tert-Butoxyca...)
Affinity DataIC50:  0.290nMAssay Description:Inhibition of [125I]-BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholecystokinin receptor type A/Gastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Centre De Pharmacologie-Endocrinologie (Montpellier, France)

Curated by ChEMBL
LigandPNGBDBM50016425((S)-3-{(S)-2-[(S)-2-(2-{(S)-2-[(S)-2-tert-Butoxyca...)
Affinity DataIC50:  0.300nMAssay Description:Ability of compound to Inhibit the binding of [125I]BH-CCK-8 to Cholecystokinin receptor in isolated guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholecystokinin receptor type A(Cavia porcellus)
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50016425((S)-3-{(S)-2-[(S)-2-(2-{(S)-2-[(S)-2-tert-Butoxyca...)
Affinity DataIC50:  0.930nMAssay Description:In vitro ability to inhibit [3H]propionyl-CCK-8 binding to Cholecystokinin type A receptor in guinea pig pancreasMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholecystokinin receptor type A/Gastrin/cholecystokinin type B receptor(RAT)
Centre De Pharmacologie-Endocrinologie (Montpellier, France)

Curated by ChEMBL
LigandPNGBDBM50016425((S)-3-{(S)-2-[(S)-2-(2-{(S)-2-[(S)-2-tert-Butoxyca...)
Affinity DataIC50:  1.5nMAssay Description:Ability of compound to Inhibit the binding of [125I]BH-CCK-8 to Cholecystokinin receptor in isolated rat pancreatic aciniMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(RAT)
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50016425((S)-3-{(S)-2-[(S)-2-(2-{(S)-2-[(S)-2-tert-Butoxyca...)
Affinity DataIC50:  2.30nMAssay Description:In vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic aciniMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGastrin/cholecystokinin type B receptor(RAT)
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50016425((S)-3-{(S)-2-[(S)-2-(2-{(S)-2-[(S)-2-tert-Butoxyca...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of [125I]-BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic aciniMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPancreatic alpha-amylase(Homo sapiens (Human))
Ep Cnrs 51

Curated by ChEMBL
LigandPNGBDBM50016425((S)-3-{(S)-2-[(S)-2-(2-{(S)-2-[(S)-2-tert-Butoxyca...)
Affinity DataEC50:  0.0500nMAssay Description:Tested in vitro for amylase release from rat pancreatic aciniMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed