Home
About
Info
Download
WebServices
Contact
Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
18
hits in this display
Target
DNA topoisomerase 2-alpha
(Homo sapiens (Human))
Kumamoto University
Curated by
ChEMBL
Ligand
BDBM50242374
(CHEMBL505529 | topostatin)
Copy SMILES
Copy InChI
Affinity Data
IC50: 4.00E+3nM
Assay Description:
Inhibition human placenta topoisomerase 2 assessed as conversion of supercoiled pBR322 DNA to relaxed form
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
KEGG
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
DNA topoisomerase 2-alpha
(Homo sapiens (Human))
Kumamoto University
Curated by
ChEMBL
Ligand
BDBM50242374
(CHEMBL505529 | topostatin)
Copy SMILES
Copy InChI
Affinity Data
IC50: 4.00E+3nM
Assay Description:
Inhibition human placenta topoisomerase 2 assessed as conversion of catenated kinetoplast DNA to minicircle monomer
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
KEGG
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Type II restriction enzyme ScaI
(Streptomyces caespitosus)
Kumamoto University
Curated by
ChEMBL
Ligand
BDBM50242374
(CHEMBL505529 | topostatin)
Copy SMILES
Copy InChI
Affinity Data
IC50: 7.00E+3nM
Assay Description:
Inhibition of Streptomyces caespitosus Sca 1 assessed as undigested supercoiled pBR322 DNA concentration
More data for this Ligand-Target Pair
Target Info
UniProtKB/SwissProt
GoogleScholar
Ligand Info
CHEMBL
KEGG
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
DNA topoisomerase
(Bos taurus)
Kumamoto University
Curated by
ChEMBL
Ligand
BDBM50242374
(CHEMBL505529 | topostatin)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.70E+4nM
Assay Description:
Inhibition calf thymus gland topoisomerase 1 assessed as conversion of supercoiled pBR322 DNA to relaxed form
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/TrEMBL
GoogleScholar
Ligand Info
CHEMBL
KEGG
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
DNA topoisomerase 1
(Cercopithecus aethiops)
Kumamoto University
Curated by
ChEMBL
Ligand
BDBM50242374
(CHEMBL505529 | topostatin)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.70E+4nM
Assay Description:
Inhibition topoisomerase 1 in african green monkey Vero cells assessed as conversion of supercoiled pBR322 DNA to relaxed form
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
KEGG
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Type II restriction enzyme HindIII
(Haemophilus influenzae)
Kumamoto University
Curated by
ChEMBL
Ligand
BDBM50242374
(CHEMBL505529 | topostatin)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.70E+4nM
Assay Description:
Inhibition of Haemophilus influenzae Hind 3 assessed as undigested supercoiled pBR322 DNA concentration
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
KEGG
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Type II restriction enzyme PstI
(Providencia stuartii)
Kumamoto University
Curated by
ChEMBL
Ligand
BDBM50242374
(CHEMBL505529 | topostatin)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.90E+4nM
Assay Description:
Inhibition of Providencia stuartii Pst 1 assessed as undigested supercoiled pBR322 DNA concentration
More data for this Ligand-Target Pair
Target Info
UniProtKB/SwissProt
GoogleScholar
Ligand Info
CHEMBL
KEGG
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
DNA topoisomerase 1
(Homo sapiens (Human))
Kumamoto University
Curated by
ChEMBL
Ligand
BDBM50242374
(CHEMBL505529 | topostatin)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.90E+4nM
Assay Description:
Inhibition topoisomerase 1 in human HeLa cells assessed as conversion of supercoiled pBR322 DNA to relaxed form
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
KEGG
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
DNA topoisomerase 1
(Mus musculus)
Kumamoto University
Curated by
ChEMBL
Ligand
BDBM50242374
(CHEMBL505529 | topostatin)
Copy SMILES
Copy InChI
Affinity Data
IC50: 4.70E+4nM
Assay Description:
Inhibition topoisomerase 1 in mouse NIH/3T3 cells assessed as conversion of supercoiled pBR322 DNA to relaxed form
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
KEGG
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
DNA topoisomerase 1
(Homo sapiens (Human))
Kumamoto University
Curated by
ChEMBL
Ligand
BDBM50242374
(CHEMBL505529 | topostatin)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5.00E+4nM
Assay Description:
Inhibition topoisomerase 1 in human COLO201 cells assessed as conversion of supercoiled pBR322 DNA to relaxed form
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
KEGG
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
DNA topoisomerase 1
(Homo sapiens (Human))
Kumamoto University
Curated by
ChEMBL
Ligand
BDBM50242374
(CHEMBL505529 | topostatin)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5.50E+4nM
Assay Description:
Inhibition topoisomerase 1 in human A549 cells assessed as conversion of supercoiled pBR322 DNA to relaxed form
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
KEGG
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Type II restriction enzyme BamHI
(Bacillus amyloliquefaciens)
Kumamoto University
Curated by
ChEMBL
Ligand
BDBM50242374
(CHEMBL505529 | topostatin)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.85E+5nM
Assay Description:
Inhibition of Bacillus amyloliquifaction Bam H1 assessed as undigested supercoiled pBR322 DNA concentration
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
KEGG
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Ribonuclease pancreatic
(Bison bison (American bison))
Kumamoto University
Curated by
ChEMBL
Ligand
BDBM50242374
(CHEMBL505529 | topostatin)
Copy SMILES
Copy InChI
Affinity Data
IC50: >2.50E+5nM
Assay Description:
Inhibition of bovine pancreas RNase A assessed as undigested supercoiled pBR322 DNA concentration
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
CHEMBL
KEGG
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Telomerase reverse transcriptase
(Homo sapiens (Human))
Kumamoto University
Curated by
ChEMBL
Ligand
BDBM50242374
(CHEMBL505529 | topostatin)
Copy SMILES
Copy InChI
Affinity Data
IC50: >2.50E+5nM
Assay Description:
Inhibition of telomerase from human COLO201 cell
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
KEGG
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
DNA ligase
(Bacteriophage T4)
Kumamoto University
Curated by
ChEMBL
Ligand
BDBM50242374
(CHEMBL505529 | topostatin)
Copy SMILES
Copy InChI
Affinity Data
IC50: >2.50E+5nM
Assay Description:
Inhibition of T4 ligase from bacteriophage infected Escherichia coli assessed as ligation of supercoiled pBR322 DNA
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
CHEMBL
KEGG
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Deoxyribonuclease-2-alpha
(Sus scrofa)
Kumamoto University
Curated by
ChEMBL
Ligand
BDBM50242374
(CHEMBL505529 | topostatin)
Copy SMILES
Copy InChI
Affinity Data
IC50: >2.50E+5nM
Assay Description:
Inhibition of porcine spleen DNase 2 assessed as undigested supercoiled pBR322 DNA concentration
More data for this Ligand-Target Pair
Target Info
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
CHEMBL
KEGG
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Deoxyribonuclease-1
(Bos taurus)
Kumamoto University
Curated by
ChEMBL
Ligand
BDBM50242374
(CHEMBL505529 | topostatin)
Copy SMILES
Copy InChI
Affinity Data
IC50: >2.50E+5nM
Assay Description:
Inhibition of bovine pancreas DNase 1 assessed as undigested supercoiled pBR322 DNA concentration
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
CHEMBL
KEGG
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Type II restriction enzyme EcoRI
(Escherichia coli)
Kumamoto University
Curated by
ChEMBL
Ligand
BDBM50242374
(CHEMBL505529 | topostatin)
Copy SMILES
Copy InChI
Affinity Data
IC50: >2.50E+5nM
Assay Description:
Inhibition of Escherichia coli Eco R1 assessed as undigested supercoiled pBR322 DNA concentration
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
KEGG
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI