Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)
Found 30 hits in this display
BDBM439497(US10633379, Example 35 | US10633379, Example 82)
BDBM439497(US10633379, Example 35 | US10633379, Example 82)
BDBM439497(US10633379, Example 35 | US10633379, Example 82)
Ki: 1.40nMAssay Description:Compound dilution series were prepared in DMSO via an approximately 3-fold serial dilution. Compound dilutions were added directly into white, low-vo...More data for this Ligand-Target Pair
BDBM439497(US10633379, Example 35 | US10633379, Example 82)
BDBM439497(US10633379, Example 35 | US10633379, Example 82)
Ki: 1.60nMAssay Description:Inhibition of human N-terminal His6 tagged BRD4 BD2 (352 to 457) residues expressed in Escherichia coli BL21(DE3) cells after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
BDBM439497(US10633379, Example 35 | US10633379, Example 82)
BDBM439497(US10633379, Example 35 | US10633379, Example 82)
BDBM439497(US10633379, Example 35 | US10633379, Example 82)
Ki: 426nMAssay Description:Compound dilution series were prepared in DMSO via an approximately 3-fold serial dilution. Compound dilutions were added directly into white, low-vo...More data for this Ligand-Target Pair
BDBM439497(US10633379, Example 35 | US10633379, Example 82)
BDBM439497(US10633379, Example 35 | US10633379, Example 82)
Ki: 520nMAssay Description:Inhibition of human N-terminal His6 tagged BRD4 BD1 (57 to 168) residues expressed in Escherichia coli BL21(DE3) cells after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
BDBM439497(US10633379, Example 35 | US10633379, Example 82)
BDBM439497(US10633379, Example 35 | US10633379, Example 82)
Ki: 1.03E+3nMAssay Description:Compound dilution series were prepared in DMSO via an approximately 3-fold serial dilution. Compound dilutions were added directly into white, low-vo...More data for this Ligand-Target Pair
BDBM439497(US10633379, Example 35 | US10633379, Example 82)
BDBM439497(US10633379, Example 35 | US10633379, Example 82)
BDBM439497(US10633379, Example 35 | US10633379, Example 82)
BDBM439497(US10633379, Example 35 | US10633379, Example 82)
BDBM439497(US10633379, Example 35 | US10633379, Example 82)
BDBM439497(US10633379, Example 35 | US10633379, Example 82)
IC50: 1.80nMAssay Description:Inhibition of BRD4-BD2 (unknown origin) preincubated for 30 mins followed by substrate addition and measured after 3 hr by HTRFMore data for this Ligand-Target Pair
BDBM439497(US10633379, Example 35 | US10633379, Example 82)
IC50: 3.30nMAssay Description:Inhibition of His-tagged BRD4 bromodomain 2 (unknown origin) using [Lys (5,8,12,16) Ac] H4(1-21) as substrate by fluorescence based assayMore data for this Ligand-Target Pair
BDBM439497(US10633379, Example 35 | US10633379, Example 82)
BDBM439497(US10633379, Example 35 | US10633379, Example 82)
BDBM439497(US10633379, Example 35 | US10633379, Example 82)
IC50: 300nMAssay Description:Inhibition of BRD4-BD1 (unknown origin) preincubated for 30 mins followed by substrate addition and measured after 3 hr by HTRF assayMore data for this Ligand-Target Pair
BDBM439497(US10633379, Example 35 | US10633379, Example 82)
IC50: 328nMAssay Description:Inhibition of His-tagged BRD4 bromodomain 1 (unknown origin) using [Lys (5,8,12,16) Ac] H4(1-21) as substrate by fluorescence based assayMore data for this Ligand-Target Pair
BDBM439497(US10633379, Example 35 | US10633379, Example 82)
BDBM439497(US10633379, Example 35 | US10633379, Example 82)
BDBM439497(US10633379, Example 35 | US10633379, Example 82)
BDBM439497(US10633379, Example 35 | US10633379, Example 82)
BDBM439497(US10633379, Example 35 | US10633379, Example 82)
BDBM439497(US10633379, Example 35 | US10633379, Example 82)
BDBM439497(US10633379, Example 35 | US10633379, Example 82)
Kd: 2.10nMAssay Description:Binding affinity to human partial length BRD4 BD2 expressed in bacterial expression system assessed as dissociation constant by BROMOscan assayMore data for this Ligand-Target Pair