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PDB Reactome pathway KEGG
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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 0.5nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 0.501nMAssay Description:Inhibition of SERTMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 0.790nMAssay Description:Ability to inhibit [3H]-paroxetine binding to cloned human serotonin (5-HT) transporterMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 0.800nMAssay Description:Ability to inhibit the reuptake of 5-HT at human serotonin transporterMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 1.80nMMore data for this Ligand-Target Pair

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Reactome pathway
UniProtKB/TrEMBL
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Transporter(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 3nMAssay Description:Displacement of [3H]nisoxetine from rat NET in rat cerebral cortexMore data for this Ligand-Target Pair

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Norepinephrine transporter(RAT)
Mcgill University

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 3nMMore data for this Ligand-Target Pair

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Norepinephrine transporter(RAT)
Mcgill University

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 3.60nMMore data for this Ligand-Target Pair

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Reactome pathway
UniProtKB/TrEMBL
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Transporter(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 3.90nMAssay Description:Inhibition of rat NETMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 4.60nMAssay Description:Inhibition constant against serotonin transporterMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 4.60nMAssay Description:Displacement of [3H]citalopram from SERT in Sprague-dawley rat frontal cortex by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair

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Reactome pathway KEGG
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Sodium-dependent noradrenaline transporter(Homo sapiens (Human))TBA

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 4.60nMAssay Description:Inhibitory activity against Dihydrofolate reductase in Neisseria gonorrhoeaeMore data for this Ligand-Target Pair

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Details PubMed DrugBank

Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 4.60nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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PDB Reactome pathway KEGG
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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 5nMAssay Description:Displacement of [3H]5HT from human 5HT transporter expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 5nMAssay Description:Displacement of [3H]citalopram from human SERT expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair

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Reactome pathway KEGG
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Sodium-dependent noradrenaline transporter(Homo sapiens (Human))TBA

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 5.97nMAssay Description:Inhibition of human NETMore data for this Ligand-Target Pair

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Reactome pathway KEGG
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Sodium-dependent noradrenaline transporter(Homo sapiens (Human))TBA

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 7.45nMAssay Description:Ability to inhibit [3H]-nisoxatine binding to cloned human norepinephrine (NE) transporterMore data for this Ligand-Target Pair

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Reactome pathway KEGG
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Sodium-dependent noradrenaline transporter(Homo sapiens (Human))TBA

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 7.5nMMore data for this Ligand-Target Pair

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Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium-dependent noradrenaline transporter(Homo sapiens (Human))TBA

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 7.5nMAssay Description:Ability to inhibit the reuptake of NE at human norepinephrine transporterMore data for this Ligand-Target Pair

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Reactome pathway KEGG
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Sodium-dependent noradrenaline transporter(Homo sapiens (Human))TBA

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 7.94nMAssay Description:Inhibition of NETMore data for this Ligand-Target Pair

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Norepinephrine transporter(RAT)
Mcgill University

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 15.6nMMore data for this Ligand-Target Pair

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Reactome pathway KEGG
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Sodium-dependent noradrenaline transporter(Homo sapiens (Human))TBA

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 16nMAssay Description:Inhibition constant against norepinephrine transporterMore data for this Ligand-Target Pair

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Reactome pathway
UniProtKB/TrEMBL
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Transporter(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 16nMAssay Description:Displacement of [3H]nisoxetine from Sprague-dawley rat NET by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair

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Reactome pathway KEGG
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Sodium-dependent noradrenaline transporter(Homo sapiens (Human))TBA

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 45nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair

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Reactome pathway KEGG
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Sodium-dependent noradrenaline transporter(Homo sapiens (Human))TBA

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 45nMAssay Description:Displacement of [3H]noradrenaline from human NET receptor expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair

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NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium-dependent dopamine transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 240nMAssay Description:Ability to inhibit the reuptake of dopamine at human dopamine transporterMore data for this Ligand-Target Pair

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NCI pathway Reactome pathway KEGG
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Sodium-dependent dopamine transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 240nMMore data for this Ligand-Target Pair

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NCI pathway Reactome pathway KEGG
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Sodium-dependent dopamine transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 240nMAssay Description:Ability to inhibit [3H]-WIN-35,428 binding to cloned human dopamine (DA) transporterMore data for this Ligand-Target Pair

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NCI pathway Reactome pathway KEGG
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Sodium-dependent dopamine transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 251nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair

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NCI pathway Reactome pathway KEGG
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Sodium-dependent dopamine transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 316nMAssay Description:Displacement of [3H]WIN35428 from human recombinant DAT transfected in HEK293 cell membraneMore data for this Ligand-Target Pair

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Reactome pathway KEGG
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Sodium-dependent dopamine transporter(Rattus norvegicus (rat))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 369nMMore data for this Ligand-Target Pair

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NCI pathway Reactome pathway KEGG
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Sodium-dependent dopamine transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 370nMAssay Description:Inhibition constant against dopamine transporterMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
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5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 419nMMore data for this Ligand-Target Pair

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NCI pathway Reactome pathway KEGG
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Sodium-dependent dopamine transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 435nMAssay Description:Displacement of [3H]dopamine from human DAT receptor expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair

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NCI pathway Reactome pathway KEGG
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Sodium-dependent dopamine transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 435nMAssay Description:Displacement of [3H]dopamine from human DAT expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair

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PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 504nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
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5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 916nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 4(GUINEA PIG)
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
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Adenosine receptor A1(Rattus norvegicus (rat))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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Reactome pathway KEGG
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Adenosine receptor A2b(BOVINE)
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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Sodium/nucleoside cotransporter(RAT)
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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Reactome pathway KEGG
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Adenylate cyclase type 3(RAT)
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Alpha-1A adrenergic receptor(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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Reactome pathway
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Alpha-1B adrenergic receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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Alpha-2A adrenergic receptor(Homo sapiens (Human))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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Alpha-2B adrenergic receptor(MOUSE)
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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Beta-1 adrenergic receptor(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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PDB MMDB Reactome pathway
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Beta-2 adrenergic receptor(Rattus norvegicus)
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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PDB Reactome pathway
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Voltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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PDB Reactome pathway
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Voltage-dependent N-type calcium channel subunit alpha-1B(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
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Gastrin/cholecystokinin type B receptor(MOUSE)
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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Gastrin/cholecystokinin type B receptor(MOUSE)
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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Reactome pathway
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Muscarinic acetylcholine receptor M1(Homo sapiens (Human))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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Muscarinic acetylcholine receptor M2(Homo sapiens (Human))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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D(1A) dopamine receptor(RAT)
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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Gamma-aminobutyric acid receptor subunit alpha-1(BOVINE)
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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Gamma-aminobutyric acid receptor subunit alpha-1(BOVINE)
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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Gamma-aminobutyric acid receptor subunit alpha-1(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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Glutamate receptor 3(RAT)
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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Glutamate receptor ionotropic, kainate 1(RAT)
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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Glutamate receptor ionotropic, NMDA 1(RAT)
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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Glutamate receptor ionotropic, NMDA 1(RAT)
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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Glycine receptor subunit alpha-1(RAT)
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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Glycine receptor subunit alpha-1(RAT)
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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Histamine H2 receptor(Cavia porcellus (domestic guinea pig))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2(RAT)
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
B.MOAD GoogleScholar

Substance-P receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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Substance-K receptor(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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Neuromedin-K receptor(mouse)
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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PDB MMDB
UniProtKB/SwissProt
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Alpha-bungarotoxin(Bungarus multicinctus)
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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Nitric oxide synthase, brain(Rattus norvegicus (rat))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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Neuropeptide Y receptor type 1(Homo sapiens (Human))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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5'-nucleotidase(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Delta-type opioid receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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PDB
UniProtKB/SwissProt
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Kappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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Mu-type opioid receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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Mu-type opioid receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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ATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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Calcium-activated potassium channel subunit beta-1(RAT)
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Protein kinase C alpha type(MOUSE)
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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Sigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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Sigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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Sodium channel protein type 1 subunit alpha(Rattus norvegicus)
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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Sodium channel protein type 2 subunit alpha(Rattus norvegicus)
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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Somatostatin(RAT)
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 2.10E+3nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 2.26E+3nMMore data for this Ligand-Target Pair

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Histamine H1 receptor(Homo sapiens (Human))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 2.30E+3nMMore data for this Ligand-Target Pair

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Muscarinic acetylcholine receptor M2(Homo sapiens (Human))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 3.00E+3nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 3.00E+3nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1E(Homo sapiens (Human))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 3.73E+3nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 3.96E+3nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 4.45E+3nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 5.00E+3nMMore data for this Ligand-Target Pair

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Histamine H3 receptor(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: >5.00E+3nMAssay Description:Displacement of [3H]-N-R-methylhistamine from rat H3 receptorMore data for this Ligand-Target Pair

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Histamine H3 receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: >5.00E+3nMAssay Description:Displacement of [3H]-N-R-methylhistamine from human H3 receptor isolated from C6 cellsMore data for this Ligand-Target Pair

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Alpha-1A adrenergic receptor(Homo sapiens (Human))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 8.30E+3nMMore data for this Ligand-Target Pair

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Alpha-2A adrenergic receptor(Homo sapiens (Human))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: 8.60E+3nMMore data for this Ligand-Target Pair

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Amine oxidase [flavin-containing] A(Rattus norvegicus (rat))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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Amine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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D(2) dopamine receptor(Homo sapiens (Human))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 0.316nMAssay Description:Inhibition of human recombinant SERT expressed in HEK293 cells assessed as inhibition of [3H]5HT reuptakeMore data for this Ligand-Target Pair

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Sodium-dependent noradrenaline transporter(Homo sapiens (Human))TBA

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 1.60nMAssay Description:Inhibition of human recombinant NET expressed in HEK293 cells assessed as inhibition of [3H]NE reuptakeMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 3nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in human JAR cellsMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 3nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in JAR cellsMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 3nMAssay Description:Inhibition of human SERT expressed in human JAR cellsMore data for this Ligand-Target Pair

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Sodium-dependent noradrenaline transporter(Homo sapiens (Human))TBA

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 4nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in MDCK cellsMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 4nMAssay Description:Inhibition of [3H]5-HT uptake at human 5HTT expressed in HEK293 cellsMore data for this Ligand-Target Pair

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Sodium-dependent noradrenaline transporter(Homo sapiens (Human))TBA

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 4nMAssay Description:Inhibition of human NET transfected in MDCK-Net6 cellsMore data for this Ligand-Target Pair

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Sodium-dependent noradrenaline transporter(Homo sapiens (Human))TBA

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 4nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair

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Sodium-dependent noradrenaline transporter(Homo sapiens (Human))TBA

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 5nMAssay Description:Inhibition of [3H]NA uptake at human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 6nMAssay Description:Inhibition of [3H]5-HT uptake at 5HT transporter expressed in HEK293 cellsMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 6nMAssay Description:Inhibition of [3H]5HT from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 6nMAssay Description:Inhibition of [3H]5-HT reuptake at 5HT transporter in HEK293 cellsMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 6.60nMAssay Description:Inhibition of human SERTMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 6.60nMAssay Description:Displacement of [alpha,beta-3H(N)]-5-hydroxytryptamine from human cloned SERT expressed in HEK293 cells by microplate scintillation counterMore data for this Ligand-Target Pair

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Sodium-dependent noradrenaline transporter(Homo sapiens (Human))TBA

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 8.90nMAssay Description:Inhibition of human NETMore data for this Ligand-Target Pair

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Sodium-dependent noradrenaline transporter(Homo sapiens (Human))TBA

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 8.90nMAssay Description:Displacement of Levo[ring-2,5,6-3H]norepinephrine from human cloned NET expressed in HEK293 cells by microplate scintillation counterMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 10nMAssay Description:Inhibition of serotonin reuptake at human SERT expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assayMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 10nMAssay Description:Inhibition of human SERT expressed in HEK293 cells at incubated for 15 mins by neurotransmitter reuptake assayMore data for this Ligand-Target Pair

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Sodium-dependent noradrenaline transporter(Homo sapiens (Human))TBA

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 19nMAssay Description:Inhibition of [3H]NA reuptake at NA transporter in HEK293 cellsMore data for this Ligand-Target Pair

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Sodium-dependent noradrenaline transporter(Homo sapiens (Human))TBA

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 19nMAssay Description:Inhibition of [3H]NA from human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair

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Sodium-dependent noradrenaline transporter(Homo sapiens (Human))TBA

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 19nMAssay Description:Inhibition of [3H]NA uptake at NA transporter expressed in HEK293 cellsMore data for this Ligand-Target Pair

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Sodium-dependent dopamine transporter(Rattus norvegicus (rat))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 370nMAssay Description:Displacement of [125I]RTI55 from DAT in Sprague-dawley rat striatum by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair

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Cytochrome P450 3A4(Homo sapiens (Human))
Korea University

Curated by ChEMBL

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 440nMAssay Description:Inhibition of recombinant human CYP3A4 preincubated for 5 mins before fluorescent substrate addition by fluorescence assayMore data for this Ligand-Target Pair

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Cytochrome P450 3A4(Homo sapiens (Human))
Korea University

Curated by ChEMBL

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 440nMAssay Description:Inhibition of human recombinant CYP3A4 incubated for 5 mins by fluorescence assayMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by PDSP K_i Database

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 515nMAssay Description:Inhibition of human NET expressed in HEK293 cells at incubated for 15 mins by neurotransmitter reuptake assayMore data for this Ligand-Target Pair

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Sodium-dependent noradrenaline transporter(Homo sapiens (Human))TBA

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 515nMAssay Description:Inhibition of norepinephrine reuptake at human NET expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assayMore data for this Ligand-Target Pair

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Sodium-dependent dopamine transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 590nMAssay Description:Inhibition of [3H]DA uptake at human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair

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Sodium-dependent dopamine transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 660nMAssay Description:Inhibition of human DATMore data for this Ligand-Target Pair

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Sodium-dependent dopamine transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 660nMAssay Description:Displacement of 3,4-[ring-2,5,6-3H]dihydroxyphenylethylamine from human cloned DAT expressed in HEK293 cells by microplate scintillation counterMore data for this Ligand-Target Pair

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Sodium-dependent dopamine transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 870nMAssay Description:Inhibition of [3H]DA reuptake at DA transporter in HEK293 cellsMore data for this Ligand-Target Pair

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Sodium-dependent dopamine transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 870nMAssay Description:Inhibition of [3H]DA from human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair

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Sodium-dependent dopamine transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 870nMAssay Description:Inhibition of DA transporter expressed in HEK293 cellsMore data for this Ligand-Target Pair

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Sodium-dependent dopamine transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 977nMAssay Description:Inhibition of DA reuptake at human DAT expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assayMore data for this Ligand-Target Pair

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Sodium-dependent dopamine transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 977nMAssay Description:Inhibition of human DAT expressed in HEK293 cells at incubated for 15 mins by neurotransmitter reuptake assayMore data for this Ligand-Target Pair

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Cytochrome P450 2D6(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 1.00E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair

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Sodium-dependent dopamine transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: >1.00E+3nMAssay Description:Displacement of [3H]WIN-35428 form human DAT expressed in CHO cell membranesMore data for this Ligand-Target Pair

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Cytochrome P450 2D6(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 1.58E+3nMAssay Description:Inhibition of human recombinant CYP2D6 incubated for 5 mins by fluorescence assayMore data for this Ligand-Target Pair

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Cytochrome P450 2D6(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 1.60E+3nMAssay Description:Inhibition of recombinant human CYP2D6 preincubated for 5 mins before fluorescent substrate addition by fluorescence assayMore data for this Ligand-Target Pair

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Cytochrome P450 2D6(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 2.00E+3nMAssay Description:Inhibition of human recombinant CYP2D6 by luminescence assayMore data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1F/alpha-1S(Homo sapiens (Human))
Chantest

Curated by ChEMBL

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 2.80E+3nMAssay Description:Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunitsMore data for this Ligand-Target Pair

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Cytochrome P450 2C19(Homo sapiens (Human))
Korea University

Curated by ChEMBL

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 4.10E+3nMAssay Description:Inhibition of recombinant human CYP2C19 preincubated for 5 mins before fluorescent substrate addition by fluorescence assayMore data for this Ligand-Target Pair

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Cytochrome P450 2C19(Homo sapiens (Human))
Korea University

Curated by ChEMBL

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 4.10E+3nMAssay Description:Inhibition of human recombinant CYP2C19 incubated for 5 mins by fluorescence assayMore data for this Ligand-Target Pair

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Potassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 5.01E+3nMAssay Description:Inhibition of rapid delayed inward rectifying potassium current (IKr) measured using manual patch clamp assayMore data for this Ligand-Target Pair

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Cytochrome P450 1A2(Homo sapiens (Human))
Korea University

Curated by ChEMBL

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 5.30E+3nMAssay Description:Inhibition of human recombinant CYP1A2 incubated for 5 mins by fluorescence assayMore data for this Ligand-Target Pair

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Cytochrome P450 1A2(Homo sapiens (Human))
Korea University

Curated by ChEMBL

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 5.30E+3nMAssay Description:Inhibition of recombinant human CYP1A2 preincubated for 5 mins before fluorescent substrate addition by fluorescence assayMore data for this Ligand-Target Pair

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D-amino-acid oxidase(Homo sapiens (Human))
National Taiwan University

US Patent

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 5.47E+3nMAssay Description:The DAAO enzymatic activity assay was modified according to the report of Oguri et al (Oguri, S., Screening of d-amino acid oxidase inhibitor by a ne...More data for this Ligand-Target Pair

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Potassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 6.31E+3nMAssay Description:Inhibition of fast sodium current (INa) in HEK293 cells transfected with human Nav1.5 measured using IonWorks Quattro automated patch clamp platformMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium channel protein type 5 subunit alpha(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 7.94E+3nMAssay Description:Inhibition of fast sodium current (INa) in Chinese Hamster Ovary (CHO) K1 cells transfected with human Nav1.5 measured using IonWorks Quattro automat...More data for this Ligand-Target Pair

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Potassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 1.00E+4nMAssay Description:Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) K1 cells stably expressing hERG measured using I...More data for this Ligand-Target Pair

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Potassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

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Sodium channel protein type 5 subunit alpha(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 1.58E+4nMAssay Description:Inhibition of fast sodium current (INa) in HEK293 cells transfected with human Nav1.5 measured using IonWorks Quattro automated patch clamp platformMore data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 2.51E+4nMAssay Description:Inhibition of long-lasting type calcium current (ICaL) in HEK293 cells (alpha1C/beta2a/alpha2delta1) cells measured using IonWorks Barracuda automat...More data for this Ligand-Target Pair

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Cytochrome P450 2C9(Homo sapiens (Human))
Korea University

Curated by ChEMBL

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 2.90E+4nMAssay Description:Inhibition of recombinant human CYP2C9 preincubated for 5 mins before fluorescent substrate addition by fluorescence assayMore data for this Ligand-Target Pair

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Cytochrome P450 2C9(Homo sapiens (Human))
Korea University

Curated by ChEMBL

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 2.91E+4nMAssay Description:Inhibition of human recombinant CYP2C9 incubated for 5 mins by fluorescence assayMore data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 1.00E+5nMAssay Description:Inhibition of fast sodium current (INa) in HEK293 cells transfected with human Nav1.5 measured using IonWorks Quattro automated patch clamp platformMore data for this Ligand-Target Pair

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Potassium voltage-gated channel subfamily D member 3(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: 1.00E+5nMAssay Description:Inhibition of slow delayed inward rectifying potassium current (Iks) in Chinese Hamster Ovary (CHO) cells expressing hKvLQT1/hminK measured using Ion...More data for this Ligand-Target Pair

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ATP-binding cassette sub-family C member 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair

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ATP-binding cassette sub-family C member 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair

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ATP-binding cassette sub-family C member 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL

BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair

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Bile salt export pump(Homo sapiens (Human))
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BDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)

IC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair

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