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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
25
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Target
Beta-3 adrenergic receptor
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50092645
((R)-N-(4-(2-(2-hydroxy-2-(pyridin-3-yl)ethylamino)...)
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Affinity Data
IC50: 46nM
Assay Description:
In vitro functional efficacy as increased cAMP in chinese hamster ovary (CHO) cells expressing human beta-3 receptor
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50092645
((R)-N-(4-(2-(2-hydroxy-2-(pyridin-3-yl)ethylamino)...)
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Affinity Data
IC50: 220nM
Assay Description:
Binding affinity to human ERG channel
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Target
Beta-2 adrenergic receptor
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50092645
((R)-N-(4-(2-(2-hydroxy-2-(pyridin-3-yl)ethylamino)...)
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Affinity Data
IC50: 670nM
Assay Description:
Displacement of [125]I-cyanopindolol from human recombinant beta2 adrenergic receptor after 1 hr by scintillation counting method
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Target
Beta-1 adrenergic receptor
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50092645
((R)-N-(4-(2-(2-hydroxy-2-(pyridin-3-yl)ethylamino)...)
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Affinity Data
IC50: 1.00E+3nM
Assay Description:
Displacement of [125]I-cyanopindolol from recombinant human beta1 adrenergic receptor after 1 hr by scintillation counting method
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Target
Voltage-dependent L-type calcium channel subunit alpha-1C
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50092645
((R)-N-(4-(2-(2-hydroxy-2-(pyridin-3-yl)ethylamino)...)
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Affinity Data
IC50: 1.70E+3nM
Assay Description:
Displacement of [3H]-diltiazem from human Cav1.2 channel
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Target
Beta-2 adrenergic receptor
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50092645
((R)-N-(4-(2-(2-hydroxy-2-(pyridin-3-yl)ethylamino)...)
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Affinity Data
IC50: 2.30E+3nM
Assay Description:
Displacement of [125I]cyanopindolol from human beta 2 adrenergic receptor expressed in CHO cells at 10 uM after 3 to 4 hrs by scintillation counter
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Target
Beta-2 adrenergic receptor
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50092645
((R)-N-(4-(2-(2-hydroxy-2-(pyridin-3-yl)ethylamino)...)
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Affinity Data
IC50: 2.30E+3nM
Assay Description:
Binding affinity was evaluated on chinese hamster ovary (CHO) cells expressing the cloned human beta-2 adrenergic receptor in the presence of [125I]-...
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Target
Beta-1 adrenergic receptor
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50092645
((R)-N-(4-(2-(2-hydroxy-2-(pyridin-3-yl)ethylamino)...)
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Affinity Data
IC50: 2.30E+3nM
Assay Description:
Binding affinity was evaluated on chinese hamster ovary (CHO) cells expressing the cloned human beta-1 adrenergic receptor in the presence of [125I]-...
More data for this Ligand-Target Pair
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Target
Beta-1 adrenergic receptor
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50092645
((R)-N-(4-(2-(2-hydroxy-2-(pyridin-3-yl)ethylamino)...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.30E+3nM
Assay Description:
Displacement of [125I]cyanopindolol from human beta 1 adrenergic receptor expressed in CHO cells at 10 uM after 3 to 4 hrs by scintillation counter
More data for this Ligand-Target Pair
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Target
Sodium-dependent serotonin transporter
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50092645
((R)-N-(4-(2-(2-hydroxy-2-(pyridin-3-yl)ethylamino)...)
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Affinity Data
IC50: 5.00E+3nM
Assay Description:
Inhibition of human SERT expressed in HEK293 cells preincubated for 30 mins followed by fluorescent substrate addition measured after 30 mins by plat...
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Target
Cytochrome P450 3A4
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50092645
((R)-N-(4-(2-(2-hydroxy-2-(pyridin-3-yl)ethylamino)...)
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Affinity Data
IC50: 9.30E+3nM
Assay Description:
Inhibition of CYP3A4 in human liver microsomes assessed as testosterone 6beta-hydroxylation
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Target
Cytochrome P450 2D6
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50092645
((R)-N-(4-(2-(2-hydroxy-2-(pyridin-3-yl)ethylamino)...)
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Affinity Data
IC50: 1.10E+4nM
Assay Description:
Inhibition of CYP2D6 in human liver microsomes assessed as dextraomethorphan O-demethylation
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Target
Cytochrome P450 2C9
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50092645
((R)-N-(4-(2-(2-hydroxy-2-(pyridin-3-yl)ethylamino)...)
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Affinity Data
IC50: 2.40E+4nM
Assay Description:
Inhibition of CYP2C9 in human liver microsomes assessed as diclofenac alpha'-hydroxylation
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Target
Beta-3 adrenergic receptor
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50092645
((R)-N-(4-(2-(2-hydroxy-2-(pyridin-3-yl)ethylamino)...)
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Affinity Data
EC50: 3.60nM
Assay Description:
Agonistic activity at human beta3 adrenergic receptor expressed in CHO cells assessed as amount of cAMP released after 1 hr by fluorescence resonance...
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Target
Beta-3 adrenergic receptor
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50092645
((R)-N-(4-(2-(2-hydroxy-2-(pyridin-3-yl)ethylamino)...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 3nM
Assay Description:
Agonist activity (EC50) was assessed by measuring cAMP levels in CHO cells expressing cloned human Beta-3 adrenergic receptor
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Target
Beta-3 adrenergic receptor
(Canis familiaris)
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50092645
((R)-N-(4-(2-(2-hydroxy-2-(pyridin-3-yl)ethylamino)...)
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Affinity Data
EC50: 25nM
Assay Description:
Agonist activity at dog beta3 adrenergic receptor expressed in CHO cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay
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Target
Beta-3 adrenergic receptor
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50092645
((R)-N-(4-(2-(2-hydroxy-2-(pyridin-3-yl)ethylamino)...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 7.90nM
Assay Description:
Agonist activity at human adrenergic beta3 receptor expressed in CHO cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay in presenc...
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Target
Beta-3 adrenergic receptor
(Macaca mulatta)
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50092645
((R)-N-(4-(2-(2-hydroxy-2-(pyridin-3-yl)ethylamino)...)
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Affinity Data
EC50: 17nM
Assay Description:
Agonist activity at rhesus monkey beta3 adrenergic receptor expressed in CHO cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay in...
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Target
Beta-3 adrenergic receptor
(Macaca mulatta)
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50092645
((R)-N-(4-(2-(2-hydroxy-2-(pyridin-3-yl)ethylamino)...)
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Affinity Data
EC50: 0.430nM
Assay Description:
Agonist activity at rhesus monkey beta3 adrenergic receptor expressed in CHO cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay
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Target
Beta-3 adrenergic receptor
(Rattus norvegicus)
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50092645
((R)-N-(4-(2-(2-hydroxy-2-(pyridin-3-yl)ethylamino)...)
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Affinity Data
EC50: 3.40E+3nM
Assay Description:
Agonist activity at rat beta3 adrenergic receptor expressed in CHO cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay
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Target
Beta-3 adrenergic receptor
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50092645
((R)-N-(4-(2-(2-hydroxy-2-(pyridin-3-yl)ethylamino)...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 2nM
Assay Description:
Agonist activity at human beta3 adrenergic receptor expressed in CHO cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay
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Target
Beta-3 adrenergic receptor
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50092645
((R)-N-(4-(2-(2-hydroxy-2-(pyridin-3-yl)ethylamino)...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 3nM
Assay Description:
Agonist activity at human adrenergic beta-3 receptor expressed in CHO cells assessed as cAMP production
More data for this Ligand-Target Pair
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Target
Beta-1 adrenergic receptor
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50092645
((R)-N-(4-(2-(2-hydroxy-2-(pyridin-3-yl)ethylamino)...)
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Affinity Data
EC50: 4.80E+3nM
Assay Description:
In vitro functional efficacy in stimulating increase in cAMP in chinese hamster ovary (CHO) cells expressing the cloned human beta1 receptor.
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Target
Beta-3 adrenergic receptor
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50092645
((R)-N-(4-(2-(2-hydroxy-2-(pyridin-3-yl)ethylamino)...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 3.60nM
Assay Description:
In vitro functional efficacy as increased cAMP in chinese hamster ovary (CHO) cells expressing human beta3 receptor
More data for this Ligand-Target Pair
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Target
Beta-2 adrenergic receptor
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50092645
((R)-N-(4-(2-(2-hydroxy-2-(pyridin-3-yl)ethylamino)...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 2.40E+3nM
Assay Description:
In vitro functional efficacy in stimulating increase in cAMP in chinese hamster ovary (CHO) cells expressing the cloned human beta2 receptor.
More data for this Ligand-Target Pair
Target Info
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