Query String: 1415-EET
BDBM595327 US12195427, Compound 1415 US12351648, Compound 1415 US11584714, Compound 1415
US9302989, 1415 BDBM217276
BDBM266184 US9718790, I-1415
BDBM545922 US11286268, Compound 1415
US11780845, Example 1415 BDBM624395
BDBM50138830 CHEMBL3752659 US10233190, Example 1415
US10508120, Compound I-1415 BDBM424911
BDBM424745 US11046698, Compound I-1415 US10508120, Compound I-1415 US10508120, Compound I-1249 US10577373, Compound I-1249
US11780845, Example 1414 US11780845, Example 1415 BDBM624380 US11780845, Example 1400
5-[4-amino-5-(trifluoromethyl)- pyrrolo[2,1-f][1,2,4]triazin-7- yl]-N-[(3R,4S)-4-fluoro-1-(3- hydroxy-3-methylbutan-2- yl)pyrrolidin-3-yl]-2-methoxy- pyridine-3-carboxamide BDBM600125 US11618753, Example 1415
5-[4-amino-5-(trifluoromethyl)- pyrrolo[2,1-f][1,2,4]triazin-7- yl]-N-[(3R,4S)-4-fluoro-1-(3- hydroxy-3-methylbutan-2-yl)- pyrrolidin-3-yl]-2-methoxy- pyridine-3-carboxamide BDBM600124 US11618753, Example 1407 US11618753, Example 1415
- Falck, JR; Koduru, SR; Mohapatra, S; Manne, R; Atcha, KR; Atcha, R; Manthati, VL; Capdevila, JH; Christian, S; Imig, JD; Campbell, WB 14,15-Epoxyeicosa-5,8,11-trienoic Acid (14,15-EET) surrogates: carboxylate modifications. J Med Chem 57: 6965-72 (2014)
- Falck, JR; Kodela, R; Manne, R; Atcha, KR; Puli, N; Dubasi, N; Manthati, VL; Capdevila, JH; Yi, XY; Goldman, DH; Morisseau, C; Hammock, BD; Campbell, WB 14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxide hydrolase inhibition. J Med Chem 52: 5069-75 (2010)
- ChEMBL_1669596 (CHEMBL4019484) Inhibition of sEH in human HepG2 cells using 14(15)-EET-d11 as substrate assessed as reduction in conversion of 14(15)-EET-d11 to 14(15)-DHET-d11 preincubated for 15 mins followed by substrate addition measured after 10 mins LC-MS/MS analysis
- ChEMBL_716998 (CHEMBL1671070) Inhibition of soluble epoxide hydrolase in HUVEC assessed inhibition of as conversion of 14, 15-EET to 14, 15-DHET
- ChEMBL_1580943 (CHEMBL3812611) Inhibition of soluble epoxide hydrolase (unknown origin) using 14,15-EET as substrate incubated for 20 mins by LC-MS/MS analysis
- ChEMBL_2461162 Inhibition of C57BL/6J mouse brain sEH using 14,15-EET as substrate preincubated for 15 mins followed by substrate addition by LC-MS analysis
- ChEMBL_2461178 Inhibition of full length human sEH (1 to 555 residues) using 14,15-EET as substrate preincubated for 15 mins followed by substrate addition by LC-MS analysis
- ChEMBL_2487810 Inhibition of sEH in C57BL/6J mouse brain homogenate using 14, 15-EET as substrate preincubated for 10 mins followed by substrate addition by UPLC-MS/MS analysis
- ChEMBL_965766 (CHEMBL2393705) Inhibition of human soluble epoxide hydrolase overexpressed in HEK293F cells using EET as substrate assessed as formation of DHET incubated for 30 mins prior to substrate addition measured after 60 mins by ELISA
- ChEMBL_2212880 (CHEMBL5125829) Inhibition of human sEH BacMam transduced HEK293 cells assessed as reduction in 14,15-DHET formation using 14,15-EET as substrate preincubated for 30 mins followed by susbtrate addition and measured after 90 mins by fluorescence polarization assay
- ChEMBL_1785252 (CHEMBL4256769) Inhibition of human sEH in human HepG2 cells using (+/-)14(15)-EET-d11 as substrate assessed as formation of (+/-)14(15)-DHET-d11 preincubated for 15 mins followed by substrate addition and measured after 10 mins by LC-MS/MS analysis