2-(6-Isopropenyl-3-methyl-cyclohex-2-enyl)-5-pentyl-benzene-1,3-diol (Cannabidiol) CBD 2-(6-Isopropenyl-3-methyl-cyclohex-2-enyl)-5-pentyl-benzene-1,3-diol Cannabidiol BDBM50121429
US11485700, Compound (+)-CBD BDBM579473
BDBM576352 US11485700, Compound (+)-CBD-ME
BDBM579476 US11485700, Compound (+)-CBD-HPE
BDBM84915 NSC_3060519 CAS_3060519 CBD, abnormal
US11485700, Compound (+)-CBD-GE BDBM579474
CBD-V GWP42006 Cannabidivarin BDBM50532215 CBDV
CHEMBL190461 BDBM50318484 CANNABIDIOL 2-((1R,6R)-6-Isopropenyl-3-methyl-cyclohex-2-enyl)-5-pentyl-benzene-1,3-diol
BDBM50318485 CHEMBL498672 Cannabidiol acid 2,4-dihydroxy-3-((1R,6R)-3-methyl-6-(prop-1-en-2-yl)cyclohex-2-enyl)-6-pentylbenzoic acid
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- ChEMBL_2441768 Inhibition of EBP in human Mesenchymal stem cells assessed as zymostenol accumulation by GCMS analysis
- ChEMBL_2193362 (CHEMBL5105722) Inhibition of alpha5beta1 integrin receptor expressed on human surface of adipose tissue-derived stem cells
- ChEMBL_927365 (CHEMBL3072565) Binding affinity to Chilo suppressalis (rice stem borer) EcR
- ChEMBL_1348201 (CHEMBL3270316) Inhibition of cKit in stem cell factor-stimulated bone marrow derived mouse mast cells assessed as phosphorylation after 1 hr incubation
- ChEBML_140108 Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)
- ChEMBL_105473 (CHEMBL708303) Inhibition of Mast/stem cell growth factor receptor (c-kit) autophosphorylation
- ChEMBL_105474 (CHEMBL708304) Inhibition of Mast/stem cell growth factor receptor (c-kit) autophosphorylation
- ChEMBL_105477 (CHEMBL708307) Inhibition of Mast/stem cell growth factor receptor (c-Kit kinase)
- ChEMBL_496792 (CHEMBL1008805) Displacement of [3H]citalopram from SERT in rat brain stem membrane
- ChEMBL_154374 (CHEMBL758983) Ability to promote differentiation of C3H10T1/2 stem cells to adipocytes using lipogenesis assay mediated through activation of Peroxisome proliferator activated receptor gamma
- ChEMBL_154375 (CHEMBL758984) Ability to promote differentiation of C3H10T1/2 stem cells to adipocytes using lipogenesis assay mediated through activation of Peroxisome proliferator activated receptor gamma
- ChEMBL_1848045 (CHEMBL4348586) Antagonist activity at His6 -tagged Pseudomonas aeruginosa PqsR CBD domain expressed in Escherichia coli Rosetta 2 (DE3)
- ChEMBL_140108 (CHEMBL752109) Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)
- ChEMBL_649987 (CHEMBL1219685) Displacement of [3H]citalopram from SERT in rat brain stem by scintillation counting
- ChEMBL_1779722 (CHEMBL4236714) Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of CBD-induced Ca2+ levels preincubated for 5 mins followed by agonist addition by Fuo-4-AM based spectrofluorimetry
- ChEMBL_924226 (CHEMBL3075970) Agonist activity at Chilo suppressalis (rice stem borer) tyramine receptor TyR1 expressed in HEK293 cells assessed as reduction in forskolin-induced cAMP accumulation incubated for 20 min
- ChEMBL_105475 (CHEMBL708305) In vitro inhibition of Mast/stem cell growth factor receptor (c-Kit kinase) expressed in baculovirus
- ChEMBL_105476 (CHEMBL708306) In vitro inhibition of Mast/stem cell growth factor receptor (c-Kit kinase) expressed in baculovirus
- ChEMBL_1278612 (CHEMBL3095443) Displacement of [3H]citalopram from Sprague-Dawley rat brain stem SERT site S1 by scintillation counting analysis
- ChEMBL_2437022 Inhibition of IRE1alpha RNase activity (Q470 to L977 residues) (unknown origin) expressed in Sf9 cells using mini-XBP-1 stem-loop RNA as substrate measured every 2 mins interval for 50 mins by FRET assay
- ChEMBL_1621704 (CHEMBL3863987) Displacement of [3H]citalopram from SERT in Sprague-Dawley rat brain stem membranes incubated for 60 mins by radioligand binding assay
- ChEMBL_2019487 (CHEMBL4673065) Competitive inhibition of IRE1alpha LKR domain (Q470 to L997 residues) (unknown origin) expressed in Sf9 insect cells using mini-XBP-1 stem-loop RNA as substrate and measured every 2 mins for 50 mins by FRET assay
- ChEMBL_1349566 (CHEMBL3265635) Inhibition of human recombinant puritin-His-tagged IRE-1 RNase expressed in SF21 cells using XBP-1 RNA stem loop as substrate incubated for 30 mins prior to substrate addition measured after 2 hrs by FRET-suppression assay
- ChEMBL_2170293 (CHEMBL5055352) Binding affinity to CM5 immobilized N-terminal His/Sumo tagged Influenza A virus (A/WSN/1933(H1N1)) PB2 CBD (318 to 486 residues) expressed in Escherichia coli by surface plasmon resonance assay
- ChEMBL_2186099 (CHEMBL5098181) Partial agonist activity at CBR2 V1133.32M mutant (unknown origin) expressed in HEK293T assessed as increase in picometer shifts of reflected light wavelengths in presence of cannabidiol by DMR assay
- ChEMBL_2186105 (CHEMBL5098187) Partial agonist activity at CBR2 V361.35M mutant (unknown origin) expressed in HEK293T assessed as increase in picometer shifts of reflected light wavelengths in presence of cannabidiol by DMR assay
- ChEMBL_2186111 (CHEMBL5098193) Partial agonist activity at CBR2 A2827.36M mutant (unknown origin) expressed in HEK293T assessed as increase in picometer shifts of reflected light wavelengths in presence of cannabidiol by DMR assay
- ChEMBL_2186117 (CHEMBL5098199) Partial agonist activity at CBR2 S2857.39L mutant (unknown origin) expressed in HEK293T assessed as increase in picometer shifts of reflected light wavelengths in presence of cannabidiol by DMR assay
- HIF-1alpha transactivation assays NIH3T3-EPO-luc cells were maintained at 37° C. in a humidified atmosphere containing 5% CO2 in DMEM supplemented with 10% fetal calf serum (FBS), and 1% (v/v) penicillin/streptomycin. Deferoxamine (DFX) was purchased from Sigma-Aldrich (USA). Cells (1×104/well in 96-well plates) were seeded the day before the assay. The next day, the cells were stimulated with increasing concentrations of either Cannabidiol (CBD), VCE-004 or compounds II to X. After six hours of stimulation the cells were lysed in 25 mM Tris-phosphate pH 7.8, 8 mM MgCl2, 1 mM DTT, 1% Triton X-100, and 7% glycerol during 15 min at RT in a horizontal shaker. Luciferase activity was measured using a microplate luminometer (Berthold) following the instructions of the luciferase assay kit (Promega, Madison. Wis., USA).
- ChEMBL_2186067 (CHEMBL5098149) Partial agonist activity at CBR2 V1133.32M mutant (unknown origin) expressed in HEK293T assessed as increase in ERK1/2 phosphorylation incubated for 7 mins in presence of cannabidiol by AlphaScreenSureFire method
- ChEMBL_2186073 (CHEMBL5098155) Partial agonist activity at CBR2 V361.35M mutant (unknown origin) expressed in HEK293T assessed as increase in ERK1/2 phosphorylation incubated for 7 mins in presence of cannabidiol by AlphaScreenSureFire method
- ChEMBL_2186079 (CHEMBL5098161) Partial agonist activity at CBR2 A2827.36M mutant (unknown origin) expressed in HEK293T assessed as increase in ERK1/2 phosphorylation incubated for 7 mins in presence of cannabidiol by AlphaScreenSureFire method
- ChEMBL_2186086 (CHEMBL5098168) Partial agonist activity at CBR2 S2857.39L mutant (unknown origin) expressed in HEK293T assessed as increase in ERK1/2 phosphorylation incubated for 7 mins in presence of cannabidiol by AlphaScreenSureFire method
- ChEMBL_2186092 (CHEMBL5098174) Partial agonist activity at wild type CB2 receptor (unknown origin) expressed in HEK293T assessed as increase in picometer shifts of reflected light wavelengths in presence of cannabidiol by DMR assay
- ChEMBL_2186061 (CHEMBL5098143) Partial agonist activity at wild type CB2 receptor (unknown origin) expressed in HEK293T assessed as increase in ERK1/2 phosphorylation incubated for 7 mins in presence of cannabidiol by AlphaScreenSureFire method
- ChEMBL_1285734 (CHEMBL3107723) Inhibition of Clostridium botulinum Hall A hyper BoNT/A light chain expressed in human induced pluripotent stem cell-derived neurons after 8 hrs by Western blot analysis
- ChEMBL_1824281 (CHEMBL4324045) Inhibition of topoisomerase 2alpha in human SW620 organoids transfected with VimPro-GFP reporter assessed as reversion of epithelial-mesenchymal transition by measuring reduction in vimentin expression after 72 hrs by Hoechst 33342 staining based GFP reporter gene assay
- ChEMBL_1824282 (CHEMBL4324046) Inhibition of topoisomerase 2alpha in human SW620 organoids transfected with EcadPro-RFP reporter assessed as reversion of epithelial-mesenchymal transition by measuring increase in E-cadherin expression after 72 hrs by Hoechst 33342 staining based mCherryRFP reporter gene assay
- ChEMBL_987932 (CHEMBL2438239) Inhibition of Clostridium botulinum A Hall BoNT LC/A in human induced pluripotent stem cell-derived neurons assessed as inhibition of intracellular SNAP-25 cleavage after 8 hrs by Western blot analysis
- ChEMBL_2186031 (CHEMBL5098113) Partial agonist activity at wild type CB2 receptor (unknown origin) stably expressed in HEK293T assessed as decrease in forskolin induced cAMP level preincubated for 15 mins followed by forskolin addition incubated for 15 mins in presence of cannabidiol by HTRF assay
- ChEMBL_2186036 (CHEMBL5098118) Partial agonist activity at CBR2 V1133.32M mutant (unknown origin) stably expressed in HEK293T assessed as decrease in forskolin induced cAMP level preincubated for 15 mins followed by forskolin addition incubated for 15 mins in presence of cannabidiol by HTRF assay
- ChEMBL_2186042 (CHEMBL5098124) Partial agonist activity at CBR2 V361.35M mutant (unknown origin) stably expressed in HEK293T assessed as decrease in forskolin induced cAMP level preincubated for 15 mins followed by forskolin addition incubated for 15 mins in presence of cannabidiol by HTRF assay
- ChEMBL_2186049 (CHEMBL5098131) Partial agonist activity at CBR2 A2827.36M mutant (unknown origin) stably expressed in HEK293T assessed as decrease in forskolin induced cAMP level preincubated for 15 mins followed by forskolin addition incubated for 15 mins in presence of cannabidiol by HTRF assay
- ChEMBL_2186055 (CHEMBL5098137) Partial agonist activity at CBR2 S2857.39L mutant (unknown origin) stably expressed in HEK293T assessed as decrease in forskolin induced cAMP level preincubated for 15 mins followed by forskolin addition incubated for 15 mins in presence of cannabidiol by HTRF assay
- HIF-1alpha transactivation assays HaCaT-EPO-Luc cells were maintained at 37° C. in a humidified atmosphere containing 5% CO2 in DMEM supplemented with 10% fetal calf serum (FBS), and 1% (v/v) penicillin/streptomycin. The cells (1×105/well in 24-well plates) were seeded the day before the assay and then stimulated with increasing concentrations of either Cannabidiol (CBD), VCE-004 or compounds II to X. After six hours of stimulation the cells were lysed in 25 mM Tris-phosphate pH 7.8, 8 mM MgCi2, 1 mM DTT, 1% Triton X-100, and 7% glycerol during 15 min at RT in a horizontal shake. Luciferase activity was measured in the cell lysates as indicated for NIH3T3-EPO-Luc cells. The RLUs are calculated and the EC50 and IRA (Intrinsic relative activity) values in both cell lines were determined relative to 150 μM deferoxamine (DFX) using the following equation: IRA coefficient=(EC50-DFX×Emax)/(EC50×Emax-DFX), where EC50 and Emax denote EC50 and Emax of the agonist, and EC50-DFX and Emax-DFX denote EC50 and Emax values of the standard agonist DFX.
- ChEMBL_1899714 (CHEMBL4401829) Inhibition of dephosphorylated IRE1alpha (G547 to L977 residues) (unknown origin) -dependent cleavage of FAM-labeled stem-loop RNA containing the XBP1 cleavage site preincubated for 30 mins followed by RNA XBP1 substrate addition and measured after 15 mins by FRET assay
- ChEMBL_1899749 (CHEMBL4401864) Activation of dephosphorylated IRE1alpha (G547 to L977 residues) (unknown origin)-dependent cleavage of FAM-labeled stem-loop RNA containing the XBP1 cleavage site preincubated for 30 mins followed by RNA XBP1 substrate addition and measured after 15 mins by FRET assay
- ChEMBL_549611 (CHEMBL1016757) Inhibition of LFA1/ICAM1-mediated adhesion of HL60 cells to CHO-ICAM1 cells
- ChEMBL_930033 (CHEMBL3074514) Inhibition of 5-lipoxygenase in Rattus norvegicus Rat basophil leukemia cells (RBL) cells
- ChEMBL_2272231 Inhibition of HIV1 gp120-mediated cell-cell fusion between HIV1 ADA infected human H9 cells to human TZM-bl cells transmitting cells treated for 1 hr followed by washout cells incubated 24 hrs with acceptor cells by luciferase reporter gene based CXCR4 tropic assay
- ChEMBL_633352 (CHEMBL1120572) Inhibition of integrin alpha-V-beta-3-mediated adhesion of human cells M21 cells
- ChEMBL_2272232 Inhibition of HIV1 gp120-mediated cell-cell fusion between HIV1 3B infected human MOLT-4 cells to human TZM-bl cells transmitting cells treated for 1 hr followed by washout cells incubated 24 hrs with acceptor cells by luciferase reporter gene based CCR5 tropic assay
- ChEMBL_1892160 (CHEMBL4394081) Inhibition of human COX2 expressed in CHO cells cells assessed as reduction in PGE2 release
- ChEBML_155244 Inhibition plasmin in human mast cells
- ChEMBL_2275083 Inhibition of IDO1 in HEK293 cells
- ChEMBL_2346257 Inhibition of VEGFR2 in HUVEC cells
- ChEMBL_2374863 Inhibition of IDO1 in HEK293 cells
- ChEMBL_2433794 Inhibition of ASK1 in HEK293 cells
- ChEMBL_2434297 Inhibition of BRD4 in HEK293T cells
- ChEMBL_2460957 Inhibition of human Endothelial cells eNOS
- ChEMBL_334417 (CHEMBL864331) cAMP elevation in U937 cells
- Ray2010 Assay 10 HEK-mu cells [21].
- Ray2010 Assay 26 ketanserin Gf-6 cells .
- ChEMBL_38702 (CHEMBL651598) Inhibition of Ras farnesylation in Human Ha-Ras oncogene-transformed BALB/c 3T3 cells (EJ3 cells)
- ChEMBL_663470 (CHEMBL1251069) Displacement of [3H]8-OH-DPAT from human adrenergic 5HT1A expressed in human HeLa cells cells
- ChEMBL_1926632 (CHEMBL4429704) Inhibition of JAK2 V617F mutant expressed in mouse BaF3 cells cells assessed as reduction in cell viability
- ChEMBL_861676 (CHEMBL2173013) Inhibition of SYK in human B-cells cells assessed as reduction in FcepsilonR1/FcgammaR-mediated signaling responses
- ChEBML_208498 Inhibition of thrombin in human mast cells
- ChEBML_225607 Inhibition of thymidylate synthase from L1210 cells
- ChEBML_99371 Inhibition of EGFR phosphorylation in LoVo cells
- ChEMBL_1753711 (CHEMBL4188471) Inhibition of BACE1 in HEK293 cells
- ChEMBL_1856593 (CHEMBL4357322) Inhibition of COX2 human HCA7 cells
- ChEMBL_1989559 (CHEMBL4623294) Inhibition of mTOR in HEK293 cells
- ChEMBL_2025274 (CHEMBL4679087) Inhibition of TDO in HEK cells
- ChEMBL_2025562 (CHEMBL4679375) Inhibition of TDO in HEK cells
- ChEMBL_2185245 (CHEMBL5097327) Activation of ERK5 in MEF cells
- ChEMBL_2185548 (CHEMBL5097630) Inhibition of MNK1 in HEK293 cells
- ChEMBL_2194158 (CHEMBL5106518) Inhibition of SSAO in HMEC cells
- ChEMBL_2220399 (CHEMBL5133733) Activation of Nrf2 in HEK293T cells
- ChEMBL_2261285 (CHEMBL5216296) Inhibition of IDO1 in HEK293 cells
- ChEMBL_2261488 (CHEMBL5216499) Inhibition of ABCG2 in HEK293 cells
- ChEMBL_2275080 Inhibition of IDO1 in human HeLa cells
- ChEMBL_2276102 Agonist activity at FXR in HEK293 cells
- ChEMBL_2278138 Inhibition of FGFR4 in mouse BaF3 cells
- ChEMBL_2279095 Inhibition of CYP17AI in human LNCaP cells
- ChEMBL_2279096 Inhibition of CYP17AI in human 22Rv1 cells
- ChEMBL_2281667 Inhibition of HDAC in human HeLa cells
- ChEMBL_2281668 Inhibition of HDAC in human K562 cells
- ChEMBL_2283142 Inhibition of FNIP1 in human HEK293T cells
- ChEMBL_2302774 Inhibition of GSG in mouse MEB5 cells
- ChEMBL_2321785 Inhibition of XPO1 in human HPBALL cells
- ChEMBL_2336435 Inhibition of ABCB1 in human HEK293 cells
- ChEMBL_2346017 Inhibition of HDAC1 in human K562 cells
- ChEMBL_2346018 Inhibition of HDAC2 in human K562 cells
- ChEMBL_2346231 Inhibition of ABL1 in human HeLa cells
- ChEMBL_2350643 Inhibition of human RSK2 in MCF7 cells
- ChEMBL_2355762 Inhibition of human NOX2 in PBMC cells
- ChEMBL_2374864 Inhibition of IDO1 in human HeLa cells
- ChEMBL_2424421 Inhibition of BTK in human Ramos cells
- ChEMBL_2434265 Inhibition of AKT in human SW620 cells
- ChEMBL_2434370 Inhibition of MCT1 in rat RBE4 cells
- ChEMBL_2434525 Inhibition of STS in human MCF7 cells
- ChEMBL_2460958 Inhibition of mouse iNOS in RAW264.7 cells
- ChEMBL_2463645 Inhibition of GCN2 in human MOLM16 cells
- ChEMBL_2463646 Inhibition of MAP2K5 in human MOLM16 cells
- ChEMBL_2463647 Inhibition of NEK1 in human MOLM16 cells
- ChEMBL_2463648 Inhibition of PEK in human MOLM16 cells
- ChEMBL_2463649 Inhibition of PIK3C2B in human MOLM16 cells
- ChEMBL_2463650 Inhibition of RIPK2 in human MOLM16 cells
- ChEMBL_2463651 Inhibition of RIPK3 in human MOLM16 cells
- ChEMBL_2463652 Inhibition of ZAK in human MOLM16 cells
- ChEMBL_2467276 Inhibition of human NAMPT in A2780 cells
- ChEMBL_2488426 Inhibition of PI3Kalpha in human T47D cells
- ChEMBL_2490820 Inhibition of NRF2 in human A549 cells
- ChEMBL_2491657 Inhibition of CSF1R in mouse BMDM cells
- ChEMBL_2504839 Inhibition of KDR in human HUVEC cells
- ChEMBL_2574534 Inhibition of JAK1 in mouse BaF3 cells
- ChEMBL_2574535 Inhibition of JAK2 in mouse BaF3 cells
- ChEMBL_2574536 Inhibition of JAK3 in mouse BaF3 cells
- ChEMBL_2574537 Inhibition of TYK2 in mouse BaF3 cells
- ChEMBL_365495 (CHEMBL867911) Degradation of Her2 in SKBR3 cells
- ChEMBL_365496 (CHEMBL867912) Degradation of Her2 in SKOV3 cells
- ChEMBL_365497 (CHEMBL867913) Upregulation of Hsp70 in SKBR3 cells
- ChEMBL_365498 (CHEMBL867914) Upregulation of Hsp70 in SKOV3 cells
- ChEMBL_375289 (CHEMBL865405) Transactivation of PPARgamma in CV1 cells
- ChEMBL_438576 (CHEMBL887681) Inhibition of erbB2 in NH3T3 cells
- ChEMBL_440468 (CHEMBL890784) Inhibition of HDAC1 in HeLa cells
- ChEMBL_440469 (CHEMBL890785) Inhibition of HDAC3 in HeLa cells
- ChEMBL_442378 (CHEMBL892540) Antiproliferative activity against human HCT116 cells
- ChEMBL_442379 (CHEMBL892541) Antiproliferative activity against human H460a cells
- ChEMBL_442380 (CHEMBL892542) Antiproliferative activity against human SW480 cells
- ChEMBL_442381 (CHEMBL892543) Antiproliferative activity against human MDA435 cells
- ChEMBL_442382 (CHEMBL892544) Antiproliferative activity against human SJSA1 cells
- ChEMBL_442383 (CHEMBL892545) Antiproliferative activity against human RKO cells
- ChEMBL_443489 (CHEMBL893747) Inhibition of KSP in KB31 cells
- ChEMBL_448858 (CHEMBL898004) Inhibition of HDAC in HeLa cells
- ChEMBL_729919 (CHEMBL1695273) Inhibition of VEGFR2 expressed HEK293 cells
- ChEMBL_874976 (CHEMBL2183852) Inhibition of BACE1 in HEK293 cells
- ChEBML_1724 Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)
- ChEMBL_1828972 (CHEMBL4328846) Inhibition of HIV1 gp41-induced cell-cell fusion between viral protein expressing human HL2/3 cells and TZM-bl target cells preincubated overnight with TZM-bl cells followed by co-incubation with HL2/3 cells for 6 hrs by luciferase reporter gene assay
- Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, CA) Network: NIH Molecular Libraries Probe Production Centers Network (MLPCN) Grant Number: 1 R03 DA030556-01A1 Assay Provider: Dr. Yan Jessie Zhang, University of Texas, Austin, TX Human Scp phosphatases are regulators involved in neuronal gene silencing. This family of phosphatases exhibits specificity for phosphoryl-Ser5 in the heptad repeats of the C-terminal domain of RNA polymerase II (RNA Pol II) and thus inhibit initiation of transcription [1, 2]. Scps strongly associate with the REST/NRSF neuronal silencing complex that functions to inhibit transcription of neuronal genes in neuronal stem cells and in nonneuronal tissues [1]. Inhibition of Scps by dominant negative forms of the enzyme or by premature expression of the nervous system-specific microRNA miR-124, results in differentiation of neuronal stem cells into mature neurons [
- ChEMBL_1724 (CHEMBL616929) Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)
- ChEMBL_32455 (CHEMBL643403) Inhibition of [3H]-prazosin binding to cloned human Alpha-1D adrenergic receptor in CHO cells (chinese hamster ovary cells)
- ChEMBL_33743 (CHEMBL647058) Inhibition of [3H]prazosin binding to cloned human Alpha-1A adrenergic receptor in CHO cells (chinese hamster ovary cells)
- ChEMBL_34461 (CHEMBL651993) Inhibition of [3H]prazosin binding to cloned human Alpha-1B adrenergic receptor in CHO cells (chinese hamster ovary cells)
- ChEMBL_34462 (CHEMBL651994) Inhibition of [3H]-prazosin binding to cloned human Alpha-1B adrenergic receptor in CHO cells (chinese hamster ovary cells)
- ChEMBL_446249 (CHEMBL895354) Inhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate cells
- ChEMBL_556464 (CHEMBL955681) Antagonist activity at human adenosine A3 cells expressed in CHO cells assessed as inhibition of NECA-induced cAMP accumulation
- ChEMBL_65110 (CHEMBL674009) Inhibition of EGF-stimulated DNA synthesis in ER22 cells, by measuring [3H]Me-dT incorporation into ER 22 cells
- ChEMBL_2117951 (CHEMBL4827017) Agonist activity at RORgammat in C57 mouse CD4+ T cells cells assessed as induction of Th17 cells differentiation by measuring increase in IL17 production measured after 4 days by flow cytometry analysis
- ChEMBL_540889 (CHEMBL1026563) Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
- ChEMBL_541079 (CHEMBL1034062) Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
- ChEMBL_543512 (CHEMBL1019461) Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
- Cell-Based Phosho-ERK Assay Mutant BRAF WM266.4 Cells.
- ChEBML_154440 Inhibition of HDJ2 farnesylation in PSN-1 cells
- ChEBML_1662802 Inhibition of human CYP11B1 expressed in HEK293A cells
- ChEBML_1680152 Inhibition of human PDE4A4 expressed in sf9 cells
- ChEBML_1680153 Inhibition of human PDE4B1 expressed in sf9 cells
- ChEBML_1680154 Inhibition of human PDE4C1 expressed in sf9 cells
- ChEBML_1680156 Inhibition of human PDE4D3 expressed in sf9 cells
- ChEBML_216837 Inhibition of c-Kit autophosphorylation in intact cells
- ChEBML_54593 Inhibition of Dihydrofolate reductase in mouse L1210 cells
- ChEBML_64453 Inhibition of EGF-receptor autophosphorylation in intact cells
- ChEBML_90259 Inhibition of insulin beta-R in HepG2 cells
- ChEMBL_1276354 (CHEMBL3088372) Inhibition of FMS in mouse BMDM cells
- ChEMBL_1285181 (CHEMBL3106971) Inhibition of aromatase in human MCF7 cells
- ChEMBL_1350728 (CHEMBL3266113) Inhibition of MEK1 in human COLO205 cells
- ChEMBL_1350729 (CHEMBL3266114) Inhibition of MEK1 in human HCT116 cells
- ChEMBL_1350730 (CHEMBL3266115) Inhibition of MEK1 in human A549 cells
- ChEMBL_1467952 (CHEMBL3413309) Inhibition of KMO in rat microglia cells
- ChEMBL_1514949 (CHEMBL3615815) Inhibition of STS in human MCF7 cells
- ChEMBL_155720 (CHEMBL760598) Inhibition of PDE4 enzyme from U937 cells
- ChEMBL_155721 (CHEMBL760599) Inhibition of phosphodiesterase 4 from U937 cells
- ChEMBL_157048 (CHEMBL765691) Inhibition of PDE4 from U937 monocytic cells
- ChEMBL_1580725 (CHEMBL3811330) Inhibition of AXL in human GIST cells
- ChEMBL_158266 (CHEMBL762446) Inhibition of cyclooxygenase from RBL-1 cells.
- ChEMBL_1589968 (CHEMBL3831057) Inhibition of CYP2C19 in human TC5 cells
- ChEMBL_1589969 (CHEMBL3831058) Inhibition of CYP2C9 in human TC5 cells
- ChEMBL_1589970 (CHEMBL3831059) Inhibition of CYP2D6 in human TC5 cells
- ChEMBL_1589971 (CHEMBL3831060) Inhibition of CYP3A4 in human TC5 cells
- ChEMBL_1656350 (CHEMBL4005820) Inhibition of STS in human MCF7 cells
- ChEMBL_1750396 (CHEMBL4185156) Inhibition of APE1 in human HeLa cells
- ChEMBL_1776178 (CHEMBL4233170) Inhibition of ACAT1 in mouse J774 cells
- ChEMBL_1799004 (CHEMBL4271296) Inhibition of PAK1 in human A549 cells
- ChEMBL_1800849 (CHEMBL4273141) Inhibition of TrxR in human SGC7901 cells
- ChEMBL_1801908 (CHEMBL4274200) Inhibition of EGFR in human HepG2 cells
- ChEMBL_1829775 (CHEMBL4329649) Inhibition of PLD1 in human Calu1 cells
- ChEMBL_1830573 (CHEMBL4330581) Inhibition of CYP1B1 in human HepG2 cells
- ChEMBL_1838985 (CHEMBL4339118) Inhibition of TDO in human HEK cells
- ChEMBL_1839556 (CHEMBL4339771) Transactivation of PXR in human HepG2 cells
- ChEMBL_1843573 (CHEMBL4344000) Inhibition of STING in human THP1 cells
- ChEMBL_1843599 (CHEMBL4344026) Activation of HIF1 in human T47D cells
- ChEMBL_1848923 (CHEMBL4349464) Inhibition of NTRK1 in human KM12 cells
- ChEMBL_1850434 (CHEMBL4351058) Inhibition of FGFR4 in mouse BAF3 cells
- ChEMBL_1850463 (CHEMBL4351087) Inhibition of PI3Kdelta in human B-cells
- ChEMBL_1850465 (CHEMBL4351089) Inhibition of PI3Kdelta in human Pfeiffer cells
- ChEMBL_1850487 (CHEMBL4351111) Inhibition of PI3Kdelta in human Neutrophil cells
- ChEMBL_1850488 (CHEMBL4351112) Inhibition of PI3Kgamma in human Neutrophil cells
- ChEMBL_1850492 (CHEMBL4351116) Inhibition of PI3Kdelta in human Raji cells
- ChEMBL_1850493 (CHEMBL4351117) Inhibition of PI3Kgamma in human Raji cells
- ChEMBL_1850502 (CHEMBL4351126) Inhibition of PI3Kdelta in human SUDHL6 cells
- ChEMBL_1850503 (CHEMBL4351127) Inhibition of PI3Kgamma in human SUDHL6 cells
- ChEMBL_1896393 (CHEMBL4398428) Inhibition of RAF1 in human MCF7 cells
- ChEMBL_1896414 (CHEMBL4398449) Inhibition of ERalpha in human MCF7 cells
- ChEMBL_1896416 (CHEMBL4398451) Inhibition of ERbeta in human MCF7 cells
- ChEMBL_1908902 (CHEMBL4411348) Inhibition of tyrosinase in mouse B16 cells
- ChEMBL_1922274 (CHEMBL4425230) Inhibition of Hsp90 in human MG63 cells
- ChEMBL_1922276 (CHEMBL4425232) Inhibition of Hsp90 in human SKBR3 cells
- ChEMBL_1928127 (CHEMBL4431199) Inhibition of sPLA2 in human HepG2 cells
- ChEMBL_1934532 (CHEMBL4480184) Inhibition of FAK in human MCF7 cells
- ChEMBL_1973105 (CHEMBL4605923) Inhibition of arginase1 in mouse BMDM cells
- ChEMBL_1977524 (CHEMBL4610659) Inhibition of HDAC in human A2780 cells
- ChEMBL_1977526 (CHEMBL4610661) Inhibition of HDAC in human Cal27 cells
- ChEMBL_1980318 (CHEMBL4613580) Activation of p53 in human SMMC7721 cells
- ChEMBL_1980319 (CHEMBL4613581) Activation of Bax in human SMMC7721 cells
- ChEMBL_1982473 (CHEMBL4615735) Inhibition of HDAC1 in mouse N2A cells
- ChEMBL_1982474 (CHEMBL4615736) Inhibition of HDAC6 in mouse N2A cells
- ChEMBL_1986808 (CHEMBL4620355) Inhibition of IDO1 in human HeLa cells
- ChEMBL_2025275 (CHEMBL4679088) Inhibition of IDO1 in human SKOV3 cells
- ChEMBL_2025561 (CHEMBL4679374) Inhibition of IDO1 in human SKOV3 cells
- ChEMBL_2046569 (CHEMBL4701268) Transactivation of PXR in human HepG2 cells
- ChEMBL_206637 (CHEMBL810154) Inhibition against Swiss 3T3 murine fibroblast cells.
- ChEMBL_2078885 (CHEMBL4734676) Inhibition of IDO1 in human HeLa cells
- ChEMBL_210696 (CHEMBL817294) Inhibition of Tryptase in human mast cells
- ChEMBL_2116013 (CHEMBL4824954) Inhibition of Axl in mouse BaF3 cells
- ChEMBL_2116014 (CHEMBL4824955) Inhibition of Mer in mouse BaF3 cells
- ChEMBL_2119346 (CHEMBL4828412) Inhibition of IDO1 in human HeLa cells
- ChEMBL_212683 (CHEMBL815468) Inhibition of trypsin in human mast cells
- ChEMBL_2149260 (CHEMBL5033658) Inhibition of IDO1 in human HeLa cells
- ChEMBL_2152616 (CHEMBL5037163) Inhibition of hERG expressed in HEK293 cells
- ChEMBL_2201646 (CHEMBL5114354) Inhibition of SCD in human HepG2 cells
- ChEMBL_2224445 (CHEMBL5137958) Inhibition of IDO1 in human HeLa cells
- ChEMBL_2236228 (CHEMBL5150124) Inhibition of CDK1 in human A549 cells
- ChEMBL_2236229 (CHEMBL5150125) Inhibition of CDK2 in human A549 cells
- ChEMBL_2236230 (CHEMBL5150126) Inhibition of CDK3 in human A549 cells
- ChEMBL_2252727 (CHEMBL5166937) Inhibition of notum in human SW620 cells
- ChEMBL_2261257 (CHEMBL5216268) Inhibition of IDO1 in human HeLa cells
- ChEMBL_2266738 Inhibition of nSMase in human U-937 cells
- ChEMBL_2267435 Inhibition of human IGF1R expressed in SUM149 cells
- ChEMBL_2268379 Inhibition of Gal4-fused Nur77 in HEK293T cells
- ChEMBL_2268545 Inhibition of aromatase in human JEG-3 cells
- ChEMBL_2272638 Inhibition of human G9a expressed in HEK293 cells
- ChEMBL_2276099 Agonist activity at FXR2 in human HepG2 cells
- ChEMBL_2279105 Inhibition of AR LBD in human LNCaP cells
- ChEMBL_2283137 Induction of BRD4 degradation in human 231MFP cells
- ChEMBL_2287254 Antagonist activity at FXR in human HepG2 cells
- ChEMBL_2304143 Agonist activity at PPARalpha in human HepG2 cells
- ChEMBL_2304144 Agonist activity at PPARgamma in human HepG2 cells
- ChEMBL_2311805 Inhibition of AAK1 expressed in human HEK293K cells
- ChEMBL_2319008 Inhibition of FLT3 in human MOLM-13 cells
- ChEMBL_2321001 Inhibition of EGFR in human NCI-H1975 cells
- ChEMBL_2321784 Inhibition of XPO1 in human MOLT-16 cells
- ChEMBL_2323232 Induction of AR degradation in human LNCaP cells
- ChEMBL_2323233 Induction of AR degradation in human VCaP cells
- ChEMBL_2327415 Inhibition of human G9a expressed in HEK293 cells
- ChEMBL_2339740 Induction of ERalpha degradation in human MCF7 cells
- ChEMBL_2340140 Inhibition of recombinant human SLC13A5 in HEK293T cells
- ChEMBL_2342480 Inhibition of LRRK2 G2019S mutant in HEK293 cells
- ChEMBL_2344031 Inhibition of 5-LOX in human PMNL cells
- ChEMBL_2346229 Inhibition of eIF4E phosphorylation in human HeLa cells
- ChEMBL_2346461 Inhibition of ERK2 phosphorylation in human A549 cells
- ChEMBL_2349658 Inhibition of arginase 2 in human LNCaP cells
- ChEMBL_2369814 Induction of NAMPT degradation in human A2780 cells
- ChEMBL_2375095 Activation of human TRPV1 expressed in HEK293F cells
- ChEMBL_2434375 Inhibition of MCT1 in human DLD-1 cells
- ChEMBL_2444428 Inhibition of CPT1B (unknown origin) in KB cells
- ChEMBL_2453930 Inhibition of 5-LOX in human PMNL cells
- ChEMBL_2460938 Inhibition of 5-LOX in human PMNL cells
- ChEMBL_2467336 Inhibition of WRN in human HCT-116 cells
- ChEMBL_2471386 Induction of ERalpha degradation in human MCF7 cells
- ChEMBL_2479769 Inhibition of human METTL3 expressed in HeLa cells
- ChEMBL_2490819 Inhibition of NRF2 in human KYSE-70 cells
- ChEMBL_2499076 Inhibition of tyrosinase in human MNT-1 cells
- ChEMBL_2504782 Inhibition of human KCNK13 transfected in HEK293 cells
- ChEMBL_2504783 Inhibition of mouse KCNK13 transfected in HEK293 cells
- ChEMBL_2526113 Inhibition of EGFR expressed in mouse NIH3T3 cells
- ChEMBL_2526114 Inhibition of ERBB2 expressed in mouse NIH3T3 cells
- ChEMBL_304761 (CHEMBL829358) Inhibitory concentration against Adenosine Kinase (intact cells)
- ChEMBL_305922 (CHEMBL833469) Inhibition of TNFalpha expression in U937 cells
- ChEMBL_310170 (CHEMBL824826) Reduced farnesylation in H-Ras NIH3T3 cells
- ChEMBL_312368 (CHEMBL837481) Inhibition of TNFalpha expression in U937 cells
- ChEMBL_333862 (CHEMBL864091) Activity at LPA1 receptor transfected RH7777 cells
- ChEMBL_333863 (CHEMBL865901) Activity at LPA2 receptor transfected RH7777 cells
- ChEMBL_333864 (CHEMBL865902) Activity at LPA3 receptor transfected RH7777 cells
- ChEMBL_338348 (CHEMBL865333) Efficacy against TRAF-alpha-1 reporter cells
- ChEMBL_338350 (CHEMBL865335) Efficacy against TRAF-beta-1 reporter cells
- ChEMBL_339196 (CHEMBL867749) Inhibition of EGFR autophosphorylation in DiFi cells
- ChEMBL_357668 (CHEMBL854264) Inhibition of endogenous FLT3 in EOL1 cells
- ChEMBL_360913 (CHEMBL870879) Inhibition of alphavbeta6 integrin in HT29 cells
- ChEMBL_425031 (CHEMBL912552) Activity at human PPARgamma in CV1 cells
- ChEMBL_425035 (CHEMBL912556) Activity at human PPARalpha in CV1 cells
- ChEMBL_438142 (CHEMBL887273) Inhibition of IGF1R expressed in Sal cells
- ChEMBL_438575 (CHEMBL887682) Inhibition of erbB2 expressed in Sf9 cells
- ChEMBL_440733 (CHEMBL889830) Inhibition of BACE expressed in HEK293 cells
- ChEMBL_440843 (CHEMBL889938) Inhibition of JAK3 expressed in Sf21 cells
- ChEMBL_444045 (CHEMBL893213) Inhibition of MMP2 expressed in insect cells
- ChEMBL_444090 (CHEMBL893253) Inhibition of BACE2 expressed in HEK293 cells
- ChEMBL_445497 (CHEMBL895788) Inhibition of recombinant HDAC1 in HeLa cells
- ChEMBL_450016 (CHEMBL899112) Inhibition of CDK1 expressed in Sf21 cells
- ChEMBL_453677 (CHEMBL885678) Inhibition of ICMT expressed in Sf9 cells
- ChEMBL_455801 (CHEMBL887807) Inhibition of RET in mouse NIH3T3MEN2A cells
- ChEMBL_457184 (CHEMBL941658) Inhibition IGF1R phosphorylation in human MiaPaCa2 cells
- ChEMBL_457215 (CHEMBL940816) Inhibition of tyrosinase in Melan-a cells
- ChEMBL_457444 (CHEMBL941016) Inhibition of hERG expressed in HEK cells
- ChEMBL_458313 (CHEMBL925644) Inhibition of PTP1B expressed in Sf9 cells
- ChEMBL_461211 (CHEMBL926150) Inhibition of HDAC1 expressed in 293T cells
- ChEMBL_461212 (CHEMBL926151) Inhibition of HDAC4 expressed in 293T cells
- ChEMBL_461213 (CHEMBL926152) Inhibition of HDAC6 expressed in 293T cells
- ChEMBL_461927 (CHEMBL944774) Inhibition of transketolase in human HCT116 cells
- ChEMBL_462590 (CHEMBL928516) Inhibition of IGF1R expressed in SAL cells
- ChEMBL_464968 (CHEMBL947140) Inhibition of HDAC1 from human HeLa cells
- ChEMBL_465841 (CHEMBL950125) Inhibition of human HDAC in HeLa cells
- ChEMBL_468405 (CHEMBL934305) Inhibition of human transketolase in HCT116 cells
- ChEMBL_468615 (CHEMBL947912) Inhibition of transketolase in human HCT116 cells
- ChEMBL_473651 (CHEMBL937669) Inhibition of bPDGFR in human PAC1 cells
- ChEMBL_473674 (CHEMBL921718) Inhibition of human VEGFR1 in HUVEC cells
- ChEMBL_473675 (CHEMBL921717) Inhibition of human VEGFR2 in HUVEC cells
- ChEMBL_475569 (CHEMBL921401) Inhibition of human HDAC in HeLa cells
- ChEMBL_492193 (CHEMBL951569) Inhibition of human PDE4B in Sf9 cells
- ChEMBL_492887 (CHEMBL942218) Inhibition of Hsp90 in human A2058 cells
- ChEMBL_492908 (CHEMBL945296) Inhibition of iNOS in mouse ANA1 cells
- ChEMBL_497566 (CHEMBL998623) Inhibition of PLD1 in human Calu1 cells
- ChEMBL_506200 (CHEMBL941404) Inhibition of EGFR in human A431 cells
- ChEMBL_511280 (CHEMBL996935) Inhibition of CYP26A1 in human MCF7 cells
- ChEMBL_531102 (CHEMBL976910) Inhibition of human Her2 in SKBR3 cells
- ChEMBL_531103 (CHEMBL976911) Inhibition of human Her2 in BT474 cells
- ChEMBL_531104 (CHEMBL977765) Inhibition of human Her2 in A431 cells
- ChEMBL_531105 (CHEMBL977766) Inhibition of human Her2 in SW620 cells
- ChEMBL_540911 (CHEMBL1027336) Inhibition of ACAT in human HepG2 cells
- ChEMBL_543920 (CHEMBL1020355) Inhibition of Her2 in human SKBR3 cells
- ChEMBL_561225 (CHEMBL1012771) Inhibition of 5-LO in PMNL cells
- ChEMBL_566795 (CHEMBL957604) Inhibition of human PLD1 in Calu1 cells
- ChEMBL_571846 (CHEMBL1034714) Inhibition of HDAC2 in human HeLa cells
- ChEMBL_572012 (CHEMBL1023674) Inhibition of human ERG in MCF7 cells
- ChEMBL_579847 (CHEMBL1062386) Inhibition of CYP2C19 in human TC5 cells
- ChEMBL_579848 (CHEMBL1062387) Inhibition of CYP2D6 in human TC5 cells
- ChEMBL_579855 (CHEMBL1063241) Inhibition of CYP2C9 in human TC5 cells
- ChEMBL_579880 (CHEMBL1063266) Inhibition of CYP3A4 in human TC5 cells
- ChEMBL_604755 (CHEMBL1072549) Inhibition of CXCR3 in human T cells
- ChEMBL_604756 (CHEMBL1072550) Inhibition of CXCR4 in human T cells
- ChEMBL_608836 (CHEMBL1069055) Inhibition of CHK2 in human HT29 cells
- ChEMBL_612148 (CHEMBL1073570) Inhibition of PARP1 in human C41 cells
- ChEMBL_652152 (CHEMBL1228261) Inhibition of IGF1R in IGF1R-SAL cells
- ChEMBL_654655 (CHEMBL1243699) Inhibition of UCHL1 in human H1299 cells
- ChEMBL_654656 (CHEMBL1243700) Inhibition of UCHL3 in human H1299 cells
- ChEMBL_662818 (CHEMBL1252218) Inhibition of CYP24A1 expressed in CHO cells
- ChEMBL_662819 (CHEMBL1252219) Inhibition of CYP27A1 expressed in CHO cells
- ChEMBL_663402 (CHEMBL1250950) Inhibition of PLD1 in human calu1 cells
- ChEMBL_684653 (CHEMBL1285620) Inhibition of GluR4 expressed in HEK293 cells
- ChEMBL_684654 (CHEMBL1285621) Inhibition of GluR1 expressed in HEK cells
- ChEMBL_684657 (CHEMBL1285624) Inhibition of rat recombinant GluR4 in cells
- ChEMBL_684662 (CHEMBL1285629) Inhibition of GluR3 expressed in HEK cells
- ChEMBL_686273 (CHEMBL1293029) Inhibition of PSMA in human LNCaP cells
- ChEMBL_729862 (CHEMBL1695216) Activation of CCR5 in human PBMC cells
- ChEMBL_771238 (CHEMBL1839320) Inhibition of SCD1 in human HepG2 cells
- ChEMBL_771247 (CHEMBL1839329) Inhibition of SCD1 in rat Hep cells
- ChEMBL_810825 (CHEMBL2016219) Inhibition of human Erg expressed CHO cells
- ChEMBL_827456 (CHEMBL2051313) Inhibition of GSK3B in human Rd cells
- ChEMBL_830680 (CHEMBL2061615) Inhibition of NRAMP1 expressed in CHO cells
- ChEMBL_836523 (CHEMBL2077053) TP_TRANSPORTER: trans-stimulation in OAT1-COS7 cells
- ChEMBL_853105 (CHEMBL2154573) Inhibition of BACE by cells based assay
- ChEMBL_853423 (CHEMBL2155281) Inhibition of 11betaHSD1 expressed in HEK cells
- ChEMBL_857795 (CHEMBL2169038) Inhibition of FASN in human SKBR3 cells
- ChEMBL_857799 (CHEMBL2169042) Inhibition of FASN in human A375 cells
- ChEMBL_857802 (CHEMBL2169045) Inhibition of FASN in human HepG2 cells
- ChEMBL_864815 (CHEMBL2175304) Inhibition of telomerase in human U937 cells
- ChEMBL_872757 (CHEMBL2185582) Inhibition of BACE1 in human neuroblastoma cells
- ChEMBL_876774 (CHEMBL2183591) Inhibition of DGAT1 in human HuTu80 cells
- ChEMBL_887626 (CHEMBL2217235) Inhibition of RSK2 transfected in HEK293 cells
- ChEMBL_887638 (CHEMBL2217247) Inhibition of Btk in human Ramos cells
- ChEMBL_942123 (CHEMBL2341279) Inhibition of EGFR in human A431 cells
- ChEMBL_945805 (CHEMBL2339152) Inhibition of SCD1 in rat H42E cells
- ChEMBL_945806 (CHEMBL2339153) Inhibition of SCD1 in human HepG2 cells
- ChEMBL_949753 (CHEMBL2350851) Inhibition of SYK in human Ramos cells
- ChEMBL_961358 (CHEMBL2390685) Binding affinity to MC4R in HEK293 cells
- ChEMBL_977780 (CHEMBL2421001) Inhibition of NAMPT in human U87 cells
- ChEMBL_99370 (CHEMBL709030) Inhibition of Akt phosphorylation in LoVo cells
- ChEMBL_99373 (CHEMBL709033) Inhibition of MEK1 phosphorylation in LoVo cells
- ChEBML_209022 In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2
- ChEMBL_143025 (CHEMBL750039) Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
- ChEMBL_143234 (CHEMBL752377) Binding affinity against nicotinic acetylcholine receptor alpha2-beta4 using [3H]epibatidine as radioligand expressed in HEK293 cells or tsA cells
- ChEMBL_143411 (CHEMBL750054) Binding affinity against nicotinic acetylcholine receptor alpha3-beta4 using [3H]epibatidine as radioligand expressed in HEK293 cells or tsA cells
- ChEMBL_143881 (CHEMBL751864) Binding affinity against nicotinic acetylcholine receptor alpha4-beta2 using [3H]epibatidine as radioligand expressed in HEK293 cells or tsA cells
- ChEMBL_144019 (CHEMBL750434) Binding affinity against nicotinic acetylcholine receptor alpha4-beta4 using [3H]epibatidine as radioligand expressed in HEK293 cells or tsA cells
- ChEMBL_2493321 Inhibition of human CYP1B1 overexpressed in CHO cells assessed as protein catalyzed estradiol hydroxylation in living cells by measuring residual activity
- ChEMBL_320955 (CHEMBL885362) Binding affinity for 1 uM [3H]diprenorphine against human Opioid receptor kappa expressed in chinese hamster ovary cells (CHO cells)
- ChEMBL_559971 (CHEMBL1014570) Antagonist activity at human cloned adenosine A2B cells expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP production
- ChEMBL_2117948 (CHEMBL4827014) Inverse agonist activity at RORgammat in C57 mouse CD4+ T cells cells assessed as inhibition of Th17 cells differentiation by measuring decrease in IL17 production measured after 4 days by flow cytometry analysis
- ChEMBL_1513077 (CHEMBL3610414) Inhibition of CXCR4 assessed as reduction in fusion of human ACTOne-X4 cells as target cells expressing only CXCR4) with effector cells expressing HIV-8x envelope (CD4-independent requiring only CXCR4 and not CD4)
- ChEMBL_2132495 (CHEMBL4842010) Inhibition of PD-1/PD-L1 interaction in human Jurkat T cells expressing PD-1 cocultured with CHO cells expressing PD-Ll/TCR assessed as activation of Jurkat cells by luciferase reporter gene assay
- ChEMBL_935203 (CHEMBL2317572) Inhibition of LFA-1/ICAM-1 interaction in mouse Lim51b cells assessed as PMA-induced adhesion to ICAM-1 expressing HSE cells measured per 10'5 cells after 30 mins by fluorometric microplate reader analysis
- ChEMBL_1460689 (CHEMBL3396020) Displacement of [125I]NGF from full length human TrkA expressed in HEKN3S cells cells by gamma counting based radioligand competition assay
- ChEMBL_1693 (CHEMBL616900) Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)
- ChEMBL_1766804 (CHEMBL4202051) Inhibition of ALDH1A3 in human PEO1 cells assessed as reduction in aldefluor positive cells incubated for 30 mins by aldefluor assay
- ChEMBL_1766805 (CHEMBL4202052) Inhibition of ALDH1A3 in human OVCAR5 cells assessed as reduction in aldefluor positive cells incubated for 30 mins by aldefluor assay
- ChEMBL_2432505 Inhibition of protein-protein interaction of PD-1 (unknown origin) overexpressed in human Jurkat cells overexpressing NFAT/PD-L1 (unknown origin) overexpressed in CHO cells overexpressing TCR ligand preincubated with CHO cells for 0.5 hrs followed by Jurkat cells addition incubated for 5 hrs by luciferase reporter gene assay
- Antiviral Activity Assay Ec50 of SARS-CoV-infected VeroE6 cells.
- ChEBML_209808 Growth inhibition of thymidylate synthase(TS) in L1210 cells
- ChEBML_209977 Inhibitory activity against thymidylate synthase in murine tumor cells
- ChEBML_214866 Binding affinity towards Vasopressin V2 receptor in LLCPK cells
- ChEBML_216839 Inhibition of c-Met autophosphorylation of in intact cells
- ChEBML_225192 Inhibition of human sst1 receptor expressed in CHO cells
- ChEBML_225193 Inhibition of human sst2 receptor expressed in CHO cells
- ChEBML_225194 Inhibition of human sst3 receptor expressed in CHO cells
- ChEBML_225195 Inhibition of human sst4 receptor expressed in CHO cells
- ChEBML_225196 Inhibition of human sst5 receptor expressed in CHO cells
- ChEBML_3892 Inhibition of 5-Lipoxygenase of rat basophilic leukemia cells
- ChEBML_3971 Inhibition of 5-lipoxygenase in rat RBL-1 cells
- ChEBML_43647 In vitro inhibition of Ras processing in COS cells
- ChEBML_54443 Inhibition of dihydrofolate reductase (DHFR) from murine leukemia cells
- ChEBML_54447 Inhibition of dihydrofolate reductase(DHFR) from L1210/R81 cells
- ChEBML_64198 Antagonist activity against human ETA receptor using CHO cells
- ChEBML_665230 Inhibition of Rap1A geranylgeranylation expressed in mouse NIH3T3 cells
- ChEBML_72877 Inhibitory concentration against cAMP production in hGR-CHO cells
- ChEBML_78728 Transcriptional repression in HepG2 cells expressing human glucocorticoid receptor
- ChEBML_90654 Inhibition of IGF-receptor 1 autophosphorylation in intact cells
- ChEBML_99369 Inhibition of MEK-1 Kinase phosphorylation in LoVo cells
- ChEBML_99839 Inhibition of [3H]- LTB4 binding on human whole cells
- ChEMBL_1281035 (CHEMBL3100173) Inhibition of human ERG expressed in CHO cells
- ChEMBL_1285712 (CHEMBL3106822) Inhibition of 11beta-HSD1 in human HEK cells
- ChEMBL_1293690 (CHEMBL3123229) Inhibition of human ERG expressed in HEK293 cells
- ChEMBL_1293691 (CHEMBL3123230) Inhibition of human ERG expressed in CHO cells
- ChEMBL_1352588 (CHEMBL3265847) Inhibition of human ERG expressed in CHO cells
- ChEMBL_1432947 (CHEMBL3383922) Inhibition of 5-LO in rat RBL1 cells
- ChEMBL_1439893 (CHEMBL3388593) Inhibition of mPGES-1 in human A549 cells
- ChEMBL_145008 (CHEMBL756270) Efficacy for human ORL1 receptor expressing HEK293 cells
- ChEMBL_1456091 (CHEMBL3366822) Inhibition of human CYP11B2 expressed in G402 cells
- ChEMBL_1460642 (CHEMBL3395883) Inhibition of ATM kinase in human glioma cells
- ChEMBL_1474497 (CHEMBL3423786) Inhibition of human ERG expressed in CHO cells
- ChEMBL_1499717 (CHEMBL3585033) Inhibition of RON phosphorylation in human PC3 cells
- ChEMBL_1499718 (CHEMBL3585034) Inhibition of RON phosphorylation in human HT29 cells
- ChEMBL_151535 (CHEMBL762248) Inhibition of p56lck kinase autophosphorylation in Jurkat cells
- ChEMBL_1520985 (CHEMBL3624289) Activation of human Kv7.4 expressed in CHOK1 cells
- ChEMBL_1520990 (CHEMBL3624294) Activation of rat Kv7.4 expressed in CHOK1 cells
- ChEMBL_1521039 (CHEMBL3624470) Inhibition of EGFR phosphorylation in human H838 cells
- ChEMBL_1521447 (CHEMBL3627244) Inhibition of STS activity in human MCF7 cells
- ChEMBL_152445 (CHEMBL761270) Inhibition of PDGF-receptor autophosphorylation in intact cells
- ChEMBL_1543532 (CHEMBL3750533) Binding affinity to NPY1R in human MCF7 cells
- ChEMBL_1549436 (CHEMBL3755587) Inhibition of human ERG transfected in HEK293 cells
- ChEMBL_157035 (CHEMBL765678) Inhibition of Phosphodiesterase 4 from human U937 cells
- ChEMBL_157036 (CHEMBL765679) Inhibition of Phosphodiesterase 4 from human U937 cells
- ChEMBL_157039 (CHEMBL765682) Inhibition of Phosphodiesterase 4 from human U937 cells
- ChEMBL_157046 (CHEMBL765689) Inhibition of human phosphodiesterase 4 from U937 cells
- ChEMBL_157047 (CHEMBL765690) Inhibition of human phosphodiesterase 4 from U937 cells
- ChEMBL_157057 (CHEMBL769679) Inhibition of Phosphodiesterase 4 from human U937 cells
- ChEMBL_157197 (CHEMBL768610) Inhibition of phosphodiesterase 4 (PDE4) from U937 cells
- ChEMBL_1577317 (CHEMBL3808048) Inhibition of estrone sulfatase in human MCF7 cells
- ChEMBL_1584430 (CHEMBL3819973) Inhibition of POP (unknown origin) in living cells
- ChEMBL_160925 (CHEMBL767164) Cytotoxic activity in rat liver Huh-7 cells
- ChEMBL_1623178 (CHEMBL3865530) Inhibition of PAK1 phosphorylation in human MCF10A cells
- ChEMBL_1623179 (CHEMBL3865531) Inhibition of PAK1 phosphorylation in human OVCAR3 cells
- ChEMBL_1650134 (CHEMBL3999268) Inhibition of human ERG expressed in HEK293 cells
- ChEMBL_1662802 (CHEMBL4012483) Inhibition of human CYP11B1 expressed in HEK293A cells
- ChEMBL_1666588 (CHEMBL4016384) Inhibition of 11beta-HSD1 in mouse 3T3L1 cells
- ChEMBL_1667913 (CHEMBL4017801) Inhibition of human Nav1.7 expressed in HEK293 cells
- ChEMBL_1667914 (CHEMBL4017802) Inhibition of human Nav1.5 expressed in HEK293 cells
- ChEMBL_168 (CHEMBL615380) Inhibition of 1-lipoxygenase (LOX)in RBL cells
- ChEMBL_1680156 (CHEMBL4030433) Inhibition of human PDE4D3 expressed in sf9 cells
- ChEMBL_1722254 (CHEMBL4137254) Inhibition of human ERG expressed in CHO cells
- ChEMBL_1747458 (CHEMBL4181968) Inhibition of human CYP1A1 expressed in yeast cells
- ChEMBL_1747459 (CHEMBL4181969) Inhibition of human CYP1B1 expressed in yeast cells
- ChEMBL_1747460 (CHEMBL4181970) Inhibition of human CYP1A2 expressed in yeast cells
- ChEMBL_1747461 (CHEMBL4181971) Inhibition of human CYP2A6 expressed in yeast cells
- ChEMBL_1747462 (CHEMBL4181972) Inhibition of human CYP2B6 expressed in yeast cells
- ChEMBL_1747463 (CHEMBL4181973) Inhibition of human CYP2C8 expressed in yeast cells
- ChEMBL_1747464 (CHEMBL4181974) Inhibition of human CYP2E1 expressed in yeast cells
- ChEMBL_1747465 (CHEMBL4181975) Inhibition of human CYP2J2 expressed in yeast cells
- ChEMBL_1764016 (CHEMBL4199263) Inhibition of GSTO1-1 in human HeLa cells
- ChEMBL_1775324 (CHEMBL4232316) Inhibition of HER2 in human MCF-7 cells
- ChEMBL_1776289 (CHEMBL4233281) Inhibition of EGFR isolated from human A431 cells
- ChEMBL_1817411 (CHEMBL4317071) Inhibition of GSK3beta in human human MM1S cells
- ChEMBL_1829027 (CHEMBL4328901) Inhibition of COX-2 in human 143982 cells
- ChEMBL_1842486 (CHEMBL4342913) Inhibition of Aurora A in human MCF7 cells
- ChEMBL_1842487 (CHEMBL4342914) Inhibition of Aurora B in human MCF7 cells
- ChEMBL_1850461 (CHEMBL4351085) Inhibition of PI3Kdelta in human SU-DHL6 cells
- ChEMBL_1870043 (CHEMBL4371210) Inhibition of Src autophosphorylation in mouse GL261 cells
- ChEMBL_1874653 (CHEMBL4375942) Inhibition of AKT phosphorylation in human K562 cells
- ChEMBL_1876846 (CHEMBL4378240) Inhibition of ALK in mouse NIH-3T3 cells
- ChEMBL_1882417 (CHEMBL4383916) Inhibition of tyrosinase in mouse B16-F1 cells
- ChEMBL_1894956 (CHEMBL4396991) Inhibition of HIF-1alpha in human U373 cells
- ChEMBL_1896984 (CHEMBL4399019) Inhibition of steroid sulfatase in human MCF7 cells
- ChEMBL_196561 (CHEMBL802429) Binding affinity against L929 cells AdoHcy hydrolase activity
- ChEMBL_1973104 (CHEMBL4605922) Inhibition of arginase1 in human HEK 293 cells
- ChEMBL_1980320 (CHEMBL4613582) Activation of caspase 9 in human SMMC7721 cells
- ChEMBL_1980321 (CHEMBL4613583) Activation of caspase 3 in human SMMC7721 cells
- ChEMBL_1985949 (CHEMBL4619355) Induction of ERalpha degradation in human T47D cells
- ChEMBL_1989569 (CHEMBL4623304) Inhibition of Vps34 in human MCF7-LC3 cells
- ChEMBL_199699 (CHEMBL802927) Inhibition of selectin E in human endothelial cells
- ChEMBL_201876 (CHEMBL807239) Binding affinity against sigma receptor of MCF cells
- ChEMBL_2025270 (CHEMBL4679083) Inhibition of mouse IDO1 expressed in HEK cells
- ChEMBL_2027822 (CHEMBL4681980) Inhibition of human ERG expressed in HEK293 cells
- ChEMBL_2059264 (CHEMBL4714265) Inhibition of human BTK in human microglia cells
- ChEMBL_2067866 (CHEMBL4723119) Inhibition of human tyrosinase expressed in HEK293 cells
- ChEMBL_2069748 (CHEMBL4725001) Inhibition of human SGLT2 expressed in COS7 cells
- ChEMBL_2070667 (CHEMBL4726201) Inhibition of EGFR phosphorylation in human A431 cells
- ChEMBL_2078860 (CHEMBL4734651) Inhibition of human IDO1 expressed in HEK293 cells
- ChEMBL_2081968 (CHEMBL4737759) Inhibition of human ERG expressed in CHO cells
- ChEMBL_208603 (CHEMBL812056) Inhibition of topoisomerase II purified from HeLa cells
- ChEMBL_209957 (CHEMBL820613) Inhibition of Thymidylate synthase activity in L1210 cells
- ChEMBL_2103956 (CHEMBL4812459) Inhibition of human ERG expressed in CHO cells
- ChEMBL_2105258 (CHEMBL4813761) Inhibition of human IDO1 in human Hela cells
- ChEMBL_2107067 (CHEMBL4815742) Inhibition of RIPK2 in human U-937 cells
- ChEMBL_2132300 (CHEMBL4841815) Inhibition of human ERG expressed in HEK293 cells
- ChEMBL_2134635 (CHEMBL4844245) Inhibition of human TRPM2 expressed in HEK293 cells
- ChEMBL_213758 (CHEMBL817160) Inhibition of Ha-Ras processing in whole cells
- ChEMBL_213809 (CHEMBL818854) Inhibition of VCAM-1 in human endothelial cells
- ChEMBL_217442 (CHEMBL823341) Inhibition of Alpha4-beta1 integrin in Jurkat cells
- ChEMBL_2186012 (CHEMBL5098094) Inhibition of NQO1 in human HT-29 cells
- ChEMBL_2187487 (CHEMBL5099569) Inhibition of HDAC in human NCI-H522 cells
- ChEMBL_2187488 (CHEMBL5099570) Inhibition of HDAC in human HCT-116 cells
- ChEMBL_2196527 (CHEMBL5109043) Degradation of ER alpha in human MCF7 cells
- ChEMBL_2196576 (CHEMBL5109092) Inhibition of cGAS in human THP-1 cells
- ChEMBL_2199557 (CHEMBL5112073) Inhibition of EGFR in human NCI-H1975 cells
- ChEMBL_2209375 (CHEMBL5122324) Inhibition of IL-1beta in mouse BMDM cells
- ChEMBL_2211254 (CHEMBL5124203) Agonist activity at AT2 receptor in HEK293 cells
- ChEMBL_2215659 (CHEMBL5128791) Inhibition of human11beta-HSD1 in human PBMC cells
- ChEMBL_2218274 (CHEMBL5131608) Inhibition of AAK1 kinase in HEK-293 cells
- ChEMBL_2218275 (CHEMBL5131609) Binding affinity to AAK1 in HEK-293 cells
- ChEMBL_2223281 (CHEMBL5136615) Binding affinity to human RIPK2 in HEK293 cells
- ChEMBL_2224230 (CHEMBL5137743) Inhibition of human pyruvate kinase in embryonic cells
- ChEMBL_2224231 (CHEMBL5137744) Inhibition of human pyruvate kinase in tumor cells
- ChEMBL_2238667 (CHEMBL5152563) Inhibition of Perforin-1 in human Jurkat cells
- ChEMBL_2250305 (CHEMBL5164515) Agonist activity at AhR in mouse Hepa2Dluc cells
- ChEMBL_2260713 (CHEMBL5215724) Inhibition of TDO in overexpressing human SW48 cells
- ChEMBL_2261031 (CHEMBL5216042) Inhibition of MCT4 in human NCI-H358 cells
- ChEMBL_2261251 (CHEMBL5216262) Inhibition of IDO1 in human BT-549 cells
- ChEMBL_2261252 (CHEMBL5216263) Inhibition of TDO in human BT-549 cells
- ChEMBL_2261254 (CHEMBL5216265) Inhibition of IDO1 in human A-172 cells
- ChEMBL_2261286 (CHEMBL5216297) Inhibition of TDO in human A-172 cells
- ChEMBL_2266635 Agonist activity at human TLR2 transfected in HEK293 cells
- ChEMBL_2266639 Agonist activity at TLR2 in HEK-Blue hTLR2 cells
- ChEMBL_2268033 Inhibition of STAT3 phosphorylation in human HL-60 cells
- ChEMBL_2268034 Inhibition of STAT3 phosphorylation in human MOLM-13 cells
- ChEMBL_2268035 Inhibition of STAT3 phosphorylation in human Kasumi 1 cells
- ChEMBL_2268377 Inhibition of Gal4-fused Nurr1 in mouse MN9D cells
- ChEMBL_2269256 Inhibition of human FIH expressed in H5 insect cells
- ChEMBL_2269257 Inhibition of human PHD1 expressed in H5 insect cells
- ChEMBL_2269258 Inhibition of human PHD2 expressed in H5 insect cells
- ChEMBL_2269259 Inhibition of human PHD3 expressed in H5 insect cells
- ChEMBL_2271232 Inhibition of B-Raf in human A-375 cells
- ChEMBL_2271419 Inhibition of KDM5B in HEK293 cells by NanoBRET assay
- ChEMBL_2271437 Inhibition of wild type Abl in mouse BaF3 cells
- ChEMBL_2271438 Inhibition of Abl T315I mutant in mouse BaF3 cells
- ChEMBL_2273264 Agonist activity at human P2Y1R in human 1321N1 cells
- ChEMBL_2275092 Inhibition of IDO1 in human MDA-MB-231 cells
- ChEMBL_2276508 Inhibition of amyloid beta 42 in human HEK293 cells
- ChEMBL_2276509 Inhibition of amyloid beta 42 in human H4 cells
- ChEMBL_2277296 Inhibition of Akt phosphorylation in human HCT-116 cells
- ChEMBL_2277830 Induction of degradation of EZH2 in human EOL1 cells
- ChEMBL_2283422 Inhibition of human SOAT1 expressed in mouse AC29 cells
- ChEMBL_2283423 Inhibition of human SOAT2 expressed in mouse AC29 cells
- ChEMBL_2285095 Inhibition of rat 11beta-HSD1 expressed in Leydig cells
- ChEMBL_2285973 Inhibition of STAT3 phosphorylation a in human MOLM16 cells
- ChEMBL_2292574 Agonist activity at GPBAR1 in human NCI-H716 cells
- ChEMBL_2292784 Antagonist activity at human TRPM8 expressed in CHO cells
- ChEMBL_2292788 Agonist activity at mouse TRMP8 expressed in HEK293 cells
- ChEMBL_2292789 Agonist activity at human TRMP8 expressed in HEK293 cells
- ChEMBL_2292809 Antagonist activity at human TRPM8 expressed in HEK293 cells
- ChEMBL_2296984 Agonist activity at human P2Y14 expressed in HEK293 cells
- ChEMBL_2298651 Inhibition of TDO (unknown origin) expressed in HEK cells
- ChEMBL_2300990 Cytotoxicity against human NB1 cells measured after 8 days
- ChEMBL_2302291 Inhibition of telomerase activity in human CNE-2 cells
- ChEMBL_2318456 Inhibition of human ERG expressed in CHO-K1 cells
- ChEMBL_2319006 Inhibition of JAK2 V617F mutant in human SET2 cells
- ChEMBL_2319007 Inhibition of JAK2 V617F mutant in mouse BaF3 cells
- ChEMBL_2320999 Inhibition of EGFR del19 mutant in human HCC827 cells
- ChEMBL_2321002 Inhibition of wild type EGFR in human A549 cells
- ChEMBL_2321802 Inhibition of K-Ras in human NCI-H460 cells
- ChEMBL_2335974 Inhibition of human DHODH in MOLM-13 AML cells
- ChEMBL_2342479 Inhibition of wildtype full length LRRK2 in HEK293 cells
- ChEMBL_2347835 Activation of wildtype CFTR in human Calu-3 cells
- ChEMBL_2347846 Activation of human CFTR expressed in rat FRT cells
- ChEMBL_2348100 Agonist activity at rat TRPA1 expressed in HEK293 cells
- ChEMBL_2350277 Inhibition of human CD73 expressed in A-375 cells
- ChEMBL_2350527 Antagonist activity at P2X7 in human THP-1 cells
- ChEMBL_2353771 Induction of degradation of NSD2 in human U2OS cells
- ChEMBL_2355734 Inhibition of NOX2 (unknown origin) transfected in HEK cells
- ChEMBL_2355735 Inhibition of NOX5 (unknown origin) transfected in HEK cells
- ChEMBL_2355761 Inhibition of human NOX4 in T-REx-293 cells
- ChEMBL_2374861 Inhibition of TDO (unknown origin) expressed in HEK293 cells
- ChEMBL_2377311 Inhibition of Nav1.8 in HEK293 cells under resting state
- ChEMBL_2422978 Inhibition of TRPV6 (unknown origin) expressed in Sf9 cells
- ChEMBL_2432611 Inhibition of mouse NLRP3 inflammasome expressed in NG5 cells
- ChEMBL_2434161 Inhibition of human recombinant CDK2 expressed in insect cells
- ChEMBL_2434267 Inhibition of wild-type EGFR in human A549 cells
- ChEMBL_2434288 Inhibition of FLT3 ITD mutant in mouse BaF3 cells
- ChEMBL_2434317 Inhibition of AMPK signalling pathway in human HepG2 cells
- ChEMBL_2439282 Inhibition of HDAC in human HeLa cells nuclear extract
- ChEMBL_2444179 Inhibition of KRAS G12C mutant in human HCC1171 cells
- ChEMBL_2444433 Inhibition of SPTSSB (unknown origin) expressed in HEK293T cells
- ChEMBL_2468243 Inhibition of CDK4/Cyclin D1 in human MCF7 cells
- ChEMBL_2468244 Inhibition of CDK6/Cyclin D1 in human MCF7 cells
- ChEMBL_2469772 Inhibition of human CYP11B1 expressed in HEK293-A cells
- ChEMBL_2492825 Agonist activity at rat TRPA1 expressed in HEK293 cells
- ChEMBL_2512801 Binding affinity to UFO in human Hs-578T cells
- ChEMBL_2512802 Binding affinity to FER in human Hs-578T cells
- ChEMBL_2512803 Binding affinity to MAP2K5 in human Hs-578T cells
- ChEMBL_2512804 Binding affinity to ABL1 in human Hs-578T cells
- ChEMBL_2512805 Binding affinity to SRC in human Hs-578T cells
- ChEMBL_2516401 Inhibition of CSF1R autophosphorylation in human THP-1 cells
- ChEMBL_28296 (CHEMBL644835) Inhibition of Acetylcholinesterase from human red blood cells
- ChEMBL_304187 (CHEMBL829182) Reduced farnesylation of H-ras transformed NIH3T3 cells
- ChEMBL_304599 (CHEMBL828487) Inhibitory concentration against histone deacetylase of HeLa cells
- ChEMBL_305000 (CHEMBL829436) Inhibition of HER2 kinase in intact CSH12 cells
- ChEMBL_305059 (CHEMBL831695) Inhibition of HER1 kinase in intact DHER14 cells
- ChEMBL_305383 (CHEMBL832897) Inhibition of Insulin receptor kinase in P19 cells
- ChEMBL_305425 (CHEMBL830918) Inhibition of mTOR protein isolated from HeLa cells
- ChEMBL_305576 (CHEMBL828024) Inhibition against U2OS cells expressing rat Glucocorticoid receptor
- ChEMBL_305783 (CHEMBL827972) Inhibition of CHO-K1 cells expressing glucocorticoid receptor
- ChEMBL_326286 (CHEMBL864497) Inhibition of human ACAT1 expressed in Hi5 cells
- ChEMBL_326287 (CHEMBL864498) Inhibition of human ACAT2 expressed in Hi5 cells
- ChEMBL_326598 (CHEMBL863463) Inhibitory activity against MRP1 in HeLa-T5 cells
- ChEMBL_326942 (CHEMBL860291) Antagonistic potency at TLR2 expressed in HEK293 cells
- ChEMBL_327150 (CHEMBL864040) Inhibition of telomerase activity from human A2780 cells
- ChEMBL_327335 (CHEMBL865150) Inhibition of HDAC in human leukemic CEM cells
- ChEMBL_328206 (CHEMBL863945) Inhibition of TNF alpha release in THP1 cells
- ChEMBL_329870 (CHEMBL870600) Activity against human EAAT1 transfected in HEK293 cells
- ChEMBL_329871 (CHEMBL870601) Activity against human EAAT2 transfected in HEK293 cells
- ChEMBL_329872 (CHEMBL870602) Activity against human EAAT3 transfected in HEK293 cells
- ChEMBL_330652 (CHEMBL867030) Inhibition of HCV RNA replication in Huh7 cells
- ChEMBL_332323 (CHEMBL867015) Agonist activity at PPARalpha transfected in HEK293 cells
- ChEMBL_332324 (CHEMBL867016) Agonist activity at PPARdelta transfected in HEK293 cells
- ChEMBL_332325 (CHEMBL865192) Agonist activity at PPARgamma transfected in HEK293 cells
- ChEMBL_333617 (CHEMBL864130) Inhibition of 17-beta HSD1 in T47D cells
- ChEMBL_333865 (CHEMBL865903) Inhibition of recombinant ATX from transfected HEK293 cells
- ChEMBL_338131 (CHEMBL867658) Inhibitory activity against hMC1R transfected in HEK293 cells
- ChEMBL_338132 (CHEMBL867659) Inhibitory activity against hMC3R transfected in HEK293 cells
- ChEMBL_338133 (CHEMBL867660) Inhibitory activity against hMC4R transfected in HEK293 cells
- ChEMBL_338134 (CHEMBL867662) Inhibitory activity against hMC5R transfected in HEK293 cells
- ChEMBL_339277 (CHEMBL867230) Transactivation by human PPAR alpha in COS1 cells
- ChEMBL_339278 (CHEMBL867231) Transactivation by human PPAR delta in COS1 cells
- ChEMBL_339279 (CHEMBL868414) Transactivation by human PPAR gamma in COS1 cells
- ChEMBL_355604 (CHEMBL853174) Effect on human PPARalpha transactivation in 293T cells
- ChEMBL_355605 (CHEMBL853176) Effect on human PPARgamma transactivation in 293T cells
- ChEMBL_355606 (CHEMBL853178) Effect on human PPARdelta transactivation in 293T cells
- ChEMBL_36134 (CHEMBL648323) Binding affinity against Androgen receptor expressed COS cells
- ChEMBL_363879 (CHEMBL863210) Activation of human PEPT1 expressed in MDCK cells
- ChEMBL_364999 (CHEMBL867505) Inhibition of Her2 in SKBr3 cells by ELISA
- ChEMBL_365766 (CHEMBL871419) Antiproliferative activity against K562 cells expressing Bcr-Abl
- ChEMBL_368633 (CHEMBL867451) Inhibition of human ERG expressed in HEK293 cells
- ChEMBL_375630 (CHEMBL871428) Inhibition of mouse Dyrk1A autophosphorylation in HEk293 cells
- ChEMBL_3818 (CHEMBL618005) Inhibition of human 5-lipoxygenase in human cells
- ChEMBL_390294 (CHEMBL869836) Inhibition of DA transporter expressed in HEK293 cells
- ChEMBL_420086 (CHEMBL855347) Inhibition of Aurora-B immunoprecipitated from mitotic cells
- ChEMBL_424060 (CHEMBL855069) Inhibition of human ACAT1 expressed in Hi5 cells
- ChEMBL_424061 (CHEMBL855070) Inhibition of human ACAT2 expressed in Hi5 cells
- ChEMBL_425046 (CHEMBL910807) Inhibition of NF-kappaB in human HEK293 cells
- ChEMBL_425375 (CHEMBL909070) Inhibition of PTP1B expressed in human HepG2 cells
- ChEMBL_425780 (CHEMBL855770) Binding affinity to hERG expressed in HEK293 cells
- ChEMBL_429175 (CHEMBL914431) Inhibition of human CYP1A2 expressed in insect cells
- ChEMBL_429176 (CHEMBL913811) Inhibition of human CYP2C9 expressed in insect cells
- ChEMBL_429177 (CHEMBL913812) Inhibition of human CYP2C19 expressed in insect cells
- ChEMBL_429178 (CHEMBL913813) Inhibition of human CYP2D6 expressed in insect cells
- ChEMBL_429179 (CHEMBL913814) Inhibition of human CYP3A4 expressed in insect cells
- ChEMBL_432580 (CHEMBL919725) Inhibition of cSrc in COS7 cells by ELISA
- ChEMBL_43536 (CHEMBL656267) Antiviral activity against HIV-1 in CEM cells
- ChEMBL_435529 (CHEMBL903889) Inhibition of endogenous FLT3 autophosphorylation in EOL1 cells
- ChEMBL_436999 (CHEMBL886015) Effect on PPARalpha transactivation activity in HEK293 cells
- ChEMBL_437000 (CHEMBL886016) Effect on PPARdelta transactivation activity in HEK293 cells
- ChEMBL_437001 (CHEMBL886017) Effect on PPARgamma transactivation activity in HEK293 cells
- ChEMBL_437578 (CHEMBL906014) Inhibition of human GR expressed in hGRAF cells
- ChEMBL_438154 (CHEMBL907547) Inhibition of human KDR phosphorylation in NIH3T3 cells
- ChEMBL_440133 (CHEMBL890443) Activity at human GR expressed in SW1353 cells
- ChEMBL_441127 (CHEMBL891341) Inhibition of calcium channel Cav2.2 in IMR32 cells
- ChEMBL_443490 (CHEMBL893748) Inhibition of KSP in KBV1 cells overexpressing Pgp
- ChEMBL_444089 (CHEMBL893252) Inhibition of human BACE1 expressed in HEK293 cells
- ChEMBL_444091 (CHEMBL893254) Inhibition of cathepsin D expressed in HEK293 cells
- ChEMBL_444966 (CHEMBL894122) Antiproliferative activity against HeLa cells by MTS assay
- ChEMBL_446023 (CHEMBL895119) Inhibition of human Chk1 expressed in Sf9 cells
- ChEMBL_446748 (CHEMBL895927) Inhibition of human NHE1 expressed in PS120 cells
- ChEMBL_447771 (CHEMBL896780) Inhibition of human S1P expressed in CHOK1 cells
- ChEMBL_447924 (CHEMBL898174) Inhibition of human DAT expressed in COS1 cells
- ChEMBL_448871 (CHEMBL898017) Inhibition of EGFR kinase autophosphorylation in A431 cells
- ChEMBL_449214 (CHEMBL899477) Binding affinity to human ERG in HEK cells
- ChEMBL_451386 (CHEMBL901590) Inhibition of CXCR4 in MDA-MB-231 cells
- ChEMBL_453163 (CHEMBL902315) Inhibition of c-Jun phosphorylation in HepG2 cells
- ChEMBL_453209 (CHEMBL902363) Inhibition of human HSD1 expressed in HEK cells
- ChEMBL_453666 (CHEMBL885667) Inhibition of human ACAT2 expressed in Hi5 cells
- ChEMBL_453667 (CHEMBL885668) Inhibition of human ACAT1 expressed in Hi5 cells
- ChEMBL_457645 (CHEMBL923922) Inhibition of human EGFR autophosphorylation in A431 cells
- ChEMBL_457993 (CHEMBL925324) Inhibition of human HDAC1 expressed in 293T cells
- ChEMBL_457994 (CHEMBL925325) Inhibition of human HDAC4 expressed in 293T cells
- ChEMBL_457995 (CHEMBL925326) Inhibition of mouse HDAC6 expressed in 293T cells
- ChEMBL_461854 (CHEMBL927847) Inhibition of human NEU1 expressed in HEK293 cells
- ChEMBL_461855 (CHEMBL927848) Inhibition of human NEU2 expressed in HEK293 cells
- ChEMBL_461856 (CHEMBL927849) Inhibition of human NEU3 expressed in HEK293 cells
- ChEMBL_461857 (CHEMBL927850) Inhibition of human NEU4 expressed in HEK293 cells
- ChEMBL_461861 (CHEMBL927854) Inhibition of HER2 sheddase in human BT474 cells
- ChEMBL_462111 (CHEMBL945883) Inhibition of memapsin 2 expressed in CHO cells
- ChEMBL_462257 (CHEMBL945091) Inhibition of cathepsin B in human HepG2 cells
- ChEMBL_462258 (CHEMBL945092) Inhibition of cathepsin L in human HepG2 cells
- ChEMBL_462259 (CHEMBL945093) Inhibition of cathepsin S in human ramos cells
- ChEMBL_462988 (CHEMBL928909) Inhibition of human erbB2 autophosphorylation in MCF7 cells
- ChEMBL_464363 (CHEMBL950297) Inhibition of cathepsin B in mouse B16F10 cells
- ChEMBL_464890 (CHEMBL949089) Inhibition of human recombinant FAAH expressed COS7 cells
- ChEMBL_465869 (CHEMBL951088) Inhibition of Akt1 phosphorylation in human C33a cells
- ChEMBL_465870 (CHEMBL951089) Inhibition of Akt2 phosphorylation in human C33a cells
- ChEMBL_468600 (CHEMBL947897) Inhibition of erB2 autophosphorylation in clone 24 cells
- ChEMBL_473793 (CHEMBL937058) Inhibition of IGF1R autophosphorylation in human MCF7 cells
- ChEMBL_473843 (CHEMBL921091) Inhibition of Aurora kinase B in MCF7 cells
- ChEMBL_476088 (CHEMBL926963) Inhibition of HIV1 protease dimerization in MT2 cells
- ChEMBL_479641 (CHEMBL921442) Inhibition of human HDAC1 expressed in 293T cells
- ChEMBL_479642 (CHEMBL921443) Inhibition of human HDAC4 expressed in 293T cells
- ChEMBL_479643 (CHEMBL921444) Inhibition of human HDAC6 expressed in 293T cells
- ChEMBL_489066 (CHEMBL987286) Inhibition of alpha-mannosidase in human LNZ308 cells
- ChEMBL_489067 (CHEMBL987287) Inhibition of alpha-mannosidase in human LN18 cells
- ChEMBL_491086 (CHEMBL982109) Inhibition of STAT6 activation in FW4 reporter cells
- ChEMBL_491716 (CHEMBL949571) Inhibition of recombinant HDAC1 expressed in HEK293 cells
- ChEMBL_491717 (CHEMBL949572) Inhibition of recombinant HDAC6 expressed in HEK293 cells
- ChEMBL_491919 (CHEMBL947427) Activity at rat mGluR5 expressed in HEK293A cells
- ChEMBL_493106 (CHEMBL940369) Inhibition of human HDAC1 expressed in mammalian cells
- ChEMBL_493107 (CHEMBL940370) Inhibition of human HDAC2 expressed in mammalian cells
- ChEMBL_493108 (CHEMBL940371) Inhibition of human HDAC3 expressed in mammalian cells
- ChEMBL_493111 (CHEMBL940374) Inhibition of human HDAC6 expressed in mammalian cells
- ChEMBL_493421 (CHEMBL944378) Inhibition of human ERG expressed in CHO cells
- ChEMBL_497163 (CHEMBL1002063) Inhibition of human Caco-2 cells-derived DPP4
- ChEMBL_508140 (CHEMBL1004877) Inhibition of neutrophil elastase in human U937 cells
- ChEMBL_508141 (CHEMBL1004878) Inhibition of cathepsin G in human U937 cells
- ChEMBL_508142 (CHEMBL1004879) Inhibition of proteinase-3 in human U937 cells
- ChEMBL_508759 (CHEMBL1007371) Inhibition of human JAK2 expressed in COS7 cells
- ChEMBL_509684 (CHEMBL1007322) Inhibition of human EGFR expressed in SF9 cells
- ChEMBL_513492 (CHEMBL975398) Inhibition of human MRP1 in human 2008 cells
- ChEMBL_535643 (CHEMBL987971) Inhibition of aromatase expressed in human H295R cells
- ChEMBL_535644 (CHEMBL987972) Inhibition of human aromatase expressed in CHO cells
- ChEMBL_537397 (CHEMBL992587) Inhibition of human Syk expressed in Sf9 cells
- ChEMBL_537398 (CHEMBL992588) Inhibition of human ZAP70 expressed in Sf9 cells
- ChEMBL_540211 (CHEMBL1029840) Inhibition of Tie2 autophosphorylation in human Ea.hy926 cells
- ChEMBL_540786 (CHEMBL1033189) Inhibition of human 5LOX expressed in HEK293 cells
- ChEMBL_541512 (CHEMBL1022217) Inhibition of GSK3-beta expressed in Sf9 cells
- ChEMBL_543921 (CHEMBL1020356) Binding affinity to Hsp90 in human SKBR3 cells
- ChEMBL_545066 (CHEMBL1017182) Inhibition of human VEGFR2 expressed in Sf9 cells
- ChEMBL_54597 (CHEMBL667320) Concentration inhibiting Dihydrofolate reductase derived from L1210 cells
- ChEMBL_54598 (CHEMBL667321) Concentration inhibiting dihydrofolate reductase derived from L1210 cells
- ChEMBL_54605 (CHEMBL667327) Inhibitory activity of Dihydrofolate reductase in L1210 cells
- ChEMBL_551732 (CHEMBL998269) Inhibition of human COX1 expressed in sf9 cells
- ChEMBL_551733 (CHEMBL998270) Inhibition of human COX2 expressed in sf9 cells
- ChEMBL_556139 (CHEMBL957461) Inhibition of EGFR expressed in human tumor cells
- ChEMBL_556140 (CHEMBL957462) Inhibition of VEGFR1 expressed in human tumor cells
- ChEMBL_556141 (CHEMBL957463) Inhibition of VEGFR2 expressed in human tumor cells
- ChEMBL_556142 (CHEMBL957464) Inhibition of PDGFRbeta expressed in human tumor cells
- ChEMBL_556965 (CHEMBL958151) Inhibition of human recombinant ERG in CHOK1 cells
- ChEMBL_560485 (CHEMBL1020505) Inhibition of BACE1 expressed in human 293T cells
- ChEMBL_560486 (CHEMBL1020506) Inhibition of BACE2 expressed in human 293T cells
- ChEMBL_566796 (CHEMBL957605) Inhibition of GFP-labelled human PLD2 HEK293 cells
- ChEMBL_578563 (CHEMBL1052405) Inhibition of human 11betaHSD1 expressed in CHO cells
- ChEMBL_578564 (CHEMBL1052406) Inhibition of mouse 11betaHSD1 expressed in CHO cells
- ChEMBL_585220 (CHEMBL1059198) Inhibition of EGFR autophosphorylation in human A549 cells
- ChEMBL_591408 (CHEMBL1054528) Inhibition of human ERG expressed in HEK cells
- ChEMBL_591415 (CHEMBL1054535) Inhibition of human ERG expressed in HEK cells
- ChEMBL_592525 (CHEMBL1044081) Inhibition of human SERT expressed in JAR cells
- ChEMBL_606335 (CHEMBL1071989) Inhibition of GSK2beta phosphorylation in human BT474 cells
- ChEMBL_606889 (CHEMBL1071275) Agonist activity at PR in human T47D cells
- ChEMBL_619932 (CHEMBL1113143) Inhibition of EGFR autophosphorylation in human A431 cells
- ChEMBL_633355 (CHEMBL1120575) Inhibition of human CaSR expressed in HEK293 cells
- ChEMBL_633891 (CHEMBL1120457) Inhibition of human SMO expressed in HEPM cells
- ChEMBL_635107 (CHEMBL1119417) Inhibition of cathepsin S in human B cells
- ChEMBL_642273 (CHEMBL1177153) Inhibition of interleukin-5 in mouse Y16 cells
- ChEMBL_658253 (CHEMBL1246645) Inhibition of EGFR autophosphorylation in human A431 cells
- ChEMBL_660305 (CHEMBL1249801) Inhibition of rat ROCK2 expressed in Sf9 cells
- ChEMBL_660306 (CHEMBL1249802) Inhibition of human PKBalpha expressed in SF9 cells
- ChEMBL_661533 (CHEMBL1253097) Inhibition of ERalpha expressed in human tumor cells
- ChEMBL_661840 (CHEMBL1252156) Inhibition of EGFR expressed in human A431 cells
- ChEMBL_661841 (CHEMBL1252157) Inhibition of VEGFR2 expressed in human A431 cells
- ChEMBL_661842 (CHEMBL1252158) Inhibition of PDGFRbeta expressed in human A431 cells
- ChEMBL_664468 (CHEMBL1259850) Inhibition of rat mGluR1 expressed in HEK293 cells
- ChEMBL_665321 (CHEMBL1260998) Transactivation of mouse PPARalpha expressed in CV1 cells
- ChEMBL_665322 (CHEMBL1260999) Transactivation of mouse PPARdelta expressed in CV1 cells
- ChEMBL_674155 (CHEMBL1274252) Inhibition of EphB4 autophosphorylation expressed in CHOK1 cells
- ChEMBL_674163 (CHEMBL1274260) Inhibition of PDGFRbeta phosphorylation in human MG63 cells
- ChEMBL_674536 (CHEMBL1274447) Inhibition of cathepsin G in human MOLT4 cells
- ChEMBL_684656 (CHEMBL1285623) Inhibition of GluR2 flop expressed in HEK cells
- ChEMBL_686697 (CHEMBL1290877) Inhibition of human Cat B in HepG2 cells
- ChEMBL_696902 (CHEMBL1639418) Inhibition of rat TRPV1 expressed in HEK cells
- ChEMBL_696903 (CHEMBL1639419) Inhibition of human TRPV1 expressed in HEK cells
- ChEMBL_70035 (CHEMBL681437) Inhibition of GAR transformylase from mammalian L1210 cells
- ChEMBL_70036 (CHEMBL681438) Inhibition of GAR transformylase from mammalian L1210 cells
- ChEMBL_716794 (CHEMBL1670716) Inhibition of human ERG expressed in CHO cells
- ChEMBL_745548 (CHEMBL1775865) Inhibition of human PI3Kalpha expressed in Sf9 cells
- ChEMBL_745550 (CHEMBL1775867) Inhibition of human PI3Kbeta expressed in Sf9 cells
- ChEMBL_745551 (CHEMBL1775868) Inhibition of human PI3Kgamma expressed in Sf9 cells
- ChEMBL_745552 (CHEMBL1775869) Inhibition of human PI3Kdelta expressed in Sf9 cells
- ChEMBL_746399 (CHEMBL1776358) Agonist activity at PPARgamma in mouse 3T3L1 cells
- ChEMBL_749027 (CHEMBL1781812) Inhibition of human Oat1 expressed in HEK293 cells
- ChEMBL_76105 (CHEMBL684606) Antiviral activity against HIV-I infected H9 cells
- ChEMBL_762551 (CHEMBL1817008) Binding affinity to human PepT2 in SKTP cells
- ChEMBL_775568 (CHEMBL1913252) Inhibition of 11beta-HSD1 in human HEK cells
- ChEMBL_775569 (CHEMBL1913253) Inhibition of 11beta-HSD1 in mouse 3T3L1 cells
- ChEMBL_808205 (CHEMBL1961117) Inhibition of GSK3-beta in human RD cells
- ChEMBL_821011 (CHEMBL2039198) Inhibition of c-Kit in human Mo7e cells
- ChEMBL_82640 (CHEMBL693027) Inhibition of interaction between HUVEC cells and fibronectin
- ChEMBL_829805 (CHEMBL2061324) Inhibition of squalene synthase in rat hepatic cells
- ChEMBL_835072 (CHEMBL2073616) Inhibition of PDE8B expressed in Sf9 insect cells
- ChEMBL_835936 (CHEMBL2077074) TP_TRANSPORTER: inhibition of PGF2alpha in OAT2-S2 cells
- ChEMBL_835958 (CHEMBL2077096) TP_TRANSPORTER: inhibition of PGF2alpha in OAT2-S2 cells
- ChEMBL_836602 (CHEMBL2077343) TP_TRANSPORTER: inhibition of Daunorubicin transport in G185 cells
- ChEMBL_836690 (CHEMBL2077645) TP_TRANSPORTER: inhibition of Cephalexin uptake in SKPT cells
- ChEMBL_836972 (CHEMBL2075812) TP_TRANSPORTER: inhibition of Chephalexin uptake in SKPT cells
- ChEMBL_838653 (CHEMBL2078384) TP_TRANSPORTER: cell accumulation in MCF7/MRP1-M6 cells
- ChEMBL_838654 (CHEMBL2078385) TP_TRANSPORTER: cell accumulation in MCF7/MRP1-M24 cells
- ChEMBL_838655 (CHEMBL2078386) TP_TRANSPORTER: cell accumulation in MCF7/MRP1-10 cells
- ChEMBL_839291 (CHEMBL2077962) TP_TRANSPORTER: drug resistance (paclitaxel) in HCT15/CL02 cells
- ChEMBL_853549 (CHEMBL2153967) Inhibition of human ERG expressed in CHOK1 cells
- ChEMBL_873133 (CHEMBL2182982) Agonist activity at mGLUR3 expressed in CHO cells
- ChEMBL_873325 (CHEMBL2185178) Agonist activity at mGLUR2 expressed in CHO cells
- ChEMBL_877119 (CHEMBL2187242) Inhibition of human ERG expressed in CHO cells
- ChEMBL_87890 (CHEMBL698808) Inhibition of Histone deacetylase 4 in mammalian cells.
- ChEMBL_879169 (CHEMBL2209140) Inhibition of topoisomerase 1 in human HuH7 cells
- ChEMBL_879170 (CHEMBL2209141) Inhibition of topoisomerase 2a in human HuH7 cells
- ChEMBL_880057 (CHEMBL2213406) Inhibition of PDGFRbeta phosphorylation in human MG63 cells
- ChEMBL_880060 (CHEMBL2213409) Inhibition of KIT phosphorylation in human H526 cells
- ChEMBL_887296 (CHEMBL2216275) Inhibition of human ERG overexpressed in HEK cells
- ChEMBL_90433 (CHEMBL697422) Effective concentration against GluR5 expressed in HEK293 cells
- ChEMBL_957421 (CHEMBL2378091) Inhibition of 11beta-HSD1 in human HEK293 cells
- ChEMBL_960200 (CHEMBL2382572) Inhibition of human ERG expressed in CHO cells
- ChEMBL_961868 (CHEMBL2390160) Inhibition of human TRPV6 transfected in HEK293 cells
- ChEMBL_985247 (CHEMBL2434497) Inhibition of 5-lipoxygenase in rat RBL1 cells
- ChEMBL_99372 (CHEMBL709032) Inhibit ion of MAPK phosphorylation in LoVo cells
- Wild-type HCT116 Cell proliferation assay for wild-type cells
- ChEBML_1619372 Inhibition of porcupine in mouse L Wnt3A cells co-cultured with HEK293 cells after 48 hrs by Super-top flash reporter gene assay
- ChEMBL_161099 (CHEMBL771560) Increased percentage of formazan production in drug treated virus infected cells to equal 50% control drug free uninfected cells on serotype 14
- ChEMBL_2270806 Inhibition of CDK2/cyclin E (unknown origin) expressed in Sf9 cells using histone H1 cells in presence of gamma33P-ATP by kinase assay
- ChEMBL_2487774 Inhibition of cGAS in human THP-1 cells expressed in baculovirus infected insect cells incubated for 18 hrs by Lucia luciferase reporter assay
- ChEMBL_38294 (CHEMBL647098) In vitro agonist activity by increase in cAMP levels in chinese hamster ovary cells (CHO) cells stimulated by human Beta-2 Adrenoceptor
- ChEMBL_1659718 (CHEMBL4009330) Activation of BTN3A1 in human Vgamma9Vdelta2 T cells assessed as induction of T effector cells mediated K562 cell lysis preincubated with K562 cells for 2 hrs followed by T effector cell addition measured after 4 hrs
- ChEMBL_1719033 (CHEMBL4134033) Activation of BTN3A1 in human PBMC-derived Vgamma9Vdelta2 T cells assessed as induction of interferon gamma production in response to K562 cells preincubated for 4 hrs with K562 cells followed by 11 days incubation post compound wash out with subsequent coculturing with Vgamma9Vdelta2 T cells for 20 hrs by ELISA
- ChEBML_41854 In vitro for inhibition of [14C]taurocholate uptake in baby hamster kidney cells transfected with the cDNA of human Bile acid transporter (H14 cells)
- ChEMBL_1478489 (CHEMBL3430390) Inhibition of long-lasting type calcium current (ICaL) in HEK293 cells (alpha1C/beta2a/alpha2delta1) cells measured using IonWorks Barracuda automated patch clamp platform
- ChEMBL_1478490 (CHEMBL3430391) Inhibition of long-lasting type calcium current (ICaL) in HEK293 cells (alpha1C/beta2a/alpha2delta1) cells measured using IonWorks Barracuda automated patch clamp platform
- ChEMBL_1478494 (CHEMBL3430395) Inhibition of long-lasting type calcium current (ICaL) in HEK293 cells (alpha1C/beta2a/alpha2delta1) cells measured using IonWorks Barracuda automated patch clamp platform
- ChEMBL_1478498 (CHEMBL3430399) Inhibition of long-lasting type calcium current (ICaL) in HEK293 cells (alpha1C/beta2a/alpha2delta1) cells measured using IonWorks Barracuda automated patch clamp platform
- ChEMBL_1478499 (CHEMBL3430400) Inhibition of long-lasting type calcium current (ICaL) in HEK293 cells (alpha1C/beta2a/alpha2delta1) cells measured using IonWorks Barracuda automated patch clamp platform
- ChEMBL_1478502 (CHEMBL3430403) Inhibition of long-lasting type calcium current (ICaL) in HEK293 cells (alpha1C/beta2a/alpha2delta1) cells measured using IonWorks Barracuda automated patch clamp platform
- ChEMBL_1478504 (CHEMBL3430405) Inhibition of long-lasting type calcium current (ICaL) in HEK293 cells (alpha1C/beta2a/alpha2delta1) cells measured using IonWorks Barracuda automated patch clamp platform
- ChEMBL_1478505 (CHEMBL3430406) Inhibition of long-lasting type calcium current (ICaL) in HEK293 cells (alpha1C/beta2a/alpha2delta1) cells measured using IonWorks Barracuda automated patch clamp platform
- ChEMBL_1478509 (CHEMBL3430410) Inhibition of long-lasting type calcium current (ICaL) in HEK293 cells (alpha1C/beta2a/alpha2delta1) cells measured using IonWorks Barracuda automated patch clamp platform
- ChEMBL_1478510 (CHEMBL3430411) Inhibition of long-lasting type calcium current (ICaL) in HEK293 cells (alpha1C/beta2a/alpha2delta1) cells measured using IonWorks Barracuda automated patch clamp platform
- ChEMBL_1478511 (CHEMBL3430412) Inhibition of long-lasting type calcium current (ICaL) in HEK293 cells (alpha1C/beta2a/alpha2delta1) cells measured using IonWorks Barracuda automated patch clamp platform
- ChEMBL_1478512 (CHEMBL3430413) Inhibition of long-lasting type calcium current (ICaL) in HEK293 cells (alpha1C/beta2a/alpha2delta1) cells measured using IonWorks Barracuda automated patch clamp platform
- ChEMBL_161098 (CHEMBL771559) Increased percentage of formazan production in drug treated virus infected cells to equal 50% of control drug free uninfected cells on serotype 14
- ChEMBL_1619372 (CHEMBL3861541) Inhibition of porcupine in mouse L Wnt3A cells co-cultured with HEK293 cells after 48 hrs by Super-top flash reporter gene assay
- ChEMBL_205713 (CHEMBL807960) Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
- ChEMBL_2237085 (CHEMBL5150981) Inhibition of human group IIE phospholipase A2 expressed in Escherichia coli BL21 cells incubated for 10 to 20 mins cells by radiometric assay
- ChEMBL_2237087 (CHEMBL5150983) Inhibition of human group IB phospholipase A2 expressed in Escherichia coli BL21 cells incubated for 10 to 20 mins cells by radiometric assay
- ChEMBL_37254 (CHEMBL651575) In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor
- ChEMBL_38295 (CHEMBL647099) In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-2 adrenergic receptor
- ChEMBL_38918 (CHEMBL652020) In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-3 adrenergic receptor
- ChEMBL_2110972 (CHEMBL4819822) Inhibition of PD-1/PD-L1 interaction in CHO cells expressing PD-Ll/TCR cocultured with human Jurkat cells expressing PD-1 assessed as activation of effector Jurkat T cells incubated for 6 hrs by luciferase reporter gene assay
- ChEMBL_1575843 (CHEMBL3801886) Inhibition of 17betaHSD3 (unknown origin) transfected in HEK293 cells
- ChEMBL_305503 (CHEMBL831105) Inhibition of androgen receptor in human MDA-453 cells
- ChEMBL_326797 (CHEMBL860146) Binding affinity to human MCHr1 from neuronal IMR32 cells
- ChEMBL_331164 (CHEMBL854091) Binding to human 5HT2A receptor expressed in CHO cells
- ChEMBL_331165 (CHEMBL854092) Binding to human 5HT2B receptor expressed in CHO cells
- ChEMBL_331166 (CHEMBL854093) Binding to human 5HT2C receptor expressed in CHO cells
- ChEMBL_430506 (CHEMBL917755) Inhibition of human CYP24 hydroxylase expressed in V79 cells
- ChEMBL_430508 (CHEMBL917757) Inhibition of human CYP27B hydroxylase expressed in SW900 cells
- ChEMBL_457566 (CHEMBL922766) Inhibition of human cloned cPLA2 expressed in HEK293 cells
- ChEMBL_597105 (CHEMBL1045391) Inhibition of human DPP4 from human Caco-2 cells
- ChEMBL_600842 (CHEMBL1041988) Inhibition of human recombinant MAOA expressed in BTI cells
- ChEMBL_600843 (CHEMBL1041989) Inhibition of human recombinant MAOB expressed in BTI cells
- ChEMBL_754867 (CHEMBL1805851) Agonist activity at mineralocorticoid receptor in human A549 cells
- ChEMBL_835969 (CHEMBL2077107) TP_TRANSPORTER: inhibition of VCR transport in HL60/MRP cells
- ChEMBL_835971 (CHEMBL2077109) TP_TRANSPORTER: inhibition of DNR transport in HL60/MRP cells