- insulin-like growth factor 1 receptor beta chain
- insulin-like growth factor 2 mrna-binding protein 1
- growth factor-like peptide
- opioid growth factor receptor-like protein 1 (orl1)
- hepatocyte growth factor-like protein alpha chain
- delta and notch-like epidermal growth factor-related receptor
- fibroblast growth factor 1 (fgf-1)
- fibroblast growth factor receptor 1
- transforming growth factor beta-1
- fibroblast growth factor receptor 1 (fgfr-1)
- epidermal growth factor receptor [1-973]
- gst-fibroblast growth factor receptor 1 (fgfr-1)
- basic fibroblast growth factor receptor 1 (fgfr1)
- epidermal growth factor receptor [1-745,751-967]
- epidermal growth factor receptor [1-751,75360-1210]
- epidermal growth factor receptor [1-999,l858r]
- vascular endothelial growth factor receptor 1/2
- catenin beta-1/transcription factor 7-like 2
- epidermal growth factor receptor [1-745,751-1210,c797s]
- epidermal growth factor receptor [1-745,751-1210,t790m]
- epidermal growth factor receptor [1-746,750-1210,a750p]
- fibroblast growth factor receptor 1/2/3/4
- transforming growth factor-beta-activated kinase 1 (tak1)
- kelch-like ech-associated protein 1/nuclear factor erythroid 2-related factor 2
- epidermal growth factor receptor [1-18,20-1210,t790m,c797s]
- epidermal growth factor receptor [1-18,20-745,747-749,751-1210]
- epidermal growth factor receptor [1-249,301-1210,t790m,l858r]
- epidermal growth factor receptor [1-745,751-1210,t790m,c797s]
- epidermal growth factor receptor [1-746,748-748,750-1210,a750p]
- epidermal growth factor receptor [1-763,'fhea',764-1210]
- epidermal growth factor receptor [1-769,'asv',770-1210]
- epidermal growth factor receptor [1-769,'svd',770-1210]
- epidermal growth factor receptor [1-770,'npg',771-1210]
- epidermal growth factor receptor [1-770,'svd',771-1210]
- epidermal growth factor receptor [1-773,'nph',774-1210]
- fibroblast growth factor receptor 1 (fgfr1)(aa 308-731)
- mast/stem cell growth factor receptor kit 1 (d816v)
- mast/stem cell growth factor receptor kit [1-973]
- epidermal growth factor receptor
- fibroblast growth factor receptor
- hepatocyte growth factor receptor
- keratinocyte growth factor receptor
- pro-epidermal growth factor
- vascular endothelial growth factor receptor 1 and 2 (flt-1 and kdr)
- transcription factor 7-like 2
- focal adhesion kinase 1/vascular endothelial growth factor receptor 3
- kelch-like ech-associated protein 1 [321-624]/nuclear factor erythroid 2-related factor 2
- epidermal growth factor receptor (egfr)
- epidermal growth factor receptor [g719s]
- epidermal growth factor receptor [s768i]
- epidermal growth factor receptor(l858r)
- epidermal/hepatocyte growth factor receptor
- fibroblast growth factor receptor 2
- fibroblast growth factor receptor 3
- hepatocyte growth factor receptor (hgfr)
- hepatocyte growth factor receptor (met)
- hepatocyte growth factor receptor [d1228h]
- hepatocyte growth factor receptor [d1228n]
- hepatocyte growth factor receptor [l1195v]
- hepatocyte growth factor receptor [y1230c]
- nt-3 growth factor receptor
- slow nerve growth factor receptor
- vascular endothelial growth factor receptor
- macrophage migration inhibitory factor-like protein
- insulin receptor substrate 1
- beta platelet-derived growth factor receptor
- epidermal growth factor receptor (egfr)(del19)
- epidermal growth factor receptor (egfr)(l861q)
- epidermal growth factor receptor (egfr)(t790m)
- epidermal growth factor receptor (t790m/l858r)
- epidermal growth factor receptor [645-1186]
- epidermal growth factor receptor [695-1022]
- epidermal growth factor receptor [l858r,c797s]
- epidermal growth factor receptor(l858r, t790m)
- epidermal growth factor receptor/interleukin-3
- fibroblast growth factor receptor 2 (fgfr2)
- fibroblast growth factor receptor 3 (fgfr3)
- fibroblast growth factor receptor 4 (fgfr4)
- growth factor receptor-bound protein 2
- hepatocyte growth factor receptor (met)(del14)
- hepatocyte growth factor receptor (met)(f1200i)
- hepatocyte growth factor receptor (met)(y1230h)
- hepatocyte growth factor receptor (met)(y1230s)
- hepatocyte growth factor receptor [1038-1346]
- hepatocyte growth factor receptor [960-1390]
- platelet-derived endothelial cell growth factor
- platelet-derived growth factor a chain
- platelet-derived growth factor receptor (d842v)
- platelet-derived growth factor receptor alpha
- vascular endothelial growth factor receptor 2
- alpha-type platelet-derived growth factor receptor
- beta-type platelet-derived growth factor receptor
- epidermal growth factor receptor (egfr)(del19/c797s)
- epidermal growth factor receptor (egfr)(del19/t790m)
- epidermal growth factor receptor (egfr)(t790m/l858r)
- epidermal growth factor receptor [671-1210,l858r]
- epidermal growth factor receptor [696-1022,l858r]
- epidermal growth factor receptor [696-1022,t790m]
- epidermal growth factor receptor [696-1210,t790m]
- epidermal growth factor receptor [l858r,t790m,c797s]
- fibroblast growth factor receptor 2 [400-821]
- fibroblast growth factor receptor 2 [406-821]
- fibroblast growth factor receptor 3 (fgfr-3)
- fibroblast growth factor receptor 3 (fgfr3)(v555m)
- fibroblast growth factor receptor 4 [388-802]
- high affinity nerve growth factor receptor [g667c]
- mast/stem cell growth factor receptor kit
- mast/stem cell growth factor receptor precursor
- platelet-derived growth factor receptor alpha (pdgfr +-)
- platelet-derived growth factor receptor alpha (pdgfra)
- platelet-derived growth factor receptor alpha /beta
- platelet-derived growth factor receptor beta (pdgfrb)
- vascular endothelial cell growth factor 165 receptor
- vascular endothelial growth factor receptor 2 (vegfr2)
- vascular endothelial growth factor receptor kinase 2
- insulin receptor substrate 1 (irs1)
- epidermal growth factor receptor [668-1210,t790m,l858r]
- epidermal growth factor receptor [696-1022,t790m,l858r]
- fibroblast growth factor receptor 2 (fgfr2)(403-822)
- gst-fibroblast growth factor receptor 3 (fgfr-3)
- hepatocyte growth factor receptor (r974-s1390) (a1209g) (v1290l)
- hepatocyte growth factor receptor [1078-1345,h1094r,l1272v]
- hepatocyte growth factor receptor [1078-1345,m1250t,l1272v]
- hepatocyte growth factor receptor [1078-1345,v1092i,l1272v]
- hepatocyte growth factor receptor [1078-1345,y1230h,l1272v]
- high affinity nerve growth factor receptor (trka)(g595r)
- high affinity nerve growth factor receptor [440-796]
- high affinity nerve growth factor receptor [441-796]
- mast/stem cell growth factor receptor kit [n822k]
- mast/stem cell growth factor receptor kit [v559d]
- mast/stem cell growth factor receptor kit [v560g]
- pdgfr-beta/platelet-derived growth factor receptor alpha
- vascular endothelial cell growth factor 165 receptor 2
- vascular endothelial growth factor receptor 2 [790-1356]
- kqt-like 1
- bcl2-like 1 isoform 1
- epidermal growth factor receptor (egfr)(del 747-752)(p753s)
- epidermal growth factor receptor [669-769,'asv',770-1210]
- epidermal growth factor receptor [695-745,751-1022,t790m,c797s]
- fibroblast growth factor receptor 3 (fgfr3)(aa 399-806)
- fibroblast growth factor receptor 4 (fgfr4)(aa 460-802)
- mast/stem cell growth factor receptor kit (v559d/v654a)
- mast/stem cell growth factor receptor kit [544-976]
- mast/stem cell growth factor receptor kit [v560g,d816v]
- platelet-derived growth factor receptor alpha [551-1089,v561d]
- vascular endothelial growth factor receptor 3 (short) [798-1298]
- vascular endothelial growth factor receptor 3 [818-948,1003-1077]
- dcn1-like protein 1
- dynamin-1-like protein
- lysophospholipase-like protein 1
- misshapen-like kinase 1
- p2y purinoceptor 1-like
- protease inhibitor 1-like
- subtilisin-like protease 1
- vkorc1-like 1 (hvkorc1l1)
- vkorc1-like 1 (rvkorc1l1)
- polo-like kinase 1 (plk-1)
- epidermal growth factor receptor/receptor tyrosine-protein kinase erbb-2
- activin receptor-like kinase 1 (alk-1)
- bcl-2-like protein 1 [1-209]
- bcl-2-like protein 1 [1-212]
- bcl-2-like protein 1
- cdc2-like kinase 1 (clk1)
- cyclin-dependent kinase-like 1
- elav-like protein 1 [i180a]
- glucagon-like peptide 1 receptor
- hepatocyte growth factor receptor met isoform 2 [974-1390,a1209g,v1290l]
- hepatocyte growth factor receptor/proto-oncogene tyrosine-protein kinase receptor ret
- isoform trka-i of high affinity nerve growth factor receptor (trkai)
- ccr4-associated factor 1
- neutrophil cytosol factor 1
- neutrophil cytosolic factor 1
- insulin receptor
- chymotrypsin-like elastase family member 1
- inositol polyphosphate phosphatase-like protein 1
- kelch-like ech-associated protein 1
- kinesin-like protein kif18a [1-467]
- niemann-pick c1-like 1 protein
- npc1-like intracellular cholesterol transporter 1
- s-adenosylhomocysteine hydrolase-like protein 1
- ubiquitin-like modifier-activating enzyme 1
- isoform 1 of misshapen-like kinase 1 (mink-delta)
- macrophage colony-stimulating factor 1 (csf-1)
- growth hormone secretagogue receptor type 1
- growth hormone secretagogue receptor type 1/isoform 1b of growth hormone secretagogue receptor type 1 (1b)
- colony stimulating factor 1 receptor
- corticotropin releasing factor receptor 1
- corticotropin-releasing factor receptor 1
- hypoxia-inducible factor 1-alpha
- ankyrin-like with transmembrane domains protein 1
- bcl-2-like protein 1 (bcl-xl)
- chymotrypsin-like elastase family member 1/2a
- cyclin-dependent kinase-like 1 [2-358]
- g-protein coupled receptor 37-like 1
- heat shock 70 kda protein 1-like
- toll/interleukin-1 receptor-like protein 3
- insulin-responsive aminopeptidase
- bcl-2-like protein 1 (bcl-xl) [1-44,87-209]
- catenin beta-1/transcription factor 4
- corticotropin-releasing factor receptor 1/2
- friend leukemia integration 1 transcription factor
- macrophage colony-stimulating factor 1 receptor
- rho guanine nucleotide exchange factor 1
- kelch-like ech-associated protein 1 [321-609]
- scm-like with four mbt domains protein 1
- insulin receptor [964-1370]
- insulin receptor beta subunit
- phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/vascular endothelial growth factor receptor 2
- dimer of growth hormone secretagogue receptor type 1
- activin receptor-like kinase 1 (alk1)(aa 166-493)
- vesicle amine transport protein 1 homolog (t. californica)-like
- adp-ribosylation factor gtpase-activating protein 1
- cyclic amp-dependent transcription factor atf-1
- eukaryotic translation initiation factor 4 gamma 1
- egl nine homolog 1/hypoxia-inducible factor 1-alpha [788-822]
- voltage-gated potassium channel subunit kv7.1/misshapen-like kinase 1
- histone acetyltransferase p300/hypoxia-inducible factor 1-alpha
- macrophage colony-stimulating factor 1 receptor (c-fms)
- macrophage colony-stimulating factor 1 receptor [538-972]
- transcription initiation factor tfiid subunit 1 [1381-1497]
- phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/platelet-derived growth factor receptor beta [525-1106]
- phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/platelet-derived growth factor receptor beta [525-1106]
- insulin receptor-binding protein grb-ir
- dopamine2-like
- lysophospholipase-like
- prolylendopeptidase-like
- macrophage colony-stimulating factor 1 receptor (aa 538-972)
- macrophage colony-stimulating factor 1 receptor [538-678,753-922]
- cobra venom factor/complement factor b/complement factor d
- isoform 4 of lethal(3)malignant brain tumor-like protein 1 (4)
- coagulation factor vii/tissue factor
- macrophage colony-stimulating factor 1 receptor (csf1r) or (c-fms)
- 3c-like protease
- c3 like protease
- gcn2-like protein
- kqt-like 2
- kqt-like 4
- p2y-like receptor
- ring3-like protein
- sir2-like protein
- spp-like 2a
- spp-like 2b
- friend leukemia integration 1 transcription factor (proto-oncogene fli-1)/rna-binding protein ews
BDBM50087726 Glucagon like peptide-1(GLP-1)analogue CHEMBL409983
BDBM50087727 CHEMBL437277 Glucagon like peptide-1(GLP-1)analogue
BDBM50087728 CHEMBL412234 Glucagon like peptide-1(GLP-1)analogue
BDBM50087729 CHEMBL439181 Glucagon like peptide-1(GLP-1)analogue
BDBM50087733 CHEMBL440075 Glucagon like peptide-1(GLP-1)analogue
BDBM50087734 CHEMBL412115 Glucagon like peptide-1(GLP-1)analogue
BDBM50087735 CHEMBL428152 Glucagon like peptide-1(GLP-1)analogue
BDBM50087737 CHEMBL427943 Glucagon like peptide-1(GLP-1)analogue
BDBM50087738 CHEMBL412541 Glucagon like peptide-1(GLP-1)analogue
BDBM50087739 CHEMBL441580 Glucagon like peptide-1(GLP-1)analogue
BDBM50087744 CHEMBL269779 Glucagon like peptide-1(GLP-1)analogue
BDBM50087745 CHEMBL439481 Glucagon like peptide-1(GLP-1)analogue
BDBM50087747 CHEMBL439305 Glucagon like peptide-1(GLP-1)analogue
BDBM50087748 Glucagon like peptide-1(GLP-1)analogue CHEMBL269494
BDBM50087749 CHEMBL261911 Glucagon like peptide-1(GLP-1)analogue
BDBM50087750 Glucagon like peptide-1(GLP-1)analogue CHEMBL409300
BDBM50087755 CHEMBL438212 Glucagon like peptide-1(GLP-1)analogue
BDBM50087756 CHEMBL439099 Glucagon like peptide-1(GLP-1)analogue
BDBM50087757 CHEMBL441931 Glucagon like peptide-1(GLP-1)analogue
BDBM50087758 CHEMBL409270 Glucagon like peptide-1(GLP-1)analogue
BDBM50087759 CHEMBL414971 Glucagon like peptide-1(GLP-1)analogue
CHEMBL266046 BDBM50087741 Glucagon like peptide-1(GLP-1)analogue
CHEMBL269543 Glucagon like peptide-1(GLP-1)analogue BDBM50087751
CHEMBL410575 Glucagon like peptide-1(GLP-1)analogue BDBM50087743
CHEMBL411138 Glucagon like peptide-1(GLP-1)analogue BDBM50087742
CHEMBL411170 Glucagon like peptide-1(GLP-1)analogue BDBM50087754
CHEMBL412948 BDBM50087736 Glucagon like peptide-1(GLP-1)analogue
CHEMBL424733 Glucagon like peptide-1(GLP-1)analogue BDBM50087732
CHEMBL427768 BDBM50087730 Glucagon like peptide-1(GLP-1)analogue
CHEMBL428330 Glucagon like peptide-1(GLP-1)analogue BDBM50087731
CHEMBL429398 BDBM50087752 Glucagon like peptide-1(GLP-1)analogue
CHEMBL430245 BDBM50087761 Glucagon like peptide-1(GLP-1)analogue
CHEMBL437467 Glucagon like peptide-1(GLP-1)analogue BDBM50087740
CHEMBL439091 BDBM50087760 Glucagon like peptide-1(GLP-1)analogue
CHEMBL441203 Glucagon like peptide-1(GLP-1)analogue BDBM50087753
BDBM50087746 GLP-1(7-37) Glucagon like peptide-1(GLP-1) CHEMBL428139
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- Hubbard, RD; Bamaung, NY; Palazzo, F; Zhang, Q; Kovar, P; Osterling, DJ; Hu, X; Wilsbacher, JL; Johnson, EF; Bouska, J; Wang, J; Bell, RL; Davidsen, SK; Sheppard, GS Pyrazolo[3,4-d]pyrimidines as potent inhibitors of the insulin-like growth factor receptor (IGF-IR). Bioorg Med Chem Lett 17: 5406-9 (2007)
- Zhu, YF; Wang, XC; Connors, P; Wilcoxen, K; Gao, Y; Gross, R; Strack, N; Gross, T; McCarthy, JR; Xie, Q; Ling, N; Chen, C Quinoline-carboxylic acids are potent inhibitors that inhibit the binding of insulin-like growth factor (IGF) to IGF-binding proteins. Bioorg Med Chem Lett 13: 1931-4 (2003)
- Chen, C; Zhu, YF; Liu, XJ; Lu, ZX; Xie, Q; Ling, N Discovery of a series of nonpeptide small molecules that inhibit the binding of insulin-like growth factor (IGF) to IGF-binding proteins. J Med Chem 44: 4001-10 (2001)
- A highly selective dual insulin receptor (IR)/insulin-like growth factor 1 receptor (IGF-1R) inhibitor derived from an extracellular signal-regulated kinase (ERK) inhibitor.
- Liu, X; Xie, H; Luo, C; Tong, L; Wang, Y; Peng, T; Ding, J; Jiang, H; Li, H Discovery and SAR of thiazolidine-2,4-dione analogues as insulin-like growth factor-1 receptor (IGF-1R) inhibitors via hierarchical virtual screening. J Med Chem 53: 2661-5 (2010)
- Wittman, MD; Balasubramanian, B; Stoffan, K; Velaparthi, U; Liu, P; Krishnanathan, S; Carboni, J; Li, A; Greer, A; Attar, R; Gottardis, M; Chang, C; Jacobson, B; Sun, Y; Hansel, S; Zoeckler, M; Vyas, DM Novel 1H-(benzimidazol-2-yl)-1H-pyridin-2-one inhibitors of insulin-like growth factor I (IGF-1R) kinase. Bioorg Med Chem Lett 17: 974-7 (2007)
- Hubbard, RD; Bamaung, NY; Fidanze, SD; Erickson, SA; Palazzo, F; Wilsbacher, JL; Zhang, Q; Tucker, LA; Hu, X; Kovar, P; Osterling, DJ; Johnson, EF; Bouska, J; Wang, J; Davidsen, SK; Bell, RL; Sheppard, GS Development of multitargeted inhibitors of both the insulin-like growth factor receptor (IGF-IR) and members of the epidermal growth factor family of receptor tyrosine kinases. Bioorg Med Chem Lett 19: 1718-21 (2009)
- Mayer, SC; Banker, AL; Boschelli, F; Di, L; Johnson, M; Kenny, CH; Krishnamurthy, G; Kutterer, K; Moy, F; Petusky, S; Ravi, M; Tkach, D; Tsou, HR; Xu, W Lead identification to generate isoquinolinedione inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment. Bioorg Med Chem Lett 18: 3641-5 (2008)
- Zhu, YF; Wilcoxen, K; Gross, T; Connors, P; Strack, N; Gross, R; Huang, CQ; McCarthy, JR; Xie, Q; Ling, N; Chen, C 6,7-dihydroxyisoquinoline-3-carboxylic acids are potent inhibitors on the binding of insulin-like growth factor (IGF) to IGF-binding proteins: optimization of the 1-position benzoyl side chain. Bioorg Med Chem Lett 13: 1927-30 (2003)
- Patnaik, S; Stevens, KL; Gerding, R; Deanda, F; Shotwell, JB; Tang, J; Hamajima, T; Nakamura, H; Leesnitzer, MA; Hassell, AM; Shewchuck, LM; Kumar, R; Lei, H; Chamberlain, SD Discovery of 3,5-disubstituted-1H-pyrrolo[2,3-b]pyridines as potent inhibitors of the insulin-like growth factor-1 receptor (IGF-1R) tyrosine kinase. Bioorg Med Chem Lett 19: 3136-40 (2009)
- Miller, LM; Mayer, SC; Berger, DM; Boschelli, DH; Boschelli, F; Di, L; Du, X; Dutia, M; Floyd, MB; Johnson, M; Kenny, CH; Krishnamurthy, G; Moy, F; Petusky, S; Tkach, D; Torres, N; Wu, B; Xu, W Lead identification to generate 3-cyanoquinoline inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment. Bioorg Med Chem Lett 19: 62-6 (2009)
- Mulvihill, MJ; Ji, QS; Coate, HR; Cooke, A; Dong, H; Feng, L; Foreman, K; Rosenfeld-Franklin, M; Honda, A; Mak, G; Mulvihill, KM; Nigro, AI; O'Connor, M; Pirrit, C; Steinig, AG; Siu, K; Stolz, KM; Sun, Y; Tavares, PA; Yao, Y; Gibson, NW Novel 2-phenylquinolin-7-yl-derived imidazo[1,5-a]pyrazines as potent insulin-like growth factor-I receptor (IGF-IR) inhibitors. Bioorg Med Chem 16: 1359-75 (2008)
- Engen, W; O'Brien, TE; Kelly, B; Do, J; Rillera, L; Stapleton, LK; Youngren, JF; Anderson, MO Synthesis of aryl-heteroaryl ureas (AHUs) based on 4-aminoquinoline and their evaluation against the insulin-like growth factor receptor (IGF-1R). Bioorg Med Chem 18: 5995-6005 (2010)
- Jin, M; Petronella, BA; Cooke, A; Kadalbajoo, M; Siu, KW; Kleinberg, A; May, EW; Gokhale, PC; Schulz, R; Kahler, J; Bittner, MA; Foreman, K; Pachter, JA; Wild, R; Epstein, D; Mulvihill, MJ Discovery of novel insulin-like growth factor-1 receptor inhibitors with unique time-dependent binding kinetics. ACS Med Chem Lett 4: 627-31 (2013)
- Degorce, SL; Boyd, S; Curwen, JO; Ducray, R; Halsall, CT; Jones, CD; Lach, F; Lenz, EM; Pass, M; Pass, S; Trigwell, C Discovery of a Potent, Selective, Orally Bioavailable, and Efficacious Novel 2-(Pyrazol-4-ylamino)-pyrimidine Inhibitor of the Insulin-like Growth Factor-1 Receptor (IGF-1R). J Med Chem 59: 4859-66 (2016)
- BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR.
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- Bell, IM; Stirdivant, SM; Ahern, J; Culberson, JC; Darke, PL; Dinsmore, CJ; Drakas, RA; Gallicchio, SN; Graham, SL; Heimbrook, DC; Hall, DL; Hua, J; Kett, NR; Kim, AS; Kornienko, M; Kuo, LC; Munshi, SK; Quigley, AG; Reid, JC; Trotter, BW; Waxman, LH; Williams, TM; Zartman, CB Biochemical and structural characterization of a novel class of inhibitors of the type 1 insulin-like growth factor and insulin receptor kinases. Biochemistry 44: 9430-40 (2005)
- Li, R; Pourpak, A; Morris, SW Inhibition of the insulin-like growth factor-1 receptor (IGF1R) tyrosine kinase as a novel cancer therapy approach. J Med Chem 52: 4981-5004 (2010)
- Wittman, MD; Carboni, JM; Yang, Z; Lee, FY; Antman, M; Attar, R; Balimane, P; Chang, C; Chen, C; Discenza, L; Frennesson, D; Gottardis, MM; Greer, A; Hurlburt, W; Johnson, W; Langley, DR; Li, A; Li, J; Liu, P; Mastalerz, H; Mathur, A; Menard, K; Patel, K; Sack, J; Sang, X; Saulnier, M; Smith, D; Stefanski, K; Trainor, G; Velaparthi, U; Zhang, G; Zimmermann, K; Vyas, DM Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development. J Med Chem 52: 7360-3 (2009)
- Targeting insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) for the treatment of cancer.
- Ducray, R; Simpson, I; Jung, FH; Nissink, JW; Kenny, PW; Fitzek, M; Walker, GE; Ward, LT; Hudson, K Discovery of novel imidazo[1,2-a]pyridines as inhibitors of the insulin-like growth factor-1 receptor tyrosine kinase. Bioorg Med Chem Lett 21: 4698-701 (2011)
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- ChEBML_90404 Ability to displace Insulin-Like Growth Factor (IGF-I) from its binding to human insulin-like growth factor binding protein 3 (hIGFBP-3)
- ChEBML_90403 Ability of compound to displace Insulin-Like Growth Factor (IGF-I) from its binding to Insulin-like growth factor binding protein 3 (IGFBP-3)
- ChEBML_90543 Ability of compound to displace Insulin-Like Growth Factor (IGF-I) from its binding to Insulin-like growth factor binding protein 5 (IGFBP-5)
- ChEBML_90397 Inhibition of Insulin-like growth factor I receptor
- ChEBML_90282 Inhibition of human insulin-like growth factor I receptor
- ChEMBL_90285 (CHEMBL697504) Inhibition of Insulin-like growth factor I receptor
- ChEMBL_90396 (CHEMBL698351) Inhibition of Insulin-like growth factor I receptor
- ChEMBL_305115 (CHEMBL831583) Inhibition of human insulin-like growth factor I receptor
- ChEMBL_90405 (CHEMBL698360) Inhibitory activity against Insulin-like growth factor binding protein 3
- ChEMBL_90401 (CHEMBL698356) The compound was tested for binding affinity against insulin-like growth factor binding protein 1
- ChEMBL_90284 (CHEMBL697349) In vitro inhibition of Insulin-like growth factor I receptor expressed in baculovirus
- ChEMBL_90402 (CHEMBL698357) The compound was tested for binding affinity against insulin-like growth factor binding protein 2
- ChEMBL_90406 (CHEMBL698361) The compound was tested for binding affinity against Insulin-like growth factor binding protein 4
- ChEMBL_90407 (CHEMBL698362) The compound was tested for binding affinity against Insulin-like growth factor binding protein 4
- ChEMBL_90544 (CHEMBL700614) The compound was tested for binding affinity against Insulin-like growth factor binding protein 5
- ChEMBL_90545 (CHEMBL700615) The compound was tested for binding affinity against Insulin-like growth factor binding protein 6
- ChEMBL_90408 (CHEMBL698363) Dissociation constant binding to Insulin-like growth factor binding protein 5 at the residue L-81
- ChEMBL_90424 (CHEMBL698181) Dissociation constant in binding to Insulin-like growth factor binding protein 5 at the residue L73
- ChEMBL_90425 (CHEMBL698182) Dissociation constant in binding to Insulin-like growth factor binding protein 5 at the residue L81
- ChEMBL_90426 (CHEMBL697415) Dissociation constant in binding to Insulin-like growth factor binding protein 5 at the residue R87
- ChEMBL_90427 (CHEMBL697416) Dissociation constant in binding to Insulin-like growth factor binding protein 5 at the residue S85
- ChEMBL_90428 (CHEMBL697417) Dissociation constant in binding to Insulin-like growth factor binding protein 5 at the residue Y50
- ChEMBL_90429 (CHEMBL697418) Dissociation constant in binding to Insulin-like growth factor binding protein 5 at the residue Y86
- ChEMBL_90281 (CHEMBL697346) Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Insulin-like growth factor I receptor
- ChEMBL_90409 (CHEMBL698364) Dissociation constant in BS binding to Insulin-like growth factor binding protein 5 at the residue K91
- ChEMBL_90410 (CHEMBL698365) Dissociation constant in DMSO binding to Insulin-like growth factor binding protein 5 at the residue K91
- ChEMBL_90411 (CHEMBL698366) Dissociation constant in DMSO binding to Insulin-like growth factor binding protein 5 at the residue L73
- ChEMBL_90412 (CHEMBL698367) Dissociation constant in DMSO binding to Insulin-like growth factor binding protein 5 at the residue L81
- ChEMBL_90413 (CHEMBL698368) Dissociation constant in DMSO binding to Insulin-like growth factor binding protein 5 at the residue R87
- ChEMBL_90414 (CHEMBL698369) Dissociation constant in DMSO binding to Insulin-like growth factor binding protein 5 at the residue S85
- ChEMBL_90415 (CHEMBL698218) Dissociation constant in DMSO binding to Insulin-like growth factor binding protein 5 at the residue Y50
- ChEMBL_90416 (CHEMBL698219) Dissociation constant in DMSO binding to Insulin-like growth factor binding protein 5 at the residue Y86
- ChEMBL_90417 (CHEMBL698220) Dissociation constant in PBS binding to Insulin-like growth factor binding protein 5 at the residue K91
- ChEMBL_90418 (CHEMBL698221) Dissociation constant in PBS binding to Insulin-like growth factor binding protein 5 at the residue L73
- ChEMBL_90419 (CHEMBL698222) Dissociation constant in PBS binding to Insulin-like growth factor binding protein 5 at the residue L81
- ChEMBL_90420 (CHEMBL698223) Dissociation constant in PBS binding to Insulin-like growth factor binding protein 5 at the residue R87
- ChEMBL_90421 (CHEMBL698838) Dissociation constant in PBS binding to Insulin-like growth factor binding protein 5 at the residue S85
- ChEMBL_90422 (CHEMBL698839) Dissociation constant in PBS binding to Insulin-like growth factor binding protein 5 at the residue Y50
- ChEMBL_90423 (CHEMBL698180) Dissociation constant in PBS binding to Insulin-like growth factor binding protein 5 at the residue Y86
- ChEBML_213959 Inhibition of vascular endothelial growth factor receptor 1
- ChEBML_213960 Inhibition of Vascular endothelial growth factor receptor 1
- ChEBML_70625 Inhibitory activity against Fibroblast growth factor receptor 1
- ChEMBL_305210 (CHEMBL832463) Inhibition of Epidermal growth factor receptor 1
- ChEMBL_70618 (CHEMBL678674) Inhibition of Fibroblast growth factor receptor 1
- ChEMBL_70628 (CHEMBL678684) Dissociation constant for Fibroblast growth factor 1
- ChEBML_66577 Inhibition of human Epidermal growth factor receptor, HER-1
- ChEMBL_213964 (CHEMBL811941) Inhibition of Vascular endothelial growth factor receptor 1
- ChEMBL_305013 (CHEMBL829448) Inhibition of human fibroblast growth factor receptor 1
- ChEMBL_305253 (CHEMBL832663) Inhibition of human fibroblast growth factor receptor 1
- ChEMBL_66585 (CHEMBL680016) Inhibition of Epidermal growth factor receptor, HER-1
- ChEMBL_208097 (CHEMBL814453) Inhibition of Transforming growth factor beta-1 receptor (TbetaRI)
- ChEMBL_305482 (CHEMBL830273) Inhibition of human epidermal growth factor receptor (HER-1)
- ChEMBL_66577 (CHEMBL683037) Inhibition of human Epidermal growth factor receptor, HER-1
- ChEMBL_208098 (CHEMBL814454) Inhibition of Transforming growth factor beta-1 receptor (TbetaRI) autophosphorylation
- ChEMBL_305591 (CHEMBL828038) Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)
- ChEBML_63790 Antagonism towards Epidermal growth factor receptor
- ChEBML_66573 Inhibition of Epidermal growth factor receptor
- ChEBML_67063 Inhibition of Epidermal growth factor receptor
- ChEBML_67064 Inhibition of Epidermal growth factor receptor
- ChEBML_67065 Inhibition of Epidermal growth factor receptor
- ChEBML_67067 Inhibition of Epidermal growth factor receptor
- ChEBML_67204 Inhibition of Epidermal growth factor receptor
- ChEBML_67211 Inhibition of epidermal growth factor receptor
- ChEMBL_158351 (CHEMBL768495) Inhibition of Platelet-derived growth factor receptor (Inactive at 1 mM ATP)
- ChEMBL_70624 (CHEMBL678680) In vitro inhibition of Fibroblast growth factor receptor 1 expressed in baculovirus
- ChEMBL_213957 (CHEMBL811935) In vitro inhibition of Vascular endothelial growth factor receptor 1 (VEGFR-1) expressed in baculovirus
- ChEMBL_213958 (CHEMBL811936) In vitro inhibition of Vascular endothelial growth factor receptor 1 (VEGFR-1) expressed in baculovirus
- ChEBML_221782 Inhibition of epidermal growth factor receptor (EGFR)
- ChEBML_225788 Inhibition of nerve growth factor receptor, trkA
- ChEBML_63595 Inhibit of epidermal growth factor receptor (EGFR)
- ChEBML_66904 Inhibition of the epidermal growth factor receptor.
- ChEBML_66906 Inhibition of epidermal growth factor receptor (EGFR)
- ChEBML_66907 Inhibition of epidermal growth factor receptor (EGFR)
- ChEBML_67058 Inhibitory activity against epidermal growth factor receptor
- ChEBML_67068 Inhibition of Epidermal growth factor receptor (EGFr)
- ChEBML_70637 Inhibition of Fibroblast growth factor receptor 2
- ChEBML_78745 Inhibition of human Epidermal growth factor receptor
- ChEMBL_305263 (CHEMBL832813) Inhibition of epidermal growth factor receptor
- ChEMBL_306181 (CHEMBL830975) Inhibition of Epidermal growth factor receptor
- ChEMBL_306396 (CHEMBL828737) Inhibition of Epidermal growth factor receptor
- ChEMBL_67049 (CHEMBL677887) Inhibition of Epidermal growth factor receptor
- ChEMBL_67054 (CHEMBL674103) Inhibition of Epidermal growth factor receptor
- ChEMBL_67208 (CHEMBL678293) Inhibition of Epidermal growth factor receptor
- ChEMBL_67211 (CHEMBL678296) Inhibition of epidermal growth factor receptor
- ChEMBL_67212 (CHEMBL678297) Inhibition of Epidermal growth factor receptor
- ChEMBL_67213 (CHEMBL677529) Inhibition of Epidermal growth factor receptor
- ChEMBL_67214 (CHEMBL677530) Inhibition of Epidermal growth factor receptor
- ChEMBL_67215 (CHEMBL677531) Selectivity against Epidermal growth factor receptor
- ChEMBL_70490 (CHEMBL676887) Inhibition of Fibroblast growth factor receptor
- ChEMBL_70491 (CHEMBL676888) Inhibition of Fibroblast growth factor receptor
- ChEMBL_70493 (CHEMBL676890) Inhibition of Fibroblast growth factor receptor
- ChEMBL_84064 (CHEMBL697832) Inhibition of Hepatocyte growth factor receptor
- ChEBML_70464 Binding affinity for human fibroblast growth factor 1 in surface plasmon resonance (SPR) assay
- ChEMBL_306384 (CHEMBL828725) Inhibition of mouse Fibroblast growth factor receptor 1 expressed in NIH 3T3 fibroblasts
- ChEBML_158502 Inhibition of the platelet-derived growth factor receptor.
- ChEBML_213951 Inhibitory activity against Vascular endothelial growth factor receptor
- ChEBML_213967 Inhibition of Vascular endothelial growth factor receptor 2
- ChEBML_213970 Inhibition of Vascular endothelial growth factor receptor 2
- ChEBML_214231 Inhibition of Vascular endothelial growth factor receptor 2
- ChEBML_214243 Inhibition of Vascular endothelial growth factor receptor 2
- ChEBML_214253 Inhibition of Vascular endothelial growth factor receptor 3
- ChEBML_63607 Inhibition of tyrosine kinase Epidermal growth factor receptor
- ChEBML_64439 Inhibition of epidermal growth factor receptor (EGF-R)
- ChEBML_66581 Inhibition of Epidermal Growth Factor Receptor (EGFR) autophosphorylation
- ChEBML_67041 Inhibition of epidermal growth factor receptor (EGF-R)
- ChEBML_88298 Inhibition of human epidermal growth factor receptor-2
- ChEMBL_158490 (CHEMBL764769) Inhibition of Platelet-derived growth factor receptor
- ChEMBL_158491 (CHEMBL764770) Inhibition of Platelet-derived growth factor receptor
- ChEMBL_158494 (CHEMBL764773) Inhibition of Platelet-derived growth factor receptor
- ChEMBL_158495 (CHEMBL765708) Inhibition of Platelet-derived growth factor receptor
- ChEMBL_158496 (CHEMBL765709) Inhibition of Platelet-derived growth factor receptor
- ChEMBL_158503 (CHEMBL765716) Inhibition of Platelet-derived growth factor receptor
- ChEMBL_213950 (CHEMBL811928) Inhibition of Vascular endothelial growth factor receptor
- ChEMBL_305211 (CHEMBL832464) Inhibition of Fibroblast growth factor receptor 2
- ChEMBL_305359 (CHEMBL832739) Inhibition of Platelet derived growth factor receptor
- ChEMBL_305858 (CHEMBL832718) Inhibition of human epidermal growth factor receptor
- ChEMBL_306570 (CHEMBL832087) Inhibition of Vascular endothelial growth factor receptor
- ChEMBL_63595 (CHEMBL675242) Inhibit of epidermal growth factor receptor (EGFR)
- ChEMBL_63755 (CHEMBL679943) Inhibition of Epidermal growth factor receptor autophosphorylation
- ChEMBL_63757 (CHEMBL679945) Inhibition of Epidermal growth factor receptor autophosphorylation
- ChEMBL_65256 (CHEMBL673947) Inhibition of epidermal growth factor receptor (EGFR)
- ChEMBL_66578 (CHEMBL683038) Inhibition of human Epidermal growth factor receptor
- ChEMBL_66579 (CHEMBL683039) Inhibition of human epidermal growth factor receptor
- ChEMBL_66582 (CHEMBL683042) Inhibition of human epidermal growth factor receptor
- ChEMBL_67055 (CHEMBL674104) Inhibition of Epidermal growth factor receptor autophosphorylation
- ChEMBL_67058 (CHEMBL674107) Inhibitory activity against epidermal growth factor receptor
- ChEMBL_70638 (CHEMBL678694) Dissociation constant for Fibroblast growth factor 2
- ChEMBL_67043 (CHEMBL677881) In vitro inhibition of Epidermal growth factor receptor (HER-1,ErbB) expressed in baculovirus
- ChEMBL_67045 (CHEMBL677883) In vitro inhibition of Epidermal growth factor receptor (HER-1,ErbB) expressed in baculovirus
- ChEMBL_2567996 Inhibition of IGF-1R phosphorylation in IGF-1 stimulated human HepG2 cells preincubated with compound for 30 mins followed by IGF-1 stimulation for 10 mins by Immunoblot analysis
- ChEMBL_1570037 (CHEMBL3789400) Inhibition of IGF-1 receptor (unknown origin)
- ChEBML_214094 Inhibition of human vascular endothelial growth factor receptor 2
- ChEBML_214117 Inhibitory activity against Vascular endothelial growth factor receptor 2
- ChEBML_63617 Inhibition of Epidermal growth factor receptor autophosphorylation, 0.05-0.10
- ChEBML_67205 Tested for inhibitory activity against Epidermal growth factor receptor
- ChEBML_72494 Inhibitory activity against Growth factor receptor bound protein 2
- ChEBML_88297 Inhibition of human epidermal growth factor receptor-2 autophosphorylation
- ChEMBL_158502 (CHEMBL765715) Inhibition of the platelet-derived growth factor receptor.
- ChEMBL_158511 (CHEMBL764074) Inhibition of Platelet-derived growth factor receptor alpha
- ChEMBL_158657 (CHEMBL763443) Inhibition of Platelet-derived growth factor receptor beta
- ChEMBL_158678 (CHEMBL766068) Inhibition of Platelet-derived growth factor receptor beta
- ChEMBL_158679 (CHEMBL766069) Inhibition of Platelet-derived growth factor receptor beta
- ChEMBL_213947 (CHEMBL811925) Inhibition of Vascular endothelial growth factor receptor 3
- ChEMBL_213951 (CHEMBL811929) Inhibitory activity against Vascular endothelial growth factor receptor
- ChEMBL_214113 (CHEMBL820699) Inhibition of Vascular endothelial growth factor receptor 2
- ChEMBL_214115 (CHEMBL820701) Inhibition of Vascular endothelial growth factor receptor 2
- ChEMBL_214240 (CHEMBL819558) Inhibition of Vascular endothelial growth factor receptor 2
- ChEMBL_214243 (CHEMBL820211) Inhibition of Vascular endothelial growth factor receptor 2
- ChEMBL_214250 (CHEMBL820849) Inhibition of Vascular endothelial growth factor receptor 3
- ChEMBL_305182 (CHEMBL832771) Inhibition of platelet-derived growth factor receptor alpha
- ChEMBL_305183 (CHEMBL876146) Inhibition of vascular endothelial growth factor receptor 2
- ChEMBL_305378 (CHEMBL832893) In vitro inhibition of Epidermal growth factor receptor
- ChEMBL_305535 (CHEMBL828555) Inhibition of vascular endothelial growth factor receptor 2
- ChEMBL_321229 (CHEMBL881229) Inhibitory activity against Fibroblast growth factor receptor 3
- ChEMBL_321279 (CHEMBL857667) Inhibitory concentration against platelet-derived growth factor receptor
- ChEMBL_582001 (CHEMBL1055738) Inhibition of IGF1R in growth factor-stimulated NHDF
- ChEMBL_63610 (CHEMBL676154) Inhibition of Epidermal growth factor receptor tyrosine kinase
- ChEMBL_63780 (CHEMBL677384) Inhibition of epidermal growth factor receptor kinase autophosphorylation
- ChEMBL_64439 (CHEMBL674014) Inhibition of epidermal growth factor receptor (EGF-R)
- ChEMBL_66876 (CHEMBL676067) Inhibitory activity against epidermal growth factor receptor (EGFR)
- ChEMBL_67041 (CHEMBL677879) Inhibition of epidermal growth factor receptor (EGF-R)
- ChEMBL_67051 (CHEMBL677889) Inhibition of Epidermal growth factor receptor-dependent phosphorylation
- ChEMBL_70488 (CHEMBL676885) Inhibitory activity against fibroblast growth factor receptor (FGFr)
- ChEMBL_850923 (CHEMBL2156906) Inhibition of Platelet-derived growth factor subunit B
- ChEMBL_877987 (CHEMBL2189053) Inhibition of vascular endothelial growth factor receptor 2
- Insulin reductase assay Insulin reductase assay.
- ChEBML_90654 Inhibition of IGF-receptor 1 autophosphorylation in intact cells
- ChEBML_214087 Inhibition of vascular endothelial growth factor receptor 2 activity with 1 mM ATP and biotinylated lck peptide
- ChEMBL_208100 (CHEMBL814456) Inhibition of human Transforming growth factor (TGF) beta-1 receptor (T204D mutation) autophosphorylation in Sf9 cells
- ChEMBL_208101 (CHEMBL814457) In vitro inhibitory activity against human Transforming growth factor beta-1 receptor kinase (TGF-beta RIK)
- ChEBML_63781 Inhibition of peptide substrate phosphorylation by epidermal growth factor receptor
- ChEBML_70479 Inhibition of Fibroblast growth factor receptor in NIH 3T3 cells
- ChEMBL_152446 (CHEMBL761271) Inhibition of Platelet-derived growth factor receptor tyrosine kinase
- ChEMBL_154585 (CHEMBL761933) Inhibition of platelet-derived growth factor receptor (PDGF-R)
- ChEMBL_158492 (CHEMBL764771) Inhibition of Platelet-derived growth factor receptor-dependent phosphorylation
- ChEMBL_158524 (CHEMBL768951) Inhibition of Platelet-derived growth factor receptor beta phosphorylation
- ChEMBL_214107 (CHEMBL820693) Inhibition of human Vascular endothelial growth factor receptor 2
- ChEMBL_305323 (CHEMBL833545) Inhibition of human platelet-derived growth factor receptor beta
- ChEMBL_305462 (CHEMBL830958) Inhibitory concentration against growth factor receptor bound protein 2
- ChEMBL_305511 (CHEMBL831112) inhibitory activity against Vascular endothelial growth factor receptor 2
- ChEMBL_305656 (CHEMBL829514) Inhibition of Epidermal growth factor receptor in P19 cells
- ChEMBL_305679 (CHEMBL828051) Inhibition of human Vascular endothelial growth factor receptor 2
- ChEMBL_306103 (CHEMBL830878) Inhibitory concentration against Vascular endothelial growth factor receptor 2
- ChEMBL_312997 (CHEMBL873338) Inhibition of human epidermal growth factor receptor (EGFR) autophosphorylation
- ChEMBL_321286 (CHEMBL856815) Inhibitory activity against Platelet-derived growth factor receptor alpha
- ChEMBL_63617 (CHEMBL676161) Inhibition of Epidermal growth factor receptor autophosphorylation, 0.05-0.10
- ChEMBL_66897 (CHEMBL675521) Inhibition of Epidermal growth factor receptor (EGFr) tyrosine kinase
- ChEMBL_66898 (CHEMBL675380) Inhibition of epidermal growth factor receptor (EGFr) tyrosine kinase
- ChEMBL_67042 (CHEMBL677880) In vitro inhibitory activity against epidermal growth factor receptor
- ChEMBL_67206 (CHEMBL678292) Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinase
- ChEMBL_129905 (CHEMBL740149) In vitro inhibition of transforming growth factor- beta dependent luciferase growth in mouse fibroblasts (NIH 3T3)
- ChEMBL_699678 (CHEMBL1648321) Inhibition of insulin receptor after 1 hr
- ChEBML_158665 Inhibition of Platelet-derived growth factor receptor beta (PDGF beta-R)
- ChEBML_210742 Inhibition of receptor Tyrosine kinase A, TrkA (nerve growth factor receptor)
- ChEBML_66896 Inhibition of Epidermal growth factor receptor autophosphorylation in A431 cell membranes
- ChEBML_67061 Inhibition of Epidermal growth factor receptor (EGF-R) tyrosine kinase activity
- ChEMBL_213948 (CHEMBL811926) Inhibitory activity against vascular endothelial growth factor receptor 2 (FLK1)
- ChEMBL_213949 (CHEMBL811927) Inhibitory activity against vascular endothelial growth factor receptor 2 (FLK1)
- ChEMBL_214241 (CHEMBL819559) Inhibition of Vascular endothelial growth factor receptor 2 (VEGFR-2)
- ChEMBL_302139 (CHEMBL841763) Dissociation constant value against growth factor receptor bound protein 2
- ChEMBL_305356 (CHEMBL832736) Inhibition of epidermal growth factor receptor in cell-free assay
- ChEMBL_305416 (CHEMBL830909) Inhibition of epidermal growth factor receptor in cell-intact assay
- ChEMBL_305452 (CHEMBL830127) Inhibition of hepatocyte growth factor receptor in cell-intact assay
- ChEMBL_305774 (CHEMBL827963) In vitro inhibition of Vascular endothelial growth factor receptor 2
- ChEMBL_305880 (CHEMBL832743) Inhibition of Platelet-derived growth factor receptor in P19 cells
- ChEMBL_305999 (CHEMBL832673) Inhibitory concentration against Epidermal growth factor receptor tyrosine kinase activity
- ChEMBL_321426 (CHEMBL881957) Inhibitory concentration against human Vascular endothelial growth factor receptor 2
- ChEMBL_63592 (CHEMBL675239) Inhibition of heparin-binding epidermal growth factor (HB-EGF) shedding
- ChEMBL_63781 (CHEMBL677385) Inhibition of peptide substrate phosphorylation by epidermal growth factor receptor
- ChEMBL_66889 (CHEMBL675513) Inhibition of epidermal growth factor receptor tyrosine kinase (EGFR TK)
- ChEBML_72352 In vitro binding assay of Shc-derived phosphopeptide to Growth factor receptor bound protein 2 SH2 in B104-1-1 cells was determined
- ChEBML_214091 Inhibition of Vascular endothelial growth factor receptor 2 at 5 uM ATP
- ChEBML_214114 Inhibition of vascular endothelial growth factor receptor 2 autophosphorylation in intact cells
- ChEBML_66717 Inhibition of the epidermal growth factor receptor expressed in A431 cell line
- ChEBML_72354 Binding affinity against Growth factor receptor bound protein 2 using ELISA assay
- ChEMBL_105473 (CHEMBL708303) Inhibition of Mast/stem cell growth factor receptor (c-kit) autophosphorylation
- ChEMBL_105474 (CHEMBL708304) Inhibition of Mast/stem cell growth factor receptor (c-kit) autophosphorylation
- ChEMBL_105477 (CHEMBL708307) Inhibition of Mast/stem cell growth factor receptor (c-Kit kinase)
- ChEMBL_158357 (CHEMBL770468) Inhibitory concentration of compound against mouse Platelet-derived growth factor receptor
- ChEMBL_210741 (CHEMBL818317) Inhibition of receptor Tyrosine kinase A, TrkA (nerve growth factor receptor)
- ChEMBL_213973 (CHEMBL812622) Inhibition of Vascular endothelial growth factor receptor 2 (VEGFR-2) autophosphorylation
- ChEMBL_302160 (CHEMBL829228) Apparent dissociation constant for human growth factor receptor bound protein 2
- ChEMBL_305501 (CHEMBL831103) Inhibition of fibroblast growth factor receptor 2 in cell-intact assay
- ChEMBL_305649 (CHEMBL829507) Inhibition of human vascular endothelial growth factor receptor 2 (VEGFR-2)
- ChEMBL_305849 (CHEMBL829589) Inhibition of human vascular endothelial growth factor receptor 2 kinase activity
- ChEMBL_313008 (CHEMBL874202) Inhibition of human epidermal growth factor receptor-2 (HER-2) autophosphorylation
- ChEMBL_63613 (CHEMBL676157) Inhibition of epidermal growth factor receptor (EGF-R) in A431 cells.
- ChEMBL_66597 (CHEMBL680028) Inhibition of autophosphorylation of cytoplasmic domain of epidermal growth factor receptor
- ChEMBL_66886 (CHEMBL675510) Inhibition of Epidermal growth factor receptor mediated mitogenesis of NIH3T3 cells
- ChEMBL_67044 (CHEMBL677882) In vitro inhibition of Epidermal growth factor receptor expressed in baculovirus
- ChEMBL_70623 (CHEMBL678679) In vitro inhibition of Fibroblast growth factor receptor expressed in baculovirus
- ChEMBL_72355 (CHEMBL686442) Binding affinity for Growth factor receptor bound protein 2 SH2 domain
- ChEMBL_72359 (CHEMBL686446) Inhibition of Growth factor receptor bound protein 2 SH2-domain binding
- ChEMBL_72352 (CHEMBL686439) In vitro binding assay of Shc-derived phosphopeptide to Growth factor receptor bound protein 2 SH2 in B104-1-1 cells was determined
- ChEMBL_840552 (CHEMBL2090017) Inhibition of human IGF1R phosphorylation expressed in IGF-1-stimulated knockout mouse R+ cells treated 30 mins before IGF-1 stimulation measured after 20 mins by immunoblotting
- ChEBML_88868 Inhibition of insulin receptor kinase (Inactive at 1 mM ATP)
- ChEMBL_1570093 (CHEMBL3789695) Inhibition of full length insulin receptor (unknown origin) autophosphorylation transfected in HEK293 cells pretreated for 60 mins followed by IGF-1 stimulation measured after 10 mins by quantitative Western blot analysis
- ChEBML_158518 Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells
- ChEBML_72490 Inhibition of Growth factor receptor bound protein 2 SH2 domain binding in ELISA
- ChEBML_72495 Inhibition of Growth factor receptor bound protein 2 SH2 domain binding in ELISA
- ChEMBL_213976 (CHEMBL820672) In vitro inhibition of Vascular endothelial growth factor receptor 2 (VEGFR-2)
- ChEMBL_213978 (CHEMBL817492) In vitro inhibitory concentration against human vascular endothelial growth factor receptor 2
- ChEMBL_305757 (CHEMBL829528) Inhibition of vascular endothelial growth factor receptor 2 in cell-free assay
- ChEMBL_305819 (CHEMBL829472) Inhibition of platelet-derived growth factor receptor alpha in cell-intact assay
- ChEMBL_305820 (CHEMBL829563) Inhibition of vascular endothelial growth factor receptor 2 in cell-intact assay
- ChEMBL_305842 (CHEMBL829583) Stimulation of Transforming growth factor beta receptor I kinase in HepG2 cells
- ChEMBL_306481 (CHEMBL874567) Inhibition of Platelet derived growth factor receptor beta autophosphorylation in CHO cells
- ChEMBL_306571 (CHEMBL832088) Inhibition of Vascular endothelial growth factor receptor 2(KDR) without DTT (dithiothreitol)
- ChEMBL_306585 (CHEMBL832932) Inhibition of Vascular endothelial growth factor receptor 2(KDR) with DTT (dithiothreitol)
- ChEMBL_66717 (CHEMBL674640) Inhibition of the epidermal growth factor receptor expressed in A431 cell line
- ChEMBL_66724 (CHEMBL674647) Inhibition of EGFR(epidermal growth factor receptor) autophosphorylation in ER22 cell membranes
- ChEMBL_66895 (CHEMBL675519) Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells.
- ChEMBL_72354 (CHEMBL686441) Binding affinity against Growth factor receptor bound protein 2 using ELISA assay
- ChEMBL_72358 (CHEMBL686445) Inhibition against Growth factor receptor bound protein 2 binding using ELISA technique
- ChEMBL_72364 (CHEMBL686601) Inhibitory activity against Growth factor receptor bound protein 2 using ELISA assay
- ChEMBL_72492 (CHEMBL685525) Inhibition of binding to Growth factor receptor bound protein 2 SH2 domain
- ChEMBL_49316 (CHEMBL660835) Tested for binding affinity against human Coagulation factor Xa (trypsin-like serine protease)
- ChEBML_1586035 Inhibition of IGF-1R (unknown origin) incubated for 1 hr by spectrophotometric analysis
- ChEMBL_1570070 (CHEMBL3789672) Inhibition of IGF-1 receptor (unknown origin) in presence of [gamma33P]ATP
- ChEBML_158654 Inhibition of wild type Platelet-derived growth factor receptor beta phosphorylation in CHO cells
- ChEBML_66598 Tested for inhibition of Epidermal growth factor receptor from A431 vulval squamous carcinoma cells
- ChEBML_66899 In vitro activity against Epidermal growth factor receptor (using poly(Glu4Tyr1) as a substrate)
- ChEBML_72349 Inhibitory concentration against Growth factor receptor bound protein 2 in MDA-MB-453 cells
- ChEBML_72365 Inhibition of Growth factor receptor-bound protein 2 (Grb2) SH2 domain binding by ELISA
- ChEMBL_144432 (CHEMBL753642) Competitive binding against Nerve growth factor to p75-NGF receptor in PC12 cells
- ChEMBL_154586 (CHEMBL761934) Inhibition of platelet-derived growth factor receptor (PDGF-R) from NIH 3T3 cells
- ChEMBL_158666 (CHEMBL764169) In vitro inhibition of Platelet-derived growth factor receptor beta expressed in baculovirus
- ChEMBL_158667 (CHEMBL766057) In vitro inhibition of Platelet-derived growth factor receptor beta expressed in baculovirus
- ChEMBL_582000 (CHEMBL1055737) Inhibition for IGF1R-induced S6 ribosomal protein phosphorylation in growth factor-stimulated NHDF
- ChEMBL_63767 (CHEMBL677209) In vitro inhibition of the Epidermal growth factor receptor activity in A431 membranes
- ChEMBL_66569 (CHEMBL679550) Inhibition of EGF-stimulated autophosphorylation of Epidermal growth factor receptor in A431 cells
- ChEMBL_66570 (CHEMBL679551) Inhibition of EGF-stimulated autophosphorylation of epidermal growth factor receptor in A431 cells
- ChEMBL_67052 (CHEMBL677890) Inhibitory activity against protein tyrosine kinase of Epidermal growth factor receptor was determined
- ChEMBL_72356 (CHEMBL686443) In vitro Growth factor receptor bound protein 2-binding affinity in ELISA method
- ChEMBL_72360 (CHEMBL686597) Inhibition of Growth factor receptor bound protein 2 binding by ELISA assay method
- ChEMBL_72362 (CHEMBL686599) Inhibition of binding to Growth factor receptor bound protein 2 (Grb2) SH2 domain
- ChEMBL_146113 (CHEMBL754582) Inhibition of [125I]-Tyr14-nociceptin binding to human Opioid receptor like 1 (opioid receptor like 1) in CHO cells
- ChEMBL_146113 (CHEMBL754582) Inhibition of [125I]Tyr14-nociceptin binding to human Opioid receptor like 1 (opioid receptor like 1) in CHO cells
- ChEMBL_687494 (CHEMBL1292170) Inhibition of IGF-1R
- ChEMBL_727271 (CHEMBL1687365) inhibition of IGF-1R
- ChEMBL_793900 (CHEMBL1932873) Inhibition of IGF-1R
- ChEMBL_821814 (CHEMBL2039258) Inhibition of IGF-1R
- ChEMBL_887620 (CHEMBL2217229) Inhibition of IGF-1R
- ChEBML_1570071 Inhibition of full length IGF-1 receptor (unknown origin) autophosphorylation transfected in HEK293 cells pretreated for 60 mins followed by IGF-1 stimulation measured after 10 mins by quantitative Western blot analysis
- ChEMBL_2379023 Inhibition of SARS-CoV-1 papain-like protease
- ChEMBL_735641 (CHEMBL1693343) Inhibition of polo-like kinase 1 activity
- ChEMBL_2527721 Inhibition of Insulin receptor expressed in HEK293 cells assessed as reduction insulin-stimulated INSR phosphorylation incubated for 1 hr by sandwich ELISA analysis
- ChEBML_63769 Displacement of [gamma-32P]-ATP from Epidermal growth factor receptor in A431 cell-free extracts
- ChEBML_72485 Inhibition of Growth factor receptor bound protein 2 SH2 domain binding to p185erbB-2 receptor
- ChEMBL_158654 (CHEMBL763440) Inhibition of wild type Platelet-derived growth factor receptor beta phosphorylation in CHO cells
- ChEMBL_306228 (CHEMBL831136) In vitro inhibition of Vascular endothelial growth factor receptor 2 at 10 uM ATP
- ChEMBL_313055 (CHEMBL835746) Inhibition of vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cell proliferation
- ChEMBL_321627 (CHEMBL871636) Inhibition of Vascular endothelial growth factor receptor 2 kinase phosphorylation of pGAT-biotin peptide
- ChEMBL_63600 (CHEMBL675247) Inhibition of human epidermal growth factor 2 (Her-2) degradation in MCF-7 cells
- ChEMBL_63766 (CHEMBL677208) Inhibition of Epidermal growth factor receptor activity against tripeptide RR-Src at 10 uM
- ChEMBL_64442 (CHEMBL674017) Inhibition of EGF-stimulated autophosphorylation of epidermal growth factor receptor (EGFR) in A431 cells
- ChEMBL_66596 (CHEMBL680027) Concentration required to inhibit autophosphorylation of cytoplasmic domain of epidermal growth factor receptor (EGFR)
- ChEMBL_66598 (CHEMBL680029) Tested for inhibition of Epidermal growth factor receptor from A431 vulval squamous carcinoma cells
- ChEMBL_67046 (CHEMBL677884) Inhibition of autophosphorylation of epidermal growth factor receptor (EGF-R) in a cellular assay
- ChEMBL_72363 (CHEMBL686600) Inhibition of Growth factor receptor bound protein 2 SH2 domain in extracellular binding assay
- ChEMBL_72493 (CHEMBL685526) Inhibition of Growth factor receptor bound protein 2 SH2 domain in extracellular binding assay
- ChEMBL_1586035 (CHEMBL3820499) Inhibition of IGF-1R (unknown origin) incubated for 1 hr by spectrophotometric analysis
- ChEMBL_2527288 Inhibition of human recombinant IGF-1 receptor in presence of ATP by ELISA analysis
- ChEMBL_1570071 (CHEMBL3789673) Inhibition of full length IGF-1 receptor (unknown origin) autophosphorylation transfected in HEK293 cells pretreated for 60 mins followed by IGF-1 stimulation measured after 10 mins by quantitative Western blot analysis
- ChEMBL_69669 (CHEMBL682007) Tested for inhibitory activity against Coagulation factor Xa (trypsin-like serine protease) of the compound
- ChEBML_90257 Inhibition of insulin receptor
- ChEBML_90271 Inhibition of Insulin receptor
- ChEMBL_2276619 Inhibition of IGF-1R (unknown origin)
- ChEMBL_2283209 Inhibition of IGF-1R (unknown origin)
- ChEMBL_827000 (CHEMBL2050064) Inhibition of human IGF-1R
- ChEMBL_146116 (CHEMBL754585) Binding affinity for opioid receptor like type, human Opioid receptor like 1 expressed in membrane homogenates of COS-1 or CHO cells
- ChEMBL_1869997 (CHEMBL4371164) Inhibition of human placental insulin receptor expressed in CHO cells assessed as decrease in insulin-stimulated [3H]-2-deoxyglucose uptake preincubated for 1 hr
- ChEBML_70634 Binding affinity for human fibroblast growth factor 2 in surface plasmon resonance (SPR) assay (No binding)
- ChEBML_72488 Inhibition of Growth factor receptor bound protein 2 SH2 domain binding to phospho-EGFR by ELISA
- ChEMBL_154584 (CHEMBL761932) Inhibition of platelet-derived growth factor receptor (PDGF-R) in human aortic smooth muscle cells
- ChEMBL_161599 (CHEMBL769139) Concentration required to inhibit autophosphorylation of cytoplasmic domain of human epidermal growth factor receptor-2
- ChEMBL_213975 (CHEMBL812788) In vitro inhibition of Vascular endothelial growth factor receptor 2 (VEGFR-2) expressed in baculovirus
- ChEMBL_66566 (CHEMBL677833) In vitro inhibition of Epidermal growth factor receptor tyrosine kinase isolated from A431 (human carcinoma).
- ChEMBL_72485 (CHEMBL685518) Inhibition of Growth factor receptor bound protein 2 SH2 domain binding to p185erbB-2 receptor
- ChEMBL_72486 (CHEMBL685519) Dissociation constant for binding to SH2 domain of Growth factor receptor bound protein 2, Grb2
- ChEMBL_72496 (CHEMBL683674) Inhibition of Growth factor receptor bound protein 2 SH2 domain binding in plasmon resonance assay
- ChEMBL_72497 (CHEMBL683931) Inhibition of Growth factor receptor bound protein 2 SH2 domain binding in plasmon resonance assay
- ChEMBL_759533 (CHEMBL1811059) Inhibition of insulin-induced autophosphorylation of human insulin receptor expressed in CHO cells
- ChEMBL_2527456 Inhibition of human recombinant IGF-1 receptor expressed in mouse Hepa-1 cells treated for 15 mins by ELISA analysis
- ChEBML_90277 Inhibition of insulin receptor autophosphorylation
- ChEMBL_334490 (CHEMBL862525) Inhibition of insulin receptor
- ChEMBL_377345 (CHEMBL865408) Inhibition of Insulin receptor
- ChEMBL_506205 (CHEMBL941409) Inhibition of insulin receptor
- ChEMBL_581990 (CHEMBL1058970) Inhibition of insulin receptor
- ChEMBL_635332 (CHEMBL1119645) Inhibition of insulin receptor
- ChEMBL_698757 (CHEMBL1648482) Inhibition of insulin receptor
- ChEMBL_759532 (CHEMBL1811058) Inhibition of insulin receptor
- ChEMBL_794804 (CHEMBL1935987) Inhibition of insulin receptor
- ChEMBL_825876 (CHEMBL2044753) Inhibition of insulin receptor
- ChEMBL_90267 (CHEMBL699132) Inhibition of Insulin receptor
- ChEMBL_90276 (CHEMBL699141) Inhibition of Insulin receptor
- ChEBML_214092 Inhibitory activity against vascular endothelial growth factor receptor 2 (VEGFR2) at a concentration of 5 uM ATP.
- ChEBML_66902 Inhibition of Grb-SH2 domain binding to phosphorylated carboxy-terminal intracellular domain of epidermal growth factor receptor
- ChEMBL_105475 (CHEMBL708305) In vitro inhibition of Mast/stem cell growth factor receptor (c-Kit kinase) expressed in baculovirus
- ChEMBL_105476 (CHEMBL708306) In vitro inhibition of Mast/stem cell growth factor receptor (c-Kit kinase) expressed in baculovirus
- ChEMBL_63758 (CHEMBL679946) Concentration required to inhibit phosphorylation of isolated human epidermal growth factor tyrosine kinase receptor by 50%
- ChEMBL_64443 (CHEMBL674018) Inhibition of phosphorylation of glutamic acid/tyrosine random copolymer by isolated epidermal growth factor receptor (EGFR)
- ChEMBL_66575 (CHEMBL679676) Inhibition of phosphorylation of glutamic acid/tyrosine random copolymer by isolated epidermal growth factor receptor (EGFR)
- ChEMBL_66576 (CHEMBL856168) Inhibition of phosphorylation of glutamic acid/tyrosine random copolymer by isolated epidermal growth factor receptor (EGFR)
- ChEMBL_67040 (CHEMBL677878) Concentration required for inhibition of epidermal growth factor receptor (EGF-R) by tyrosine kinase enzyme activity
- ChEMBL_70634 (CHEMBL678690) Binding affinity for human fibroblast growth factor 2 in surface plasmon resonance (SPR) assay (No binding)
- ChEMBL_72351 (CHEMBL686438) Inhibition of Growth factor receptor bound protein 2 SH2 domain binding in plasmon resonance binding assay
- ChEMBL_72368 (CHEMBL680931) Inhibition of Growth factor receptor bound protein 2 SH2 domain binding in plasmon resonance binding assay
- ChEMBL_1519160 (CHEMBL3624353) Inhibition of human recombinant IGF-1R
- ChEMBL_1830194 (CHEMBL4330202) Inhibition of IGF-1R (unknown origin)
- ChEMBL_2061600 (CHEMBL4716853) Inhibition of IGF-1R (unknown origin)
- ChEMBL_2105791 (CHEMBL4814466) Inhibition of IGF-IR (unknown origin)
- ChEMBL_739832 (CHEMBL1762892) Inhibition of IGF-1R by ELISA
- ChEMBL_321445 (CHEMBL880253) In vitro inhibitory concentration against IGF-1R Sal kinase with ATP concentration at 1/2Km
- ChEMBL_1706543 (CHEMBL4057776) Inhibition of insulin stimulated INSR phosphorylation in human HeLa cells preincubated for 1 hr followed by insulin addition measured after 5 mins by Western blot analysis
- ChEBML_50977 Antagonistic activity for Corticotropin releasing factor receptor 1
- ChEMBL_146106 (CHEMBL754508) Affinity for human Opioid receptor like 1 (ORL-1) expressed in HEK293 cells
- ChEMBL_146117 (CHEMBL754586) Affinity for human Opioid receptor like 1 (ORL-1) expressed in HEK293 cells
- ChEMBL_2543214 Inhibition of IGF-1R in mouse IGF-1R-Sal cells assessed as inhibition of p44 MAPK phosphorylation at 0.1 to 1000 nmol/L incubated for 1 hr by Western blotting analysis
- ChEMBL_123678 (CHEMBL728561) In vitro inhibition of transforming growth factor- beta dependent luciferase production in mink lung cells (p3TP Lux)
- ChEMBL_158513 (CHEMBL768940) Binding affinity against abl SH2 domain of Platelet-derived growth factor receptor beta in Sf9 insect cells
- ChEMBL_158651 (CHEMBL763437) Inhibition of platelet-derived growth factor receptor beta phosphorylation in MG63 cells in the absence of plasma
- ChEMBL_214249 (CHEMBL820848) In vitro inhibition of Vascular endothelial growth factor receptor 3 [VEGFR-3(Flt-4)] expressed in baculovirus
- ChEMBL_306667 (CHEMBL832268) In vitro inhibition of Platelet derived growth factor receptor beta autophosphorylation in MG-63 cells without plasma
- ChEMBL_63615 (CHEMBL676159) Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Epidermal growth factor receptor (EGF RTK).
- ChEMBL_72357 (CHEMBL686444) In vitro Growth factor receptor bound protein 2-binding affinity in in surface plasmon resonance (SPR) method
- ChEMBL_767244 (CHEMBL1825356) Inhibition of ALK in human KARPAS299 cells assessed as growth factor-induced autophosphorylation by sandwich ELISA method
- ChEMBL_767247 (CHEMBL1825359) Inhibition of RON in mouse 3T3 cells assessed as growth factor-induced autophosphorylation by sandwich ELISA method
- ChEMBL_767249 (CHEMBL1825361) Inhibition of AXL in human HEK293 cells assessed as growth factor-induced autophosphorylation by sandwich ELISA method
- ChEMBL_767252 (CHEMBL1825364) Inhibition of TIE2 in mouse 3T3-E cells assessed growth factor-induced autophosphorylation by sandwich ELISA method
- ChEMBL_767352 (CHEMBL1825464) Inhibition of IR in human HEK293 cells assessed as growth factor-induced autophosphorylation by sandwich ELISA method
- ChEMBL_767355 (CHEMBL1825467) Inhibition of LCK in human Jurkat cells assessed as growth factor-induced autophosphorylation by sandwich ELISA method
- ChEMBL_2543213 Inhibition of IGF-1R in mouse IGF-1R-Sal cells assessed as inhibition of Akt phosphorylation at Ser473 at 0.1 to 1000 nmol/L incubated for 1 hr by Western blotting analysis
- ChEMBL_1279808 (CHEMBL3095509) Activation of glucokinase in rat INS-1 cells assessed as glucose-stimulated insulin secretion
- ChEMBL_1672669 (CHEMBL4022698) Inhibition of human insulin receptor tyrosine kinase after 1 hr by scintillation counting method
- ChEMBL_884454 (CHEMBL2212216) Inhibition of human recombinant TRX-1 up to 60 mins by insulin reduction assay
- ChEMBL_2527471 Inhibition of human recombinant IGF-1 receptor in 90% mouse plasma measured by HPLC-MS/MS analysis
- ChEMBL_2527472 Inhibition of human recombinant IGF-1 receptor in 90% human plasma measured by HPLC-MS/MS analysis
- ChEBML_305510 Inhibitory activity against Opioid receptor like 1 expressed in HEK293 cells
- ChEBML_90279 Inhibition of Insulin receptor kinase-beta
- ChEMBL_2544064 Inhibition of insulin receptor (unknown origin)
- ChEMBL_563807 (CHEMBL994319) Inhibition of human insulin receptor
- ChEMBL_655044 (CHEMBL1244088) Inhibition of human insulin receptor
- ChEMBL_741336 (CHEMBL1764805) Inhibition of insulin receptor kinase
- ChEMBL_847963 (CHEMBL2150263) Inhibition of IGF-1R after 5 mins
- ChEBML_47907 Antagonism towards Colony stimulating factor 1 receptor (CSF-1R)
- ChEBML_1565754 Inhibition of human recombinant hepatocyte growth factor activator using H2N(EEdansyl)GKQLRVVNGG (KDabcyl)-NH2 as substrate by fluorometric analysis
- ChEBML_70635 In vitro inhibition against autophosphorylation of Fibroblast growth factor receptor 2 in the human scirrhous gastric carcinoma cell line
- ChEBML_72366 Inhibitory concentration required against Src homology (SH2) domain of Growth factor receptor bound protein 2 by ELISA binding assay
- ChEMBL_158652 (CHEMBL763438) Inhibition of platelet derived growth factor receptor beta phosphorylation in MG63 cells in the presence of human plasma
- ChEMBL_213979 (CHEMBL817493) Inhibition of VEGFR induced autophosphorylation of human Vascular endothelial growth factor receptor 2 (VEGFR2) transfected in CHO cells
- ChEMBL_302172 (CHEMBL829239) In vitro binding affinity for growth factor receptor bound protein 2 SH2 domain from human breast cancer cells
- ChEMBL_302173 (CHEMBL830076) In vitro binding affinity for growth factor receptor bound protein 2 SH2 domain from human breast cancer cells
- ChEMBL_72369 (CHEMBL680932) Inhibitory activity against binding of Growth factor receptor bound protein 2 to biotinylated KPFY*VNVEF Peptide by ELISA.
- ChEMBL_767349 (CHEMBL1825461) Inhibition of ABL in mouse BaF3-BCL cells assessed as growth factor-induced autophosphorylation by sandwich ELISA method