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TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50088386(Bunazosin | Bunazosin HCl)
Affinity DataIC50:  1.20nMAssay Description:Antagonist activity at Adrenergic alpha-1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM29568(CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)
Affinity DataIC50:  1.20nMAssay Description:Antagonist activity at Adrenergic alpha-1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50033111(1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetra...)
Affinity DataIC50:  5nMAssay Description:Antagonist activity at Adrenergic alpha-1 receptor in human Prostate cell in presence of (125I)-Heat by Competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50048803(5-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)et...)
Affinity DataIC50:  11nMAssay Description:Inhibitory concentration against alpha adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50545275(CHEMBL4645677)
Affinity DataIC50:  14nMAssay Description:Inhibition of adrenergic receptor alpha1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50033110(ALFUZOSIN | CHEMBL709 | N-{3-[(4-amino-6,7-dimetho...)
Affinity DataIC50:  23nMAssay Description:Antagonist activity at Adrenergic alpha-1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50005836(4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl...)
Affinity DataIC50:  30nMAssay Description:Concentration required for inhibition of alpha-1 adrenergic receptor using [3H]prazosin as the radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50005836(4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl...)
Affinity DataIC50:  30nMAssay Description:Binding affinity to adrenergic alpha-1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50007559(5-[2-(4-Naphthalen-1-yl-piperazin-1-yl)-ethyl]-1,3...)
Affinity DataIC50:  45nMAssay Description:Inhibitory concentration against alpha adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50092053(2-[4-(4-Chloro-benzyl)-piperazin-1-yl]-1-(2,3-dihy...)
Affinity DataIC50:  88nMAssay Description:Inhibitory concentration against alpha adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50151930(3-[4-(4-Benzo[1,3]dioxol-5-yl-piperazin-1-yl)-buty...)
Affinity DataIC50:  100nMAssay Description:In vitro inhibitory activity against Factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50105070(1-{3-[(6-Chloro-benzo[1,3]dioxol-5-ylmethyl)-amino...)
Affinity DataIC50:  174nMAssay Description:Inhibition of alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50105105(CHEMBL116463 | {1-[4,4-Bis-(4-fluoro-phenyl)-butyl...)
Affinity DataIC50:  417nMAssay Description:Inhibition of alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50005127(1,1-Dioxo-2-[4-(4-pyrimidin-2-yl-piperazin-1-yl)-b...)
Affinity DataIC50:  500nMAssay Description:In vitro inhibitory activity against Factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50151946(3-{4-[4-(4-Methoxy-phenyl)-piperazin-1-yl]-butyl}-...)
Affinity DataIC50:  700nMAssay Description:In vitro inhibitory activity against Factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50545276(CHEMBL4637801)
Affinity DataIC50:  980nMAssay Description:Inhibition of adrenergic receptor alpha1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50105102(4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazine-1-c...)
Affinity DataIC50:  993nMAssay Description:Inhibition of alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50151935(5-Methoxy-3-{4-[4-(4-methoxy-phenyl)-piperazin-1-y...)
Affinity DataIC50:  1.00E+3nMAssay Description:In vitro inhibitory activity against Factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50093789(CHEMBL541829 | Succinic acid mono-(2-dimethylamino...)
Affinity DataIC50: >1.00E+3nMAssay Description:The compound was evaluated for the ability to displace [3H]prazosin binding to Alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50218390(CHEMBL311278)
Affinity DataIC50: >1.00E+3nMAssay Description:The compound was evaluated for the ability to displace [3H]prazosin binding to Alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50218389(CHEMBL84505)
Affinity DataIC50: >1.00E+3nMAssay Description:The compound was evaluated for the ability to displace [3H]prazosin binding to Alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50218393(CHEMBL79542)
Affinity DataIC50: >1.00E+3nMAssay Description:The compound was evaluated for the ability to displace [3H]prazosin binding to Alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50286670(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-naphth...)
Affinity DataIC50: >1.00E+3nMAssay Description:Compound was tested for its affinity towards Alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50213737(7-nitro-1,1-dioxo-3-(2-phenoxy-phenylamino)-1,4-di...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of adrenergic alpha-1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50105109(4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazine-1-c...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50119970(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-((R)-2-me...)
Affinity DataIC50:  1.12E+3nMAssay Description:Inhibitory concentration against alpha adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50105106(1-[1-(2-Chloro-4-methyl-benzyl)-piperidin-4-yl]-1,...)
Affinity DataIC50:  1.15E+3nMAssay Description:Inhibition of alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50105103(1-{4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazin-1...)
Affinity DataIC50:  1.17E+3nMAssay Description:Inhibition of alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50119892(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataIC50:  1.26E+3nMAssay Description:Inhibitory concentration against alpha adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50105094(1-[1-(6-Chloro-benzo[1,3]dioxol-5-ylmethyl)-piperi...)
Affinity DataIC50:  1.33E+3nMAssay Description:Inhibition of alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50105061(4-(2-Oxo-2,3-dihydro-benzoimidazol-1-yl)-piperidin...)
Affinity DataIC50:  1.34E+3nMAssay Description:Inhibition of alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50105101(4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazine-1-c...)
Affinity DataIC50:  1.64E+3nMAssay Description:Inhibition of alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50151982(5-{4-[4-(5-Cyano-1H-indol-3-yl)-butyl]-piperazin-1...)
Affinity DataIC50:  1.98E+3nMAssay Description:In vitro inhibitory activity against Factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50105107(1-{4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazin-1...)
Affinity DataIC50:  2.19E+3nMAssay Description:Inhibition of alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50105076(8-(3-Phenoxy-benzyl)-1-phenyl-1,3,8-triaza-spiro[4...)
Affinity DataIC50:  2.83E+3nMAssay Description:Inhibition of alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50105088(1-Phenyl-8-[1,3,4]thiadiazolo[3,4-a]pyridazin-6-yl...)
Affinity DataIC50:  4.25E+3nMAssay Description:Inhibition of alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50105066(1-[1-(6-Chloro-benzo[1,3]dioxol-5-ylmethyl)-piperi...)
Affinity DataIC50:  4.92E+3nMAssay Description:Inhibition of alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50033447(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-o-toly...)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor alpha was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50009073(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory concentration against Alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50284690(1-(4-{3-[(E)-2-(5-Fluoro-benzothiazol-2-yl)-vinyl]...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory concentration against Alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50284689(7-Chloro-2-((E)-2-{3-[4-(2-methyl-imidazo[4,5-c]py...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory concentration against Alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50181840((1R,7aS)-hexahydro-1H-pyrrolizin-1-ylmethyl 1-Meth...)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity to adrenergic alpha-1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50181836(4-Amino-N-(1-aza-tricyclo[3.3.1.0*3,7*]non-4-yl)-5...)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity to adrenergic alpha-1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50005833((exo)4-Amino-5-chloro-N-(hexahydro-pyrrolizin-1-yl...)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity to adrenergic alpha-1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50181837((1S,7aR)-hexahydro-1H-pyrrolizin-1-ylmethyl 1-meth...)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity to adrenergic alpha-1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50181841((1S,7aR)-hexahydro-1H-pyrrolizin-1-ylmethyl 1H-ind...)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity to adrenergic alpha-1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50181839(CHEMBL202434 | N-exo-((4S,7alphaS)-tetrahydro-1H-p...)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity to adrenergic alpha-1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50181836(4-Amino-N-(1-aza-tricyclo[3.3.1.0*3,7*]non-4-yl)-5...)
Affinity DataIC50: >1.00E+4nMAssay Description:Concentration required for inhibition of alpha-1 adrenergic receptor using [3H]prazosin as the radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50155152(4-Amino-N-(1-aza-tricyclo[3.3.1.1*3,7*]dec-4-yl)-5...)
Affinity DataIC50: >1.00E+4nMAssay Description:Concentration required for inhibition of alpha-1 adrenergic receptor using [3H]prazosin as the radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50155153(4-Amino-N-(1-aza-tricyclo[3.3.1.1*3,7*]dec-4-ylmet...)
Affinity DataIC50: >1.00E+4nMAssay Description:Concentration required for inhibition of alpha-1 adrenergic receptor using [3H]prazosin as the radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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