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Found 11 of ic50 for monomerid = 50435990
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))TBA
LigandPNGBDBM50435990(GALETERONE | TOK-001 | US9611270, galaterone | VN/...)
Affinity DataIC50:  12nMAssay Description:Inhibition of CYP17AI in human 22Rv1 cellsMore data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))TBA
LigandPNGBDBM50435990(GALETERONE | TOK-001 | US9611270, galaterone | VN/...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human recombinant CYP17A1 incubated for 5 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))TBA
LigandPNGBDBM50435990(GALETERONE | TOK-001 | US9611270, galaterone | VN/...)
Affinity DataIC50:  28nMAssay Description:Inhibition of C-terminal His-tagged recombinant human CYP17A1delta19H mutant expressed in Escherichia coli DH5alpha assessed as decrease in progester...More data for this Ligand-Target Pair
TargetSteroid 21-hydroxylase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50435990(GALETERONE | TOK-001 | US9611270, galaterone | VN/...)
Affinity DataIC50:  77nMAssay Description:Inhibition of C-terminal His-tagged recombinant human CYP21A2deltaH mutant expressed in Escherichia coli DH5alpha assessed as decrease in progesteron...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))TBA
LigandPNGBDBM50435990(GALETERONE | TOK-001 | US9611270, galaterone | VN/...)
Affinity DataIC50:  140nMAssay Description:Inhibition of CYP17 (unknown origin)More data for this Ligand-Target Pair
TargetSteroid 21-hydroxylase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50435990(GALETERONE | TOK-001 | US9611270, galaterone | VN/...)
Affinity DataIC50:  248nMAssay Description:Complementary assays were utilized for the quantitative comparison of compound activity data for CYP17A1 and CYP21A2. Progesterone is a substrate for...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))TBA
LigandPNGBDBM50435990(GALETERONE | TOK-001 | US9611270, galaterone | VN/...)
Affinity DataIC50:  282nMAssay Description:Complementary assays were utilized for the quantitative comparison of compound activity data for CYP17A1 and CYP21A2. Progesterone is a substrate for...More data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))TBA
LigandPNGBDBM50435990(GALETERONE | TOK-001 | US9611270, galaterone | VN/...)
Affinity DataIC50:  300nMAssay Description:Inhibition of human CYP17 expressed in Escherichia coliMore data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))TBA
LigandPNGBDBM50435990(GALETERONE | TOK-001 | US9611270, galaterone | VN/...)
Affinity DataIC50:  752nMAssay Description:Inhibition of human truncated CYP17A1 expressed in Escherichia coliMore data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
Shanghai Institute Of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50435990(GALETERONE | TOK-001 | US9611270, galaterone | VN/...)
Affinity DataIC50:  1.11E+3nMAssay Description:Antagonist activity at DHT-induced Androgen receptor transcriptional activity in human HEK293 cells measured after 24 hrs by Steady-Glo reagent based...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))TBA
LigandPNGBDBM50435990(GALETERONE | TOK-001 | US9611270, galaterone | VN/...)
Affinity DataIC50:  3.55E+3nMAssay Description:Inhibition of CYP17AI in human LNCaP cellsMore data for this Ligand-Target Pair