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Found 20 Enz. Inhib. hit(s) with Target = 'Atypical chemokine receptor 3' and Ligand = 'BDBM50555343'
TargetAtypical chemokine receptor 3(Homo sapiens (Human))
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50555343(CHEMBL4782111 | US11306078, Example 4.032)
Affinity DataKi:  0.530nMAssay Description:Binding affinity to SNAP-tag fused human CXCR7 expressed in HEK293 cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtypical chemokine receptor 3(Homo sapiens (Human))
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50555343(CHEMBL4782111 | US11306078, Example 4.032)
Affinity DataIC50:  0.864nMAssay Description:Insurmountable antagonist activity at CXCR7 (unknown origin) expressed in human U2OS cells co-expressing beta-arrestin assessed as reduction in CXCL1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtypical chemokine receptor 3(Homo sapiens (Human))
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50555343(CHEMBL4782111 | US11306078, Example 4.032)
Affinity DataIC50:  0.900nMAssay Description:Insurmountable antagonist activity at CXCR7 (unknown origin) expressed in human U2OS cells co-expressing beta-arrestin assessed as reduction in CXCL1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtypical chemokine receptor 3(Homo sapiens (Human))
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50555343(CHEMBL4782111 | US11306078, Example 4.032)
Affinity DataIC50:  0.903nMAssay Description:Insurmountable antagonist activity at CXCR7 (unknown origin) expressed in human U2OS cells co-expressing beta-arrestin assessed as reduction in CXCL1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtypical chemokine receptor 3(Homo sapiens (Human))
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50555343(CHEMBL4782111 | US11306078, Example 4.032)
Affinity DataIC50:  0.962nMAssay Description:Insurmountable antagonist activity at CXCR7 (unknown origin) expressed in human U2OS cells co-expressing beta-arrestin assessed as reduction in CXCL1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtypical chemokine receptor 3(Homo sapiens (Human))
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50555343(CHEMBL4782111 | US11306078, Example 4.032)
Affinity DataIC50:  0.985nMAssay Description:Insurmountable antagonist activity at CXCR7 (unknown origin) expressed in human U2OS cells co-expressing beta-arrestin assessed as reduction in CXCL1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtypical chemokine receptor 3(Homo sapiens (Human))
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50555343(CHEMBL4782111 | US11306078, Example 4.032)
Affinity DataIC50:  0.989nMAssay Description:Insurmountable antagonist activity at CXCR7 (unknown origin) expressed in human U2OS cells co-expressing beta-arrestin assessed as reduction in CXCL1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtypical chemokine receptor 3(Homo sapiens (Human))
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50555343(CHEMBL4782111 | US11306078, Example 4.032)
Affinity DataIC50:  1.20nMAssay Description:Insurmountable antagonist activity at CXCR7 (unknown origin) expressed in human U2OS cells co-expressing beta-arrestin assessed as reduction in CXCL1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtypical chemokine receptor 3(Homo sapiens (Human))
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50555343(CHEMBL4782111 | US11306078, Example 4.032)
Affinity DataIC50:  1.70nMAssay Description:Insurmountable antagonist activity at CXCR7 (unknown origin) expressed in human U2OS cells co-expressing beta-arrestin assessed as reduction in CXCL1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtypical chemokine receptor 3(Homo sapiens (Human))
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50555343(CHEMBL4782111 | US11306078, Example 4.032)
Affinity DataIC50:  1.80nMAssay Description:Insurmountable antagonist activity at CXCR7 (unknown origin) expressed in human U2OS cells co-expressing beta-arrestin assessed as reduction in CXCL1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtypical chemokine receptor 3(Homo sapiens (Human))
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50555343(CHEMBL4782111 | US11306078, Example 4.032)
Affinity DataIC50:  2nMAssay Description:Insurmountable antagonist activity at CXCR7 (unknown origin) expressed in human U2OS cells co-expressing beta-arrestin assessed as reduction in CXCL1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtypical chemokine receptor 3(Mus musculus)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50555343(CHEMBL4782111 | US11306078, Example 4.032)
Affinity DataIC50:  2.30nMAssay Description:Antagonist activity at mouse CXCR7 expressed in human U2OS cells co-expressing beta-arrestin assessed as reduction in CXCL12-alpha induced response i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtypical chemokine receptor 3(Canis lupus familiaris)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50555343(CHEMBL4782111 | US11306078, Example 4.032)
Affinity DataIC50:  2.30nMAssay Description:Antagonist activity at dog CXCR7 expressed in CHO-K1 cells co-expressing beta-arrestin assessed as reduction in CXCL12-alpha induced response incubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtypical chemokine receptor 3(Homo sapiens (Human))
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50555343(CHEMBL4782111 | US11306078, Example 4.032)
Affinity DataIC50:  2.30nMAssay Description:Insurmountable antagonist activity at CXCR7 (unknown origin) expressed in human U2OS cells co-expressing beta-arrestin assessed as reduction in CXCL1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtypical chemokine receptor 3(Homo sapiens (Human))
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50555343(CHEMBL4782111 | US11306078, Example 4.032)
Affinity DataIC50:  2.80nMAssay Description:Insurmountable antagonist activity at CXCR7 (unknown origin) expressed in human U2OS cells co-expressing beta-arrestin assessed as reduction in CXCL1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtypical chemokine receptor 3(Homo sapiens (Human))
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50555343(CHEMBL4782111 | US11306078, Example 4.032)
Affinity DataIC50:  2.80nMAssay Description:Insurmountable antagonist activity at CXCR7 (unknown origin) expressed in human U2OS cells co-expressing beta-arrestin assessed as reduction in CXCL1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtypical chemokine receptor 3(Homo sapiens (Human))
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50555343(CHEMBL4782111 | US11306078, Example 4.032)
Affinity DataIC50:  3nMAssay Description:Tango CXCR7-bla U2OS cells are detached from culture dishes with 0.05% trypsin-EDTA and collected in growing medium (McCoy's 5A 90% (v/v), dialyz...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAtypical chemokine receptor 3(Homo sapiens (Human))
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50555343(CHEMBL4782111 | US11306078, Example 4.032)
Affinity DataIC50:  3nMAssay Description:Tango CXCR7-bla U2OS cells are detached from culture dishes with 0.05% trypsin-EDTA and collected in growing medium (McCoy's 5A 90% (v/v), dialyz...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAtypical chemokine receptor 3(Rattus norvegicus)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50555343(CHEMBL4782111 | US11306078, Example 4.032)
Affinity DataIC50:  3.10nMAssay Description:Antagonist activity at rat CXCR7 expressed in HEK293 cells co-expressing beta-arrestin assessed as reduction in CXCL12-alpha induced response incubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtypical chemokine receptor 3(Homo sapiens (Human))
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50555343(CHEMBL4782111 | US11306078, Example 4.032)
Affinity DataIC50:  3.20nMAssay Description:Antagonist activity at CXCR7 (unknown origin) expressed in human U2OS cells co-expressing beta-arrestin assessed as reduction in CXCL12-alpha induced...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed