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Found 4 Enz. Inhib. hit(s) with Target = 'Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial' and Ligand = 'BDBM101847'
TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial(Homo sapiens (Human))
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM101847(CHEMBL2147985 | US8530490, 110)
Affinity DataIC50:  39nMAssay Description:Inhibition of human dUTPase-mediated formation of [5-3H]dUMP expressed in Escherichia coli BL21 (DE3) after 15 mins by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial(Homo sapiens (Human))
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM101847(CHEMBL2147985 | US8530490, 110)
Affinity DataIC50:  50nMAssay Description:The inhibitory activity of the compound against human dUTPase was determined by measuring the production of [5-3H]deoxyuridine monophosphate from [5-...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial(Homo sapiens (Human))
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM101847(CHEMBL2147985 | US8530490, 110)
Affinity DataIC50:  3.82E+4nMAssay Description:Inhibition of human dUTPase-mediated cell proliferation in HeLa S3 cells after 72 hrs by crystal violet stainingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial(Homo sapiens (Human))
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM101847(CHEMBL2147985 | US8530490, 110)
Affinity DataEC50:  66nMAssay Description:Inhibition of human dUTPase-mediated cell proliferation in HeLa S3 cells assessed as compound concentration required to reduce 50% of 1 uM of FdUrd T...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed