Found 8 Enz. Inhib. hit(s) with Target = 'Dual specificity tyrosine-phosphorylation-regulated kinase 1A' and Ligand = 'BDBM50567047' TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
University Of Sussex
Curated by ChEMBL
University Of Sussex
Curated by ChEMBL
Affinity DataIC50: 76nMAssay Description:Displacement of Kinase tracer 236 from biotinylated DYRK1A (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 1.5 hrs by TR-FRET...More data for this Ligand-Target Pair
3D Structure (crystal)TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
University Of Sussex
Curated by ChEMBL
University Of Sussex
Curated by ChEMBL
Affinity DataIC50: 220nMAssay Description:Inhibition of full length GST-tagged human DYRK1A phosphorylation expressed in baculovirus expression system in presence of [gamma-33P]ATP by radiome...More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
University Of Sussex
Curated by ChEMBL
University Of Sussex
Curated by ChEMBL
Affinity DataIC50: 464nMAssay Description:Inhibition of recombinant human DYRK1A expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scin...More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
University Of Sussex
Curated by ChEMBL
University Of Sussex
Curated by ChEMBL
Affinity DataIC50: 590nMAssay Description:Inhibition of human DYRK1A-mediated tau phosphorylation expressed in HEK293 cells incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
University Of Sussex
Curated by ChEMBL
University Of Sussex
Curated by ChEMBL
Affinity DataKd: 0.240nMAssay Description:Binding affinity to human DYRK1A assessed as equilibrium dissociation constant measured upto 240 min by TR-FRET assayMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
University Of Sussex
Curated by ChEMBL
University Of Sussex
Curated by ChEMBL
Affinity DataKd: 85nMAssay Description:Binding affinity to biotinylated DYRK1A (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant measured up to 5 ...More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
University Of Sussex
Curated by ChEMBL
University Of Sussex
Curated by ChEMBL
Affinity DataKon: 0.240M-1s-1Assay Description:Binding affinity to biotinylated DYRK1A (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as dissociation rate constant measured up ...More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
University Of Sussex
Curated by ChEMBL
University Of Sussex
Curated by ChEMBL
Affinity DataKd: 3nMAssay Description:Binding affinity to wild-type human partial length DYRK1A (H129 to S509 residues) expressed in mammalian expression system measured after 1 hr by com...More data for this Ligand-Target Pair
