Compile Data Set for Download or QSAR
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Found 21 Enz. Inhib. hit(s) with Target = 'E-selectin' and Ligand = 'BDBM50450369'
TargetE-selectin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50: >1.00E+4nMAssay Description:Compound was evaluated for the Selectin E binding activity.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE-selectin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50:  3.00E+5nMAssay Description:Ability to inhibit the binding to Selectin E immobilized on SPA beads of radiolabeled HL-60 cell membrane was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetE-selectin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50:  3.00E+5nMAssay Description:In vitro inhibitory activity against binding of Selectin E to human recombinant AGP (alpha-1 acid glycoprotein) containing sLex derivativeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE-selectin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50:  3.00E+5nMAssay Description:Compound was tested for its ability to inhibit the binding to recombinant human Selectin E immobilized on SPA beads of radiolabeled HL60 cell membran...More data for this Ligand-Target Pair
In DepthDetails Article
TargetE-selectin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50:  5.00E+5nMAssay Description:Ability to inhibit sialyl Lewis X binding to Selectin E was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetE-selectin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50:  6.00E+5nMAssay Description:Inhibitory activity against human chimeric E-selectin-IgMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE-selectin(Mus musculus)
Kanebo

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50:  6.00E+5nMAssay Description:In vitro inhibitory activity against Selectin E-sialyl Lewis X (sLex) bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE-selectin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50:  6.00E+5nMAssay Description:Inhibitory concentration against blocking of E-selectin during migration of inflammatory cells to inflammatory siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE-selectin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50:  6.00E+5nMAssay Description:Displacement of sialyl Lewis X (sLex) from selectin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE-selectin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50:  6.00E+5nMAssay Description:In vitro inhibitory activity of compound was determined against Selectin E binding by ELISA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE-selectin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50:  7.00E+5nMAssay Description:Inhibitory concentration against E-selectinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE-selectin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50: <1.00E+6nMAssay Description:Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin B recep...More data for this Ligand-Target Pair
In DepthDetails
TargetE-selectin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50:  1.09E+6nMAssay Description:Compound was tested in a cell-free SLe-polyacrylamide glycoconjugate binding assay (assay B) in Selectin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE-selectin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50:  1.09E+6nMAssay Description:Compound was tested in a cell-free SLe-polyacrylamide glycoconjugate binding assay (assay B) in Selectin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE-selectin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50:  3.00E+6nMAssay Description:In vitro inhibition of HL60 (human leukemia) cell binding to human recombinant e-selectin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE-selectin(Mus musculus)
Kanebo

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50:  3.00E+6nMAssay Description:Compound was tested for its ability to inhibit sialyl Lewis X dependent binding of HL-60 cells to Selectin E fusion proteinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetE-selectin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50:  3.30E+6nMAssay Description:Tested in vitro for the concentration to inhibit sLex bearing HL-60 cells binding to Selectin E-IgG fusion proteins by 50%.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE-selectin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50:  5.00E+6nMAssay Description:Concentration required to inhibit the interaction of Selectin E and HL-60 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE-selectin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50:  5.00E+6nMAssay Description:Concentration required to inhibit the interaction of Selectin E and HL-60 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE-selectin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataIC50:  5.00E+6nMAssay Description:Concentration required to inhibit the interaction of Selectin E and HL-60 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE-selectin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50450369(SIALYL LEWIS X | Sialyl LeX | Sialyl lewis-x | sLe...)
Affinity DataKd:  1.00E+6nMAssay Description:Affinity of compound to Selectin E was determinedMore data for this Ligand-Target Pair
In DepthDetails Article