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Found 3 Enz. Inhib. hit(s) with Target = 'Glycogen synthase kinase-3 alpha' and Ligand = 'BDBM173195'
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM173195(US10137122, Compound 3 | US9096594, 3)
Affinity DataIC50:  161nMT: 2°CAssay Description:The GSK3beta primary screen was conducted in assay ready 1536 plates (Aurora 29847) that contain 2.5 mL/well of 10 mM compound. Human GSK3beta as a G...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM173195(US10137122, Compound 3 | US9096594, 3)
Affinity DataIC50:  343nMpH: 7.5 T: 2°CAssay Description:Purified GSK3beta was incubated with tested compounds in doses in the presence of 4.3 uM of ATP and 1.5uM peptide substrate (Peptide 15, Caliper, MA)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM173195(US10137122, Compound 3 | US9096594, 3)
Affinity DataIC50:  550nMAssay Description:A solution of 4× inhibitor (5 μL), 4× substrate/ATP-Metal solution (5 μL), and 2× Kinase solution (10 μL) was prepared with assay buff...More data for this Ligand-Target Pair
In DepthDetails US Patent