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Target
Glycogen synthase kinase-3 alpha
Ligand
BDBM173195
Substrate
n/a
Meas. Tech.
Mobility Shift Microfluidics Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
343± 187 nM
Comments
extracted
Citation
 Wagner, FF; Bishop, JA; Gale, JP; Shi, X; Walk, M; Ketterman, J; Patnaik, D; Barker, D; Walpita, D; Campbell, AJ; Nguyen, S; Lewis, M; Ross, L; Weïwer, M; An, WF; Germain, AR; Nag, PP; Metkar, S; Kaya, T; Dandapani, S; Olson, DE; Barbe, AL; Lazzaro, F; Sacher, JR; Cheah, JH; Fei, D; Perez, J; Munoz, B; Palmer, M; Stegmaier, K; Schreiber, SL; Scolnick, E; Zhang, YL; Haggarty, SJ; Holson, EB; Pan, JQ Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-Wide Selectivity and Their Functional Effects. ACS Chem Biol 11:1952-63 (2016) [PubMed]  Article 
Target
Name:
Glycogen synthase kinase-3 alpha
Synonyms:
GSK-3 alpha | GSK3A | GSK3A_HUMAN | Glycogen synthase kinase 3 alpha (GSKalpha) | Glycogen synthase kinase-3 | Glycogen synthase kinase-3 alpha | Glycogen synthase kinase-3 alpha (GSK3 Alpha) | Glycogen synthase kinase-3 alpha (GSK3A) | Glycogen synthase kinase-3 alpha (GSK3alpha)
Type:
Enzyme
Mol. Mass.:
50991.79
Organism:
Homo sapiens (Human)
Description:
P49840
Residue:
483
Sequence:
MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS
  
Inhibitor
Name:
BDBM173195
Synonyms:
US10137122, Compound 3 | US9096594, 3
Type:
Small organic molecule
Emp. Form.:
C19H21N3O
Mol. Mass.:
307.3895
SMILES:
Cc1[nH]nc2NC3=C([C@H](c12)c1ccccc1)C(=O)CC(C)(C)C3 |r,c:6|
Structure:
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