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Found 7 Enz. Inhib. hit(s) with Target = 'Heat shock protein HSP 90-alpha/90-beta' and Ligand = 'BDBM50485825'
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Myrexis

Curated by ChEMBL
LigandPNGBDBM50485825(CHEMBL2170470)
Affinity DataIC50:  60nMAssay Description:Inhibition of human HSP90 in HCT116 cells expressing Her2 gene assessed as degradation of Her2 after 4 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Myrexis

Curated by ChEMBL
LigandPNGBDBM50485825(CHEMBL2170470)
Affinity DataIC50:  100nMAssay Description:Inhibition of human HSP90 in HCT116 cells assessed as degradation of Her2 incubated for 24 hrs by Western blot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Myrexis

Curated by ChEMBL
LigandPNGBDBM50485825(CHEMBL2170470)
Affinity DataIC50:  100nMAssay Description:Inhibition of human HSP90 in DU145 cells assessed as degradation of Akt incubated for 24 hrs by Western blot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Myrexis

Curated by ChEMBL
LigandPNGBDBM50485825(CHEMBL2170470)
Affinity DataIC50:  100nMAssay Description:Inhibition of human HSP90 in HCT116 cells assessed as degradation of Akt incubated for 24 hrs by Western blot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Myrexis

Curated by ChEMBL
LigandPNGBDBM50485825(CHEMBL2170470)
Affinity DataIC50:  100nMAssay Description:Inhibition of human HSP90 in NCI-N87 cells assessed as degradation of Her2 incubated for 24 hrs by Western blot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Myrexis

Curated by ChEMBL
LigandPNGBDBM50485825(CHEMBL2170470)
Affinity DataIC50:  100nMAssay Description:Inhibition of human HSP90 in DU145 cells assessed as degradation of Her2 incubated for 24 hrs by Western blot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Myrexis

Curated by ChEMBL
LigandPNGBDBM50485825(CHEMBL2170470)
Affinity DataIC50:  140nMAssay Description:Inhibition of human HSP90 using BODIPY labelled geldanamycin as substrate by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed