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Found 16 Enz. Inhib. hit(s) with Target = 'Indoleamine 2,3-dioxygenase 1' and Ligand = 'BDBM310195'
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM310195((-)-(R)-3-(5-fluoro-1H- indol-3-yl)pyrrolidine- 2,...)
Affinity DataIC50:  120nMAssay Description:To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...More data for this Ligand-Target Pair
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM310195((-)-(R)-3-(5-fluoro-1H- indol-3-yl)pyrrolidine- 2,...)
Affinity DataIC50:  120nMAssay Description:The compounds of the present invention inhibit the enzymatic activity of human IDO1.To measure enzymatic activity of human IDO1, the reaction mixture...More data for this Ligand-Target Pair
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM310195((-)-(R)-3-(5-fluoro-1H- indol-3-yl)pyrrolidine- 2,...)
Affinity DataIC50:  120nMAssay Description:To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...More data for this Ligand-Target Pair
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM310195((-)-(R)-3-(5-fluoro-1H- indol-3-yl)pyrrolidine- 2,...)
Affinity DataIC50:  120nMAssay Description:Inhibition of human recombinant IDO-1 using L-Trp as substrate after 15 mins by PDMAB-based assayMore data for this Ligand-Target Pair
TargetIndoleamine 2,3-dioxygenase 1(Dog)
Pfizer

US Patent
LigandPNGBDBM310195((-)-(R)-3-(5-fluoro-1H- indol-3-yl)pyrrolidine- 2,...)
Affinity DataIC50:  200nMAssay Description:To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM310195((-)-(R)-3-(5-fluoro-1H- indol-3-yl)pyrrolidine- 2,...)
Affinity DataIC50:  200nMAssay Description:To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...More data for this Ligand-Target Pair
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM310195((-)-(R)-3-(5-fluoro-1H- indol-3-yl)pyrrolidine- 2,...)
Affinity DataIC50:  200nMAssay Description:Inhibition of human recombinant IDO-1 using tryptophan as substrate after 22 mins by LC-MS/MS methodMore data for this Ligand-Target Pair
TargetIndoleamine 2,3-dioxygenase 1(Mus musculus)
Pfizer

US Patent
LigandPNGBDBM310195((-)-(R)-3-(5-fluoro-1H- indol-3-yl)pyrrolidine- 2,...)
Affinity DataIC50:  730nMAssay Description:To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM310195((-)-(R)-3-(5-fluoro-1H- indol-3-yl)pyrrolidine- 2,...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of IDO-1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine production after 16 to 24 hrs by PDMAB methodMore data for this Ligand-Target Pair
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM310195((-)-(R)-3-(5-fluoro-1H- indol-3-yl)pyrrolidine- 2,...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of IDO-1 in IFN-gamma/LPS-stimulated human THP1 cells assessed as decrease in kynurenine production after 16 to 24 hrs by PDMAB methodMore data for this Ligand-Target Pair
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM310195((-)-(R)-3-(5-fluoro-1H- indol-3-yl)pyrrolidine- 2,...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of IDO-1 in IFN-gamma/LPS-stimulated human whole blood assessed as decrease in kynurenine production after 24 hrs by LC-MS/MS methodMore data for this Ligand-Target Pair
TargetIndoleamine 2,3-dioxygenase 1(Mus musculus)
Pfizer

US Patent
LigandPNGBDBM310195((-)-(R)-3-(5-fluoro-1H- indol-3-yl)pyrrolidine- 2,...)
Affinity DataIC50:  7.30E+3nMAssay Description:Inhibition of mouse IDO-1 using tryptophan as substrate after 22 mins by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM310195((-)-(R)-3-(5-fluoro-1H- indol-3-yl)pyrrolidine- 2,...)
Affinity DataKd:  6.00E+3nMAssay Description:Binding affinity to ferrous form of human recombinant IDO-1More data for this Ligand-Target Pair
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM310195((-)-(R)-3-(5-fluoro-1H- indol-3-yl)pyrrolidine- 2,...)
Affinity DataKd:  160nMAssay Description:Binding affinity to ferric form of human recombinant IDO-1 in absence of oxygenMore data for this Ligand-Target Pair
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM310195((-)-(R)-3-(5-fluoro-1H- indol-3-yl)pyrrolidine- 2,...)
Affinity DataKd:  150nMAssay Description:Binding affinity to ferric form of human recombinant IDO-1 in absence of oxygen and presence of tryptophanMore data for this Ligand-Target Pair
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM310195((-)-(R)-3-(5-fluoro-1H- indol-3-yl)pyrrolidine- 2,...)
Affinity DataKd:  7.00E+3nMAssay Description:Binding affinity to ferric form of human recombinant IDO-1More data for this Ligand-Target Pair