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Found 10 Enz. Inhib. hit(s) with Target = 'Lysosomal acid glucosylceramidase' and Ligand = 'BDBM50196623'
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Northwestern University

US Patent
LigandPNGBDBM50196623(CHEMBL3976182 | US10167270, Example 00164 | US1050...)
Affinity DataIC50:  5.20nMAssay Description:The compounds in DMSO solution (0.5 μL/well) were transferred to a black 96-well plate (the final titration started from 100 μM, a 12 or 24...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Northwestern University

US Patent
LigandPNGBDBM50196623(CHEMBL3976182 | US10167270, Example 00164 | US1050...)
Affinity DataIC50:  5.20nMpH: 5.9Assay Description:Inhibition of synthetic recombinant wild type GCase enzyme velaglucerase alfa (unknown origin) at pH 5.9 preincubated for 5 mins followed by addition...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Northwestern University

US Patent
LigandPNGBDBM50196623(CHEMBL3976182 | US10167270, Example 00164 | US1050...)
Affinity DataIC50:  5.20nMAssay Description:The enzyme in GCase enzyme activity buffer (25 μL/well) was added to a 384-well black plate. The fluorescent probe 3 (25 nL/well, 50 nM final co...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Northwestern University

US Patent
LigandPNGBDBM50196623(CHEMBL3976182 | US10167270, Example 00164 | US1050...)
Affinity DataIC50:  5.20nMAssay Description:pH = 5.9.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Northwestern University

US Patent
LigandPNGBDBM50196623(CHEMBL3976182 | US10167270, Example 00164 | US1050...)
Affinity DataIC50:  6.60nMpH: 7.0Assay Description:Inhibition of synthetic recombinant wild type GCase enzyme velaglucerase alfa (unknown origin) at pH 7 preincubated for 5 mins followed by addition o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Northwestern University

US Patent
LigandPNGBDBM50196623(CHEMBL3976182 | US10167270, Example 00164 | US1050...)
Affinity DataIC50:  6.60nMAssay Description:The compounds in DMSO solution (0.5 μL/well) were transferred to a black 96-well plate (the final titration started from 100 μM, a 12 or 24...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Northwestern University

US Patent
LigandPNGBDBM50196623(CHEMBL3976182 | US10167270, Example 00164 | US1050...)
Affinity DataIC50:  6.60nMAssay Description:pH = 7.0.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Northwestern University

US Patent
LigandPNGBDBM50196623(CHEMBL3976182 | US10167270, Example 00164 | US1050...)
Affinity DataIC50:  8.90nMAssay Description:The compounds in DMSO solution (0.5 μL/well) were transferred to a black 96-well plate (the final titration started from 100 μM, a 12 or 24...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Northwestern University

US Patent
LigandPNGBDBM50196623(CHEMBL3976182 | US10167270, Example 00164 | US1050...)
Affinity DataIC50:  8.90nMpH: 5.0Assay Description:Inhibition of synthetic recombinant wild type GCase enzyme velaglucerase alfa (unknown origin) at pH 5 preincubated for 5 mins followed by addition o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Northwestern University

US Patent
LigandPNGBDBM50196623(CHEMBL3976182 | US10167270, Example 00164 | US1050...)
Affinity DataIC50:  8.90nMAssay Description:pH = 5.0.More data for this Ligand-Target Pair
In DepthDetails US Patent