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Found 3 Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 5' and Ligand = 'BDBM50207078'
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50207078(4-(3,5-Difluorophenyl)-N-(6-methylpyrindin-2-yl)pi...)
Affinity DataKi:  43nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50207078(4-(3,5-Difluorophenyl)-N-(6-methylpyrindin-2-yl)pi...)
Affinity DataIC50:  98nMAssay Description:Antagonist activity at rat mGluR5 expressed in HEK293A cells assessed as glutamate-induced calcium flux preincubated for 140 sec before glutamate cha...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50207078(4-(3,5-Difluorophenyl)-N-(6-methylpyrindin-2-yl)pi...)
Affinity DataIC50:  160nMAssay Description:Antagonist activity at mGluR5 expressed in CHO cells assessed as phosphoinositide hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed