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Found 3 Enz. Inhib. hit(s) with Target = 'Nuclear receptor ROR-gamma' and Ligand = 'BDBM50502388'
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Piramal Enterprises

US Patent
LigandPNGBDBM50502388(CHEMBL4525318 | US11084784, Example 1)
Affinity DataIC50:  25nMAssay Description:CHO-K1 cells stably transfected with RORĪ³t are maintained in MEM-EBS with 5% FBS, 1% penicillin streptomycin solution and 1 mg/mL G418. The cells ar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Piramal Enterprises

US Patent
LigandPNGBDBM50502388(CHEMBL4525318 | US11084784, Example 1)
Affinity DataIC50:  32nMAssay Description:Inverse agonist activity at human biotinylated HN-Avi-MBPS-TCS-RORC2 (258 to 518 residues) assessed as recruitment of SRC-1-derived coactivator measu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Piramal Enterprises

US Patent
LigandPNGBDBM50502388(CHEMBL4525318 | US11084784, Example 1)
Affinity DataIC50:  79nMAssay Description:Inverse agonist activity at RORC2 in human Th17 cells assessed as inhibition of IL-17A secretion incubated for 4 days by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed