Found 4 Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2' and Ligand = 'BDBM50511342' TargetPhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2(Mus musculus)
University Of East Anglia
Curated by ChEMBL
University Of East Anglia
Curated by ChEMBL
Affinity DataIC50: 390nMAssay Description:Inhibition of SHIP2 in serum-starved mouse Mm1 cells assessed as reduction in Akt phosphorylation incubated for 30 mins by Western blot analysisMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2(Homo sapiens (Human))
School Of Biological Sciences, Uea
Curated by ChEMBL
School Of Biological Sciences, Uea
Curated by ChEMBL
Affinity DataIC50: 1.02E+3nMAssay Description:Displacement of 2FAMInsP5 from recombinant human N-terminal His-tagged SHIP2 (419 to 832 residues) expressed in Escherichia coli Rosetta2 (DE3) cells...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2(Homo sapiens (Human))
School Of Biological Sciences, Uea
Curated by ChEMBL
School Of Biological Sciences, Uea
Curated by ChEMBL
Affinity DataIC50: 6.93E+4nMAssay Description:Displacement of Ins(1,3,4,5)P4 from recombinant human N-terminal His-tagged SHIP2 (419 to 832 residues) expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2(Homo sapiens (Human))
School Of Biological Sciences, Uea
Curated by ChEMBL
School Of Biological Sciences, Uea
Curated by ChEMBL
Affinity DataIC50: 1.08E+5nMAssay Description:Inhibition of His-tagged SHIP2 (unknown origin) incubated for 5 mins using Ins(1,3,4,5)P4 as substrate by malachite green reagent based phosphate ass...More data for this Ligand-Target Pair
