TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human SGLT2 expressed in african green monkey COS7 cells assessed as inhibition of [14C]-methyl-alpha-D-glucopyranoside uptake after 2 ...More data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 370nMAssay Description:Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...More data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 392nMAssay Description:Inhibition of human SGLT1More data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 629nMAssay Description:Inhibition of human SGLT1 expressed in CHO cells assessed as decrease in uptake of [14C]AMG after 120 mins by TopCount methodMore data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 800nMAssay Description:Inhibition of human SGLT1 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 800nMAssay Description:Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of sodium-dependent [14C]methyl-alpha-D-glucopyranoside uptake after 45 minsMore data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 803nMpH: 7.4Assay Description:A cDNA clone expressing human SGLT1/SGLT2 was bought from GenerScript. Having the sequence information, it was built into pcDNA5 carrier by using tra...More data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 810nMAssay Description:Inhibition of human SGLT1 expressed in HEK293 cells assessed as inhibition of [14C]alpha-methylglucopyranoside uptakeMore data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 885nMAssay Description:Inhibition of human SGLT1 expressed in african green monkey COS7 cells assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake by scintillation coun...More data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 890nMAssay Description:Inhibition of human SGLT1 transfected in COS-7 cells assessed as AMG uptake after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 890nMAssay Description:Inhibition of human SGLT1 expressed in african green monkey COS7 cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside uptake after 2 ...More data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 891nMAssay Description:Inhibition of human SGLT1 expressed in CHOK1 cells assessed as inhibition of [14C]-AMG uptake after 3 hrs by microbeta scintillation counting analysi...More data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 1.39E+3nMAssay Description:Inhibition of human SGLT1More data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 1.83E+3nMAssay Description:Inhibition of human SGLT1 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake preincubated for 10 mins followed by [14C]-AMG addition ...More data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 3.14E+3nMAssay Description:Inhibition of full length human SGLT1 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrs by cell-based topcount scintillation count...More data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 1.23E+4nMAssay Description:Inhibition of human full length SGLT1 expressed in NIH3T3 cells measured after 1 hr in presence of [14C]-methyl-alpha -D-glucopyranoside by scintilla...More data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataEC50: 593nMAssay Description:Inhibition of human SGLT1 expressed in CHO-K1 cells incubated for 120 mins at 37 degC by [14C]-AMG uptake assayMore data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataEC50: 860nMAssay Description:Inhibition of human SGLT1 expressed in CHO cells assessed as reduction in [14C]AMG uptake after 1 hr by microbeta counting methodMore data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataEC50: 1.39E+3nMpH: 7.2 T: 2°CAssay Description:Inhibitors were assayed for the ability to inhibit [14C]AMG uptake in a protein-free buffer over a 2 h incubation period. The response curve was fitt...More data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataEC50: 1.40E+3nMAssay Description:Inhibition of SGLT1 (unknown origin)More data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataEC50: 429nMAssay Description:Inhibition of human SGLT1 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...More data for this Ligand-Target Pair