Found 16 Enz. Inhib. hit(s) with Target = 'Stimulator of interferon genes protein' and Ligand = 'BDBM50558665' TargetStimulator of interferon genes protein(Human)
Bristol Myers Squibb Research And Development
Curated by ChEMBL
Bristol Myers Squibb Research And Development
Curated by ChEMBL
Affinity DataIC50: 7.20nMAssay Description:Displacement of fluorescein-labelled probe from human cytoplasmic domain of STING G230A/R293Q double mutant (155 to 341 residues) by time-resolved FR...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Mus musculus)
Bristol Myers Squibb Research And Development
Curated by ChEMBL
Bristol Myers Squibb Research And Development
Curated by ChEMBL
Affinity DataIC50: 7.70nMAssay Description:Displacement of fluorescein-labelled probe from wild type mouse His-tagged STING cytoplasmic domain (155 to 341 residues) by time-resolved FRET-based...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Bristol Myers Squibb Research And Development
Curated by ChEMBL
Bristol Myers Squibb Research And Development
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Displacement of fluorescein-labelled probe from wild type human His-tagged STING cytoplasmic domain (155 to 341 residues) by time-resolved FRET-based...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Bristol Myers Squibb Research And Development
Curated by ChEMBL
Bristol Myers Squibb Research And Development
Curated by ChEMBL
Affinity DataEC50: 6.40E+3nMAssay Description:Activation of STING in human blood assessed as induction of type I IFNs incubated for 18 to 20 hrs by QUANTI-Blue assayMore data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Bristol Myers Squibb Research And Development
Curated by ChEMBL
Bristol Myers Squibb Research And Development
Curated by ChEMBL
Affinity DataEC50: 3.70E+4nMAssay Description:Agonist activity at STING in human THP1 Dual cells assessed as IRF reporter activation incubated for 20 hrs by quanti-blue SEAP reporter gene assayMore data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Mus musculus)
Bristol Myers Squibb Research And Development
Curated by ChEMBL
Bristol Myers Squibb Research And Development
Curated by ChEMBL
Affinity DataEC50: 7.50E+3nMAssay Description:Agonist activity at STING in mouse RAW-Lucia ISG cells assessed as IRF reporter activation incubated for 20 hrs by quanti-blue SEAP reporter gene ass...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Bristol Myers Squibb Research And Development
Curated by ChEMBL
Bristol Myers Squibb Research And Development
Curated by ChEMBL
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at STING in human THP1 Dual KO-STING cells assessed as IRF reporter activation incubated for 20 hrs by quanti-blue SEAP reporter gen...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Mus musculus)
Bristol Myers Squibb Research And Development
Curated by ChEMBL
Bristol Myers Squibb Research And Development
Curated by ChEMBL
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at STING in mouse RAW-Lucia ISG-KO-STING cells assessed as IRF reporter activation incubated for 20 hrs by quanti-blue SEAP reporter...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Bristol Myers Squibb Research And Development
Curated by ChEMBL
Bristol Myers Squibb Research And Development
Curated by ChEMBL
Affinity DataEC50: 6.00E+4nMAssay Description:Agonist activity at STING in human THP1-Dual cells assessed as NF-kappaB reporter activation incubated for 20 hrs by quanti-blue SEAP reporter gene a...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Bristol Myers Squibb Research And Development
Curated by ChEMBL
Bristol Myers Squibb Research And Development
Curated by ChEMBL
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at STING in human THP1-Dual KO-STING cells assessed as NF-kappaB reporter activation incubated for 20 hrs by quanti-blue SEAP report...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Bristol Myers Squibb Research And Development
Curated by ChEMBL
Bristol Myers Squibb Research And Development
Curated by ChEMBL
Affinity DataEC50: 6.80E+3nMAssay Description:Binding affinity to wild type human His-tagged STING cytoplasmic domain (155 to 341 residues) assessed as induction of protein dimerization incubated...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Bristol Myers Squibb Research And Development
Curated by ChEMBL
Bristol Myers Squibb Research And Development
Curated by ChEMBL
Affinity DataEC50: 62nMAssay Description:Binding affinity to human STING G230A/R293Q double mutant cytoplasmic domain (155 to 341 residues) assessed as induction of protein dimerization incu...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Bristol Myers Squibb Research And Development
Curated by ChEMBL
Bristol Myers Squibb Research And Development
Curated by ChEMBL
Affinity DataEC50: 1.59E+4nMAssay Description:Activation of STING in human THP-1-Dual cells assessed as induction of type I IFNs by measuring stimulation of NF-kappaB pathway incubated for 48 hrs...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Mus musculus)
Bristol Myers Squibb Research And Development
Curated by ChEMBL
Bristol Myers Squibb Research And Development
Curated by ChEMBL
Affinity DataEC50: 180nMAssay Description:Binding affinity to wild type mouse His-tagged STING cytoplasmic domain (155 to 341 residues) assessed as induction of protein dimerization incubated...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Mus musculus)
Bristol Myers Squibb Research And Development
Curated by ChEMBL
Bristol Myers Squibb Research And Development
Curated by ChEMBL
Affinity DataEC50: 8.40E+3nMAssay Description:Activation of STING in mouse RAW-Lucia ISG cells assessed as induction of type I IFNs stimulation by measuring induction of IRF pathway incubated for...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Bristol Myers Squibb Research And Development
Curated by ChEMBL
Bristol Myers Squibb Research And Development
Curated by ChEMBL
Affinity DataEC50: 5.10E+3nMAssay Description:Activation of STING in human THP-1-Dual cells assessed as induction of type I IFNs by measuring stimulation of IRF pathway incubated for 48 hrs by lu...More data for this Ligand-Target Pair
