BindingDB PrimarySearch

Found 27 Enz. Inhib. hit(s) with Target = 'Tubulin beta chain' and Ligand = 'BDBM50005480'

Tubulin beta chain(Sus scrofa)
Minia University

Curated by ChEMBL

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 520nMAssay Description:Inhibition of porcine brain tubulin polymerization assessed as decrease in fluorescence intensity measured every 60 sec for 90 mins in presence of GT...More data for this Ligand-Target Pair

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3D Structure (crystal)

Tubulin beta chain(Sus scrofa)
Minia University

Curated by ChEMBL

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 600nMAssay Description:Inhibition of pig brain tubulin polymerizationMore data for this Ligand-Target Pair

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3D Structure (crystal)

Tubulin beta chain(Sus scrofa)
Minia University

Curated by ChEMBL

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 600nMAssay Description:Inhibition of porcine brain tubulin polymerization after 60 minsMore data for this Ligand-Target Pair

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3D Structure (crystal)

Tubulin beta chain(Sus scrofa)
Minia University

Curated by ChEMBL

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 600nMAssay Description:Inhibition of pig tubulin polymerizationMore data for this Ligand-Target Pair

PDB
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3D Structure (crystal)

Tubulin beta chain(Sus scrofa)
Minia University

Curated by ChEMBL

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 1.00E+3nMAssay Description:Inhibition of pig brain tubulin polymerization by spectrometric methodMore data for this Ligand-Target Pair

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3D Structure (crystal)

Tubulin beta chain(Sus scrofa)
Minia University

Curated by ChEMBL

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 1.00E+3nMAssay Description:Inhibition of pig brain tubulin assembly preincubated for 15 mins followed by GTP addition measured after 20 mins by spectrophotometric analysis in p...More data for this Ligand-Target Pair

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3D Structure (crystal)

Tubulin beta chain(Sus scrofa)
Minia University

Curated by ChEMBL

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 1.00E+3nMAssay Description:Inhibition of pig brain tubulin polymerization by spectrophotometric methodMore data for this Ligand-Target Pair

PDB
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3D Structure (crystal)

Tubulin beta chain(Sus scrofa)
Minia University

Curated by ChEMBL

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 1.06E+3nMAssay Description:Inhibition of porcine brain tubulin polymerization after 1 hr by fluorescence assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Tubulin beta chain(Sus scrofa)
Minia University

Curated by ChEMBL

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 1.10E+3nMAssay Description:Inhibition of pig brain tubulin polymerization in presence of GTP by spectrophotometric analysisMore data for this Ligand-Target Pair

PDB
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3D Structure (crystal)

Tubulin beta chain(Sus scrofa)
Minia University

Curated by ChEMBL

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 1.30E+3nMAssay Description:Inhibition of pig brain tubulin polymerization by spectrophotometeric analysisMore data for this Ligand-Target Pair

PDB
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3D Structure (crystal)

Tubulin beta chain(Sus scrofa)
Minia University

Curated by ChEMBL

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 1.32E+3nMAssay Description:Inhibition of porcine brain tubulin polymerization after 30 mins by spectrophotometryMore data for this Ligand-Target Pair

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3D Structure (crystal)

Tubulin beta chain(Sus scrofa)
Minia University

Curated by ChEMBL

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 1.60E+3nMAssay Description:Inhibition of pig brain tubulin polymerization by spectrophotometric methodMore data for this Ligand-Target Pair

PDB
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3D Structure (crystal)

Tubulin beta chain(Sus scrofa)
Minia University

Curated by ChEMBL

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 1.77E+3nMAssay Description:Inhibition of porcine brain tubulin assembly measured every 1 min for 60 mins by turbidimetric analysisMore data for this Ligand-Target Pair

PDB
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3D Structure (crystal)

Tubulin beta chain(Sus scrofa)
Minia University

Curated by ChEMBL

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 1.87E+3nMAssay Description:Inhibition of porcine brain tubulin polymerization measured at 1 min interval for 1 hr by fluorescence plate reader assayMore data for this Ligand-Target Pair

PDB
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3D Structure (crystal)

Tubulin beta chain(Sus scrofa)
Minia University

Curated by ChEMBL

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 2.12E+3nMAssay Description:Inhibition of porcine brain tubulin polymerization preincubated for 30 mins and measured every 2 mins for 60 mins by spectrophotometric analysisMore data for this Ligand-Target Pair

PDB
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3D Structure (crystal)

Tubulin beta chain(Sus scrofa)
Minia University

Curated by ChEMBL

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

PDB
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3D Structure (crystal)

Tubulin beta chain(Sus scrofa)
Minia University

Curated by ChEMBL

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 2.18E+3nMAssay Description:Inhibition of porcine brain tubulin polymerizationMore data for this Ligand-Target Pair

PDB
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3D Structure (crystal)

Tubulin beta chain(Sus scrofa)
Minia University

Curated by ChEMBL

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 2.18E+3nMAssay Description:Inhibition of porcine brain tubulin polymerizationMore data for this Ligand-Target Pair

PDB
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3D Structure (crystal)

Tubulin beta chain(Sus scrofa)
Minia University

Curated by ChEMBL

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 2.20E+3nMAssay Description:Inhibition of pig tubulin polymerization by spectrophotometryMore data for this Ligand-Target Pair

PDB
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3D Structure (crystal)

Tubulin beta chain(Sus scrofa)
Minia University

Curated by ChEMBL

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 2.48E+3nMAssay Description:Inhibition of porcine brain tubulin polymerization incubated for 60 mins by fluorescence-based assayMore data for this Ligand-Target Pair

PDB
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3D Structure (crystal)

Tubulin beta chain(Sus scrofa)
Minia University

Curated by ChEMBL

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 2.53E+3nMAssay Description:Inhibition of porcine brain tubulin polymerization measured every 2 mins for 60 mins by spectrophotometric analysisMore data for this Ligand-Target Pair

PDB
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3D Structure (crystal)

Tubulin beta chain(Sus scrofa)
Minia University

Curated by ChEMBL

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 2.61E+3nMAssay Description:Inhibition of porcine brain tubulin assessed as changes in the fluorescence intensity measured for 60 mins by cell free tubulin polymerization assayMore data for this Ligand-Target Pair

PDB
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3D Structure (crystal)

Tubulin beta chain(Sus scrofa)
Minia University

Curated by ChEMBL

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 3.90E+3nMAssay Description:Inhibition of pig brain tubulin polymerization at 37 degC by turbidimetry analysisMore data for this Ligand-Target Pair

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3D Structure (crystal)

Tubulin beta chain(Sus scrofa)
Minia University

Curated by ChEMBL

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 4.00E+3nMAssay Description:In vitro tubulin polymerization-inhibitory activity.More data for this Ligand-Target Pair

PDB
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3D Structure (crystal)

Tubulin beta chain(Sus scrofa)
Minia University

Curated by ChEMBL

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 4.22E+3nMAssay Description:Inhibition of pig brain tubulin polymerization by spectrophotometric analysisMore data for this Ligand-Target Pair

PDB
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3D Structure (crystal)

Tubulin beta chain(Sus scrofa)
Minia University

Curated by ChEMBL

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 4.50E+3nMAssay Description:Inhibition of porcine brain tubulin polymerization by turbidity assayMore data for this Ligand-Target Pair

PDB
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3D Structure (crystal)

Tubulin beta chain(Sus scrofa)
Minia University

Curated by ChEMBL

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

Kd: 3.51E+3nMAssay Description:Binding affinity to porcine brain tubulin assessed as changes in the fluorescence incubated for 10 mins tryptophan-based binding assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Filter my 27 hits

Targets 1▿
- Tubulin beta chain 27
Publications 23▿
- Eur J Med Chem 163: 428-442 (2019) 2
- Eur J Med Chem 163: 896-910 (2019) 2
- RSC Med Chem 12: 1374-1380 (2021) 1
- Bioorg Med Chem Lett 26: 4527-4535 (2016) 1
- Eur J Med Chem 235: (2022) 1
- J Med Chem 62: 993-1013 (2019) 1
- Eur J Med Chem 162: 525-533 (2019) 1
- Bioorg Med Chem 73: (2022) 1
- J Med Chem 59: 5341-55 (2016) 1
- J Med Chem 55: 2112-24 (2012) 1
- Bioorg Med Chem 24: 1729-40 (2016) 1
- J Med Chem 55: 5720-33 (2012) 1
- Bioorg Med Chem Lett 22: 6731-4 (2012) 1
- Bioorg Med Chem Lett 8: 1997-2000 (1998) 1
- Bioorg Med Chem 21: 7381-91 (2013) 1
- Bioorg Med Chem 18: 6874-85 (2010) 1
- Eur J Med Chem 184: (2019) 1
- Bioorg Med Chem 16: 4829-38 (2008) 1
- J Med Chem 56: 6829-44 (2013) 1
- Eur J Med Chem 183: (2019) 1
- Eur J Med Chem 183: (2019) 1
- Bioorg Med Chem 20: 234-42 (2012) 1
- Bioorg Med Chem 19: 6042-54 (2011) 1
Institutions 17▿
- China Pharmaceutical University 3
- Southern Medical University 3
- University Of Oslo 3
- Csir-Indian Institute Of Chemical Technology 2
- Nanjing University 2
- University Of Milan-Bicocca 1
- University Of Salford 1
- University Of Lille 1
- The University Of Tokyo 1
- Peking University 1
- Fudan University 1
- Shandong University 1
- University Of Tokyo 1
- Minia University 1
- Shanghai Institute Of Technology 1
- Duquesne University 1
- Second Military Medical University 1
Affinity: 5.2E+2 to 4.5E+3 nM▿
- IC50 26
- Kd 1
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 1