Found 11 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK3' and Ligand = 'BDBM50335231' TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Fox Chase Chemical Diversity Center
Curated by ChEMBL
Fox Chase Chemical Diversity Center
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Fox Chase Chemical Diversity Center
Curated by ChEMBL
Fox Chase Chemical Diversity Center
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of human JAK3 using GEEEEYFELVKKKK as substrate in presence of 10 uM [gamma33P]ATP by radiometric methodMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Fox Chase Chemical Diversity Center
Curated by ChEMBL
Fox Chase Chemical Diversity Center
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of human N-terminal His-tagged JAK3 (795 to 1124 residues) expressed in baculovirus expression system in presence of 6 uM ATP by HTRF assa...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Fox Chase Chemical Diversity Center
Curated by ChEMBL
Fox Chase Chemical Diversity Center
Curated by ChEMBL
Affinity DataIC50: 8nMpH: 7.5 T: 2°CAssay Description:Enzyme assay affinity-purified GST fusions of the active kinase domains (GST-Jak1(866-1154), GST-Jak2(808-1132), GST-Jak3(811-1124) and GST-Tyk2(888-...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Fox Chase Chemical Diversity Center
Curated by ChEMBL
Fox Chase Chemical Diversity Center
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of GST-tagged Jak3 expressed in insect cells using 18 uM ATPMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Fox Chase Chemical Diversity Center
Curated by ChEMBL
Fox Chase Chemical Diversity Center
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant human JAK3 (781 to 1124 residues) expressed in baculovirus expression system assessed as reduction in polypeptide substrate...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Fox Chase Chemical Diversity Center
Curated by ChEMBL
Fox Chase Chemical Diversity Center
Curated by ChEMBL
Affinity DataIC50: 525nMAssay Description:Inhibition of Jak3-mediated IL15-induced Stat5 phosphorylation in human MO7 cells by cell-based assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Fox Chase Chemical Diversity Center
Curated by ChEMBL
Fox Chase Chemical Diversity Center
Curated by ChEMBL
Affinity DataIC50: 685nMAssay Description:Inhibition of human N-terminal His-tagged JAK3 (795 to 1124 residues) expressed in baculovirus expression system in presence of 1 mM ATP by HTRF assa...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK3(Mus musculus)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 1.29E+3nMAssay Description:Inhibition of Jak3-mediated IL2-induced Stat5 phosphorylation in mouse CTLL cells by cell-based assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Fox Chase Chemical Diversity Center
Curated by ChEMBL
Fox Chase Chemical Diversity Center
Curated by ChEMBL
Affinity DataEC50: 1.04E+3nMAssay Description:Inhibition of JAK3 in human CTLL2 cells assessed as reduction in IL15-induced STAT5 phosphorylation preincubated for 2 hrs followed by IL15 stimulati...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Fox Chase Chemical Diversity Center
Curated by ChEMBL
Fox Chase Chemical Diversity Center
Curated by ChEMBL
Affinity DataEC50: 2.00E+3nMAssay Description:Inhibition of JAK3 in human CTLL2 cells assessed as reduction in IL2-induced STAT5 phosphorylation preincubated for 2 hrs followed by IL2 stimulation...More data for this Ligand-Target Pair
