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Found 316 with Last Name = 'chakrabarti' and Initial = 'pp'
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50253105(6-Chloro-N-cyclopropyl-7-(1-((S)-3-methylmorpholin...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human recombinant GST-tagged p38alphaMAPK-induced ATF2 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50253148(CHEMBL522689 | N-(S)-sec-Butyl-6-(6-methyl-3-(meth...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human recombinant GST-tagged p38alphaMAPK-induced ATF2 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50252776(CHEMBL495493 | N-Ethyl-6-methyl-7-(1-((S)-3-methyl...)
Affinity DataKi:  0.300nMAssay Description:Inhibition of human recombinant GST-tagged p38alphaMAPK-induced ATF2 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50253102(6-Methyl-7-(1-((S)-3-methylmorpholino)phthalazin-6...)
Affinity DataKi:  0.300nMAssay Description:Inhibition of human recombinant GST-tagged p38alphaMAPK-induced ATF2 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50253150(CHEMBL493496 | N,6-Dimethyl-7-(1-((R)-3-methylmorp...)
Affinity DataKi:  0.300nMAssay Description:Inhibition of human recombinant GST-tagged p38alphaMAPK-induced ATF2 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50253103(7-(1-Isopropoxyphthalazin-6-yl)-N,6-dimethylbenzo[...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of human recombinant GST-tagged p38alphaMAPK-induced ATF2 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50252735(CHEMBL495084 | N-Cyclopropyl-6-methyl-7-(1-o-tolyl...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of human recombinant GST-tagged p38alphaMAPK-induced ATF2 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50252777(CHEMBL523374 | N,6-Dimethyl-7-(1-((S)-3-methylmorp...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of human recombinant GST-tagged p38alphaMAPK-induced ATF2 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50253149(6-Chloro-N-isopropyl-7-(1-((S)-3-methylmorpholino)...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of human recombinant GST-tagged p38alphaMAPK-induced ATF2 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50252775(6-(3-(cyclopropylamino)-6-methylbenzo[d]isoxazol-7...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of human recombinant GST-tagged p38alphaMAPK-induced ATF2 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50253147(CHEMBL494305 | N-Isopropyl-6-(6-methyl-3-(methylam...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of human recombinant GST-tagged p38alphaMAPK-induced ATF2 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50253104(CHEMBL521860 | N-(6-Methyl-7-(1-((S)-3-methylmorph...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of human recombinant GST-tagged p38alphaMAPK-induced ATF2 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50252736(CHEMBL522877 | N-Cyclopropyl-6-methyl-7-(1-((S)-3-...)
Affinity DataKi:  0.700nMAssay Description:Inhibition of human recombinant GST-tagged p38alphaMAPK-induced ATF2 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50252774(1-((S)-4-(6-(3-(Cyclopropylamino)-6-methylbenzo[d]...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of human recombinant GST-tagged p38alphaMAPK-induced ATF2 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50253101(7-(1-Isopropylphthalazin-6-yl)-N,6-dimethylbenzo[d...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of human recombinant GST-tagged p38alphaMAPK-induced ATF2 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50252777(CHEMBL523374 | N,6-Dimethyl-7-(1-((S)-3-methylmorp...)
Affinity DataKi:  1.80nMAssay Description:Inhibition of human recombinant GST-tagged p38beta-induced ATF2 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50252738(6-Methyl-7-(1-((S)-3-methylmorpholino)phthalazin-6...)
Affinity DataKi:  2nMAssay Description:Inhibition of human recombinant GST-tagged p38alphaMAPK-induced ATF2 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50253151(6-Methyl-7-(1-((S)-3-methylmorpholino)phthalazin-6...)
Affinity DataKi:  16nMAssay Description:Inhibition of human recombinant GST-tagged p38alphaMAPK-induced ATF2 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264967((2S)-N-(2-(6-(2-acetamidobenzo[d]thiazol-4-yloxy)p...)
Affinity DataIC50:  0.0690nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced 45Ca2+ influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264925((S)-N-(2-(6-(2-acetamidobenzo[d]thiazol-4-yloxy)py...)
Affinity DataIC50:  0.360nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced 45Ca2+ influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50241325(CHEMBL251348 | N-(4-(2-(1-isobutyl-1,2,3,6-tetrahy...)
Affinity DataIC50:  0.400nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of acid induced calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20464((2E)-3-[2-(piperidin-1-yl)-6-(trifluoromethyl)pyri...)
Affinity DataIC50:  0.420nMAssay Description:Inhibition of capsaicin-induced calcium uptake by transient receptor potential vanilloid type 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50265041(CHEMBL525804 | N-(4-(6-(2-(1-(pyridin-2-yl)ethylam...)
Affinity DataIC50:  0.480nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced 45Ca2+ influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM20557(AMG 517 | CHEMBL229430 | JMC503515 Compound 23 | N...)
Affinity DataIC50:  0.5nMpH: 5.0Assay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of pH 5 acid-induced 45Ca2+ influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM20557(AMG 517 | CHEMBL229430 | JMC503515 Compound 23 | N...)
Affinity DataIC50:  0.5nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of acid induced calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264927((R)-N-(2-(6-(2-acetamidobenzo[d]thiazol-4-yloxy)py...)
Affinity DataIC50:  0.530nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced 45Ca2+ influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50252781(CHEMBL493670 | N-Cyclopropyl-4-methyl-3-(1-(1-meth...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of p38alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50253155(CHEMBL492266 | N-Cyclopropyl-4-methyl-3-(4-(1-meth...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of p38alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50225031(CHEMBL251565 | tert-butyl 4-(4-(2-acetamidobenzo[d...)
Affinity DataIC50:  0.600nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of acid induced calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264965((S)-N-(2-(6-(2-acetamidobenzo[d]thiazol-4-yloxy)py...)
Affinity DataIC50:  0.680nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced 45Ca2+ influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50253152(CHEMBL493708 | N-Cyclopropyl-4-methyl-3-(1-((R)-2,...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of p38alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50253154(CHEMBL492265 | N-Cyclopropyl-4-methyl-3-(1-(2-meth...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of p38alpha (unknown origin)More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM20557(AMG 517 | CHEMBL229430 | JMC503515 Compound 23 | N...)
Affinity DataIC50:  0.900nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced 45Ca2+ influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM20557(AMG 517 | CHEMBL229430 | JMC503515 Compound 23 | N...)
Affinity DataIC50:  0.900nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of capsaicin induced calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50265003(CHEMBL500900 | N-(2-(6-(2-acetamidobenzo[d]thiazol...)
Affinity DataIC50:  1nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced 45Ca2+ influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20464((2E)-3-[2-(piperidin-1-yl)-6-(trifluoromethyl)pyri...)
Affinity DataIC50:  1nMAssay Description:Inhibition of pH-induced calcium uptake by transient receptor potential vanilloid type 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50252782(CHEMBL493671 | N-Cyclopropyl-4-methyl-3-(1-((S)-2,...)
Affinity DataIC50:  1nMAssay Description:Inhibition of p38alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50241322(CHEMBL398411 | N-(4-(2-morpholino-6-(4-(trifluorom...)
Affinity DataIC50:  1.10nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of acid induced calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50252779(CHEMBL494469 | N-Cyclopropyl-4-methyl-3-(1-((3S)-3...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of p38alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50225032(CHEMBL249731 | N-(4-(2-(pyridin-4-yl)-6-(4-(triflu...)
Affinity DataIC50:  1.10nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of acid induced calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50158665((E)-3-(4-tert-Butyl-phenyl)-N-quinolin-7-yl-acryla...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of capsaicin-induced calcium uptake by transient receptor potential vanilloid type 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264968(CHEMBL500380 | N-(2-(6-(2-acetamidobenzo[d]thiazol...)
Affinity DataIC50:  1.20nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced 45Ca2+ influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50252778(CHEMBL494272 | N-Cyclopropyl-4-methyl-3-(1-(4-morp...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of p38alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50158658((E)-3-(2-Morpholin-4-yl-6-trifluoromethyl-pyridin-...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of pH-induced calcium uptake by transient receptor potential vanilloid type 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50225033(CHEMBL249983 | N-(4-(2-methyl-6-(4-(trifluoromethy...)
Affinity DataIC50:  1.40nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of acid induced calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50225038(CHEMBL250185 | N-(4-(2-(piperidin-1-yl)-6-(4-(trif...)
Affinity DataIC50:  1.5nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of acid induced calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50225027(CHEMBL400571 | N-(4-(2-(1-(pyridin-2-yl)ethylamino...)
Affinity DataIC50:  1.5nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of capsaicin induced calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50225027(CHEMBL400571 | N-(4-(2-(1-(pyridin-2-yl)ethylamino...)
Affinity DataIC50:  1.60nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of acid induced calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50225031(CHEMBL251565 | tert-butyl 4-(4-(2-acetamidobenzo[d...)
Affinity DataIC50:  1.80nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of capsaicin induced calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50158658((E)-3-(2-Morpholin-4-yl-6-trifluoromethyl-pyridin-...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of capsaicin-induced calcium uptake by transient receptor potential vanilloid type 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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