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Found 1443 with Last Name = 'gauthier' and Initial = 'jy'
TargetProstaglandin E2 receptor EP2 subtype(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
In DepthDetails PubMed
TargetProstaglandin E2 receptor EP2 subtype(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataKi:  18nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin E2 receptor EP2 subtype(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM22369(4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofu...)
Affinity DataKi:  18nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin E2 receptor EP3 subtype(RAT)
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataKi:  18nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin E2 receptor EP2 subtype(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataKi:  19.8nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin E2 receptor EP2 subtype(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataKi:  21nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin E2 receptor EP2 subtype(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM22369(4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofu...)
Affinity DataKi:  26nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin E2 receptor EP2 subtype(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataKi:  27nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin E2 receptor EP3 subtype(RAT)
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM22369(4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofu...)
Affinity DataKi:  41nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin E2 receptor EP2 subtype(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM22369(4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofu...)
Affinity DataKi:  45nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin E2 receptor EP3 subtype(RAT)
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM22369(4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofu...)
Affinity DataKi:  46nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM50174201(ARTHROTEC | GP 45840 | SOLARAZE | Sodium; [2-(2,6-...)
Affinity DataKi:  50nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin E2 receptor EP2 subtype(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataKi:  57nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin E2 receptor EP2 subtype(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataKi:  100nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM50174201(ARTHROTEC | GP 45840 | SOLARAZE | Sodium; [2-(2,6-...)
Affinity DataKi:  150nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataKi:  190nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin E2 receptor EP3 subtype(RAT)
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataKi:  300nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin E2 receptor EP2 subtype(Dog)
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataKi:  300nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM22369(4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofu...)
Affinity DataKi:  340nMMore data for this Ligand-Target Pair
TargetCysteinyl leukotriene receptor 1(GUINEA PIG)
TBA

Curated by ChEMBL
LigandPNGBDBM50025103(CHEMBL41301 | Sodium; 4-{4-[3-(4-acetyl-3-hydroxy-...)
Affinity DataKi:  400nMAssay Description:Compound was tested for inhibition of radioligand [3H]-LTD4 binding to Cysteinyl leukotriene D4 receptor in guinea pig lung membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataKi:  400nMMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM22369(4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofu...)
Affinity DataKi:  400nMMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataKi:  440nMMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM22369(4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofu...)
Affinity DataKi:  530nMMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataKi:  600nMMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM50056998(4-Hydroxy-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[e...)
Affinity DataKi:  700nMMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataKi:  960nMMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM50056998(4-Hydroxy-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[e...)
Affinity DataKi:  1.40E+3nMMore data for this Ligand-Target Pair
TargetProstaglandin E2 receptor EP2 subtype(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM22369(4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofu...)
Affinity DataKi:  2.00E+3nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCysteinyl leukotriene receptor 1(GUINEA PIG)
TBA

Curated by ChEMBL
LigandPNGBDBM50025103(CHEMBL41301 | Sodium; 4-{4-[3-(4-acetyl-3-hydroxy-...)
Affinity DataKi:  8.60E+3nMAssay Description:Compound was tested for inhibition of radioligand [3H]-LTC4 binding to Cysteinyl leukotriene D4 receptor in guinea pig lung membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP2 subtype(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM22369(4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofu...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM22369(4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofu...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM22369(4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofu...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin E2 receptor EP3 subtype(RAT)
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM22369(4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofu...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin E2 receptor EP2 subtype(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM22369(4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofu...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin E2 receptor EP2 subtype(Dog)
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM22369(4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofu...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLeukotriene B4 receptor 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM22369(4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofu...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin E2 receptor EP2 subtype(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM22369(4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofu...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCathepsin K(Oryctolagus cuniculus (rabbit))
Merck Frosst Centre For Therapeutic Research

LigandPNGBDBM19518((2S)-N-(cyanomethyl)-4-methyl-2-{[(1S)-2,2,2-trifl...)
Affinity DataIC50: <0.00500nMAssay Description:Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Oryctolagus cuniculus (rabbit))
Merck Frosst Centre For Therapeutic Research

LigandPNGBDBM19524((2S)-N-(cyanomethyl)-4-methyl-2-{[(1S)-2,2,2-trifl...)
Affinity DataIC50:  0.100nMAssay Description:Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Oryctolagus cuniculus (rabbit))
Merck Frosst Centre For Therapeutic Research

LigandPNGBDBM19530((2S)-N-(cyanomethyl)-4-methyl-2-{[(1S)-2,2,2-trifl...)
Affinity DataIC50:  0.100nMAssay Description:Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteinyl leukotriene receptor 1/2(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50069352((1-{(R)-1-{3-[(E)-2-(7,7-Dimethyl-5,6,7,8-tetrahyd...)
Affinity DataIC50:  0.170nMAssay Description:In vitro inhibition of [3H]LTD4 binding to LTD4 receptor of guinea pig lung membrane with human serum albumin (HSA).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteinyl leukotriene receptor 1/2(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50069352((1-{(R)-1-{3-[(E)-2-(7,7-Dimethyl-5,6,7,8-tetrahyd...)
Affinity DataIC50:  0.190nMAssay Description:In vitro inhibition of [3H]-LTD4 binding to LTD4 receptor of guinea pig lung membrane without human serum albumin (HSA).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteinyl leukotriene receptor 1/2(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50069356((R)-2-(1-((3-(2-(2-hydroxypropan-2-yl)phenyl)-1-(3...)
Affinity DataIC50:  0.190nMAssay Description:In vitro inhibition of [3H]-LTD4 binding to LTD4 receptor of guinea pig lung membrane without human serum albumin (HSA).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteinyl leukotriene receptor 1(GUINEA PIG)
TBA

Curated by ChEMBL
LigandPNGBDBM50286261((S)-2-{(R)-1-{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vi...)
Affinity DataIC50:  0.200nMAssay Description:Concentration required for inhibition of binding of [3H]-LTD4 to guinea pig lung membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255753(CHEMBL481611 | MK-0822 | Odanacatib)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255753(CHEMBL481611 | MK-0822 | Odanacatib)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50306309(1-(4'-((S)-1-((S)-1-(1-cyanocyclopropylamino)-4-fl...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50306307((S)-2-((S)-1-(4'-((S)-1-amino-1-oxopropan-2-yl)bip...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50306306((S)-N-(1-cyanocyclopropyl)-4-fluoro-4-methyl-2-((S...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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