TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Key Laboratory Of Technology Of Drug Preparation (Zhengzhou University)
Curated by ChEMBL
Key Laboratory Of Technology Of Drug Preparation (Zhengzhou University)
Curated by ChEMBL
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of VEGFR2 (unknown origin) using ULight-4E-BP1 peptide as substrate incubated for 1 hr in presence of ATP by fluorescence based analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0800nMAssay Description:An in vitro kinase assay was performed to evaluate the kinase suppression activity of the most promising cytotoxic candidates 4b, 4j against four dif...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Key Laboratory Of Technology Of Drug Preparation (Zhengzhou University)
Curated by ChEMBL
Key Laboratory Of Technology Of Drug Preparation (Zhengzhou University)
Curated by ChEMBL
Affinity DataIC50: 0.160nMAssay Description:Inhibition of human N-terminal His-tagged non-phosphorylated VEGFR2 preincubated for 120 mins in presence of ATP by AlphaScreen analysisMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Key Laboratory Of Technology Of Drug Preparation (Zhengzhou University)
Curated by ChEMBL
Key Laboratory Of Technology Of Drug Preparation (Zhengzhou University)
Curated by ChEMBL
Affinity DataIC50: 0.170nMAssay Description:Inhibition of VEGFR2 (unknown origin) after 1 hr by ADP-Glo reagent based luminescent assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Key Laboratory Of Technology Of Drug Preparation (Zhengzhou University)
Curated by ChEMBL
Key Laboratory Of Technology Of Drug Preparation (Zhengzhou University)
Curated by ChEMBL
Affinity DataIC50: 0.170nMAssay Description:Inhibition of VEGFR-2 (unknown origin) after 1 hrs by ADP-Glo luminescence assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Key Laboratory Of Technology Of Drug Preparation (Zhengzhou University)
Curated by ChEMBL
Key Laboratory Of Technology Of Drug Preparation (Zhengzhou University)
Curated by ChEMBL
Affinity DataIC50: 0.170nMAssay Description:Relative binding affinity for human estrogen receptor alpha by displacement of [3H]-estradiolMore data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Inhibition of EphB4 (unknown origin) after 60 mins by ADP-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.220nMAssay Description:Inhibition of EphB4 (unknown origin) after 1 hrs by ADP-Glo luminescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.220nMAssay Description:Inhibition of EPHB4 (unknown origin) after 4 hrs by ADP-Glo reagent based luminescent assayMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
King Abdulaziz University
US Patent
King Abdulaziz University
US Patent
Affinity DataIC50: 0.260nMAssay Description:An in vitro kinase assay was performed to evaluate the kinase suppression activity of the most promising cytotoxic candidates 4b, 4j against four dif...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Key Laboratory Of Technology Of Drug Preparation (Zhengzhou University)
Curated by ChEMBL
Key Laboratory Of Technology Of Drug Preparation (Zhengzhou University)
Curated by ChEMBL
Affinity DataIC50: 0.340nMAssay Description:An in vitro kinase assay was performed to evaluate the kinase suppression activity of the most promising cytotoxic candidates 4b, 4j against four dif...More data for this Ligand-Target Pair
Affinity DataIC50: 0.390nMAssay Description:Inhibition of TIE2 (unknown origin) after 4 hrs by ADP-Glo reagent based luminescent assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.390nMAssay Description:Inhibition of Tie-2 (unknown origin) after 1 hrs by ADP-Glo luminescence assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Key Laboratory Of Technology Of Drug Preparation (Zhengzhou University)
Curated by ChEMBL
Key Laboratory Of Technology Of Drug Preparation (Zhengzhou University)
Curated by ChEMBL
Affinity DataIC50: 0.450nMAssay Description:Inhibition of VEGFR2 (unknown origin) after 60 mins by ADP-Glo assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Key Laboratory Of Technology Of Drug Preparation (Zhengzhou University)
Curated by ChEMBL
Key Laboratory Of Technology Of Drug Preparation (Zhengzhou University)
Curated by ChEMBL
Affinity DataIC50: 0.480nMAssay Description:Inhibition of VEGFR-2 (unknown origin) after 1 hr by ADP-Glo assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Key Laboratory Of Technology Of Drug Preparation (Zhengzhou University)
Curated by ChEMBL
Key Laboratory Of Technology Of Drug Preparation (Zhengzhou University)
Curated by ChEMBL
Affinity DataIC50: 0.480nMAssay Description:Inhibition of VEGFR-2 (unknown origin) after 1 hr by ADP-Glo assayMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
King Abdulaziz University
US Patent
King Abdulaziz University
US Patent
Affinity DataIC50: 0.560nMAssay Description:An in vitro kinase assay was performed to evaluate the kinase suppression activity of the most promising cytotoxic candidates 4b, 4j against four dif...More data for this Ligand-Target Pair
Affinity DataIC50: 0.830nMAssay Description:Inhibition of TIE-2 (unknown origin) after 60 mins by ADP-Glo assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Key Laboratory Of Technology Of Drug Preparation (Zhengzhou University)
Curated by ChEMBL
Key Laboratory Of Technology Of Drug Preparation (Zhengzhou University)
Curated by ChEMBL
Affinity DataIC50: 0.850nMAssay Description:Inhibition of VEGFR-2 (unknown origin) after 60 mins by ADP-Glo luminescence assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Key Laboratory Of Technology Of Drug Preparation (Zhengzhou University)
Curated by ChEMBL
Key Laboratory Of Technology Of Drug Preparation (Zhengzhou University)
Curated by ChEMBL
Affinity DataIC50: 0.850nMAssay Description:Inhibition of VEGFR2 (unknown origin) using ATP measured luminescence by ADP-Glo Kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMpH: 7.8 T: 2°CAssay Description:To measure compound inhibitor effects on the ability of Raf enzymes to phosphorylate the Mek substrate, a capture ELISA utilizing streptavidin-coated...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Key Laboratory Of Technology Of Drug Preparation (Zhengzhou University)
Curated by ChEMBL
Key Laboratory Of Technology Of Drug Preparation (Zhengzhou University)
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Inhibition of VEGFR2 (unknown origin) after 30 mins by HTRF assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Key Laboratory Of Technology Of Drug Preparation (Zhengzhou University)
Curated by ChEMBL
Key Laboratory Of Technology Of Drug Preparation (Zhengzhou University)
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of VEGFR-2 (unknown origin) assessed as ATP level by luminescence analysisMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Key Laboratory Of Technology Of Drug Preparation (Zhengzhou University)
Curated by ChEMBL
Key Laboratory Of Technology Of Drug Preparation (Zhengzhou University)
Curated by ChEMBL
Affinity DataIC50: 1.30nMAssay Description:Inhibition of VEGFR2 (unknown origin) using Poly E4Y1 substrate after 1 hr by ADP-Glo assayMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human FLT3 ITD mutant using EAIYAAPFAKKK peptide as substrate in presence of 33P-gamma ATP by hotspot kinase assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Key Laboratory Of Technology Of Drug Preparation (Zhengzhou University)
Curated by ChEMBL
Key Laboratory Of Technology Of Drug Preparation (Zhengzhou University)
Curated by ChEMBL
Affinity DataIC50: 1.40nMAssay Description:Inhibition of KDR (unknown origin) incubated for 1 hr assessed as luminescence changes using ATP by ADP-Glo Kinase assayMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 2.80nMAssay Description:Inhibition of FLT3-ITD (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
National Taiwan University
Curated by ChEMBL
National Taiwan University
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of EGFR (unknown origin) incubated for 1 hr assessed as luminescence changes using ATP by ADP-Glo Kinase assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Key Laboratory Of Technology Of Drug Preparation (Zhengzhou University)
Curated by ChEMBL
Key Laboratory Of Technology Of Drug Preparation (Zhengzhou University)
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant GST-tagged VEGFR2 expressed in Sf9 insect cells after 120 mins by Kinase-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of C-RAF kinaseMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Key Laboratory Of Technology Of Drug Preparation (Zhengzhou University)
Curated by ChEMBL
Key Laboratory Of Technology Of Drug Preparation (Zhengzhou University)
Curated by ChEMBL
Affinity DataIC50: 3.10nMAssay Description:Inhibition of VEGFR-2 (unknown origin) incubated for 60 mins by Kinase-Glo luminescent kinase assayMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 3.20nMAssay Description:Inhibition of FLT3 autophosphorylation in human RS4-11 cells after 2 hrs by electrochemiluminescence assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Key Laboratory Of Technology Of Drug Preparation (Zhengzhou University)
Curated by ChEMBL
Key Laboratory Of Technology Of Drug Preparation (Zhengzhou University)
Curated by ChEMBL
Affinity DataIC50: 3.20nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of GST-fused human FLT3 cytoplasmic domain (amino acids 564 to 993) using Ulight-JAK1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Albert Einstein College Of Medicine
Curated by ChEMBL
Albert Einstein College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 4.40nMAssay Description:Inhibition of BRAF V600E mutant in human A375 cells assessed as reduction in ERK phosphorylationMore data for this Ligand-Target Pair
Affinity DataIC50: 4.5nMAssay Description:Inhibition of EphB4 (unknown origin) after 4 hrs by ADP-Glo luminescence assayMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
The First Affiliated Hospital Of Xi'An Jiaotong University
Curated by ChEMBL
The First Affiliated Hospital Of Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 4.60nMAssay Description:Inhibition of FGFR1 (unknown origin) incubated for 1 hr assessed as luminescence changes using ATP by ADP-Glo Kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.60nMAssay Description:Binding affinity against sigma receptor from guinea pig brain (minus cerebellum) homogenates, using the novel [3H]-(+/-)-4 as radioligandMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
University Of Arkansas For Medical Sciences
Curated by ChEMBL
University Of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 5.90nMAssay Description:Inhibition of RET (unknown origin)More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
University Of Arkansas For Medical Sciences
Curated by ChEMBL
University Of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 5.90nMAssay Description:Inhibition of human RET kinase using IGF1Rtide as substrate incubated for 40 mins and measured by ADP-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of RAF1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of RAF1 (unknown origin) using magnesium acetate as substrate incubated for 40 mins in presence of [gamma33P]ATP by scintillation counting...More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of RAF1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of C-Raf in presence of 5 uM ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of recombinant Raf-1 (305 to 648 residues) (unknown origin) expressed in baculovirus expression system using MEk1 as substrate after 25 mi...More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of human C-RAF measured after 40 mins by scintillation countingMore data for this Ligand-Target Pair